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Universa Medicina
Published by Universitas Trisakti
ISSN : 19073062     EISSN : 24072230     DOI : -
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Universa Medicina (univ.med) is a four-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Universa Medicina Online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic
Arjuna Subject : -
Articles 602 Documents
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Serum microRNA-126 expression as a biomarker of diabetic retinopathy Ni Made Ayu Surasmiati; Ni Made Ari Suryathi; Ari Andayani
Universa Medicina Vol. 42 No. 2 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.121-127

Abstract

BackgroundDiabetic retinopathy (DR) is a microvascular complication of diabetes mellitus (DM). Diabetic retinopathy causes permanent blindness in the productive age group and has a multifactorial pathogenesis. MicroRNA-126 (miRNA-126) regulates the expression of the vascular endothelial growth factor (VEGF) gene at the post-transcriptional level, VEGF being an important angiogenic protein regulating inflammation in DR development. This study aimed to determine serum miRNA-126 expression as a biomarker in DM patients with DR. MethodsThis was a cross-sectional study involving 4 healthy persons and 21 type 2 DM patients. Subjects consisted of 4 groups: i) healthy controls, ii) DM patients without diabetic retinopathy (NDR), iii) DM patients with non-proliferative DR (NPDR) and iv) DM patients with proliferative DR (PDR). Venous blood was collected from subjects for miRNA-126 examination by real-time polymerase chain reaction (PCR). MiRNA-126 in each group was analyzed using the One Way Anova test and p<0.05 was considered to be statistically significant. ResultsMean miRNA-126 expression was significantly decreased in PDR (1.86±1.03) and NPDR (1.01±0.43 ) groups when compared to healthy control (2.44±1.29) and NDR groups (2.15± 0.48) (p=0.027). MiRNA-126 values of less than 1.81 can differentiate NDR from the control group (sensitivity 83%, specificity 75%) and miRNA-126 of less than 1.56 can be used to predict NPDR when compared to the control group (sensitivity 86%, specificity 75%). ConclusionSerum miRNA-126 is a potential biomarker for screening of NPDR and NDR in type 2 DM patients, and could be considered a non-invasive diagnostic parameter.
Effect of Physalis angulata leaf extract cream on Interleukin-4, Interleukin-6, and Immunoglobulin-E in mice with induced atopic dermatitis Dhany Prafita Ekasari; Santosa Basuki; Wuriandaru Kurniasih; Herwinda Brahmanti; Aunur Rofiq
Universa Medicina Vol. 42 No. 2 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.150-159

Abstract

BackgroundThe prevalence of atopic dermatitis (AD) and allergic or irritant contact dermatitis has been increasing significantly in the general population. Interleukin- 4 (IL-4), interleukin-6 (IL-6), and immunoglobulin E (IgE) play a key role in the pathogenesis of AD. Physalis angulata (PA) leaves reportedly have anti-inflammatory effects by impeding IL-4, IL-6, and IgE. This study aimed to evaluate the effect of PA leaf extract cream on IL-4, IL-6, and IgE using 2,4-dinitrochlorobenzene (DNCB) to induce AD-like skin inflammation in a mice model. MethodsThis study used an experimental design involving 30 BALB/c mice, that were randomized into 3 groups: 1) control group receiving no treatment; 2) Vehicle treatment group receiving vehicle cream preparation; 3) PA treatment group receiving 10% PA leaf extract cream after induction of AD-like skin inflammation by DNCB. After 30 days, tissue samples were extracted from the skin lesions to measure IL-4 and IL-6 levels, and serum to measure IgE using ELISA. One-way Anova, Kruskal-Wallis and Mann-Whitney tests were used to analyze the data. ResultsGroup 3 (PA treatment) had significantly lower IL-4 (281.15 ± 43.14 pg/mL) than group 2 (vehicle cream treatment) (388.89±135.88 pg/ml) (p=0.001). However, although IL-6 and IgE levels were lower in group 3 than in group 2, the differences were statistically not significant (p=0.096 and p=0.479 respectively). ConclusionThere were lower levels of IL-4, IL-6, and IgE in the group receiving PA leaf extract cream than in the group receiving vehicle cream preparation. Therefore, PA leaf extract cream may have therapeutic potential in AD.
Source of household water as main risk factor of soil-transmitted helminth infections among elementary school pupils in Wamena District, Jayawijaya Regency, Papua Semuel Sandy; Tri Nury Kridningsih
Universa Medicina Vol. 42 No. 2 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.160-172

