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Universa Medicina
Published by Universitas Trisakti
ISSN : 19073062     EISSN : 24072230     DOI : -
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Universa Medicina (univ.med) is a four-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Universa Medicina Online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic
Arjuna Subject : -
Articles 602 Documents
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Clinical and laboratory aspect of leptospirosis in humans Setiawan, I Made
Universa Medicina Vol 27, No 2 (2008)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2008.v27.87-97

Abstract

Leptospirosis is a world-wide zoonotic disease, especially in tropical and subtropical regions. The disease is found in rural and urban areas with poor environmental conditions. The spectrum of human disease ranges from subclinical infection to severe clinical disease with multi-organ failure (Weil’s disease) and high mortality rate, and depends both on the host and the infecting serovar. Leptospirosis may occur either sporadically or in the context of an outbreak and is commonly related to occupational or recreational activities that involve direct or indirect contact with the urine of animal species that are reservoirs of the disease. The disease infects man through contact with contaminated environments or direct contact with carrier animals such as rats, dogs, cattle, pigs, etc. Leptospirosis has clinical symptoms similar to such diseases as dengue, malaria, typhoid, influenza, thus laboratory methods are required for early detection to facilitate appropriate treatment of patients. The diagnosis of leptospirosis should be considered in any patient presenting with an abrupt onset of fever, chills, conjunctival suffusion, headache, myalgia, and jaundice. Suspicion is further increased if there is a history of occupational or recreational exposure to infected animals or to an environment potentially contaminated with animal urine. Treatment commonly consists of administration of antibiotics such as penicillin, ampicillin, amoxicillin, tetracycline and doxycycline. Prevention by immunization is uncommon, as the available vaccines are ineffective in preventing the disease. In general, prevention is by avoiding environmental exposure.
Oxydative stress in rats caused by coal dust plus cigarette smoke Kania, Nia; Setiawan, Bambang; Kusuma, H.M.S. Chandra
Universa Medicina Vol 30, No 2 (2011)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2011.v30.80-87

Abstract

Coal dust and cigarette smoke are pollutants found in coal mines that are capable of inducing oxidative stress, the effects of which on blood malondialdehyde (MDA) level and serum superoxide dismutase (SOD) level are still unknown. The purpose of the present study was to evaluate the effect of coal dust and cigarette smoke on levels of MDA and SOD in rats. An experimental study was done on Wistar male rats divided into the following groups: control (C), coal dust exposure (14 days) (CDE), cigarette smoke exposure (14 days) (CSE), coal dust exposure (7 days) followed by cigarette smoke exposure (7 days) (CDE+CSE), cigarette smoke exposure (7 days) followed by coal dust exposure (7 days) (CSE+CDE). All exposures increased MDA levels and decreased SOD activity significantly between groups (p=0.000). All exposure groups had significantly increased blood MDA levels, compared to the control group, although there was no difference between CSE + CDE and CDE + CSE. For SOD levels, all exposure groups had significantly decreased the SOD levels compared to control. But there were no significant differences between CSE vs CDE and CDE + CSE vs CSE + CDE. We conclude that exposure to cigarette smoke significantly increases blood MDA level and decreases serum SOD activity, which was not found in exposure to coal dust. Combined exposures also increase blood MDA level and decrease serum SOD activity significantly.
Lipiodol retention pattern predicts transarterial chemoembolization therapeutic effect in hepatocellular carcinoma Margaretha Vianny; Gunawan Santosa; Eddy Soedijanto
Universa Medicina Vol. 34 No. 1 (2015)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2015.v34.52-60

Abstract

BACKGROUND Hepatocellular carcinoma (HCC) incidence is increasing in Asia and Africa. Locoregional minimally invasive transarterial chemoembolization (TACE) is the palliative therapy of choice, improving survival rate. Adequate lipiodol dose calculation in TACE is necessary to produce good therapeutic effect. Lipiodol retention pattern can predict TACE therapeutic effect. This study aimed to determine correlation of lipiodol volume/tumor volume (L/V) ratio and lipiodol volume/tumor diameter (L/D) ratio with lipiodol retention pattern in post-TACE CT-scans of HCC patients. METHODS This cohort prospective study was done from November 2013 to March 2014 on eighteen HCC patients with post-TACE therapy in Dr.Kariadi Hospital, Semarang, fullfilling inclusion and exclusion criteria. Lipiodol retention pattern was observed on 28 days post-TACE and classified as type I (lipiodol accumulation in tumor and surrounding area), type II (homogenous accumulation in tumor only), and type III (partial accumulation). The Spearman correlation test was used to determine any relationships between the various variables studied. RESULTS Spearman correlation test showed that lipiodol volume had significant moderate correlation with lipiodol retention pattern (r=-0.684; p=0.002). Both L/V and L/D ratios had moderately significant correlation with lipiodol retention pattern (r=0.511; p=0.030; and r=0.518; p=0.028, respectively). CONCLUSION Correlations of L/V ratio L/D ratio with lipiodol retention pattern were both moderately significant. Lipiodol dose calculation based on L/V ratio is suggested considering the irregular three-dimensional form of the tumor, making volumetric measurement more appropriate.
Body mass index and quality of life among the elderly Kusumaratna, Rina K.; Hidayat, Adi
Universa Medicina Vol 28, No 1 (2009)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2009.v28.34-41

