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Potensi +Dalethyne Terhadap Epitelisasi Luka pada Kulit Tikus yang Diinfeksi Bakteri MRSA William Sayogo
Jurnal Biosains Pascasarjana Vol. 19 No. 1 (2017): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1159.398 KB) | DOI: 10.20473/jbp.v19i1.2017.68-84

Abstract

AbstrakProses penyembuhan luka merupakan bagian regenerasi jaringan kulit untuk memperbaiki kerusakan. Proses ini akan terhambat dengan adanya infeksi bakteri, terutama bakteri MRSA (Methicillin resistant Staphylococcus aureus) yang resisten terhadap antibiotik dan mampu membentuk lapisan biofilm. Penelitian ini bertujuan untuk mengetahui efek topikal +dalethyne terhadap epitelisasi pada proses penyembuhan luka terinfeksi MRSA di kulit tikus wistar. Tiga puluh enam ekor tikus Wistar, berumur 3 bulan, dibagi dalam 6 kelompok, kontrol negatif (didekapitasi hari keempat dan hari keenam), kontrol positif (didekapitasi hari keempat dan keenam), perlakuan (didekapitasi hari keempat dan hari keenam). Perlukaan pada kulit punggung dengan cara diinsisi menggunakan pisau sepanjang 2 cm dan kedalaman sampai subkutan. Luka pada kontrol positif diinfeksikan MRSA, kelompok perlakuan diinfeksikan MRSA dan diaplikasikan +dalethyne. Setelah didekapitasi masing-masing kelompok pada hari ke-4 dan ke-6, jaringan kulit difiksasi dan dibuat preparat dan diberi pewarnaan Hemaktosilin Eosin. Panjang epitel diukur menggunakan Optilab yang dipasang pada mikroskop cahaya. Data panjang epitel dianalisis dengan membandingkan jumlah rerata dan SD. Panjang epitel pada kelompok perlakuan lebih tinggi dibandingkan kontrol positif {(0,46±0,19)vs(0,21±0,16);(0,63±0,76)vs(0,42±0,301), sedang dibandingkan dengan kontrol negatif tidak jauh berbeda pada hari ke-4 dan ke-6 setelah perlukaan. Kesimpulan aplikasi topikal +dalethyne mempercepat epitelisasi pada proses penyembuhan luka kulit tikus yang terinfeksi MRSA.Kata kunci: Penyembuhan luka, infeksi MRSA, +dalethyne, epitelisasi
Efektivitas Pasca Vaksinasi Hepatitis B di Kecamatan Pakal, Surabaya, Jawa Timur William Sayogo; Wira Widjaya Lindarto; Cempaka Harsa Sekarputri; Jemina Lewi Santoso; Stefani Nurhadi; Ferdinand Aprianto Tannus; Inez Purnomasari Prajitno
Gorontalo Journal of Public Health VOLUME 5 NOMOR 2, OKTOBER 2022
Publisher : Universitas Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32662/gjph.v5i2.2461

Abstract

Hepatitis is an infectious disease that is still a concern today and is at risk of becoming a chronic condition with complications of liver function failure.  Screening is carried out to determine the level of response of the body's defense system induced by the vaccine in the population of Pakal district, Surabaya. This study assesses the relationship between antibody status and protection status after vaccination. The study involved 78 people who are eligible to receive the vaccine. After receiving the vaccine, the antibody status is checked and the data obtained were statistically tested and tested for association using a contingency coefficient. From 78 hepatitis B vaccine recipients, 69 people (88,46%) are antibody reactive and 9 people (11.54%) with non-reactive antibody status. From the Chi Square test and the contingency coefficient test, it is shown that there is a relationship between antibody status and protection status (α<0.05; 95% CI). The hepatitis B vaccine provides protection against the risk of hepatitis B virus infection for residents of the Pakal district of Surabaya who have a high-risk lifestyle.
Perception of Medical Students at Ciputra University Aged 17-25 Years Regarding The Importance of Sunscreen Use Gumay, Nur Intan Permatasari; Nurhadi, Stefani; Sayogo, William; Wirya, Stephen Akihiro
Open Access Health Scientific Journal Vol. 6 No. 1 (2025): February 2025
Publisher : Griya Eka Sejahtera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55700/oahsj.v6i1.57

