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Jurnal Ilmiah Kedokteran Wijaya Kusuma
Published by Universitas Wijaya Kusuma Surabaya
ISSN : 19782071     EISSN : 25805967     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health
Jurnal Ilmiah Kedokteran Wijaya Kusuma (JIKW) is a periodically scientific publication that contains articles written in Indonesia or english. JIKW receive articles in the scope of Biomedical Sciences, degenerative diseases, infections, congenital abnormalities and public health. JIKW published twice a year. The articles will be published in JIKW only manuscript that has never be published or published in other journal. Writers who will publish the article please follow the JIKW guidelines. The entire management process both admission and review the article is done by online.
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Articles 390 Documents
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Association Between Curve Magnitude in Scoliosis and Low Body Mass Index Alya Roza Lisanti; Basuki Supartono; Feda Anisah Makkiyah; Prita Maya Savitri
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 14, No 1 (2025): EDISI MARET 2025
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v14i1.4219

Abstract

Background: Adolescent idiopathic scoliosis is a spinal deformity characterized by Cobb angle deviation of more than 10o. Objective: This study aims to determine the association between low body mass index (BMI) and curve magnitude in adolescent idiopathic scoliosis. Methods: This was a retrospective cohort study using medical record data of patients diagnosed with scoliosis at Bhayangkara Tk I Pusdokkes Polri Hospital. BMI classification was based on WHO BMI-for-ages z-scores in children and adolescents. Result: The study included 22 AIS subjects, with the majority aged 14–17 years and a higher proportion of females than males. The p-value for the association between low body mass index and adolescent idiopathic scoliosis is 0.169. Conclusion: Curve magnitude is not associated with low body mass index.
Antibacterial Effectiveness of White Champaca Flower (Michelia alba dc) Against Growth of Corynebacterium diphtheriae Tiara Nandita Putri; Nugroho Eko Wirawan Budianto; Lusiani Tjandra
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 14, No 1 (2025): EDISI MARET 2025
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v14i1.3923

Abstract

Background: Corynebacterium diphtheriae is a bacterium that attacks the respiratory tract, especially the larynx, tonsils, and throat. These bacteria can release toxins that can cause diphtheria. One of the nutritious plants that people often use is the white Champaca flower, or Michelia alba. Objective: This study aimed to examine the antibacterial effectiveness of white champaca flower (Michelia alba dc) against the growth of Corynebacterium diphtheriae. Methods: Experimental research method with post-test only control group design using Cup-plate technique of ethanol extract of white Champaca flower (Micheia alba) in various concentrations (20%, 40%, 60%, 80%, and 100%) and Erythromycin as a positive control and aquades as a negative control. Results: The results of this research are that the minimum inhibitory concentration against the growth of Corynebacterium diphtheriae bacteria at a 20% concentration is 42.16 mm, the concentration of 40% is 47.21 mm, the concentration of 60% is 51.66mm, while at the concentration of 80% the average diameter of the inhibitory zone is 54.49 mm and also at the concentration of 100% the average diameter of the inhibition zone is 54.69 mm which is the average diameter of the largest inhibition zone. The negative control with an inhibitory zone diameter of 0 mm, while the positive control with an inhibitory zone diameter of 44.21 mm. Conclusion: White Champaca flower extract (Michelia alba dc) had antibacterial effectiveness against the growth of Corynebacterium diphtheriae and at a concentration of 100% it is the most effective concentration in inhibiting the growth of Corynebacterium diphtheriae bacteria. 
Association of Low-Birthweight Incidence with Hemoglobin Levels in Pregnant Women at Puskesmas Demangan, Madiun In 2022 Noveriera, Adinda Ayu; Sahadewa, Sukma; Andiani, Andiani
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 14, No 1 (2025): EDISI MARET 2025
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v14i1.3761