Abstract

BackgroundSoil-transmitted helminth (STH) infections are caused by three types of worms: Ascaris lumbricoides, Trichuris trichiura, and hookworms. Soil-transmitted helminth infections have significant health and socioeconomic implications for communities in developing countries, particularly in Indonesia. This study aims to determine the prevalence and risk factors of STH infections among elementary school pupils in Wamena District. MethodsThe study design used was a cross-sectional design involving 317 elementary school pupils. The children were interviewed using a structured questionnaire that included demographic information, hygiene, and environmental sanitation data of the respondents. Stool samples were collected from all consenting participants in sterile plastic containers and were analyzed within 24 hours of collection, using the Kato-Katz method. The data were analyzed using bivariate statistical analysis (Chi-square) and multivariate analysis (logistic regression). ResultsThe prevalence of helminthiasis among elementary school pupils was 19.9% (63/317). STH prevalence of mild category was 17.4% (55/317). The risk factors for STH infections among school children were the habit of not washing hands with soap after defecation, with an odds ratio of 5.04 [95% CI (2.22-11.48)], and the source of water for household use, with an odds ratio of 7.22 [95% CI (3.66-14.22)]. ConclusionThe prevalence of helminthiasis was found to be 19.9% (63/317), with an STH prevalence of mild category. Risk factors for STH infections included the habit of not washing hands with soap after defecation and the source of water for household use.
Physicians' awareness and practice of home blood pressure measurement in Indonesia: Asia home blood pressure monitoring survey 2020 Yuda Turana; Noriko Matsushita; Ebtehal Salman; Arieska Ann Soenarta; Vidya Gani Wijaya; Bambang Widyantoro; Eka Harmeiwaty; Rarsari Soerarso; Tunggul Diapari Situmorang
Universa Medicina Vol. 42 No. 2 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.182-194

Abstract

BackgroundHypertension is a significant mortality risk factor. The knowledge and practice among physicians of hypertension management and home blood pressure monitoring (HBPM) in blood pressure control is important. We aimed to investigate the awareness and practice of HBPM among physicians in Indonesia after publishing of the local 2019 HBPM guidelines. MethodsThis was a cross-sectional study involving 611 physicians in Indonesia that was conducted between February and October 2020. The questionnaire covered awareness, knowledge, and practice of HBPM. ResultsA total of 330 male physicians (54.0%) aged 20-49 years participated in the survey. More than half were specialists (51.6%) and recommended HBPM to their patients with hypertension (89.0%). The awareness of HBPM benefits was substantial among the physicians; however, the knowledge of the home blood pressure (HBP) reference values of was low (7.9%). Around 54% of the respondents thought that the barriers to low recognition of HBPM are lack of HBPM guidelines or lack of understanding of HBPM among physicians. A considerable percentage provided instruction on HBPM that aligned with the local guidelines, but between 7.5-29.5% gave no instruction on HBPM. ConclusionMost physicians recommend HBPM, but there is still a lack of knowledge and attitude toward HBPM. In Indonesia, local HBPM guidelines were published in 2019, but have not yet sufficiently penetrated the country, therefore robust dissemination of the published HBPM guidelines is still needed. For efficient utilization of HBPM by physicians in clinical practice, developing user-friendly educational tools such as physicians’ pocket guide on HBPM instructions is essential.
Evaluation of clinical abdominal scoring system for predicting outcomes of blunt abdominal trauma Nico Odolf Yordanius; I Ketut Wiargitha; Nyoman Golden; I Wayan Periadijaya; I Wayan Sudarsa; I Wayan Niryana
Universa Medicina Vol. 42 No. 2 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.173-181