Abstract

Background: The use of  sunscreen is important in the efforts to protect the skin from the dangers of ultraviolet (UV) radiation. Sunscreen contains protective components measured  by sun protection factor (SPF) and UVA protection. The perception of sunscreen use is essential  for maintaining skin  health, especially among medical students who have more excellent knowledge about the harmful effects of UV radiation. Continuous exposure to UV radiation can lead to skin damage, such as sunburn, darkening, the appearance of spots on the face, dullness, premature aging, and even melanoma. This research aimed to provide evaluation, insight, and confidence regarding the importance of sunscreen use. By understanding this perception, it is hoped that we can identify shortcomings in education and develop interventions to promote sunscreen use practices in the broader community.Methods: The research employed a descriptive approach. Data collection was conducted using total sampling techniques with questionnaires distributed to 184 medical students at Ciputra University aged 17 to 25 years.Results: Descriptive tests were performed.Conclusion: Both students who use sunscreen and those who do not express that using sunscreen is important.
Effect of Acupuncture on ST36 Acite Stitches to Accessible Epitelization Accuracies in Rats of Rats Infected of MRSA Bacteria Sayogo, William
Journal of Global Research in Public Health Vol. 3 No. 1 (2018): June
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Epithelialization is part of skin tissue regeneration to repair the damage . This process will be inhibited by the presence of bacterial infections, especially Methicillin resistant Staphylococcus aureus (MRSA ) . Methods: This study aims to determine the effect of stabbing acupuncture needles on ST36 acupoint on epithelization on the healing process of MRSA infected wounds in the skin of wisting rats . Thirty six Wistar rats , 3 months old , are divided into 6 groups , 2 groups of negative control , 2 groups of positive control , 2 groups of treatment group (All are sacrificed on the fourth day and sixth day ) . Injury to the back skin of rats with a knife along the incised 2 cm and depth to subcutaneous . Wound of positive control groups infected by MRSA , wound in the treatment groups also infected MRSA and stabbing at ST36 acupoints . Each group are sacrificed to / for day 4 and 6 , the skin tissue is fixed , made histological preparations , stained with HE . Results: The measurement of the epithelial length using Optilab mounted on a light microscope . The data are analyzed by comparing the mean and SD . The epithelial length of the treatment group is higher than the positive control {(0,46±0,19 ) vs (0,21±0,16 );(0,63±0,76 ) vs (0,42±0,301 )} , being compared with the negative control is not much different . Conclusion: Stabbing acupuncture needles on ST36 acupoint accelerates epithelialization in wound healing of the skin MRSA-infected rat.
GAMBARAN KELAINAN SISTEM SARAF DAN ENDOKRIN PADA AUTISME Sayogo, William
Bahasa Indonesia Vol 1 No 1 (2020): Prominentia Medical Journal
Publisher : Universitas Ciputra Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37715/pmj.v1i1.1431

Abstract

Autisme merupakan bentuk gangguan neurologis yang bersifat kompleks dengan gejala gangguan bersosialisasi yang nyata, perilaku berulang, dan gangguan berbahasa. Autisme selain disebabkan kelainan pada sistem saraf juga disertai adanya gangguan pada sistem endokrin. Kadar hormon testosteron yang tinggi diasumsikan meningkatkan risiko terjadinya autisme pada anak usia dini. Masih sedikit penelitian mengenai hubungan antara autisme dan kelainan pada neuroendokrin. Pembahasan ini akan difokuskan pada kelainan neuroendokrin pada autisme.Kata
Deteksi Kontaminasi Toxoplasma gondii Pada Daging Kambing di Bali dengan Primer BAG1 Santoso, Jemima Lewi; Adrianto, Hebert; Tandean, Victor Setiawan; Yuwono, Victor Kurniawan; Santoso, Novian Budi; Juliasih, Ni Njoman; Sayogo, William; Bravimasta, Bracovanca Diwayestara; Firmanto, Ian Ardhiya; Afifah, Balqis
Ranah Research : Journal of Multidisciplinary Research and Development Vol. 7 No. 6 (2025): Ranah Research : Journal Of Multidisciplinary Research and Development
Publisher : Dinasti Research

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/rrj.v7i6.1710

Abstract

Toxoplasmosis is an infection caused by the protozoan parasite Toxoplasma gondii. One of the transmission routes of T. gondii infection is the consumption of undercooked meat. Goats are an important source of income for farmers in Bali and have been reported to have the potential to carry T. gondii. The aim of this study was to detect the presence of Toxoplasma gondii contamination in goat meat in Kuta and Ubud, Bali, using molecular methods with BAG1 primers. Meat samples obtained from markets in Kuta and Ubud were sectioned, followed by extraction of T. gondii DNA, amplified by PCR, and electrophoresed on a 1% agarose gel. The resulting amplification products were approximately 470 base pairs in size. The study results indicated that goat meat was only successfully obtained from the Kuta market. Examination for the presence of T. gondii parasite in goat meat from the Kuta market targeting the BAG1 gene yielded all negative results (100%). Hygiene in goat husbandry should be maintained and even improved. Meat sold in markets or stores must be routinely inspected to ensure safety. Additionally, meat should be cooked at sufficiently high temperatures, and consumption of undercooked or rare meat should be avoided
Drug Interactions in Autoimmune Systemic Lupus Erythematosus (SLE) Safitri, Rosyida Awalia; Sayogo, William; Muflihan, Yenni; Maela, Nurul; Setiawan, Yuni Wahyuningsih; Rahma, Sita Fauzia
Jurnal Multidisiplin Madani Vol. 4 No. 2 (2024): February, 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/mudima.v4i2.8146

Abstract

One of the factors that influence the success of therapy in autoimmune diseases such as SLE is the interaction of drugs with other active compounds. Several studies have stated that there are drug interactions with drugs or with other active compounds such as herbs which can support therapy or inhibit the effects of drug therapy. This review aims to investigate drug interactions in autoimmune diseases with a focus on systemic lupus erythematosus (SLE). The method used is a systematic review with literature sources in the form of international journals or research articles, and 31 articles met the inclusion criteria. There is evidence of interactions between drugs for the treatment of SLE, such as non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and immunosuppressants. In addition, results were obtained regarding the interaction of SLE therapy with herbal plants such as Cecendet or Physalis angulata L, horsetail, and fertilizing plants such as Manjakani, Kacip Fatimah, Chlorophyll, and Spirulina as well as interactions between drugs in both SLE therapies with other types of SLE drugs and with herbal medicine, these interactions can support or hinder the therapeutic effect of the drug