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All Journal Jurnal Penamas Adi Buana Folia Medica Indonesiana
Megawati, Selvi
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Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Neuroscience

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The potency of alpha lipoic acid as anti inflammatory on the complete freund's adjuvant-induced rheumatoid arthritis in rat model Megawati, Selvi; Rahmadi, Mahardian; Susilo, Imam; Khotib, Junaidi
Folia Medica Indonesiana Vol. 52, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Rheumatoid arthritis (RA) is an autoimmune diseases which is characterized by chronic inflammation of the synovial tissue in joints. This research was designed to investigate the effect of alpha lipoic acid as antioxidant on rats with complete freund's adjuvant (CFA)-induced RA by intra articular injection of complete freund's adjuvant (CFA). ALA was administered orally once a day for 7 days at 30, 60 and 120 mg doses a week after CFA injection. The severity of arthritis was evaluated by joint diameter and latency time on thermal stimulation. Joint diameter and latency time on thermal stimulation will measured on day 0, 3, 5, 7, 10, 12 and 14. Measurement of malondialdehyde (MDA) level in plasma was performed using thiobarbituric acid (TBA) method to assess lipid peroxidation. Histology of joint was examined by microscope following hematoxylin-eosin staining. The result showed that treatment with ALA at 30 mg and 60 mg significantly decreased the joint diameter compared to CFA group (p=0.003; p=0.001 respectively) and rat's latency time on thermal stimulation was also significantly increased compared to CFA group (p=0.015; p=0.026 respectively). Measurement of MDA in CFA group and ALA group had no significant difference. Histological staining indicated that the recovery of the synovial membranes of joint in ALA group had no effect. Results indicated that ALA has the effect to suppress the development of inflammation in RA but not through oxidative stress pathway.
EDUKASI PEMBUATAN SNACK NUTRASETIKA DAUN KELOR SEBAGAI UPAYA PENINGKATAN KESEHATAN MASYARAKAT DI KELURAHAN SEGALAMIDER KOTA BANDAR LAMPUNG Mahdiyyah, Ade Abiyyatun; Arta, Alfa Frista; Megawati, Selvi; Thursina, Cut Syarifa; Nurkhalika, Rachmi; Feladita, Niken; Wulandari, Shinta
Jurnal Penamas Adi Buana Vol 9 No 02 (2026): Jurnal Penamas Adi Buana
Publisher : LPPM Universitas PGRI Adi Buana Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36456/penamas.vol9.no02.a10888

Abstract

  Daun kelor (Moringa oleifera L.) kaya metabolit sekunder seperti flavonoid, antosianin, tanin, alkaloid, dan saponin yang berperan sebagai antioksidan, imunomodulator, antikanker, dan antibakteri. Potensi ini menjadikan daun kelor sebagai bahan unggul untuk produk nutrasetika, termasuk inovasi snack sehat yang bergizi, aman, dan memiliki efek terapi. Mitra Mangga Dua, komunitas ibu rumah tangga di Kelurahan Segalamider, Kota Bandar Lampung, masih memiliki pengetahuan terbatas mengenai pemanfaatan daun kelor dan pengolahan pangan fungsional. Pengembangan snack sehat berbahan daun kelor dapat meningkatkan pemahaman masyarakat mengenai pangan bergizi sekaligus mendukung tujuan SDGs ke-3 dan SDGs ke-8. Produk ini juga berpotensi dikembangkan secara berkelanjutan dan memberi nilai tambah ekonomi. Program Kemitraan Masyarakat (PKM) ini bertujuan memberikan edukasi pembuatan snack sehat daun kelor kepada komunitas Mangga Dua. Kegiatan ini diikuti oleh 18 peserta, mencakup penyuluhan, demonstrasi pembuatan produk, serta pre-test dan post-test untuk mengukur peningkatan pengetahuan. Hasil evaluasi menunjukkan adanya peningkatan pengetahuan yang sangat signifikan, dengan rata-rata nilai pre-test sebesar 30,00% yang meningkat menjadi 96,66% pada post-test. Analisis statistik menunjukkan nilai p = 0.004 (p < 0.05), menandakan adanya perbedaan bermakna sebelum dan sesudah edukasi. Temuan ini menegaskan bahwa edukasi dan demonstrasi efektif meningkatkan pemahaman masyarakat mengenai pemanfaatan daun kelor sebagai pangan fungsional bernilai gizi dan ekonomis
Co-Authors Arta, Alfa Frista Feladita, Niken Imam Susilo Junaidi Khotib Mahardian Rahmadi Mahdiyyah, Ade Abiyyatun Nurkhalika, Rachmi Shinta Wulandari, Shinta Thursina, Cut Syarifa