cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
-
Editorial Address
-
Location
Kota adm. jakarta barat,
Dki jakarta
INDONESIA
Universa Medicina
Published by Universitas Trisakti
ISSN : 19073062     EISSN : 24072230     DOI : -
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Universa Medicina (univ.med) is a four-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Universa Medicina Online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic
Arjuna Subject : -
Articles 602 Documents
 49   50   51   52   53 
Giant congenital melanocytic nevus of the back: a case report Idarto, Areta
Universa Medicina Vol. 43 No. 1 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.128-132

Abstract

BackgroundGiant congenital melanocytic nevus (GCMN) is a rare disease with an extremely low incidence, that is present from or develops at birth and typically affects the dermis but may also affect other skin layers. Its incidence is estimated at <1 in 20,000 newborns. Despite its rarity, this lesion is important because it may be associated with severe complications such as malignant melanoma. A thorough follow-up is crucial since the probability of malignancy can vary depending on the clinical course. As such, careful observation is necessary to support possible management plans. Case DescriptionIn this case report, we present a three-day-old newborn male with abrasions on a black patch on his back. He presented with fever, jaundice, and black patches on more than 50% of his trunk down to the sacral area. The black raised patches resembling nodules had wounds on the lower back near the gluteus. A histopathology examination of specimens taken from 3 nodules on the back revealed hypocellular tissues with lymphocytes, histiocytes, neutrophils, fat droplets, and mature fat cells interspersed with some erythrocytes. The lesion was, therefore, diagnosed as a giant congenital melanocytic nevus (GCMN). Parents were counseled regarding the possible future course and were asked to come for regular follow-ups. Conclusions In this instance, we document a rare occurrence of GCMN that warrants recognition and appropriate treatment. To accumulate evidence for improving disease prognosis and outcomes, children with congenital melanocytic nev
Childhood blindness from surge of advanced stage retinopathy of prematurity in premature infants during the COVID-19 pandemic: a case series Yulia, Dian Estu; Soeharto, Diajeng Ayesha
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.360-367

Abstract

Background Retinopathy of prematurity (ROP) is a proliferative disease of the ocular retinal vasculature in premature infants, being a leading cause of preventable childhood blindness. The COVID-19 pandemic serves as an additional barrier to access to care and referral, potentially leading to more cases of advanced stage ROP. Although surgery can be done, ROP at this stage is highly associated with poor functional outcome irrespective of surgery. This case series aims to report advanced stage (stage 5) ROP in premature infants during the COVID-19 pandemic. MethodsA retrospective case series of medical records of paediatric patients with ROP was performed at Cipto Mangunkusumo National Referral Hospital between March 1, 2020 and December 31, 2021. This case series included new patients that presented to our clinic from March 2020 to December 2021 with stage 5 ROP. ResultsA total of 19 eyes of 10 patients with stage 5 ROP were included in this study. Mean chronologic age at presentation to our referral centre was 7.0 4.0 months. Upon presentation, all had stage 5 ROP with negative blink reflex to light, and none of the eyes in this cohort underwent surgical intervention. Mean gestational age was 30.3 3.2 weeks and mean birth weight was 1,276.7 366.4 g. ConclusionThere was an observable surge of stage 5 ROP at our referral centre with irreversible blindness. This highlights the need for proper ROP screening in all hospitals in Indonesia to prevent delay in detection and care of advanced stage ROP.
Release of retromalleolar flexor retinaculum and combined flexor digitorum longus and flexor hallucis longus Z-plasty in checkrein deformity: a case report Irianto, Komang Agung; Leonarto, Enrico; Handoyo, Henry Ricardo
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.368-373

