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All Journal Medical Journal of Indonesia Universa Medicina Majalah Kedokteran Andalas Majalah Patologi Indonesia Indonesian Journal of Cancer The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Glosains: Jurnal Sains Global Indonesia
Nur Rahadiani
Department Of Anatomical Pathology, Faculty Of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Relationship between Clinicopathological Profile and Tumor Budding Status in Colorectal Adenocarcinoma at Dr. Cipto Mangunkusumo General National Hospital: A Retrospective Study Dhuhani, Ika; Handjari, Diah Rini; Rahadiani, Nur; Krisnuhoni, Ening; Stephanie, Marini
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 23, No 3 (2022): VOLUME 23, NUMBER 3, December 2022
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2332022193-199

Abstract

Background: Colorectal adenocarcinoma (CA) is one of the most common malignancies. Tumor budding (TB) status is associated with poor prognosis in patients. Prognosis is influenced by the clinicopathological profile. This study aims to determine the relationship between the clinicopathological profile with TB status in CA at Dr. Cipto Mangunkusumo General National Hospital.Method: A cross-sectional retrospective analytic study using secondary data in the form of cases in large bowel malignancy resection preparations at the Department of Anatomical Pathology in 2019-2021. A total of 213 samples were taken from all cases according to the inclusion and exclusion criteria. Chi square statistical analysis was performed to see the clinicopathological relationship with TB status.Results: Most common TB status were low grade with 92 cases. Most cases were ≥ 50 years old (64.3%), male (50.7%), located in the left colon (77.5%), histopathological degree low grade (85.9%), depth of invasion on pT3 (61.5%), lymphovascular invasion (LVI) (50.2%), lymph node metastasis (52.6%), stage 3 American Joint Committee on Cancer (AJCC (42.3%), without perineural invasion (PNI) (79.3%) and without distant metastases (82.6%). Statistical analysis test showed that there was a significant relationship between the degree of histopathology, depth of invasion, LVI, lymph node metastasis, and AJCC stage (p 0.001) and tumor location (p = 0.036).Conclusion: TB status was significantly related histopathological degree, LVI, lymph node metastasis, depth of invasion, AJCC stage, and tumor location. TB status was not associated with PNI and distant organ metastases. 
The Plausible Use of Mango (Mangifera indica) Peel Isoquercitrin as Adjuvant Therapy for Colorectal Cancer: Translating Research from Bench to Bedside Habiburrahman, Muhammad; Sutopo, Stefanus; Rahadiani, Nur
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 1 (2023): VOLUME 24, NUMBER 1, April, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/241202354-62

Abstract

A deadly and debilitating disease, colorectal cancer (CRC), is rapidly becoming a significant threat to public health. However, current therapeutic approaches are still hampered by various side effects. Due to its benefits and remarkable apoptotic impact on cancer cells, plant-derived flavonoids now garner interest as candidates for cancer therapy. Isoquercitrin, a flavonoid commonly found in fruit plants, especially mangoes, is notable due to its ability to inhibit cancer development through various mechanisms. This review aims to highlight the use of isoquercitrin extracted from mango peels in inhibiting CRC carcinogenesis. A literature search was done on Pubmed, Proquest, and Google Scholar using inclusion and exclusion criteria, and a narrative review was synthesised using the evidence gathered. Validity assessment was done through the the Office of Health Assessment and Translation (OHAT) and Oxford Center for Evidence-Based Medicine (CEBM) critical assessment tools. Evidence suggested that isoquercitrin is promising as adjuvant therapy in CRC. It may inhibit overaccumulation of cytoplasmic β-catenin and its translocation into the nucleus, thus downregulating the expression of target proto-oncogenes leading to carcinogenesis of colon crypts. Isoquercitrin concentration in mango peel is abundant, 557.7 mg/kg in dried mango peel and 31.0 mg/kg in pure extracts. A pharmacology study approved that a daily intake of 5.4 mg/kgBW of isoquercitrin has an effective anticancer effect. This substance has good oral bioavailability and is well-tolerated but inhibits the metabolising enzymes CYP1A1 and CYP1B1. In conclusion, isoquercitrin is a potential adjuvant in inhibiting CRC growth with minimum costs and side effects.
Perbandingan Akurasi Pemeriksaan Imunohistokimia SOX10 dengan DOG1 dalam Mendiagnosis Karsinoma Sel Asinik Kelenjar Liur pada Sediaan FFPE Ricky Handika; Ika Dhuhani; Nur Rahadiani
Majalah Patologi Indonesia Vol. 29 No. 1, Januari 2020
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v29i1.406