Abstract

Background: The incidence of low birth weight babies (LBW) is important because it is an indicator to measure a child's health status, and until now it is still one of the health problems generally faced by developing countries, including Indonesia. One of the risk factors for LBW is the level of hemoglobin (Hb). Hemoglobin is a parameter that is widely used to determine the prevalence of anemia. Objective: The purpose of this study was to analyze the relationship between hemoglobin levels of pregnant women and the incidence of low birth weight babies. Method: The research method used a cross-sectional design with a sample size of 49 respondents who were taken by simple random sampling method after fulfilling the inclusion and exclusion criteria at the Ngegong, Mangunharjo and Demangan Health Centers, Madiun City. Result: Data obtained through the patient's medical record. Data analysis in this study using the Chi Square test obtained a p- value of 0.02 <0.05 and OR = 0.75. Conclusion: So it can be concluded that there is a relationship between low hemoglobin levels and the incidence of low birth weight, where low hemoglobin levels have a 0.75 times higher risk of experiencing LBW. The Spearman rank correlation coefficient value of 0.445 indicates the strength of the relationship between these two variables in the moderate category.
Knee Osteoarthritis Risk Is Increased Five-Fold After Knee Injury In Indonesian National Police Mobile Brigade Corps Nugrahana, Raisa Yunika; Supartono, Basuki; Makkiyah, Feda Anisah; Heristyorini, Ayodya
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 14, No 1 (2025): EDISI MARET 2025
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v14i1.4174

Abstract

Abstract Background: Knee osteoarthritis (OA) is a globally alarming condition that is closely related to mechanobiological factors. Based on several previous studies, it is known that knee OA is correlated with knee injury and that play an important role in the expansion of knee OA. Objective: This research aims to find out the relationship between knee injury history with knee OA severity and to estimate the risk of knee OA after knee injury. Methods: This research used observational analytical methods with a retrospective hospital-based cohort study design. Using consecutive sampling technique. The total research sample was 68 participants who Indonesian National Police Mobile Brigade Corps had knee OA period January 1 2021-December 31 2023 at the RS Bhayangkara Tk. I Pusdokkes Polri Jakarta. Result: There was a significant relation between knee injury history with knee OA severity (p = 0.011) and odds ratio 5.0 (95% CI: 1.6-15.9). Characteristics of members of the Indonesian National Police Mobile Brigade Corps with the highest risk of knee OA, namely in the pre-elderly with an age range of 45 - ≤ 59 years (66.2%), female (51.5%), work unit of the Headquarters Mobile Brigade Corps (45.6%), had a history of knee injury (70.6%), with mild degrees (1-3) (73.5%), and the majority experienced anterior cruciate ligament (ACL) injury (23.5%).  Conclusion: The study concluded that there was a statistically significant relation between knee injury history with knee OA severity and that the risk of developing knee OA increased fivefold after knee injury.
Modulated Hepatic Expression of NF-kB and CCN1 Genes in a Breast Cancer Mouse Model Induced by DMBA and High-Fat Diet Demes Chornelia Martantiningtyas; Raden Ghita Sariwidyantry; Hana Ratnawati; Teresa Lilliana Wargasetya; Ardo Sanjaya
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 14, No 1 (2025): EDISI MARET 2025
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v14i1.4002

Abstract

Background: The study investigates the combined effects of 7,12-dimethylbenz[a]anthracene (DMBA) and a high-fat diet (HFD) on hepatic gene expression in a breast cancer mouse model. Both DMBA and HFD are associated with oxidative stress, inflammation, and fibrosis, which may contribute to cancer progression.Methods: Female C57BL/6 mice were divided into three groups: standard diet (ND), ND + DMBA, and HFD + DMBA. Mice in the ND + DMBA and HFD + DMBA groups received DMBA injections weekly for six weeks. The HFD + DMBA group was also fed a high-fat diet for four weeks prior to DMBA administration. After a 12-week treatment period, liver tissues were collected and analyzed for NF-κB and CCN1/CYR61 gene expression using semi-quantitative RT-PCR.Results: The study revealed significant upregulation of NF-κB and CCN1/CYR61 expression in the ND + DMBA and HFD + DMBA groups compared to the control group. Notably, the HFD + DMBA group exhibited the highest expression levels of these genes, suggesting that the combination of HFD and DMBA synergistically exacerbates hepatic inflammation and fibrosis.Conclusion: The findings indicate that a high-fat diet in combination with carcinogen exposure can significantly enhance hepatic gene expression related to inflammation and fibrosis, highlighting the importance of dietary management in cancer prevention and treatment. 
Delayed Diagnosis of Volvulus without Complications in Pediatric Patient : A Case Report Deny Dwi Hartanto; Yasser Maulidan
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 13, No 2 (2024): September 2024
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v13i2.3654

