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All Journal Pharmaciana: Jurnal Kefarmasian PREPOTIF : Jurnal Kesehatan Masyarakat Journal of Pharmaceutical and Health Research Archives of The Medicine and Case Reports Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Jurnal Keperawatan dan Kesehatan (JKK) Madani: Multidisciplinary Scientific Journal Journal of Pharmaceutical and Sciences. Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Siti Setianingsih
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Pengaruh Intervensi Pill Box dan Medication Chart Terhadap Kepatuhan Dan Luaran Klinis Pasien Diabetes Mellitus Tipe 2 di Puskesmas Susukan Nurul Izha Arisqa; Siti Setianingsih; Silma Kaaffah
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 3 (2025): November : Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i3.8327

Abstract

Type 2 Diabetes Mellitus (T2DM) is a major non-communicable disease in Indonesia with high morbidity and mortality. Poor adherence to antidiabetic medication is a key factor contributing to inadequate glycemic control. Practical tools such as pill boxes and medication charts have been developed to support patients in following prescribed therapy. This study aimed to evaluate the effectiveness of pill boxes and medication charts in improving medication adherence and clinical outcomes, specifically fasting blood glucose (GDP) and random blood glucose (GDS), among T2DM patients at Susukan Public Health Center. A quasi-experimental pre-test and post-test design with a control group was applied. Ninety respondents were recruited using total sampling and divided equally into pill box, medication chart, and control groups. Medication adherence was assessed using the Medication Adherence Rating Scale-10 (MARS-10), while GDP and GDS levels were measured using a glucometer. Data were analyzed with paired t-tests, Wilcoxon tests, and intergroup comparisons at a 5% significance level. Results showed significant improvement in adherence in both intervention groups compared to the control (p<0.05). In the pill box group, mean GDP decreased from 157.23 ± 53.21 mg/dL to 126.76 ± 14.82 mg/dL (p=0.000), while in the medication chart group it decreased from 162.66 ± 24.89 mg/dL to 145.66 ± 26.54 mg/dL (p=0.006). No significant change was seen in the control group (p=0.741). For GDS, a significant reduction was found only in the pill box group (p=0.005). In conclusion, both pill boxes and medication charts improved adherence among T2DM patients, with pill boxes providing greater benefit for glycemic control. These low-cost, practical strategies are recommended for routine use in primary healthcare to enhance diabetes management.are recommended for integration into primary healthcare services to optimize diabetes management.
Uji Aktivitas Antihiperlipidemia Ekstrak Etil Asetat Daun Jambu Air (Syzygium aqueum) terhadap Kadar Kolesterol Total pada Tikus Jantan Galur Wistar Setianingsih, Siti; Sumantri, Sumantri; ‘Afiah, Noni Faridatul
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 2 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i2.420

Abstract

The ethyl acetate extract of guava leaves contains secondary metabolites in the form of flavonoids and alcaloids which have been shown to have an antiperlipidemic. This study aims to determine the content and levels of the ethyl acetate extract of water guava leaves (EEADJA) and antihyperlipidemic activity in hyperlipidemic rats.This research was an experimental study with a randomized matched pre-test and post-test control group design . Hyperlipidemic rats were made by giving PTU 12.5 mg/kg/day orally for 14 days. Hyperlipidemic rats were divided into 5 groups with 5 rats each, namely group I (negative control) CMC-Na 0.5%, group II (positive control) simvastatin 0.18 mg/kgBW/day, groups III, IV and V given EEADJA (100, 200, and 400) mg/kgBW/day for 14 days orally. Differences in data on total cholesterol levels before and after treatment were tested statistically by testing the antihyperlipiemia effect using the paired t-test and One Way Anova test to determine differences in the reduction in total cholesterol levels with various dose variations. EEADJA with various doses of 100, 200, and 400 mg/kg/day has the ability to reduce total cholesterol levels in the blood of hyperlipidemic rats.
Co-Authors Abdul Rohman Afifah, Zalfa Ifri Nur Agustina, Inayah Dwi Amanda, Yusi Lusiana Delmayana, Mikna Khamdiyah Indah Kurniasih Kurniasih, Khamdiyah Indah Laela Hayu Nurani Lukman Hakim Nawangsari, Desy Nurkholis, Fiqih Nurul Izha Arisqa Raysyifa, Mugi Rahma Samodra, Galih SATRIYAS ILYAS Setyaningsih, Intan Wiji Silma Kaaffah Sumantri Sumantri ‘Afiah, Noni Faridatul