Abstract

BackgroundMorphological diversity is a challenge in establishing diagnosis of malignant tumor originated from salivary gland, especially Aciniccell carcinoma (ACC). Immunohistochemical (IHC) staining using DOG1 is often used to help diagnosis of ACC. Lately, IHC SOX10has been reported to have almost the same accuracy to DOG1 staining. This evidence-based case report aims to determine theaccuracy of SOX10 to DOG1 immunohistocheinstry staining in establishing a diagnosis of ACC.MethodsLiterature searches were carried out on the Pubmed, Clinical key, Proquest, ScienceDirect, Scopus, SpringerLink and Wileydatabases. Two journals were relevant to the clinical scenario, then a critical review is carried out using the Diagnostic StudyAppraisal Worksheet from the Center for Evidence-based Medicine, University of Oxford, 2010.ResultsThe accuracy of SOX10 in diagnosing ACC was slightly better than DOG1, with sensitivity reaching 100% and specificity reaching87.76%. The sensitivity of SOX10 and DOG1 is the same, but SOX10 is more specific, and positive predictive value is also betterthan DOG1.ConclusionThe accuracy of SOX10 is better than DOG1 in diagnosing ACC of salivary gland. However, the intensity of SOX10 staining tends tobe rather low compared to DOG1. Therefore, further research is still needed to recommend SOX10 staining in daily practice.
A Scoring System for Patients With Gastro-Intestinal Stromal Tumor Based on Preoperative Abdominal Computed Tomography Scans Findings and Neutrophil-Lymphocyte Ratio as A Predictor for Malignancy Risk Kusnadi, Dana Satria; Putranto, Agi Satria; Wibowo, Taufik Agung; Rahadiani, Nur; Kumalawati, July
Indonesian Journal of Cancer Vol 19, No 4 (2025): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i4.1386

Abstract

Background: The risk of malignancy in Gastrointestinal Stromal Tumors (GISTs) is currently determined based on the National Institute of Health (NIH) and the modified NIH consensus. Abdominal CT scans have been used to determine the characteristics of GIST; the neutrophil-to-lymphocyte ratio (NLR) has also been known to provide prognostic and predictive value in malignancies. In this study, we assessed and developed a scoring system for the malignancy risk of GIST patients based on CT scan findings and preoperative NLR values.Methods: This cross-sectional study was conducted using secondary data. CT scan findings include tumor size, location, shape, growth pattern, margins, contour, calcifications, ulceration, necrosis, organ invasion, vascular enlargement, lymphadenopathy, metastasis, and enhancement pattern. Malignancy risk data using histopathology results were obtained as a standard reference. Inclusion criteria comprised patients diagnosed with GIST through postoperative histopathology and immunohistochemistry, with complete preoperative contrast-enhanced CT scans and hematology test results. Subjects were excluded if they had incomplete data, very small tumors ( 0.5 cm), multiple GISTs or gastric cancer, infections (lung/urinary tract), or trauma at the time of NLR examination. Multivariate analyses were performed to identify predictors of malignancy risk. SPSS version 25 was used for data analysis.Results: A total of 57 subjects were included in the study. A cut-off point of 2.7 was obtained for the NLR value. Bivariate analysis showed that tumor growth patterns (p = 0.003), peritumoral vascular enlargement (p = 0.013), and high NLR values (p = 0.047) were associated with high malignancy risk. Further multivariate analysis showed exophytic growth pattern (p = 0.001, OR = 45.33), mixed growth pattern (p = 0.002, OR = 17.46), and high NLR (p = 0.010, OR = 8.95) as the predictors for malignancy risk. The scoring system using growth pattern and NLR was made with a maximum score of 3. Using a cut-off score of ≥ 2, the scoring system achieved a sensitivity rate of 77.19% and specificity of 81.25%.Conclusions: The malignancy risk of GIST can be assessed by evaluating tumor characteristics through preoperative abdominal CT scans and preoperative NLR value. A score of ≥ 2 based on tumor growth pattern and NLR can help clinicians to assess malignancy risk in GIST patients.
Ketepatan Pemeriksaan Imunohistokimia CK19 Dibandingkan dengan PDX-1 pada Tumor Pankreas dan Anak Sebarnya Rosari, Bayu Perkasa; Linggodigdo, Michelle; Wijaya, Yan Cahya; Stephanie, Marini; Nur Rahadiani
Majalah Patologi Indonesia Vol. 30 No. 3, September 2021
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v30i3.479