Abstract

Introduction: Volvulus in children is rare occurrence, it’s only about 3-5% cases in worldwide. Without abdominal radiological examination, it is difficult to make diagnosis of volvulus based on history and physical examination alone. The management procedures are also controversial, as some recommend a non-operative approach, while others recommend an operative approach in the form of Ladd's Procedure or laparoscopy. Sigmoidoscopy or a barium enema can be attempted as an initial treatment for sigmoid volvulus. Objective: The purpose of this case report is  to discuss why there was a delay in diagnosis of volvulus in this case and how to deal it. It also discusses the approach to diagnosis and management of volvulus in pediatric patients, both at the primary health center and the hospital, and why in this case. Case presentation: In this case, volvulus occurred in a pediatric patient who had sought treatment at a primary health center with a complaint of abdominal pain for nine days without improvement. The complaint was accompanied with constipation and fever. Due to limited facilities in primary health center, the patient was referred to the hospital. Result: At the hospital, after taking the history, performing physical examination, and conducting radiological examination and laboratory tests, the patient was diagnosed with ileus obstruction due to volvulus. Conclusion: Although volvulus is a rare case, volvulus should still be included as a differential diagnosis of abdominal pain in pediatric patients to avoid delayed diagnosis. Delay in diagnosis and management of volvulus can lead to serious complications and even life-threatening conditions
Profile of Ankle Sprain Patients at Pusdokkes Polri Bhayangkara Tertiary Hospital Yusticia Valen Pratidina; Basuki supartono
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 14, No 1 (2025): EDISI MARET 2025
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v14i1.4170

Abstract

Background: Ankle sprain is a musculoskeletal injury with the highest incidence rate in the world. Risk factors for ankle sprain are age, gender, sport, anatomical abnormalities, and body mass index (BMI). There is still contradiction as to whether gender is a risk factor for ankle sprain. Furthermore, there has been no research on ankle sprain regarding members of the Police Force as a risk factor. Objective: This research aims to determine the relationship between patient profile and acute ankle sprain at Pusdokkes Polri Bhayangkara Tertiary Hospital. Methods: This study took 124 research subjects, with consecutive sampling analysis, was an observational analytic study with a cross sectional research design involving patients diagnosed with ankle sprain in 2022 – 2023 at Pusdokkes Polri Bhayangkara Tertiary Hospital who met the inclusion and exclusion criteria. Result: As many as 79% of the subjects were aged 19 – 44 years (p=0.333). It was found that 52.4% of the subjects were male (p=0.944). As many as 46% of the subjects were members of the Police Force (p=0.181). Conclusion: Age, gender, and occupation had no significant association with the incidence of acute ankle sprain in this research. Male police officers aged 45 – 59 years have a higher risk of experiencing acute ankle sprain. The implication of this study is to prevent at-risk groups and/or ankle sprain patients.
Epistaxis as The Initial Presentation of Primary Sjögren Syndrome: A Case Report Stephani Linggawan; Eric Satrio Adi Prabowo; Catherine Keiko Gunawan; Budiono Raharjo; Anton Sumarpo
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 14, No 1 (2025): EDISI MARET 2025
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v14i1.4249

