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Jurnal Ilmiah Kedokteran Wijaya Kusuma

JIKW
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Published by Universitas Wijaya Kusuma Surabaya

ISSN : 19782071 EISSN : 25805967 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

Jurnal Ilmiah Kedokteran Wijaya Kusuma (JIKW) is a periodically scientific publication that contains articles written in Indonesia or english. JIKW receive articles in the scope of Biomedical Sciences, degenerative diseases, infections, congenital abnormalities and public health. JIKW published twice a year. The articles will be published in JIKW only manuscript that has never be published or published in other journal. Writers who will publish the article please follow the JIKW guidelines. The entire management process both admission and review the article is done by online.

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Articles 390 Documents

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Pengaruh Pemberian Sarang Telur Laba-Laba (Spider Silk Protein) Menemerus Bivittatus Secara Topikal Terhadap Penyembuhan Luka Insisi Pada Fase Inflamasi Tikus Putih Jantan (Rattus Norvegicus) Strain Wistar Muhammad Yusak Alfaris; Mas Mansyur
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 6, No 1 (2017): Edisi Maret 2017
Publisher : Universitas Wijaya Kusuma Surabaya

The healing of wounds is a natural process of the human body but often medicine is used, for example the use of spider silk. The purpose of this research is to know the effect of the use of spider (Menemerus Bivittatus) silk protein used topically for the healing of incision wounds in the inflammatory phase. This research is a laboratory experiment. The subjects of this research are 18 wistar rats (Rattus Norvegicus strain) that are treated in two different ways. The first is control (K1) with the use of normal saline and the second is treatment (Pl) with the use of spider silk protein topically using wound dressing. The selection of samples is done randomly using the simple random sampling. The hypothesis testing uses the Chi Square testing with α = 0.05. The results of this research shows that the use of spider silk protein topically effects the process of incision wound healing (0,005) in the inflammatory phase (0,000) on Wistar rats.

Pengaruh Serbuk Daun Kelor (Moringa oleifera) Terhadap Apoptosis Sel Hepar Pada Tikus Bunting Diabetes Mellitus Harry Kurniawan Gondo
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 11, No 1 (2022): MARET 2022
Publisher : Universitas Wijaya Kusuma Surabaya

Maternal death rate in Indonesia are still very high. One of the causes is gestasional diabetes mellitus during pregnancy. Some of healing efforts are done, one of them was utilization of plants, in this case, Moringa oleifera. The purpose of this reseach is to know the Moringa oleifera leaf powder on the pregnant wistar rats with gestasional diabetes mellitus. The study design was laboratoric experimental on the wistar rats as the experimental animal, using Control Group Post Test Design on the research. Sample was divided into 2 positive and negative control groups and 4 treatment groups given Moringa oleifera leaf powder that will be induced by alloxan and the liver histopatological result be examined. Total average of liver cell nucleus that goes through apoptosis is lower linear with the increase of the Moringa oleifera leaf powder dose given to the treatment group. After the alloxan induction, the wistar rats’ blood glucose level is increased, caused by the destruction of the beta cell pancreas. There’s a significant difference between the liver cell that go through apoptosis between the four treatment group of wistar rats. The total average of liver cell that go through apoptosis is lower linear with the increase of the Moringa oleifera leaf powder dose given to the treatment group. Oral administration of Moringa leaf powder to white rats with diabetes mellitus was able to improve the histopathological picture of the liver where the brown color was seen to decrease while the methylene green increased. As well as lowering the blood glucose levels of the rats.

Tingkat Asfiksia Neonatorum Berdasarkan Lamanya Ketuban Pecah Dini pada Persalinan Aterm Andini Kartika Sari; Yudhiakuari Sincihu; B. Triagung Ruddy
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 1 (2018): edisi Maret 2018
Publisher : Universitas Wijaya Kusuma Surabaya

Angka kematian neonatus merupakan salah satu indikator untuk menilai kesehatan di masyarakat. Berdasarkan WHO, penyebab utama kematian neonatus diantaranya adalah prematuritas, asfiksia neonatorum dan sepsis neonatorum. Faktor penyebab terjadinya asfiksia neonatorum salah satunya KPD. Tujuan penelitian ini untuk mengetahui apakah lamanya KPD pada persalinan aterm berhubungan terhadap tingkat asfiksia bayi baru lahir. Penelitian ini bersifat observasional analitik menggunakan data sekunder dengan pendekatan retrospektif, rancangan cross-sectional. Teknik pengambilan sampel menggunakan purposive sampling. Data diambil selama 18 bulan yaitu periode 1 Januari 2016 hingga 30 Juni 2017. Populasi pada penelitian ini adalah 1594 ibu yang melahirkan dan 1619 bayi yang dilahirkan. Data ibu bersalin dengan riwayat KPD terdapat sebanyak 168 dan 80 ibu dan bayinya yang memenuhi kriteria. Data dianalisis menggunakan uji korelasi Spearman’s rho. Hasil penelitian menunjukkan terdapat hubungan antara lamanya KPD dengan tingkat asfiksia nonatorum, dengan nilai signifikansi p = 0,029 (p < 0,050) dan nilai koefisien korelasi (C) - 0,244 yang termasuk koefisien korelasi rendah hubungan terbalik. Interpretasi hubungan terbalik menunjukkan bahwa semakin meningkat lama KPD maka nilai APGAR semakin menurun atau tingkat asfiksia semakin berat.