Abstract

BackgroundMetastatic adenocarcinoma of unknown origin remains a serious problem in oncology. Pancreatic cancer is often diagnosed when ithas already metastasized. Therefore immunohistochemistry (IHC) examination for detecting metastases of pancreatic origin is veryimportant IHC marker of Pancreatic duodenal homeobox-1 (PDX-1) has a good accuracy for detecting metastases of pancreaticorigin, however it is not readily available in many centers in Indonesia. Instead, IHC marker that is often being used is CK19. Thismarker is not specific, because it is also expressed by gastrointestinal and hepatobilliary tumors. This evidence-based case reportaims to determine the accuracy of CK19 compared with PDX-1 IHC for detecting pancreatic tumor and its metastases.MethodsLiterature searches were conducted on Pubmed/MEDLINE®, Scopus®, Cochrane®databases. Four articles about PDX-1 and 5 articlesabout CK19 that are relevant were found. Those articles were critically appraised.ResultsAll articles are considered valid, as they fulfilled the important criteria for journal validity. A study of CK19 IHC found that this markerhas 100% sensitivity and 6% specificity for diagnosing liver metastases from well-differentiated pancreatic ductal adenocarcinoma.Studies of PDX-1 IHC have different results; a study found that 27 out of 67 were PDX-1 positive in metastases of pancreaticadenocarcinoma origin, while another study found that PDX-1 has 72% sensitivity and 93% specificity for pancreatic neuroendocrinetumor, with 100% sensitivity and 75% specificity for pancreatic neuroendocrine tumor metastases.ConclusionCK19 IHC is highly sensitive for detecting adenocarcinoma metastases of pancreatic origin, thus it can be utilized as a screening test.However, CK19 IHC specificity for detecting adenocarcinoma metastases of pancreatic origin is low compared to PDX-1 IHC
Perbedaan Profil Histomorfologik Jaringan Hati Resipien dan Donor Pascatransplantasi Hati Anak antara Kelompok Pasien Rejeksi dan Tidak Rejeksi di Departemen Patologi Anatomik FKUI/RSCM Periode 2010-2019 Perkasa, Alif Gilang; Stephanie, Marini; Rahadiani, Nur; Handjari, Diah Rini; Krisnuhoni, Ening; Oswari, Hanifah
Majalah Patologi Indonesia Vol. 31 No. 1, Januari 2022
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v31i1.487

Abstract

BackgroundLiver rejection is an immune system response of recipient in which attacking the antigen originating from a donor that can causedamage to the transplanted organ. Although the prevalence of liver rejection has decreased due to the use of immunosuppressivedrugs, it is estimated that 20-40% of recipients still experience rejection and are at risk of re-transplantation and even death. Thisstudy aims to investigating histomorphological characteristics that can play a role as risk factors for rejection by assessing thedifferences in histomorphological characteristics before transplantation between recipient groups with rejection and non-rejection inpediatric liver transplant recipients in the Department of Anatomical Pathology, Faculty of Medicine, University of Indonesia, Dr.Cipto Mangunkusumo (PA-FKUI/RSCM)MethodsThis study was an analytical study with a cross sectional design, using secondary data from the archives of the Department ofAnatomical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo 2010-2019. The clinical andhistopathologic data obtained were analyzed using comparative statistical tests.ResultsRejection were found in 25% of recipients. Rejection were more common in the group of recipients aged >1 (75%), male (58%),cirrhosis 4C (92%) and mild portal inflammation (56%). Rejection were more common in the group of donor with male (66%) andsteatosis ≤10% (92%). There were no significant differences in the histomorphological profiles of recipients and donors with orwithout rejection.ConclusionThe histomorphologic profiles of both recipients and donors were known to be descriptively associated with complications of posttransplant liver rejection. However, in terms of analysis, there was not any significant differences
SOX2 expression in the primary tumor of castration-naive metastatic prostate adenocarcinoma in association with metastasis extent Saraswati, Meilania; Kekalih, Aria; Lisnawati; Rahadiani, Nur; Asmarinah; Hernowo, Bethy Suryawathy; Hamid, Agus Rizal Ardy Hariandy; Mochtar, Chaidir Arif
Medical Journal of Indonesia Vol. 35 No. 1 (2026): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.247588

