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All Journal Jurnal Ilmiah Kedokteran Wijaya Kusuma Syntax Literate: Jurnal Ilmiah Indonesia Journal of General Procedural Dermatology and Venereology Indonesia Jurnal Ilmu Kedokteran dan Kesehatan Gorontalo Journal of Public Health Journal Of Widya Medika Junior Jurnal Pengabdian Masyarakat Bumi Raflesia Bali Dermatology and Venereology Journal Open Access Health Scientific Journal COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat Prominentia Medical Journal Journal of General-Procedural Dermatology & Venereology Indonesia Bali Dermatology Venereology and Aesthetic Journal
Stefani Nurhadi
Fakultas Kedokteran Universitas Ciputra
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Bali Dermatology and Venereology Journal

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The high homeostatic model assessment of insulin resistance as risk factor for acne vulgaris Praharsini, I Gusti Ayu Agung; Wiraguna, Anak Agung Gde Putra; Nurhadi, Stefani
Bali Dermatology and Venereology Journal Vol 1, No 2 (2018)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (268.207 KB) | DOI: 10.15562/bdv.v1i2.8

Abstract

Background: Acne vulgaris (AV) is a common chronic skin disease involving blockage and or inflammation of pilosebaceous glands which usually affects teenagers and young adults. Elevated sebaceous gland secretion, Propionibacterium acne colonization and inflammation, high androgen effects, and follicular hyperproliferation are the main pathogenic factors of AV. IGF-1 and insulin were studied to stimulate sebaceous lipogenesis. In the skin, besides inducing lipid production in human sebocytes IGF-1 also induces keratinocyte proliferation in vitro and in vivo. HOMA-IR is an examination to determine insulin activity in the basal state.Objective: To prove that high HOMA-IR value is a risk factor for the occurrence of acne vulgaris.Methods: This study is a case control analytic study by comparing HOMA-IR in subjects with AV (case group) and non AV (control group). AV is diagnosed based on clinical predilection. Insulin testing was carried out by the immulite 2000 device through the immunochemiluminescent method.Results: Mean HOMA-IR of case group is 2.63 ± 0.29 meanwhile in the control group was 1.71 ± 0.26 (p <0.001). Subjects with high HOMA-IR had 4.8 times higher risk to experience AV compared to patients with normal HOMA-IR values (p <0.001; 95% IK 2,765-8,332). Conclusion: HOMA-IR values in acne patients were higher than controls. A high HOMA-IR value is an AV risk factor.
The high homeostatic model assessment of insulin resistance as risk factor for acne vulgaris I Gusti Ayu Agung Praharsini; Anak Agung Gde Putra Wiraguna; Stefani Nurhadi
Bali Dermatology and Venereology Journal Vol. 1 No. 2 (2018)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/bdv.v1i2.8

Abstract

Background: Acne vulgaris (AV) is a common chronic skin disease involving blockage and or inflammation of pilosebaceous glands which usually affects teenagers and young adults. Elevated sebaceous gland secretion, Propionibacterium acne colonization and inflammation, high androgen effects, and follicular hyperproliferation are the main pathogenic factors of AV. IGF-1 and insulin were studied to stimulate sebaceous lipogenesis. In the skin, besides inducing lipid production in human sebocytes IGF-1 also induces keratinocyte proliferation in vitro and in vivo. HOMA-IR is an examination to determine insulin activity in the basal state.Objective: To prove that high HOMA-IR value is a risk factor for the occurrence of acne vulgaris.Methods: This study is a case control analytic study by comparing HOMA-IR in subjects with AV (case group) and non AV (control group). AV is diagnosed based on clinical predilection. Insulin testing was carried out by the immulite 2000 device through the immunochemiluminescent method.Results: Mean HOMA-IR of case group is 2.63 ± 0.29 meanwhile in the control group was 1.71 ± 0.26 (p <0.001). Subjects with high HOMA-IR had 4.8 times higher risk to experience AV compared to patients with normal HOMA-IR values (p <0.001; 95% IK 2,765-8,332). Conclusion: HOMA-IR values in acne patients were higher than controls. A high HOMA-IR value is an AV risk factor.
Co-Authors Agnes Atmadjaja Agnes Atmadjaja Anak Agung Gde Putra Wiraguna Anak Agung Gde Putra Wiraguna Aura Dhiya Ulhaq Cempaka Harsa Sekarputri David Ferdinandus Desy Hinda Pramita Dewa Ayu Manik Utari Erik Jaya Gunawan Etha Rambung Ferdinand Aprianto Tannus Florence Pribadi Fransisca Suyanto Pangemanan Gumay, Nur Intan Permatasari Hebert Adrianto I Gusti Ayu Agung Praharsini Inez Purnomasari Prajitno Jemina Lewi Santoso Lindarto, Wira Widjaya Minarni Wartiningsih Minarni Watinin Minarni Watiningsih Praharsini, IGAA Pramita, Desy Hinda Salmon Charles P.T. Siahaan Samantha Debora Ang Sayogo, Wiliam Sayogo, William Stephanie Laurensia Budi Stephen Akihiro Wirya Sudargo, Iie Vincent Aurelius Wilhelmus Alvin Kaka Wiraguna, AAGP Wirya, Stephen Akihiro