TOXOPLASMOSIS DAN KEMUNGKINAN PENGARUHNYA TERHADAP PERUBAHAN PERILAKU Bagus Uda Palgunadi
Jurnal Ilmiah Kedokteran Wijaya Kusuma No 1 (2011): Edisi Juli 2011
Publisher : Universitas Wijaya Kusuma Surabaya

Toxoplasmosis adalah suatu penyakit zoonosis yang disebabkan oleh infeksiToxoplasma gondii. Toxoplasmosis tidak selalu menyebabkan keadaan patologis pada hospesnya,penderita seringkali tidak menyadari bahwa dirinya terinfeksi sebab seringkali asymptomatis, terutamapada penderita yang mempunyai imunitas tubuh yang baik. Toxoplasmosis akan memberikan gejala yangjelas pada penderita yang mengalami penurunan imunitas. Akhir – akhir ini toxoplasmosis diperkirakansebagai salah satu factor penyebab perubahan perilaku dan gangguan jiwa , termasuk schizophrenia.

Effects of Solo Garlic Extract in Decreasing Malondialdehyde (MDA) Levels due to E-Cigarette Exposure Aliefia Meta Duwairoh
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 2 (2018): Edisi September 2018
Publisher : Universitas Wijaya Kusuma Surabaya

The popularity of E-Cigarette has increased significantly over the last decade, and has potential to replace tobacco cigarettes. Aerosol which is produced by E-Cigarette, contains reactive carbonyl and free radicals, inducing oxidative stress and causing inflammation, proliferation, and cell damage. This oxidative stress can be seen through the Malondialdehyde (MDA) levels in the body, and reduced by antioxidant activity in Solo Garlic extract. The aim of this study is analyzing the differences of MDA levels in four treatment groups. 28 white rats were divided into four groups and three of them were exposured by E-Cigarette. This study showed that the highest MDA levels was found in the group which was exposured by E-Cigarette without solo garlic extract (7,179 nmol/ml). MDA levels can be reduced by antioxidant activity shown in the group which was exposured by E-Cigarette and solo garlic extract dose 0,05 gram/day (the smallest dose), amount 3,715 nmol/ml. The average of MDA levels in group which was given by the smallest dose of solo garlic extract, is lower than the control group. So, it can be concluded that using solo garlic extract less than 0,05 gram/day can restore MDA levels to a normal state (4,210 nmol/ml).

Stem cell dalam terapi penyakit kardiovaskular Djanggan Sargowo
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 2, No 3 (2011): Volume Edisi Khusus Desember 2011
Publisher : Universitas Wijaya Kusuma Surabaya

Penyakit Jantung, termasuk di dalamnya infark miokard dan iskemik miokard merupakan penyakit yang berhubungan dengan kehilangan yang permanen dari kardiomiosit dan vaskuler, baik dengan cara apoptosis ataupun nekrosis.

Pengaruh Pemberian Jus Buah Belimbing Wuluh (Averrhoa bilimbi L.) terhadap Kadar Kolesterol LDL Darah Tikus Putih (Rattus norvegicus) Jantan Galur Wistar dengan Diet Tinggi Lemak Kartika Dwi Rahminiwati; IGM Antara Hambarsika; Fitri Handajani
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 8, No 2 (2019): EDISI SEPTEMBER 2019 (available online since Oktober 2019)
Publisher : Universitas Wijaya Kusuma Surabaya

A high-fat diet can increase lipoprotein levels, total cholesterol, (Low Density Lipoprotein) LDL, and triglycerides. Starfruit has saponin and flavonoid compounds which are expected to reducing LDL cholesterol levels. The aim of the study was to determine the effect of starfruit juice on lowering the blood cholesterol LDL of Wistar rats fed with high-fat diet. Experimental study with post-test only control group design. As many as 24 male white rats from the Wistar strain were divided into 3 groups: negative control groups (K-) that were given standard feed for 28 days; positive control group (K+) who were given a high-fat diet for 28 days; the treatment group (KP) was given a high-fat diet for 28 days and on the 15th day 28th they were given a starfruit juice with a dose of 4ml / 200grBB / day. Day 29 measured LDL cholesterol. The statistic test showed a significant increase in LDL cholesterol levels (p=0.001) in the positive control group (x=12.125±2.642 mg/dL) compared to the negative control group (x=7.625±1.506 mg/dL). There was no significant different the mean cholesterol level of the treatment group (x=11±1.927) compared to the mean LDL cholesterol level of the positive control group (x=12.125±2.642). A high-fat diet significantly increases the mean LDL cholesterol level. Starfruit juice did not significantly reduce LDL cholesterol level.