Abstract

BACKGROUND Poor prognosis in patients with metastatic prostate adenocarcinoma (mPCa) may be due to the expression of stem cell-related genes. This study aimed to demonstrate the association between the expression of cancer stem cell markers and metastasis in patients with castration-naive mPCa. METHODS This cross-sectional, analytical study investigated a formalin-fixed paraffin-embedded prostate specimens from patients diagnosed in Cipto Mangunkusumo Hospital. Patients aged ≥50 years old were grouped based on the extent of metastases (high-volume disease [HVD] and low-volume disease [LVD]). In each case, immunohistochemical staining for CD133, CD44, SOX2, and androgen receptor was performed and analyzed using H-score. All data were recorded and analyzed using SPSS software version 20.0. RESULTS A total of 61 patients were recruited from 2020 to 2023 and divided into the HVD (n = 38) and LVD (n = 23) groups, with a mean age of 67.9 years. 45 of the patients had International Society of Urological Pathology (ISUP) grade 5 disease, while 16 of them had grade <5. A significant difference of ISUP grade and PSA serum level was observed in the HVD versus LVD group (p = 0.017 and <0.001, respectively). Additionally, a significant association was found between SOX2 expression and metastatic extent. CONCLUSIONS The LVD group showed higher SOX2 expression in the primary tumor compared to the HVD group. Different SOX2 expressions in various sites and stages may be due to the cancer cells’ systemic network.
Serum PIVKA-II as a Preoperative Predictor of Microvascular Invasion and Tumor Proliferation in HBV-Related Hepatocellular Carcinoma Irfansyah Irfansyah; Wifanto S. Jeo; Nur Rahadiani
Glosains: Jurnal Sains Global Indonesia Vol. 7 No. 1 (2026): Glosains: Jurnal Sains Global Indonesia
Publisher : Sekolah Tinggi Agama Islam Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59784/glosains.v7i1.658

Abstract

Background: Hepatocellular carcinoma (HCC) contributes significantly to cancer-related mortality worldwide, particularly in hepatitis B–endemic regions such as Indonesia. The need for reliable preoperative biomarkers remains a major gap, especially to predict microvascular invasion (MVI) and tumor proliferation. PIVKA-II was specifically selected over AFP because of its superior ability to reflect tumor-invasive biology through MET and JAK/STAT pathway activation. Objective: This study aimed to assess whether serum PIVKA-II levels can predict MVI and Ki-67 proliferation index. Methods: A retrospective study was conducted on 20 patients with HBV-related HCC who underwent liver resection at Cipto Mangunkusumo Hospital (2017–2025). Serum PIVKA-II was categorized as high (>40 mAU/mL) or low (≤40 mAU/mL). MVI was identified histologically; Ki-67 expression was categorized as high (>20%) or low (≤20%) using immunohistochemistry. Results: PIVKA-II levels showed a significant relationship with AFP (p = 0.033) and BCLC stage (p = 0.038). ROC analysis showed that PIVKA-II had fair discriminative ability (AUC = 0.703) in predicting vascular invasion, with a sensitivity of 87.5% and specificity of 75%. There was a significant relationship between high PIVKA-II levels and the occurrence of vascular invasion (p = 0.032; RR = 2.33). However, PIVKA-II did not show good predictive ability for tumor cell proliferation (Ki-67) (AUC = 0.484), and no significant relationship was found between them (p = 0.530). Conclusion: PIVKA-II is a useful preoperative biomarker for predicting microvascular invasion in HBV-related HCC. Its lack of association with Ki-67 indicates that additional markers are needed to assess tumor proliferative behavior. These findings support the integration of PIVKA-II into preoperative risk assessment.
Trends of early-onset colorectal cancer biomarkers from 1985 to 2024 : a bibliometric analysis Hamzah Haryo Prakoso; Andre Setiawan; Nur Rahadiani
Universa Medicina Vol. 45 No. 2 (2026): Ahead Of Print
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2026.v45.%p

