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Universa Medicina
Published by Universitas Trisakti
ISSN : 19073062     EISSN : 24072230     DOI : -
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Universa Medicina (univ.med) is a four-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Universa Medicina Online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic
Arjuna Subject : -
Articles 602 Documents
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Macular hole surgery under retrobulbar local anesthesia increases visual acuity Simanjuntak, Gilbert WS; Simanjuntak, Golda AM; Christine, Reinne Natali
Universa Medicina Vol 36, No 3 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.160-165

Abstract

Background Macular hole surgery can be done under general or local anesthesia, and general anesthesia is still the standard procedure. The objective of this study was to investigate the results of macular hole surgery under local anesthesia. MethodsA retrospective study on medical records of patients who had undergone macular hole surgery under local anesthesia. Funduscopic examination of macular hole had been performed and all other diseases with deterioration of visual acuity eliminated. Surgery was performed under retrobulbar local anesthesia, using 2 ml of 2% lidocaine mixed with 3 ml bupivacaine in one syringe. Vitreous tamponade used 20% sulfur hexafluoride (SF6). Demographic and clinical characteristics, visual acuity before and after surgery, and improvements that occurred were assessed. Results No significant interruption occurred during surgery. Mean age of the patients was 53.89 ± 13.3 years (22-74 years), with mean duration of symptoms of 48.83 ± 100.51 weeks (1-560 weeks). The patients comprised 20 males (55.6%) and 16 females (44.4 5). There were improvements in visual acuity after surgery in 31 patients (86.1%), the rest (13.9%) had identical or lower visual acuity after surgery. A total of 20 patients (55.6%) had postoperative visual acuity of 6/18 or better. Initial mean preoperative visual acuity was 0.08 ± 0.08 (0.01 - 0.29) and improved after the surgery to 0.38 ± 0.26 (0.00 - 1.00), the improvement being statistically significant (p=0.000). ConclusionRetrobulbar anesthesia is an effective and safe method in macular hole surgery. Macular hole surgery can be done well under local anesthesia, and visual acuity improved significantly.
High blood pressure tends to increase carotid intima-media thickness in adult females Imran, Yudhisman; Prawiroharjo, Pukovisa; Mawi, Martiem
Universa Medicina Vol 35, No 2 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.135-142

Abstract

BackgroundAtherosclerosis is initiated by endothelial dysfunction, as a result of increasing degradation of nitrit oxide by reactive oxygen species, thereby increasing oxydative stress. Dyslipidemia is one of the risk factors of endothelial dysfunction. The aim of this study was to evaluate the relationship of blood pressure and serum lipid level with carotid intima-media thickness (CIMT) in subjects aged between 55-65 years.MethodsA cross sectional study was carried out in 52 male and female subjects aged between 55-65 years. Age, gender, body mass index (BMI), blood pressure, lipid profile, and CIMT were assessed in all subjects. The independent t-test was used to to analyze the relationship between all variables and CIMT. The level of statistical significance was set at p<0.05ResultsMean age was 59.19 ± 3.68 years, prevalence of thickened CIMT was 66.5%, and plaques were found in 9 subjects. There wwre no significant differences in age, BMI, systolic and diastolic blood pressure, and lipid profile between normal and thickened CIMT (p>0.05). However, there was a significant difference in gender between the two groups (p=0.011). In females, mean systolic and diastolic blood pressure were higher in the thickened CIMT group than in the normal CIMT group, but the difference was not significant (p>0.05). ConclusionsOur findings suggest that high blood pressure tends to increase CIMT in female adults. An increasing value of CIMT should be considered as a sign of cerebrovascular disease.
Effect of range of motion and isometric strengthening exercises on grip strength and hand function in rheumatoid arthritis patients Bastiana, Yefta Daniel; Tulaar, Angela BM; Hartono, Surjanto; Albar, Zuljasri
Universa Medicina Vol 27, No 4 (2008)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2008.v27.157-164