Abstract

Background Trauma has been called the neglected disease of modern society and the most common cause of death under 45 years. Determining the optimal prospective course of action may be aided by the adoption of a scoring system to evaluate urgent laparotomy intervention. A quick and easy technique to identify whether there are any intra-abdominal injuries is to use the clinical abdominal scoring system (CASS). The objective of this study was to evaluate CASS in predicting the outcomes in patients with blunt abdominal trauma (BAT). Methods A retrospective observational study was conducted involving 80 patients with suspected BAT that arrived at the emergency department. All patients with suspected BAT were scored using CASS and radiological investigations that were done in the ED. The decision to proceed with the surgery would be made if the patient had CASS >12 and/or if the radiological investigation showed features of BAT such as air under the diaphragm. Results Mean CASS score was 10.28 ± 1.340. The majority of the subjects (75 or 93.5%) had successful laparotomies, whereas only five (6.3%) had unsuccessful ones. Injuries to the spleen (42.6%), and liver (32%), combined injuries to the spleen and liver (2.6%), intestine (16%), pancreas (1.3%), bladder (4%), and kidneys (1.5%) were all found in positive laparotomies. The CASS has specificity of 60%, sensitivity of 80%, PPV 96.7%, and NPV 16.6%. Conclusions According to our data results, The CASS has a poor ability to predict the need for laparotomy in cases of blunt abdominal injuries as it shows low specificity.
Comparative analysis of KnockOut serum replacement and fetal bovine serum for in vitro culture of human dermal fibroblasts Hidayati, Nur Ilham Risma; Kusuma, Indra; Poerwanto, Eko
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.283-293

Abstract

BACKGROUNDHuman dermal fibroblast (HDF) cultures can be used as a regenerative agent for wound healing. Fetal bovine serum (FBS) as a culture supplement is derived from animals, therefore not being constant in composition, causes variations in research results, thus requiring a substitute such as KnockOut serum replacement (KOSR). This study evaluated the defined KOSR as FBS substitute for HDF culture by measuring the relative expression of basic fibroblast growth factor (bFGF) and keratinocyte growth factor (KGF) messenger RNA (mRNA), HDF cell proliferation, and HDF migration. METHODSHuman dermal fibroblast culture was divided into 2 intervention groups receiving KOSR 5% and KOSR 10%, respectively, and a control group receiving FBS 10%. Reverse transcription polymerase chain reaction (RT-PCR) was used for bFGF and KGF mRNA relative expression at the fifth passage (P5). Cell counting kit-8 (CCK-8) reagent was used for the HDF cell proliferation assay at P5 and the scratch assay was used for HDF cell migration at P6. Data were analyzed using dependent t-test, One-way ANOVA, or Kruskal-Wallis test. RESULTSThere were no significant differences in bFGF and KGF mRNA relative expression and HDF migration velocity between the intervention and control groups (p>0.05 and p>0.05, respectively). The doubling time of the KOSR 5% group showed no significant difference (p>0.05), but KOSR 10% and FBS 10% showed significant differences between treatment days 2-6 and treatment days 6-10 (p<0.05). CONCLUSIONSThe KOSR 10% was comparable to FBS 10% in supporting bFGF and KGF mRNA relative expression, HDF cell proliferation, and HDF cell migration in HDF culture.
Indwelling ureteral stenting negatively impacts sexual function transiently after endourological procedure among adult male and female patients: a prospective cohort study Kangsaputra, Ferdy Bangun; Budiyono, Nur; Brodjonegoro, Sakti Ronggowardhana
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.276-282

