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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Ners
Suandy Suandy
Universitas Prima Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics

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Efektivitas Ekstrak Bawang Putih Tunggal Terhadap Kadar Gula Darah, HBA1C dan Histopatologi Pankreas Rattus Norvegicus Dislipidemia Suandy Suandy; Ratu Mutiara Raudhatul Jannah; Linda Chiuman
Jurnal Ners Vol. 9 No. 4 (2025): OKTOBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i4.50952

Abstract

Penyakit Diabetes Melitus merupakan masalah kesehatan global yang ditandai dengan hiperglikemia, seringkali disebabkan oleh kerusakan sel beta pankreas. Pengobatan diabetes seringkali memiliki efek samping dan biaya yang tinggi, sehingga penelitian mengenai terapi alternatif, seperti ekstrak alami diperlukan. Penelitian ini bertujuan untuk mengevaluasi efektivitas ekstrak bawang putih tunggal (Allium sativum) terhadap kadar gula darah (KGD), HbA1c, dan gambaran histopatologi pankreas pada tikus (Rattus norvegicus) yang mengalami dislipidemia. Penelitian ini menggunakan desain eksperimen dengan desain kelompok pre-test dan post-test menggunakan 24 ekor tikus yang dibagi menjadi empat kelompok perlakuan. Data dianalisis dengan uji normalitas, uji One-way ANOVA, uji Post-Hoc Tukey HSD, uji Kruskal-Wallis, dan Mann-Whitney. Hasil statistic menunjukkan perbedaan KGD yang signifikan antar kelompok pada hari ke-0 (P. 0.001) dan hari ke-28 (P. 0.001). Namun, pada uji Post-Hoc Tukey HSD, tidak ditemukan perbedaan signifikan antara kelompok kontrol positif dengan kelompok dosis 200 mg/kgBB (P. 0.499) dan 400 mg/kgBB (P. 0.866) pada hari ke-28. Pada parameter HbA1c, uji ANOVA menunjukkan tidak ada perbedaan signifikan antar kelompok pada seluruh haripengamatan (P. > 0.05). Secara visual, gambaran histopatologi menunjukkan adanya perbaikan pada struktur pankreas. Secara statistik, pemberian ekstrak bawang putih tunggal tidak menunjukkan perbedaan yang signifikan terhadap kadar KGD, HbA1c, maupun histopatologi pankreas pada tikus yang diuji.
Effectiveness of Single Garlic Extract on Fatty Liver and Liver Enzymes in Rattus Norvegicus Wistar Fahmi Syahputra; Suandy Suandy; Linda Chiuman
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.52285

Abstract

This study investigated the hepatoprotective efficacy of ethanol-extracted single garlic (EEBPT) on fatty liver and hepatic enzymes in rats. A true experimental design with pretest-posttest control group approach was employed. Twenty-four male Wistar rats (Rattus norvegicus) were randomly allocated into four groups: negative control (distilled water), positive control (simvastatin 2.1 mg/kg body weight), low-dose EEBPT (200 mg/kg body weight), and high-dose EEBPT (400 mg/kg body weight). All animals received high-fat diet supplementation for four weeks. Serum aspartate aminotransferase (SGOT/AST) and alanine aminotransferase (SGPT/ALT) were measured on days 0, 14, 21, and 28. Hepatic histopathology was assessed using hematoxylin and eosin staining. One-way ANOVA with Tukey post-hoc test and Kruskal-Wallis test were applied for statistical analysis (p<0.05). Results demonstrated that high-dose EEBPT significantly reduced SGOT and SGPT levels equivalent to simvastatin treatment and ameliorated hepatic steatosis, hepatocyte ballooning, and inflammatory infiltration. Ethanol-extracted single garlic at 400 mg/kg body weight exhibited hepatoprotective effects comparable to conventional statin therapy through antioxidative and anti-inflammatory mechanisms. Garlic extract represents a promising natural hepatoprotective agent for NAFLD management
The Effect of Age and Length of Stay on the Incidence of Ventilator Associated Pneumonia (VAP) in the ICU of Royal Prima Ayahanda Hospital During the 2022-2024 Period Faskanita Maristella Nadapdap; Talitha Syifa; Suandy Suandy
Jurnal Penelitian Pendidikan IPA Vol 11 No 11 (2025): November
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i11.13255

Abstract

Veintilatoir-assoiciateid pneiumoinia (VAP) is thei moist coimmoin noisoicoimial infeictioin affeicting patieints in inteinsivei carei units. Veintilatoir-assoiciateid pneiumoinia (VAP) is deifineid as pneiumoinia that oiccurs 48 hoiurs oir moirei afteir thei initiatioin oif meichanical veintilatioin. Thei aim oif this study was deiteirminei thei reilatioinship beitweiein agei and thei incideincei oif VAP, as weill as thei reilatioinship beitweiein thei leingth oif hoispital stay and thei incideincei oif VAP amoing ICU patieints at Roiyal Prima Ayahanda Hoispital during thei 2022-2024 peirioid whoi weirei using meichanical veintilatoirs. This study eimploiyeid a croiss-seictioinal deisign. Thei samplei coinsisteid oif 125 patieints, seileicteid using a coinseicutivei sampling teichniquei. Thei data useid weirei seicoindary data oibtaineid froim meidical reicoirds. Thei statistical teist applieid weirei Fisheir’s Eixact. Thei reisult shoiweid that 12 reispoindeints (9.6%) deiveiloipeid VAP in thei ICU oif Roiyal Prima Ayahanda Hoispital. Statistical analysis reiveialeid a p-valuei oif 0.342 beitweiein agei and thei incideincei oif VAP, and a p-valuei oif 0.003 beitweiein thei leingth oif hoispital stay and thei incideincei oif VAP. Thei coinclusioin oif this study is that theirei is a reilatioinship beitweiein agei and thei incideincei oif VAP, as weill as reilatioinship beitweiein thei leingth oif hoispital stay and thei incideincei oif VAP.
Co-Authors Fahmi Syahputra Faskanita Maristella Nadapdap Linda Chiuman Ratu Mutiara Raudhatul Jannah Talitha Syifa