Abstract

In previous studies, duration of hand exercises in patients with rheumatoid arthritis (RA) had widely varying ranges, from 3 weeks to 4 months. An experimental study was conducted to evaluate the effect of range of motion (ROM) and muscle strengthening exercises for 6 weeks on grip strength and hand function in RA patients. Seventeen patients with chronic RA were randomly assigned to a treatment group and a control group. The treatment group (n=8) was given muscle strengthening exercises and heat therapy using paraffin baths 3 times a week at the hospital and ROM exercises once a day at home for 6 weeks. The control group (n=9) was given only paraffin baths 3 times a week. After 6 weeks, there were significant differences in hand function (p=0.003), right and left grip strength (p=0.000 and p=0.001) and ROM in the interventional group only. ROM and isometric strengthening exercises significantly improved grip strength and hand function in patients with RA, while no impact was found when the patients were given paraffin baths only. In view of the small size of the study population, there is a need for further studies with larger populations.
Hair root FMRP expression for screening of fragile X full mutation females Rujito, Lantip; Kustiani, Dwi; Severijnen, Lies Anne; Hanzon, Peter; Faradz, Sultana MH; Willemsen, Rob
Universa Medicina Vol 30, No 1 (2011)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2011.v30.11-21

Abstract

The fragile X syndrome is the most common form of inherited mental retardation in humans, caused by an expansion of the cytosine-guanine-guanine (CGG) repeat in the fragile X mental retardation 1 (FMR1) gene located on the X chromosome. Antibody tests have been developed to identify fragile X patients, based on the presence or absence of fragile mental retardation protein (FMRP) in both lymphocytes and hair roots. The objective of this study was to compare correlations of hair root and lymphocyte FMRP expression with cognitive functioning in female rural area probands carrying the full mutation. Thirty females (normal, premutation, or full mutation) were selected from Indonesian fragile X families and were tested for FMRP expression in lymphocytes and hair roots using the FMRP antibody test. Subject genotype was determined by Southern blot analysis, and IQ equivalent by Raven’s Standard Progressive Matrices. Statistical analysis was by Pearson correlation. FMRP expression in blood lymphocytes was relatively higher than that in hair roots, but hair root FMRP expression was strongly correlated with cognitive functioning in female full mutation carriers (r=0.64, p=0.015), whereas no significant correlation between lymphocyte FMRP and cognitive functioning was found (r=0.31, p= 0.281). Around 14% of subjects had a normal and 7% a borderline IQ level, while 79% had mild mental impairment. In conclusion, hair root FMRP expression may be a useful marker for identification of fragile X full mutation females.
Antifungal activity of neem leaf ethanol extract on Aspergillus flavus Ayly Margaret; Hanna Yolanda; Wibisono Lies K
Universa Medicina Vol. 32 No. 2 (2013)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2013.v32.80-85

Abstract

BACKGROUNDAspergillosis is an infectious disease due to inhalation of Aspergillus spores.Drug resistance to aspergillosis has been reported since 14 years ago. Therefore,alternative treatment using herbals began to attract the attention of the medicalprofession and the community, because herbals are relatively safe and haveminimal side effects. Neem (Azadirachta indica) is an herb with broad spectrumbiological activity, but studies on the antifungal activity of neem leaves arelacking. The objective of this study was to evaluate the activity of neem leaveson Aspergillus flavus (A. flavus).METHODSThis was a laboratory experimental study using A. flavus samples obtained frombronchial washing specimens of inpatients. Neem leaf extract in ethanol (NLE)was prepared in various concentrations. Aspergillus. flavus antifungal activityof NLE were assessed by disc diffusion (using NLE at 1.0; 0.75; 0.50; 0.25 g/dL)and macrodilution (using NLE at 1.0; 0.75; 0.5; 0.25; 0.125 g/dL). Ketoconazole0.1 g/dL was used as antifungal positive control. Disc diffusion and macrodilutionwere conducted using Sabouraud dextrose agar and broth, to measure inhibitionzone diameter and minimal inhibitory concentration (MIC), respectively. Statisticalanalysis was performed using Mann-Whitney test from SPSS 15.RESULTSThere were significant differences in inhibition zone diameter (p = 0.034) betweenA. flavus samples exposed to NLE (1 g/dL) and the control group exposed toketoconazole (0.1 g/dL). The MIC of NLE against A. flavus was 0.5 g/dL.CONCLUSIONSNeem leaf ethanol extract has antifungal activity against A.flavus in vitro.
Zinc supplementation decreases basophilic stippling in rats exposed to lead Budi Santosa; Hertanto Wahyu Subagio; Lisyani Suratmo; Henna Rya Sunoko
Universa Medicina Vol. 33 No. 1 (2014)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2014.v33.11-18

