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All Journal Medical Journal of Indonesia Universa Medicina Majalah Kedokteran Andalas Majalah Patologi Indonesia Indonesian Journal of Cancer The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Glosains: Jurnal Sains Global Indonesia
Nur Rahadiani
Department Of Anatomical Pathology, Faculty Of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Profil ekspresi von Hippel-Lindau (pVHL) pada adenokarsinoma duktal pankreas dan jaringan pankreas non-neoplastik serta hubungannya dengan faktor klinikopatologi Jessica Prisscila; Marini Stephanie; Nur Rahadiani; Amelia Fossetta Manatar; Ening Krisnuhoni
Majalah Patologi Indonesia Vol. 35 No. 1, Januari 2026
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v35i1.658

Abstract

Introduction Pancreatic malignancy, primarily Pancreatic Ductal Adenocarcinoma (PDAC), presents a significant challenge due to its aggressive nature and late-stage diagnosis. This study explores the role of von Hippel-Lindau gene product (pVHL) in PDAC and non-neoplastic pancreatic tissues, investigating their relationship with PDAC clinicopathological characteristics. Method This research was carried out at the Faculty of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital.   The cases analyzed spanned from January 2012 to September 2023. Immunohistochemistry of pVHL was used, and the Histoscore/H-score calculations were utilized to classify pVHL expression as either high or low. Results A total of 54 cases of PDAC and non-neoplastic pancreatic tissue exhibited varying levels of pVHL expression. Cases of PDAC with positive surgical margin, absence of lymphovascular and perineural invasion, pT2, pN0, M0 stage, and survival exceeding 7 months were the profiles in which low pVHL expression was detected. Significant result was found on the correlation between pVHL with pN status. Conclusion The levels of pVHL expression varied between PDAC and non-neoplastic pancreatic tissue. There were no differences in the clinicopathological profile of PDAC tumors, except for pN stage. Further research, with a larger sample size, is needed to determine pVHL's diagnostic value and its expression in different clinicopathological profiles.
Co-Authors Agi Satria Putranto Agus Rizal Ardy Hariandy Hamid, Agus Rizal Ardy Hariandy Alif Gilang Perkasa Amelia Fossetta Manatar Andre Setiawan Aria Kekalih Asmarinah Bayu Perkasa Rosari Bethy Suryawathy Hernowo Chaidir Arif Mochtar Dhuhani, Ika Diah Rini Handjari Diah Rini Handjari Diah Rini Handjari Diah Rini Handjari Diah Rini Handjari Dyah Laksmi Dewi Ening Krisnuhoni Faramitha Nur Izzaty Fili Sufangga Flora Dameria Hamzah Haryo Prakoso Handjari, Diah R. Hanifah Oswari Ika Dhuhani Irfansyah Irfansyah Jessica Prisscila Kumalawati, July Kusnadi, Dana Satria Linggodigdo, Michelle Lisnawati Lydia Kencana Manatar, Amelia Fossetta Marini Stephanie Marini Stephanie Marini Stephanie Marini Stephanie Marini Stephanie Meilania Saraswati Michelle Linggodigdo Mohammad Ghozali, Mohammad Muhammad Habiburrahman, Muhammad Nita Afriani Perkasa, Alif Gilang Prisscila, Jessica Ria Kodariah Ricky Handika Rosari, Bayu Perkasa Sufangga, Fili Sutopo, Stefanus Taufik Agung Wibowo Timotius Benedict Djitro Wifanto S. Jeo Wijaya, Yan Cahya Yan Cahya Wijaya