Abstract

Background: Primary Sjögren syndrome is chronic systemic autoimmune disorder characterized by lymphocytic infiltration of the exocrine glands, most commonly presenting with dryness of the mouth and eyes. This case is very rare, which the antibody in the Sjogren's syndrome case concerns platelets. Objective: This case report emphasizes the occurrence of epistaxis in Sjögren Syndrome. Case Presentation: This case describes a 30-year-old male presenting with recurrent epistaxis as the initial clinical manifestation. Further clinical evaluation revealed hypertensive crisis and dryness in the mouth and nasal mucosa. The clinical presentation raised suspicion of an underlying autoimmune condition, prompting further testing, which confirmed the presence of anti -Sjögren’s syndrome type B (SSB) antibodies on an antinuclear antibody (ANA) profile.  Result: The criteria for Sjogren's syndrome are based on the criteria if eye and mouth symptoms, eye and mouth clinical signs, and one of autoantibodies are found Anti-Ro (SSA), Anti-La (SSB), Antinuclear antibodies (ANA), Rheumatoid factor (RF). From this case has found symptoms of mouth and antibodies SSB. Conclusion: This case highlights that epistaxis can be caused by autoimmune cases, for epistaxis it is better to do screening for autoimmune examination test, emphasizing the need for further research to elucidate the diverse clinical manifestation, progression and prognosis factor.
Analyzing the Research Trend of Vitiligo in Dermatology From 1963 until 2023: A Bibliometric Analysis Hapsari Kinanti
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 14, No 1 (2025): EDISI MARET 2025
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v14i1.3934

Abstract

Background: Vitiligo is one of the most common skin pigmentation disorders, which could significantly impact the possessor’s quality of life. Scholars have devoted considerable effort to advance the understanding of vitiligo but until now the treatment modalities often fall into a suboptimal condition. There are abundance of scientific updates which challenges healthcare providers to catch up with all the vast knowledge. Objective: This study aims to provide a global picture of vitiligo research and the trend of vitiligo research. Methods: This study was a bibliometric analysis study that used Scopus as the primary article database. A total of 1374 articles were analyzed using VOSviewer and Biblioshiny. Result: There was an increasing number of vitiligo articles published annually from 1963 until 2023. The most productive counties were United States of America, India, and the United Kingdom. There were four major global vitiligo research topics including epidemiology, psychology, conventional treatment, and advanced treatment. Evaluating the psychological aspects of vitiligo patients using DLQI (Dermatological Life Quality Index) is one of the recent research topics. The treatment for vitiligo shifting towards on targeting specific molecular, such as biological agents and janus kinase inhibitors. Understanding the pathogenesis of vitiligo is needed to find a better treatment modality that is specific, effective, and has minimum adverse effects. Conclusion: Current global research efforts in vitiligo shifting towards the modality of treatment that targeting specific molecular based on the pathogenesis, with also encompassing the management psychological aspect to ensure better quality of life of the possessors.
Effect Of Rambusa Fruit Extract (Passiflora Foetida) On The Growth Of Streptococcus Pyogenes Bacteria Gede Vito Chandra Pramana; Nugroho Eko Wirawan Budianto
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 13, No 1 (2024): March 2024
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v13i1.3057

Abstract

Streptococcus pyogenes is a bacteria that can attack the epidermis and upper respiratory tract of humans, such as pharyngitis and impetigo. The rambusa plant (Passiflora foetida L) is famous for containing larvicide bioactive compounds. It also contains alkaloids, tannins, coumarins, procyanidins, triterpenoids, flavonoids, citric acid, acetogens, polyphenols, and saponins. A minority of individuals continue to employ this herb sporadically as an antibacterial agent. Intrigued by this phenomenon, the researchers set out to examine the effect of rambusa fruit (Passiflora foetida) administration on the Streptococcus pyogenes bacterium development inhibitory zone. This research uses Only Post Test Control Group Design, exclusively experimental.  The population for this study was Streptococcus pyogenes bacteria obtained from the microbiology laboratory of the Faculty of Medicine, Wijaya Kusuma University, Surabaya.  There were 24 samples in this study, with four repetitions per sample and consisting of 6 groups, including a treatment group with 4 subgroups (10%, 20%, 40%, and 80%), as well as two control groups.  The Mann-Whitney U test showed that a concentration of 80% in the Passiflora foetida fruit extract treatment group resulted in an inhibitory zone diameter of 8.5 mm, which was statistically significant (P<0.05). The conclusion is that administration of rambusa fruit extract (Passiflora foetida) can inhibit bacterial growth of Streptococcus pyogenes, with the average highest inhibitory zone diameter being 8.5 mm

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