Abstract

Obesity in many countries is a major public health problem. The health problems associated with an increase in the proportion of elderly in the population are further compounded by the increasing prevalence of obesity and overweight in older people. The aimed of this study was to explore any difference of quality of life (QOL) attributable body mass index (BMI) categories using the WHOQOL-BREF instruments. An observational cross-sectional study was conducted in Mampang Prapatan district, South Jakarta. A total of 296 free-living elderly aged 60 years and above were participated in this study. BMI was calculated as the weight (kg) divided by the square of the height (m2). Quality of life was measured by WHOQOL-BREF questionnaire in the Indonesian language version. The results showed that the percentage of overweight subjects was 27.5% in male and 22.2% in female elderly, while the percentage of obese subjects was respectively 8.3 and 13.2.1% respectively. In males, the mean scores on each domain of the QOL were higher compared with females. The significant differences were in social relationship (p=0.000) and environment (p=0018) domains. Among male and female elderly the highest mean scores of each domain of QOL was observed in the environment domain, and mean scores of the environment domain was significantly higher in males compare with females (p=0.018). The results have practical implications for the health of older persons because they show that the overweight have a worse score in two QOL domains, namely psychological health and environment.
Soy isoflavone supplementation increases equol-producing capability in postmenopausal women with osteopenia Elly Herwana; Rianto Setiabudy; Sidartawan Soegondo; Ali Baziad; Adi Hidayat
Universa Medicina Vol. 31 No. 2 (2012)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2012.v31.120-130

Abstract

Background Isoflavone containing soy protein has been associated with beneficial health effects. Equol, a gut bacterial metabolite of the isoflavone daidzein, has been hypothesized to be the cause of the effectiveness of isoflavones. The objective of this study was to evaluate the effect of 100 mg/day soy isoflavone supplementation for 3 months on the ability to produce equol in postmenopausal women with osteopenia.MethodA pre-post experimental study was conducted to assess the effects of 100 mg/day soy isoflavone supplementation on equol production capability and the proportion of equol producers to non-equol producers in postmenopausal women with osteopenia. A total of 39 subjects received 1 supplement tablet containing 100 mg soy isoflavones (genistein, daidzein) for 3 months. Determination of serum genistein, daidzein, and equol concentrations was performed twice at baseline and at 3 months post-supplementation using high-performance liquid chromatography mass spectrophotometry (HPLC-MS). Equol producer status was determined by the detection of a serum equol concentration of 5 µg/L.Results Mean genistein and daidzein concentrations at baseline were 86.2 ± 68.4 ìg/L and 16.7 ± 18.6 ìg/L, respectively. The proportion of equol producers was 69.2%. After 3 months of soy isoflavone supplementation the serum concentrations of genistein and daidzein significantly increased to 161.0 ± 5.8 ìg/L (p=0.000) and 49.9 ± 40.4 ìg/L (p=0.000), respectively, and the proportion of equol producers also significantly increased (100.0%).ConclusionSoy isoflavone supplementation was capable of increasing the serum concentrations of isoflavones (genistein and daidzein) and the equol-producing capacity of postmenopausal women with osteopenia.
The changing paradigm of dyslipidaemia management Ekanayaka, Ruvan
Universa Medicina Vol 36, No 1 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.1-3

Abstract

The 2013 American College of Cardiology (ACC)/American Heart Association (AHA) guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults,(1) effected a change in the paradigm of dyslipidaemia management, in that it no longer advocated a target based therapy but instead posited a primary clinical basis for initiation of statin therapy. The intensity of statin therapy too was guided by clinical risk criteria rather than by absolute values of the lipid profile.
Hubungan antara konsumsi iodium dan gondok pada siswi berusia 15-17 tahun Budiman, Basuki; Sumarno, Iman
Universa Medicina Vol 26, No 2 (2007)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2007.v26.80-89

