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Jurnal Ilmiah Kedokteran Wijaya Kusuma

JIKW
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Published by Universitas Wijaya Kusuma Surabaya

ISSN : 19782071 EISSN : 25805967 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

Jurnal Ilmiah Kedokteran Wijaya Kusuma (JIKW) is a periodically scientific publication that contains articles written in Indonesia or english. JIKW receive articles in the scope of Biomedical Sciences, degenerative diseases, infections, congenital abnormalities and public health. JIKW published twice a year. The articles will be published in JIKW only manuscript that has never be published or published in other journal. Writers who will publish the article please follow the JIKW guidelines. The entire management process both admission and review the article is done by online.

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Articles 390 Documents

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ADDISON'S DISEASE Ayling Sanjaya
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 1, No 1 (2012): Edisi Juli 2012
Publisher : Universitas Wijaya Kusuma Surabaya

Penyakit Addison (Addison's disease) adalah kelainan yang disebabkan oleh ketidakmampuan korteks adrenalis memproduksi hormon kortisol dan aldosteron. Keadaan tersebut dapat disebabkan oleh insufisiensi adrenal primer seperti autoimun, infeksi dan tumor adrenal atau insufisiensi adrenal sekunder karena tumor atau infeksi, kurangnya aliran darah ke kelenjar hipofisis, radiasi kelenjar hipofisis, atau pengangkatan bagian hipotalamus atau kelenjar hipofisis. Penyakit Addison ini sangat jarang terutama pada anak-anak. Penyakit Addison dapat terjadi baik pada pria maupun wanita di semua usia. Frekuensi penyakit Addison pada populasi manusia diperkirakan 1 dari 100.000. Diagnosis penyakit Addison dapat dibuat melalui gambaran klinis dan pemeriksaan laboratorium. Pemeriksaan radiologis seperti CT Scan dan MRI dapat membantu menganalisa kelenjar adrenal dan kelenjar hipofise sehingga dapat diketahui penyebab insufisiensi kortisol yang terjadi pada penderita. Terapi penyakit Addison yaitu penggantian atau subtitusi hormon kortisol memperbaiki defisiensi glukokortikoid dan terapi standar pada keadaan krisis Addison. Diagnosis dini dan terapi yang tepat diperlukan untuk memberikan prognosis yang baik bagi pasien Addison's disease.

Cover Volume 10 Nomer 1 tahun 2021 Putu oky ari tania
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 10, No 1 (2021): MARET 2021
Publisher : Universitas Wijaya Kusuma Surabaya

Manfaat Trimetazidine Dalam Tatalaksana Pasien Chronic Coronary Syndrome Dengan Stable Angina Aldy Dion; Edgar Bezaliel Hartanto
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 11, No 1 (2022): MARET 2022
Publisher : Universitas Wijaya Kusuma Surabaya

Cardiovascular Disease (CVD) has resulted in the deaths of 17.9 million individuals in 2016, representing 31% of the global death. Coronary Artery Disease is a spectrum of CVD with a clinical manifestation called Chronic Coronary Syndrome (CCS). Stable angina is the main symptom of CCS that threatens patient safety. This paper aims to convey the in-depth benefits of Trimetazidine as an effective and safe pharmacological option for CCS patients with stable angina. This paper is a narrative review type literature study using the literature review method regarding the benefits of Trimetazidine (TMZ) for CCS patients with stable angina. As many as 16 references from research journal articles, case reports, and international guidelines are used. The analysis showed that administration of TMZ caused a significant frequency reduction of weekly angina attacks from 4.7 ± 3.5 to 2.2 ± 2.4 in the first month (p <0.001) and to 0.9 ± 1.3 in the third month (p <0.001). The decrease in weekly nitroglycerin consumption was -3.23, 95% CI: -4.23 to -2.24 (p <0.0001). The CCS classification of patients increased from 83% of patients classified in CCS class II or III to 32% after being given TMZ. There were no significant differences between the three doses of TMZ (3 × 20 mg, 2 × 35 mg, and 1 × 80 mg). TMZ has been reported to cause few mild side effects in patients. In general, the use of TMZ as monotherapy or in combination can improve the condition of CCS patients with stable angina.