Abstract

Early-onset colorectal cancer (EOCRC) is increasingly recognized as a global public health concern. Biomarker research in EOCRC has expanded across hereditary, molecular, epigenetic, liquid biopsy, microbiome, and multi-omics domains, but the overall research landscape remains fragmented. This study aimed to map global research trends and identify prominent and underdeveloped topics in EOCRC biomarker research. A bibliometric analysis was conducted using publications on EOCRC biomarkers retrieved on October 27, 2024. Eligible documents were limited to English-language articles, reviews, and conference proceedings, with a final publication stage and no restriction on publication year. After screening, 134 relevant documents published between 1985 and 2024 were included. Bibliometric indicators, including publication trends, leading contributors, influential publications, topic evolution, and keyword co-occurrence patterns, were analyzed using Biblioshiny (Bibliometrix R package v4.1.3) and VOS viewer (v1.6.18). Early-onset colorectal cancer  biomarker research showed steady growth, with an annual growth rate of 7.54% and a publication peak in 2023. The dataset included 134 documents from 92 sources and involved 1,121 authors, with international collaboration observed in 20.9% of publications. Earlier studies focused mainly on hereditary predisposition, Lynch syndrome, mismatch repair genes, and microsatellite instability. More recent research shifted toward molecular profiling, epigenetic alterations, liquid biopsy, gut microbiota, tumor microenvironment, and multi-omics approaches. Underdeveloped areas included diagnostic biomarker validation, screening implementation, gut microbiota, risk factors, and machine learning-based biomarker discovery. Overall, EOCRC biomarker research has evolved from a hereditary-centered focus toward a broader precision oncology framework, but further work is needed to strengthen validation, translational relevance, and clinical applicability across diverse populations.
Akurasi Pemeriksaan Polymerase Chain Reaction Menggunakan Primer IS6110 dan MPB64 untuk Mendeteksi Mycobacterium tuberculosis pada Spesimen Formalin-Fixed Paraffin-Embedded Timotius Benedict Djitro; Faramitha Nur Izzaty; Nur Rahadiani
Majalah Patologi Indonesia Vol. 28 No. 3, September 2019
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

BackgroundOne of the chalangges faced in controlling tuberculosis (TB) is the availability of a fast and precise diagnostictool. The current gold standard for diagnosis of TB is acid-fast bacterial culture. However, FFPE (formalin-fixedparaffin-embedded) tissues are not ammenable for culture and the time required makes this method impracticalfor many centers. PCR is an alternative rapid diagnostic tool, and can be used with FFPE tissues. PCR hasshown high sensitivity and specificity for detecting M.tuberculosis, however there has been reports of lesssensitivity and specificity when using FFPE specimens. This report aims to determine the accuracy of PCRdetection of M.tuberculosis using primer IS6110 and MPB64 on FFPE specimens.MethodsLiterature searches were carried out on the Pubmed, Scopus, Proquest, Springer Link and Cochranedatabases. Two journals were relevant to the clinical scenario, then a critical review is carreid out using theDiagnostic Study Appraisal Worksheet from the Center for Evidence-based Medicine, University of Oxford,2010.ResultsCurrently, the accuracy of PCR primer IS6110 and MPB is not satisfactory. Sensitivity ranges from 45.5-88.9%and specificity is between 88.1% - 100. This broad sensitivity range is probably caused by tissue volume andembedding process that can cause damages to the integrity of M.tuberculosis DNA.ConclusionPCR examinations using IS6110 and MPB64 primers can be used as confirmation tests in FFPE specimensdue to its high specificity value. Broad sensitivity values can produce significant false negatives if no otherexamination is used in conjunction with PCR in FFPE specimens.
Co-Authors Agi Satria Putranto Agus Rizal Ardy Hariandy Hamid, Agus Rizal Ardy Hariandy Alif Gilang Perkasa Amelia Fossetta Manatar Andre Setiawan Aria Kekalih Asmarinah Bayu Perkasa Rosari Bethy Suryawathy Hernowo Chaidir Arif Mochtar Dhuhani, Ika Diah Rini Handjari Diah Rini Handjari Diah Rini Handjari Diah Rini Handjari Diah Rini Handjari Dyah Laksmi Dewi Ening Krisnuhoni Faramitha Nur Izzaty Fili Sufangga Flora Dameria Hamzah Haryo Prakoso Handjari, Diah R. Hanifah Oswari Ika Dhuhani Irfansyah Irfansyah Jessica Prisscila Kumalawati, July Kusnadi, Dana Satria Linggodigdo, Michelle Lisnawati Lydia Kencana Manatar, Amelia Fossetta Marini Stephanie Marini Stephanie Marini Stephanie Marini Stephanie Marini Stephanie Meilania Saraswati Michelle Linggodigdo Mohammad Ghozali, Mohammad Muhammad Habiburrahman, Muhammad Nita Afriani Perkasa, Alif Gilang Prisscila, Jessica Ria Kodariah Ricky Handika Rosari, Bayu Perkasa Sufangga, Fili Sutopo, Stefanus Taufik Agung Wibowo Timotius Benedict Djitro Wifanto S. Jeo Wijaya, Yan Cahya Yan Cahya Wijaya