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Universa Medicina
Published by Universitas Trisakti
ISSN : 19073062     EISSN : 24072230     DOI : -
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Universa Medicina (univ.med) is a four-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Universa Medicina Online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic
Arjuna Subject : -
Articles 602 Documents
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Telaah kritis terapi risperidone untuk perbaikan perilaku pada gangguan spectrum autistik Pinzon, Rizaldy; Meliala, Lucas; Sutarni, Sri
Universa Medicina Vol 26, No 1 (2007)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2007.v26.39-45

Abstract

Autisme adalah sindroma klinik yang ditandai oleh gangguan interaksi sosial, hambatan komunikasi verbal, dan keterbatasan aktivitas serta minat. Sampai saat ini, tidak ada terapi untuk autisme. Pengobatan farmakologis terutama ditujukan untuk mengurangi agresivitas, perilaku obsesif kompulsif, dan perilaku melukai diri sendiri. Telaah pustaka ini menunjukkan bahwa risperidone efektif dan aman untuk terapi tantrum, agresivitas, dan perilaku melukai pada anak-anak autistik. Namun risperidon tidak dapat memperbaiki kekurang anak dalam hal interaksi sosial dan komunikasi. Diperlukan penelitian lebih lanjut untuk mengembangkan pengobatan yang efektif untuk memperbaiki gangguan intarksi sosial dan komunikasi pada penderita autistik. Efektifitas yang menjanjikan dari resperidone ini memberikan harapan untuk mengobati anak-anak yang mengalami gangguan perilaku pada autisme.
Early versus late discharge from hospital after open appendectomy Krismanuel, Hari
Universa Medicina Vol 29, No 3 (2010)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2010.v29.129-136

Abstract

To date there is increasing pressure on surgeons to minimize the time that the patient stays in hospital. Patients with acute appendicitis without perforation or peritonitis are not discharged early due to concern on the part of the surgeon that it would increase surgical wound infection rates. The aim of this study was to compare surgical wound infection rates after open appendectomy (OA) of patients with acute appendicitis without perforation or peritonitis in an early discharge (ED) group and a control group without early discharge (late discharge [LD] group. The study was also to evaluate patient acceptance of ED in comparison to the LD group. A cross sectional study was carried out on adult patients (age >14 years) with acute appendicitis without perforation or peritonitis, who underwent open appendectomy. The results showed that there was no significant difference (p>0.05) in surgical wound infection rates in both the intervention (ED) and control (LD) groups. In addition, there was a significant difference (p<0.05) in patient acceptance (satisfaction) in both groups, where patients in the ED group were more satisfied than the patients who had not been discharged early. The conclusions of this study are that early discharge from hospital after open appendectomy does not increase surgical wound infection rate and has good patient acceptance.
Andrographis paniculata extract induced apoptosis of adenocarcinoma mammae in C3H mice Nugrahaningsih Nugrahaningsih; Sarjadi Sarjadi; Edi Dharmana; Hartanto Wahyu Subagio
Universa Medicina Vol. 32 No. 2 (2013)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2013.v32.99-107

Abstract

BACKGROUNDApoptosis plays an important role in tumorigenesis. Induction of apoptosis is a strategy for developing cancer therapy. In vitro study found that andrographolide isolated from Andrographis paniculata has anticancer activity by an apoptotic mechanism in cancer cell lines. The aim of the present study was to prove theeffect of Andrographis paniculata extract administered orally on apoptosis of mammary adenocarcinoma in C3H mice.METHODSThis study was of post test randomized control group design. Twenty four C3H mice with transplanted mammary adenocarcinomas were divided into four groups. To three groups Andrographis paniculata extract was administered orally for14 days, at doses of 5, 10 and 15 mg/day, respectively, whereas to the control group no Andrographis paniculata extract was administered. On day 15 the mice were terminated. The mammary adenocarcinomas were examined by the terminal deoxynucleotide transferase dUTP nick end labeling (TUNEL) method. The values of the apoptotic index were expressed as mean±SD and analyzed using ANOVA and Pearson’s correlation test.RESULTSThe mean apoptotic index values differed significantly among the experimental groups (p=0.001). The highest value was found in the group receiving Andrographis paniculata extract 15 mg/day, while the lowest was in the control group, the values being significantly correlated (r=0.974).CONCLUSIONSOral administration of Andrographis paniculata extract induced apoptosis in C3H mice with mammary adenocarcinoma
Cataract surgical coverage rate among adults aged 40 years and older Tana, Lusianawaty
Universa Medicina Vol 28, No 3 (2009)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2009.v28.161-169