Abstract

LATAR BELAKANGKonsekuensi gangguan akibat kekurangan iodium (GAKI) yang paling utama adalah kelainan neuropsikologi dalam masa pertumbuhan janin. Remaja merupakan kelompok usia yang segera akan menghasilkan keturunan. Penelitian ini bertujuan untuk menilai adanya hubungan antara konsumsi iodium dan prevalensi gondok pada remaja. METODEPenelitian ini dirancang menggunakan desain potong-lintang. Sebanyak 300 siswa putri SMU usia 15-18 tahun di Kabupaten Minahasa (Mn, Sulawesi), Bukittinggi (Bt, Sumatera) dan Gunungkidul (Gk, Jawa), berpartisipasi dalam penelitian ini. Pembesaran tiroid (gondok) dipalpasi dengan mengikuti kriteria WHO/ICCIDD. Data yang dikumpulkan termasuk sampel urin sesaat (casual urine), perihal kesukaan remaja mengudap, contoh garam dapur rumahtangga, dan penggunaan garam beriodium. HASILPrevalensi gondok pada siswi sangat tinggi di tiga kabupaten, sebesar 51,0% (Mn), 41,6% (Bt) dan 31,1% (Gk) searah dengan gradasi proporsi defisit iodium menurut konsentrasi iodium dalam urin (KIU) (<100 mg/L bertutur-turut: 38,1%; 24,3% dan 11,6%) yang berada dalam kisaran normal. Kualitas garam beriodium di Mn paling bagus (>20 ppm iodium = 56%) begitu pula jenis garam yang dikonsumsi (92,0% garam halus) dibandingkan dengan dua kabupaten lainnya (Gk 90% garam bata; Bt 61,5 % garam curai/krosok). KESIMPULANKonsumsi iodium berhubungan dengan prevalensi gondok pada siswi berusia 15-17 tahun.
Epidemiology of osteoporosis in postmenopausal women aged 47 to 60 years Meiyanti, Meiyanti
Universa Medicina Vol 29, No 3 (2010)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2010.v29.169-176

Abstract

Osteoporosis is a disorder having the characteristic features of low bone mass and structural degeneration. There are several factors affecting the prevalence of osteoporosis in postmenopausal women, such as age, age at menarche, duration of menopause, dietary or nutritional intakes, life style and level formal education. In connection with the increasing global prevalence of osteoporotic fractures, the purpose of the present study was to determine the prevalence and the influencing factors of osteoporosis in postmenopausal women. A cross-sectional study, involving 203 postmenopausal women aged 47-60 years, was conducted in 4 villages of Mampang Prapatan subdistrict, from February to April 2010. Bone mineral density (BMD) of lumbar spine 1-4, femoral neck, and left radius was measured by dual-energy X-ray absorptiometry (Lunar DPX Bravo Nomusa densitometer, GE Medical Systems) at Budi Jaya Hospital, Jakarta. The T-score threshold, defined as £ -2.5 was used to identify subjects with osteoporosis The results of the study showed that the highest prevalence of osteopenia of 45.8% was found in the femoral neck, while the highest prevalence of osteoporosis of 30% was found in the distal radius. Age, duration of menopause, and number of pregnancies yielded a significant correlation with BMD of the lumbar vertebrae and the distal radius. Body mass index (BMI) was also significantly correlated with BMD of lumbar vertebrae, femoral neck and distal radius. Effective strategies for the prevention and management of osteopenia and osteoporosis are needed.
Occupational noise exposure and cardiovascular disease in male workers Lie T. Merijanti
Universa Medicina Vol. 32 No. 3 (2013)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2013.v32.135-136

Abstract

Noise is a common occupational hazard worldwide. The impact of noise on human health is emerging as an important public health issue. The most well-known effect of high noise levels at work (>85 dBA) is hearing loss that is significantly associated with the period of exposure.(1) In addition, noise exposure can cause non-auditory effects, such as sleep disturbance, annoyance, psychological stress, and cardiovascular disease (CVD). In a study among Korean blue collar workers, Won et al. found that the prevalence of CVD risk was 32 cases per 100 workers.(2)However, the relationship between occupational noise and cardiovascular disease remains unsettled.(3)
Women and stroke patients are more at risk for fall- related injury among older persons Darjoko, Sulistyowati Tuminah; Djoeworo, Woro Riyadina; Sapardin, Aprildah Nur
Universa Medicina Vol 35, No 1 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.10-18

Abstract

BackgroundIn Indonesia, the prevalence of injury has increased from 7.9% in 2007 to 8.2% in 2013. Among older persons, falls were the main cause of injury. The objective of this study was to determine the major risk factors and the magnitude of the risk for fall-related injury in older persons.MethodsA study of cross-sectional design was conducted on 4,222 respondents aged 60 years and over. Injury was defined as fall-related injury occurring in the previous 12 months that disturbed activity dailyu living (ADL). Data collection was done by: 1) interview about sociodemographics and health (including hearing impairment, non-communicable diseases and injury) using a questionnaire, 2) measurement of blood pressure and anthropometry (body mass index), 3) examination of vision in the right nd left eyes using tumbling E cards and pinhole eye covers. Data were analyzed using the chi square test and multiple logistic regression with 0.05 significance level.Results After controlling for age, occupation, vision disorder, educational level and economic status, older women had a 2.0-fold increased risk for fall-related injury compared to men (aOR=2.30; 95% CI: 1.93-2.73; p=0.000); subjects with a history of stroke had a 2.0-fold increased risk for fall-related injury compared to those without a history of stroke (aOR=2.07; 95% CI: 1.38-3.09; p=0.000). Educational level was a confounding factor.ConclusionWomen and stroke sufferers were at higher risk of fall-related injury among older persons. Prevention of fall-related injury should be done by older persons through periodic control of their health condition.

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