Abstract

BackgroundUreteral stents, which are widely used after endourological procedures, cause adverse effects. However, its potential impact on sexual function remains unclear in patients undergoing ureteral stenting. This study aimed to investigate sexual function in adult male and female patients undergoing endourological procedures involving ureteral stent placement. MethodsWe conducted a prospective cohort study in a double tertiary care hospital setting with 103 selected patients (53 male and 50 female). We used a self-administered questionnaire-based survey, namely the Indonesian version of the 5-item International Index of Erectile Function (IIEF-5) for male patients and the Indonesian Female Sexual Function Index (Indonesian FSFI) for female patients at three different times (pre-stenting, four weeks after stenting, and four weeks after stent removal). A paired t-test or Wilcoxon test was used for data analysis. ResultsIn the male group, significant changes were noted in the four IIEF-5 domains and overall IIEF-5 scores at pre-stenting and four weeks after stenting (p =0.000). The female group showed significant differences for all FSFI domains and overall FSFI scores at pre-stenting and four weeks after stenting (p=0.000). Most patients in both groups recovered sexual function four weeks after stent removal, as indicated by insignificant differences in the overall IIEF-5 and FSFI scores at pre-stenting and four weeks after stent removal. ConclusionUreteral stenting led to significant but transient sexual dysfunction in both groups at four weeks after stenting. In this regard, male and female patients need to receive counselling and attention, that they may experience temporal sexual dysfunction at least for 4 weeks.
Evaluation of blood metal levels of hockey teams after playing on synthetic turf fields GULLU, Esin; EFDAL, Abdulsamet; GULLU, Abdullah; CETIN, Ihsan
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.255-262

Abstract

Background Artificial turf fields are widely used as an alternative to natural grass in many areas such as parks, playgrounds, and playing fields. In this study, we aimed to evaluate the toxicological effects of the chemicals contained in the fields consisting of artificial turf and crumb rubber on the blood metal levels in field hockey players. MethodsA cross-sectional study was conducted involving 28 apparently healthy men aged 20-25 years who participated in this study voluntarily. They consisted of 17 field hockey athletes [athlete group (AG)] and 11 sedentary males [control group (CG)]. Before and after the 7-day tournament, blood samples were taken from AG and CG to measure mercury, arsenic, aluminum, lead, zinc, magnesium and iron levels. An independent t-test was used to analyze the data. ResultsIn comparisons between CG and AG, the magnesium level of AG before the tournament was higher, while the iron and mercury levels were significantly lower (p<0.05). In intragroup comparisons, a significant increase was observed in the post-tournament magnesium and iron variables in the AG group (p<0.05). In post-tournament intergroup comparisons, increases in the Mg and decreases in the Hg variables of AG were significant (p<0.05). ConclusionIt is thought that as a result of the tournament on fields with synthetic grass surfaces, the male field hockey players in the 20-25 age group were toxicologically not affected by the harmful heavy metals present in these fields, because the Hg, As, Pb, Zn, Al, Fe, and Mg levels are within the international reference ranges.
Loneliness and depression levels as risk factors of pain in geriatric prostate cancer patients CICI, Remziye; YILMAZEL, Gulay; AYAZ, Nur Pınar
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.294-302

Abstract

BackgroundProstate cancer is the most prevalent malignancy among men, and psychological symptoms may affect many patients. Although much work has been carried out on loneliness, depression, and pain in geriatric prostate cancer patients, far less research has examined their associations. Therefore, the present study explored the association of loneliness and depression with pain in geriatric prostate cancer patients. MethodsA cross-sectional study was conducted involving 83 patients between the ages of 60 and 74 years, who were diagnosed with prostate cancer and were close relatives of students studying at a health sciences university. Data were collected with the Loneliness Scale for the Elderly, Beck Depression Inventory, and Numerical Rating Scale. The duration of prostate diagnosis was evaluated according to patient files. Simple and multiple logistic regression analyses were used to analyze the data. Results It was determined that the median age of the individuals included in the study was 66 years, and the median pain duration of these patients was two years. Severe pain was found in 62.7%, loneliness in 61.4%, and depression in 68.7% of the patients. Duration of diagnosis, loneliness, and depression were significantly associated with pain intensity. Depression increases the risk of pain intensity 3.41 times among patients (aOR=3.41;95% C.I.: 3.07-8.16; p=0.038) ConclusionIt was determined that duration of diagnosis, loneliness, and depression levels were risk factors for pain intensity in geriatric prostate cancer patients. Developing interventions for patients' mental states in rehabilitation studies may help alleviate the severity of pain.
Is 'quorum quenching' a promising tool to combat antibiotic-resistant bacteria? Maddela, Naga Raju
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.249-250

Abstract

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