Abstract

Cataract is a leading cause of curable blindness. Hence, in its global declaration of ‘Vision 2020 Right to Sight’, the World Health Organization (WHO) encouraged its member countries to address the problem of incident cataract. Many factors are related to the cataract surgical coverage rate, such as gender and diabetes mellitus. The objective of this study was to determine the cataract surgical coverage rate and investigate the determinants factors of cataract surgical coverage rate among adults 40 years old and above with cataract. A cross sectional study was conducted using National Basic Health Research (Riskesdas) 2007 data. Cataract surgery was defined as surgery conducted within the last 12 months before the survey was performed. There were 6939 subjects (3105 male, 3834 female) who fulfilled the study criteria. The cataract surgical coverage rate was 19.3%. The cataract surgical coverage rate was lower in subjects with low education, in the group of farmers/fishermen/laborers, in the 40-49 years age group, in rural areas, and in subjects of low socioeconomic status (p<0.05). The cataract surgical coverage rate was not different between gender and diabetes mellitus (p>0.05). Determinants that were related to cataract surgical coverage rate were age, type of area of residence, socioeconomic status, and region of residence (p<0.001). The implementation of educational programs and reforms to local ophthalmic health services may improve the cataract surgical coverage rate.
Frailty decreases physical health domain of quality of life in nursing home elderly Handajani, Yvonne Suzy; Widjaja, Nelly Tina; Turana, Yuda
Universa Medicina Vol 34, No 3 (2015)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2015.v34.213-219

Abstract

BACKGROUND Approximately 10-27% of the population aged >65 years suffers from frailty. The percentage increases with age so that the prevalence of frailty in the population aged >85 years reaches 45%. The objective of this study was to determine the relationship between   frailty and quality of life (QOL) in nursing home elderly. METHODS This was a cross-sectional study of 138 subjects aged >60 years who were recruited from 4 nursing homes in West Jakarta. Participants with frailty status were evaluated by the Survey of Health, Ageing and Retirement in Europe (SHARE) instrument and QOL was evaluated by the WHOQOL-BREF questionnaire. One-way ANOVA and chi-square tests were used to find relations between the frailty syndrome and QOL. RESULTSThe percentages of respondents with pre-frail, frail, and non-frail status were 30.4%, 52.2%, and 17.4%, respectively. A decline in QOL scores of pre-frail and frail respondents was found for almost all QOL domains (physical, psychological and environment domains), except social relationships. The subdomains most influenced were “energy and fatigue” in the physical health domain, “thinking, learning, memory and concentration” in psychological health, and “opportunities for acquiring new information and skills” in the environment domain.CONCLUSIONS More than half of the nursing home elderly were frail and one-third were pre-frail. The main factor of frailty was weakness. The frailty syndrome in the elderly has a negative impact on QOL, especially in the physical health, psychological and environment domains in nursing home elderly.
Creatine kinase increases in adults with uncontrolled hypertension Andy Luman; Abdurrahim Rasyid Lubis
Universa Medicina Vol. 33 No. 1 (2014)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2014.v33.36-42