Abstract

BACKGROUND Lead acetate inhibits pyrimidine-5’-nucleotidase resulting in ribonucleic acid and ribosome accumulation in erythrocytes (RBC), visible as basophilic stippling (BS). Lead exposure disrupts RBC membrane, shortens the RBC life span and decreases hematocrit. Zinc supplementation increases lead-binding proteins (metallothioneins). The study objective was to determine whether zinc supplementation prior to lead exposure decreases BS and increases the hematocrit in rats. METHODS The study was a randomized post-test only control-group trial, using 28 rats allocated to one control and 3 intervention groups (Zinc I, Zinc II, Zinc III) receiving 0.2 mg, 0.4 mg, and 0.8 mg of zinc by oral gavage daily for 3 weeks. All groups were then exposed to lead at 0.5 g/kg BW/day by gavage for 10 weeks. On the last day of the 10 weeks BS was determined from Giemsastained blood smears and hematocrit by hematology analyzer. Between-group differences were tested with one-way ANOVA, followed by Bonferroni’s test. RESULTS Mean BS was significantly decreasing 7.93 ± 0.99% in controls, 6.91 ± 1.04%, 4.66 ± 0.79%, and 1.73 ± 0.88%, respectively, in intervention groups (p=0.000). Mean hematocrit was significantly increasing 26.16 ± 3.60% in controls, and 30.33 ± 6.12%, 36.83 ± 3.31%, and 40.00 ± 4.77%, respectively, in intervention groups (p=0.000). One-way Anova and Bonferroni’s test showed significant differences in BS and hematocrit between controls and intervention groups receiving zinc supplementation of 0.4 and 0.8 mg (p=0.000). CONCLUSION Zinc supplementation before lead exposure significantly decreases basophilic stippling and increases hematocrit level in rats exposed to lead
Pediatric idiopathic hypercalciuria with bilateral nephrolithiasis and hypertensive urgency Yolanda, Natharina; Irene, Irene
Universa Medicina Vol 36, No 2 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.150-156

Abstract

BackgroundPediatric nephrolithiasis is an important cause of morbidity worldwide. Even with low prevalence, nephrolithiasis can cause detrimental long-term effects on kidney function. Idiopathic hypercalciuria is the most common cause of renal stones in children. This case report presents a pediatric patient with bilateral nephrolithiasis and hydronephrosis associated with underlying idiopathic hypercalciuria.Case descriptionWe report on a 17-month-old boy presenting with two days of high fever, irritability, nausea, and poor feeding. The patient had been diagnosed with bilateral nephrolithiasis at the age of 6 months. On examination, the patient was febrile and hypertensive. Laboratory evaluation revealed anemia, leukocytosis, normokalemia, normocalcemia, and normal glomerular filtration rate. Blood gases were within normal limits. Urinalysis revealed pH 5.0, hematuria, pyuria, and bacteriuria. Urine culture was positive for Proteus mirabilis and Enterobacter gergoviae. Electrolyte analysis from urine samples revealed hypercalciuria. Ultrasonography found stones at the left ureteropelvic junction with corresponding grade I hydronephrosis and stones in the right lower calyx without hydronephrosis. The patient was treated with antibiotics, an antihypertensive agent, thiazide diuretics, and was referred to a pediatric urologist.ConclusionThis case can be considered as idiopathic. Most children with renal stones have metabolic risk factors including enteric, endocrinologic, or renal sources. Metabolic evaluation is mandatory in pediatric renal stone patients and hypercalciuria is an important etiology to be evaluated. Ignorance of the underlying metabolic abnormality or failure in its identification in pediatric urolithiasis could lead to catastrophic long-term effects.
Studi kasus : stroke iskemik dengan infark luas pada pasien laki-laki muda dengan stenosis mitral berat Muljadi, Sendjaja; Sutrisno, Alfred; Lison, Linda
Universa Medicina Vol 26, No 4 (2007)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2007.v26.160-167