The Role Of Zinc Sulphate and Omega 3 On The Improvement Of Weight and Speed Conversion Conversion on Tuberculosis Parent Patients at Surabaya Park Hospital, 2015 Fara Disa Durry; Bambang Wirjatmadi; Merryana Adriani
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 1 (2018): edisi Maret 2018
Publisher : Universitas Wijaya Kusuma Surabaya

Background: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis, can affect almost all organs of the body with the most locations in the lungs. Immunity and high nutrients such as vitamin C, zinc and other antioxidants have shown good effects for infections, including tuberculosis. One effort to help accelerate sputum conversion of people with pulmonary tuberculosis is by supplementation of Zinc Sulphate and Omega 3.Objective: Analyze the role of Zinc Sulphate and Omega 3 on sputum conversion acceleration in patients with pulmonary tuberculosis at Surabaya Paru Hospital 2015.Method: This research use Randomized Pre Post Test Post Control Group Design design. In patients with pulmonary tuberculosis with Zinc Sulphate and Omega 3 in the treatment and placebo group in the control group. A sample of 20 patients consisting of 10 treatment patients and 10 control patients. Statistical test using paired T-Test, Friedman test and Mann whitney.Results: Friedman test showed that in the treatment group showed significant difference in the number of BTA between before and after supplementation (p=0,001), while in the control group significance of 0.141. Mann-Whitney test showed no significant difference in the amount of reduction of BTA between the treatment group and the control group (p = 0.080). This means that statistically does not show any significant difference.Conclusions: Zinc Sulphate and Omega 3 play a role in accelerating sputum smear conversion of respondents. The results of smear test in pulmonary TB patients with Zinc Sulphate and Omega 3 supplementation showed positive results

RESISTENSI SERANGGA TERHADAP DDT Kartika Ishartadiati
Jurnal Ilmiah Kedokteran Wijaya Kusuma No 1 (2011): Edisi Juli 2011
Publisher : Universitas Wijaya Kusuma Surabaya

Dichloro Diphenyl Trichloroethane (DDT) adalah insektisida organik sintetik yang termasuk golonganorganoklorin (chlorinated hydrocarbon). DDT disintesis oleh Othmar Zeidler pada tahun 1873, namunefek insektisidanya baru ditemukan oleh Paul Muller pada tahun 1939. Oleh karena efikasinya yangsangat baik, DDT menjadi sangat terkenal di bidang pertanian dan bidang kesehatan masyarakat, dandigunakan secara luas sejak tahun 1945. Namun pada tahun 1948 sudah mulai dilaporkan terjadinyaresistensi DDT pada nyamuk dan lalat.

Pengaruh Pemberian Jus Buncis (Phaseolus Vulgaris Linn) terhadap Kadar Malondialdehide Tikus Model Stres Psikologis Dianti Ias Oktaviasari
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 2 (2018): Edisi September 2018
Publisher : Universitas Wijaya Kusuma Surabaya

Psychological stress is often suffered by people with body rhythm disorders, one of whom is a person with sleep disorders upside down. Psychological stress can trigger oxidative stress. Oxidative stress can be overcome by increasing antioxidants, beans as antioxidants are considered to reduce oxodative stress. The objective of the study was to examine the effect of green bean juice on the levels of Malondialdehyde (MDA) in male white wistar strains exposed to psychological stress. The design used in this research is Randomized Post Test Only Group Design. There were 5 groups tested, 2 normal and stress control groups, and 3 treatment groups. Exposure to psychological stress with reverse sleep guard pattern, so that the condition of experimental animals experiencing oxidative stress, then given bean juice with a dose of 4.5 gr / 1 ml in the treatment group. The results showed MDA levels dropped in the first hour and remained down until the 24th hour after the provision of bean juice. The effect of antioxidant flavonoids on beans decreases the amount of free radicals by scavenging mechanisms in free radicals and increases levels of endogenous antioxidants and increases insulin levels. The role of arginine in beans acts as a precursor of the formation of Nitric Oxide (NO) as vasodilator of blood vessels so as to decrease oxidative stress. A single dose of bean juice in experimental animals has been shown to overcome oxidative stress due to exposure to psychological stress since the first hour of green bean juice and its antioxidant activity persisted until the 24th hour.

Infeksi Human Papillomavirus dengan Cara Pencegahannya Akhmad Sudibya
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 2, No 1 (2011): Volume II, Nomor 1, Januari 2011
Publisher : Universitas Wijaya Kusuma Surabaya

Virus Papiloma Manusia (HPV/ Human Papillomavirus) termasuk genus Papovavirus Familia Papoviridae.

Description of osteoporosis risk based nutrition status in elderly and calcium intake in Puskesmas Sidosermo Surabaya 2015 Yuni Prabawani
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 4, No 2 (2015): Edisi Desember 2015
Publisher : Universitas Wijaya Kusuma Surabaya