Abstract

BACKGROUND A substantial proportion of uncomplicated, treated primary hypertensive patients have failure of hypertension treatment. The enzyme creatine kinase (CK) regenerates adenosine triphosphate in striated muscle, myocardium and blood vessels. Several studies showed that serum CK was found to be a predictor of blood pressure in the general population. High tissue CK precedes hypertension in populations with high hypertension risk. The hypothesis of this study was to examine that CK increases in uncontrolled hypertension subjects. METHODS A cross-sectional study from November until December 2013 was conducted in 82 adult hypertensive patients with mean age of 61.96 ± 10.76 years. Patients’ histories were taken and their blood pressure and body mass index were measured. Serum was analyzed for serum CK, random blood glucose and lipid profile. Independent t test and Mann Whitney was used to assess differences in mean CK and other variables between hypertension categories. Chi-square test was also used to assess differences between CK tertiles and status of hypertension. RESULTS There was a significant difference in mean CK between controlled hypertension (81.83 ± 29.70 U/L) and uncontrolled hypertension groups (132.17 ± 55.91 U/ L). The number of subjects in the high CK tertile (>109.33 U/L) was significantly higher in the uncontrolled hypertension group (81.5%), compared with the controlled hypertension group (18.5%) (p=0.0001). CONCLUSION Creatine kinase level increases in adults with uncontrolled hypertension. Measuring serum levels of creatine kinase may help doctors to spot patients whose hypertension will be difficult to treat.
Low body mass index increases risk of anemia in patients with HIV-AIDS receiving antiretroviral therapy Widiyanti, Mirna; Ubra, Reynold; Fitriana, Eva
Universa Medicina Vol 36, No 3 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.221-227

Abstract

BackgroundIn acquired immunodeficiency syndrome (AIDS) cases, cytopenias of all major blood cell lines were increasingly recognized in patients with HIV infection. Anemia commonly occurs during HIV infection and has been associated with increased progression to AIDS and decreased survival. The aim of this study was to determine the prevalence of anemia and associated risk factors in adults with HIV-AIDS receiving antiretroviral therapy (ART). MethodsA cross sectional study was conducted involving 90 adults with HIV-AIDS. Sociodemographic data were collected using a questionnaire. In all patients, CD4+ lymphocyte counts were performed by means of a PIMA analyzer, while hemoglobin was determined using a Sysmex hematology analyzer. The WHO cutoff value of hemoglobin was adjusted to altitude to define anemia. Mild to moderate anemia was defined as hemoglobin 8-13 g/dL for men and 8-12 g/dL for women. Severe anemia was defined as hemoglobin 8 g/dL. Data was analyzed by using logistic regression test.ResultsThere were 90 subjects with HIV-AIDS in this study. Anemia was found in 50 subjects (55.6%), consisting of 12.2% with mild anemia and 43.4% with moderate to severe anemia. Multiple logistic regression showed that an important risk factor for anemia was low body mass index (BMI) between <17-18.5 (OR=4.20; 95% CI=1.23-14.36). However, the CD4 <350 cells/mm3 was not a significant risk factor for anemia (OR=1.03; 95% CI=0.21-5.04).ConclusionsLow BMI increases the risk of anemia in subjects with HIV receiving ART. Better screening for anemia and infectious diseases, and modified harm reduction strategy for injection drug users are primary needs in HIV patients.
Gastrointestinal symptoms and sleep disturbance in female nurses Samara, Diana
Universa Medicina Vol 28, No 2 (2009)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2009.v28.100-105