Abstract

Latar belakang Meskipun terdapat kecenderungan peningkatan insidens stroke pada usia dewasa muda, namun tetap lebih jarang dijumpai dibandingkan dengan usia pertengahan dan usia yang lebih tua. Penyebab stroke iskemik pada pasien-pasien usia muda lebih heterogen dibandingkan dengan pasien-pasien yang lebih tua.Deskripsi kasus Kami melaporkan sebuah kasus, seorang laki-laki berusia 39 tahun yang mengalami kejang-kejang selama kurang lebih 30 menit dan terjadi kira-kira 1 jam sebelum pasien tersebut dibawa ke rumah sakit. Dan pada saat itu pasien dalam keadaan somnolen, hasil pemeriksaan dengan pencitraan tomografi komputer kepala (brain CT Scan) saat itu tidak menunjukkan adanya infark. Akan tetapi 12 jam kemudian, dilakukan pemeriksaan pencitraan tomografi komputer kepala yang kedua, ternyata menunjukkan adanya infark yang luas di hemisfer kanan. Pada pemeriksaan ekokardiografi menunjukkan adanya pelebaran atrium kiri, stenosis mitral pada katup-katup mitral, dengan luas area 0,94 cm2 dan skor mitral 14. Elektro kardiografi (EKG) menunjukkan sinus ritmik.Kesimpulan Pasien tersebut di atas memiliki masalah besar dengan jantungnya dan menyebabkan terjadinya oklusi pada pembuluh darah di otak (pemeriksaan dengan pencitraan tomografi komputer kepala yang kedua menunjukkan adanya infark yang luas). Pasien tersebut akhirnya meninggal setelah menjalani perawatan selama 6 hari di rumah sakit. Prognosis seorang berusia muda dengan kelainan mitral bila menderita stroke iskemik tidak begitu baik.
Host-parasite interactions and mechanisms of infection in amebiasis Suriptiastuti, Suriptiastuti
Universa Medicina Vol 29, No 2 (2010)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2010.v29.104-113

Abstract

Amebiasis is caused by E. histolytica, which is the only species pathogenic in humans, while the pathogeneicity of E. dispar and E. moshkovskii is still unclear. The disease is endemic in the developing countries, mainly due to poor sanitation and lack of clean water supplies. Infection occurs by ingestion of E. histolytica cysts in fecally contaminated food or water. Excystation in the small intestine releases motile invasive trophozoites which migrate to the large intestine, adhere to the colonic epithelium by means of galactose and an amebic surface antigen, N-acetyl-D-galactosamine-specific lectin. This results in killing of epithelial cells, neutrophils, and lymphocytes by the trophozoites, presumably through secretion of the pore-forming proteins called amebapores and activation of caspase 3. The trophozoite virulence factor, cysteine proteinase, induces an inflammatory response, resulting in neutrophil-mediated damage. Hematogenous spread of trophozoites causes extraintestinal amebiasis, particularly amebic liver abscess (ALA), in the formation of which caspase 3 presumably also plays a role. The trophozoites in the liver induce tissue destruction, cellular necrosis and formation of microabcesses that coalesce into a large solitary abscess in 65-75% of cases. Results from pediatric studies reveal that partial immunity is acquired after infection with E.histolytica, the immunity however declining with age.
Common mental disorders increase pre-eclampsia/ eclampsia risks in pregnancy Y Wibowo; M Hakimi; CR Marchira
Universa Medicina Vol. 32 No. 1 (2013)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2013.v32.60-68

Abstract

INTRODUCTION Pre-eclampsia is a multisystem complication that occurs after 20 weeks of pregnancy and can cause considerable maternal and fetal morbidity and mortality. Mental health is influenced by social support, and emotional distress during pregnancy may cause pre-ecclampsia/ecclampsia (PE/E). The objective of this study was to determine the association of social support and common mental disorders (CMD) with PE/E in pregnant women. METHODS This study was a matched case-control study. Cases were pregnant women who had been diagnosed with PE/E. Controls were those with normal pregnancies or not diagnosed as PE/E. Instruments social support questionnaire-6 (SSQ-6) was used to measure social support and self-reporting questionnaire 20 (SRQ-20) items for measuring CMD. Conditional logistic regression was used to estimate matched odds ratios (ORs) and 95% confidence intervals (95% CI). RESULTS Low social support was not directly associated with PE/E. Compared with women with high social support, those with low social support had a 26-fold increased risk of CMD (+) (OR=26.4, 95% CI: 10.67 to 77.20, p=0.001). Several variables significantly associated with PE/E were CMD (+) (OR=6.11, 95% CI: 2.99 to 14.07, p=0.001), low family income (OR=2.93, 95% CI: 1.56 to 5.82, p=0.001), history of chronic hypertension (+) (OR=7.67, 95% CI: 2.32 to 39.89, p=0.001), history of PE/E (+) (p=0.001), and history of hereditary PE/E (+) (OR=6, 95% CI: 1.34 to 55.20, p=0.013). CONCLUSION Low social support was not directly associated with PE/E but was associated with CMD. To prevent CMD in pregnant women, there is a need for social support from the family.

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