Background. The number of elderly in Indonesia in 2011 about 24 million people, or nearly 10% of the population. Experts projected that by 2020, life expectancy was 71.7 years with the elderly into estimates of the number of elderly 28.8 million people (11.34%). An increase in the number of elderly will cause problems in the elderly, especially the problem of degenerative diseases, one of them is osteoporosis. Prevalence rate of osteoporosis is higher so the need for vigilance. Causes Osteoporosis is multifactoral, such as unhealthy lifestyle and not exercising regularly, as well as the prevention of osteoporosis knowledge is lacking. The occurrence of Osteoporosis caused by lack consumption of calcium in Indonesian society. The purpose of this research was to describe the risk of osteoporosis by nutritional status and calcium intake in the elderly in health centers Sidosermo Surabaya 2015. Methodology This study is a descriptive study with cross sectional approach. A total of 28 elderly people (samples) with a total sampling method. Body weight was measured by digital scale, height was measured by microtoise staturemeter, Osteoporosis was assessed through the measurement of bone density by using Hologic Sahara Densitometry Quantitative Ultrasound (QUS) in the calcaneus bone, which is classified into three is normal, mild risk and high risk. Results: A total of 7 people (25%) had osteoporosis, 21 people had osteopenia (75%). Twelve have a normal body mass index, and 16 had abnormal body mass index. Calcium intake in 8 people (28,6%) had enough calcium intake and 20 people (71,4 %) had low calcium intake.Conclusion: The incidence of osteoporosis in the Health Center Sidosermo Surabaya occurred in elderly with abnormal BMI and inadequate calcium intake.

Perbedaan Jumlah Sel Neuron Cerebrum dan Cerebellum Mus musculus pada Kehamilan Remaja dan Dewasa Tri Purwanti; Widjiati Widjiati; Muhammad Miftahussurur
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 9, No 1 (2020): MARET 2020 available online since April 2020
Publisher : Universitas Wijaya Kusuma Surabaya

Teenage pregnancy contributes to emotional stress higher than adult women Pregnancy in adolescents will trigger negative thoughts and feelings of fear that become the root cause of stress reactions. The onset of stress will trigger the occurrence of Axis HPA activity and the release of corticotrophin releasing hormone (CRH) by the paraventricular nucleus of the hypothalamus, then stimulate the production of adrenencorticotropic hormone (ACTH) by the anterior pituitary gland. ACTH will stimulate glucocorticoids (cortisol) from the adrenal gland cortex to increase the production of CRH in the placenta and give an effect of increasing cortisol in the maternal, as well as the amount of cortisol in the fetus will also increase because it follows the blood placenta barrier. This affects the growth and development of the fetal brain, so that the process of proliferation and differentiation, migration, organization and synaptogenesis and myelination in brain cells. The growth of the brain decreases which affects the number of neuron cells. This study aims to analyze the differences in the number of neuron cells in the cerebrum and cerebellum Mus musculus newly born in adolescent and adult pregnancy. The division of the study group consisted of two groups, namely the adolescent and adult pregnancy groups each of 16 individuals. Taking the examination sample is by taking each of the 3 children from the parent with the heaviest, medium and lowest weights. Then the Mus musculus children were sacrificed by anesthesia and decapitation, then Hematoxilin-Eosin preparations were made from the child's brain. The next step is to examine Hematoxilin-Eosin to calculate the number of neuron cells in the cerebrum and cerebellum with the analysis of the Independent T test showing significant differences between the control and treatment groups with a value of p = 0,000 (p <0.05). Then the analysis of the number of brain neuron cells using the Mann Whitney test showed a difference that the control group was higher than the adolescent group.

KADAR GLIKOGEN HATI SETELAH LATIHAN AEROBIK DAN ANAEROBIK Santika Rentika Hadi
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 2, No 1 (2013): Edisi Mei 2013
Publisher : Universitas Wijaya Kusuma Surabaya

Penelitian ini mempelajari pengaruh latihan aerobik dan latihan anaerobik terhadap glikogen hati. Penelitian ini menggunakan “eksperimen laboratorik” dengan rancangan penelitian “Randomised Post Test Only Control Group Design”. Sebagai sampel adalah tikus putih jenis wistar sejumlah 30 ekor. Sampel dibagi dalam 3 kelompok dengan cara random masing-masing kelompok 10 ekor. Kelompok eksperimen 1 diberi perlakukan latihan aerobik dengan renang secara terus menerus selama 13 menit, kelompok eksperimen 2 diberi perlakuan latihan anaerobik berupa renang secara intermiten dengan 4 set dan rasio kerja : istirahat = 1:3, sedangkan kelompok kontrol tidak diberi perlakuan. Latihan dilakukan selama 8 minggu, dengan frekwensi latihan 3 kali per minggu. Glikogen hati diperiksa secara histologis dengan menghitung jumlah sel hati yang mempunyai kandungan glikogen dengan masing-masing skornya. Data dianalisis dengan statistik deskriptif, analisis varian pada taraf signifikansi 5 %, disimpulkan : (1) Latihan aerobik dalam penelitian ini tidak meningkatkan glikogen hati (2) Latihan anaerobik dalam penelitian ini tidak meningkatkan glikogen hati (3) Pengaruh latihan aerobik dan latihan anaerobik terhadap glikogen hati dalam penelitian ini tidak berbeda secara bermakna (p > 0,05).

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