Effect of fortified milk (calcium and vitamin D) and osteoporosis gymnastics toward bone density of pre elderly women in the working area of health center Banyuanyar in district Sampang Desy Prasetya; Bambang Wirjatmadi; Merryana Adriani
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 4, No 1 (2015): edisi September 2015
Publisher : Universitas Wijaya Kusuma Surabaya

Disorders of bone density becomes a major public health problem, especially in women pre elderly. Besides due to low intake of essential nutrients for bone, also because of declining estrogen due to menopause. Low bone density can lead to osteoporosis and impact on risk of bone fracture. Fortified milk is one of strategy to provide the intake of calcium and vitamin D daily. In addition, osteoporosis gymnastics also plays a role to increase the absorption of calcium in the small intestine. The aim of this study was to analyzed the effect of fortified milk (calcium and vitamin D) and osteoporosis gymnastics on bone density in women pre elderly in the working area of health center Banyuanyar Sampang. Research design used Non equivalent Control Group Design. Samples were 45 pre elderly womens (age 50-59 years) which is composed of 15 people (treatment group I) in the form of gymnastics osteoporosis, 15 (treatment group II) in the form of osteoporosis gymnastics and fortified milk, and 15 people in the control group. Statistical test using paired T-test, Wilcoxon and Kolmogorov Smirnov. There was the influence of fortified milk (calcium and vitamin D) and osteoporosis gymnastics on bone density (p = 0.037). While in the first treatment group (p = 0.217) and showed no effect on controls groups (p = 0.157). There was the influence of fortified milk (calcium and vitamin D) and osteoporosis gymnastics on bone density. Some respondents have improvement or increase of T-score.

DETECTION IS BACTERIA IN DRINKING WATER IN THE PACKAGING GALLON Asih Rahayu
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 2, No 1 (2010): Edisi Januari 2010
Publisher : Universitas Wijaya Kusuma Surabaya

Twenty four of thirty drinking water samples taken from each gallons has been identified as containing some bacteria with TPC indicator number 1 to 22 CFU/ml. TPC number of whole samples shows that the bacteria number tend to increase after it stored in water dispenser for some period of time. In two days, the TPC number has reached 2 to 98 CFU/ml, and after four days it reached 3 to 166 CFU/ml. Research shows that he three samples are not consumable after it stored in water dispenser for four days, since it contains bacteria with TPC number more than 100 CFU/ml. The increase of bacteria numbers, as the water stored in dispenser, might be caused by the reproduction of bacteria which has initially contaminated the drinking water. Otherwise, the increase of TPC number might also be caused by the bacteria in water dispenser itself. It is recommended for the consumer to clean the water dispenser before they exchange the gallons to prevent bacteria contamination in their drinking water.

Characteristics of Indonesian Wild honey and Cultivited Honey and Their Antibacterial Activity against Staphylococcus aureus and Escherichia coli Lusiani Tjandra; Budhi Setyawan; Masfufatun masfufatun
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 11, No 1 (2022): MARET 2022
Publisher : Universitas Wijaya Kusuma Surabaya

Indonesia's natural wealth is very abundant in the form of flora and fauna that can be developed as raw materials for medicine. Honey in Indonesia is very diverse from Sabang to Merauke. Different types of honey are influenced by regional origin, season at harvest, type of bee, type of plant source of nectar, way of life of bees (cultivated or wild), harvesting method and post-harvest handling. This study aims to determine the characteristics of forest bee honey and cultivated honey and to determine the potential of honey as an antibacterial in the treatment of infectious diseases caused by Staphylococcus aureus and Escherichia Coli bacteria. The materials used were Carisa honey samples from Wild honey [Wild Klanceng and Wild Cerana] and Cultivation [Cerana Cultivation], S. aureus and E. coli bacteria. The characteristic test method is in accordance with the Indonesian National Standard and the honey inhibition test against the growth of S. aureus and E. Coli bacteria using the diffusion method. The results showed that Wild Cerana (WC) and Wild Klanceng (WK) honey demonstrated higher water content, ash content, acidity and glucose from Cerana Cultivated (CC) honey. Carissa Honey (beside Cerana cultivated honey) had antibacterial activity against S. aureus and E. Coli at different concentrations. Wild Wild Honey has the highest antibacterial activity compared to other types of honey. Conclusion Indonesian wild honey showed weak antibacterial activity against Staphylococcus aureus. Meanwhile, honey that is cultivated does not have antibacterial activity.

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Jawa timur

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