Abstract

Sleep disturbance is a common symptom in the general population. An association between sleep disturbances and functional gastrointestinal (GI) disorders has been reported by several investigators. GI symptoms are more common among people with sleep disturbance in female nurses. To explore this issue further, a study using a cross sectional design was conducted to determine whether unexplained GI symptoms are more common in female nurses with self-reported sleep disturbance. This study was conducted from February through April 2007 in Hospital X in Central Jakarta. A total of 152 female nurses participated in this study. A questionnaire consisting mainly of items concerning sleep disturbance was distributed to the subjects. Significant associations were observed between gastrointestinal symptoms such as anorexia and constipation and sleep disturbance. Constipation was significantly more common in female nurses with sleep disturbance (prevalence ratio=6.1;95% C.I. 1.76 – 20.56), but the association between shift work and sleep disturbance was not statistically significant (prevalence ratio=1.67;95% C.I. 0.53-5.24). Both constipation and anorexia are more prevalent in female nurses with self-reported sleep disturbance. Further research to understand the associations between GI symptoms and sleep disturbance is warranted.
Isoflavone supplementation reduced serum sex hormone-binding globulin concentration in postmenopausal women Parwanto, ML. Edy; Indrawati, Yanti; Setiawan, Herman
Universa Medicina Vol 31, No 1 (2012)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2012.v31.52-62

Abstract

IntroductionThe bone loss that occurs with ageng in postmenopausal women is related to a decrease in serum levels of bioavailable estrogen and testosterone, which are mainly bound to sex hormone-binding globulin (SHBG) and albumin. Phytoestrogens are thought to exert hormonal effects in the body due to their structural resemblance to 17â-estradiol. The objective of this study was to evaluate the effect of isoflavone supplementation on levels of SHBG in postmenopausal women aged 47- 60 years. Methods A study of pre and post test design with controls was conducted in 70 women aged 47- 60 years. Subjects were randomly divided into 2 groups, the isoflavone group received 100 mg isoflavones/day + calcium 500 mg/day and the control group calcium 500 mg/day for 6 months. Measurement of bone mineral density was performed prior to supplementation, and serum SHBG levels before and after supplementation. Results Supplementation of isoflavones for 6 months reduced the SHBG levels by 31.1% in the isoflavone group (p=0.000), whereas supplementation of calcium for 6 months did not affect the levels of SHBG in the control group (p=0.359). Supplementation of isoflavones for 6 months reduced SHBG levels of postmenopausal women in the isoflavone group with either osteopenia (p=0.028) or osteoporosis (p=0.008).Conclusion Supplementation of isoflavones for 6 months decreased the SHBG levels of postmenopausal women in the isoflavone group with osteopenia and osteoporosis. Our findings suggest that phytoestrogens may significantly decreased SHBG levels in postmenopausal women.
Asiaticoside induces cell proliferation and collagen synthesis in human dermal fibroblasts Linda Yuliati; Etik Mardliyati; Kusmarinah Bramono; Hans Joachim Freisleben
Universa Medicina Vol. 34 No. 2 (2015)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2015.v34.96-103

Abstract

BackgroundAsiatiocoside, a saponin component isolated from Centella asiatica can improve wound healing by promoting the proliferation of human dermal fibroblasts (HDF) and synthesis of collagen. The skin-renewing cells and type I and III collagen synthesis decrease with aging, resulting in the reduction of skin elasticity and delayed wound healing. Usage of natural active compounds from plants in wound healing should be evaluated and compared to retinoic acid as an active agent that regulates wound healing. The aim of this study was to compare and evaluate the effect of asiaticoside and retinoic acid to induce greater cell proliferation and type I and III collagen synthesis in human dermal fibroblast.MethodsLaboratory experiments were conducted using human dermal fibroblasts (HDF) isolated from human foreskin explants. Seven passages of HDF were treated with asiaticoside and retinoic acid at several doses and incubated for 24 and 48 hours. Cell viability in all groups was tested with the MTT assay to assess HDF proliferation. Type I and III collagen synthesis was examined using the respective ELISA kits. Analysis of variance was performed to compare the treatment groups. ResultsAsiaticoside had significantly stronger effects on HDF proliferation than retinoic acid (p<0.05). The type III collagen production was significantly greater induction with asiaticoside compared to retinoic acid (p<0.05). ConclusionAsiaticoside induces HDF proliferation and type I and III collagen synthesis in a time- and dose-dependent pattern. Asiaticoside has a similar effect as retinoic acid on type I and type III collagen synthesis.

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