Abstract

BackgroundCheckrein deformity is a rare abnormality comprising flexor hallucis longus (FHL) tendon entrapment in the posterior foot due to post-traumatic or ischemic retraction of the FHLtendon following soft tissue trauma. The diagnosis is essentially clinical, but complemented by imaging to rule out unrecognized causes and evaluate the fracture healing process. This case report is the first Indonesian study to describe release of the flexor retinaculum and Z-plasty (lengthening) of flexor digitorum longus (FDL) and FHL tendons through a medial retromalleolar approach to repair the deformity. Case DescriptionWe present the case of a 51-year-old male who complained of clawing of his right first and second toes. The interest of this study lies in the fact that this patient had never experienced ankle or distal tibial fractures, only a trivial injury two years back when the patient kicked a stone at work and had a bruise on his right second toe with no fracture. Exploration of FHL tendons was performed at the level of the midfoot. The patient was planned for surgery with a medial retromalleolar ankle approach, which facilitates the release of the flexor retinaculum, in conjunction with a Z-tenotomy on the FHL and FDL tendons. ConclusionA correction was achieved, and two months post-surgery there were no recurrences of the deformity. However, this surgical procedure requires more cases to support an evaluation of its effectiveness. We suggest that exploration at the ankle and midfoot should be the primary surgical intervention in similar cases of checkrein deformity.
Secretome hypoxia-mesenchymal stem cells decrease tumor necrosis factor-α and interleukin-18 in kidney of type 2 diabetes mellitus model rats Irawan, Risky Chandra Satria; Putra, Agung; Setyo, Trisnadi; Ghaisani, Shabrina Syifa; Hidayah, Nurul
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.320-328

Abstract

Background Type 2 diabetes mellitus (T2DM) is a chronic disease that affects millions of people worldwide and associated with an increased risk of kidney damage caused by prolonged inflammation. Secretome hypoxia- mesenchymal stem cells (SH-MSCs) have been investigated as a potential therapy for kidney inflammation in T2DM, due to their immunomodulatory properties and ability to promote tissue repair. In this study, we investigated the effects of SH-MSCs on tumor necrosis α (TNF-á) and interleukin-18 (IL-18) in the kidney of the T2DM model rats. MethodsA post-test-only control group involving 24 male Wistar rats. The rats were treated with a high-fat diet (HFD) for 4 weeks and streptozotocin-nicotinamide with sucrose solution for 5 days to induce T2DM animal models. Rats were randomly divided into four groups: healthy, control, and groups treated with SH-MSCs T1 and T2, with doses of 250 µL and 500 µL, respectively. TNF-α and IL-18 gene expression was measured by real time polymerase chain reaction (RT-PCR). One Way ANOVA and post-hoc LSD tests were used to determine the significant difference against all groups based on their quantitative measurement. ResultsAdministration of the SH-MSCs at a dose of 500µL (T2) was able to significantly reduce TNF-α and IL-18 gene expression when compared to control (T2DM rat without treatment) (p<0.05), but not significantly when compared to healthy and SH-MSC at a dose of 250µL (T1) group (p>0.05). ConclusionThis study demonstrated that the SH-MSCs decreased the levels of proinflammatory cytokines TNF-α and IL-18 gene expression in the kidney of T2DM model rats.
Macrophage modulation in activation process induced immune thrombocytopenia Mahdaleny, Mahdaleny; Bustami, Arleni; Iswanti, Febriana Catur
Universa Medicina Vol. 43 No. 1 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.76-87

Abstract

The immune system operates like an orchestra that harmoniously maintains the homeostasis balance while protecting from external or internal pathogens attack. Inflammation is one of the key critical immune defenses to eradicate pathogens and encourage tissue repair and recovery by activating the host’s immune and non-immune cells. As a part of the immune response during inflammation, blood platelets serve various functions; however, their activation and involvement in inflammation can also contribute to pathological conditions, such as thrombosis, which results in myocardial infarction, stroke, and venous thromboembolism. Activated platelets can mobilize and release intracellular granules (alpha and dense granules), which include secondary mediators like chemokine PF4/CXCL4. In contrast to most other chemokines, PF4 participates in several long-term regulatory processes, such as cell differentiation, survival, and proliferation. However, recent findings suggest that PF4 is also responsible for modulating macrophage polarization, which can substantially impact the development of induced immune thrombotic thrombocytopenia. This review aims to explain how PF4 induced vascular problems by modulation of macrophage development during immunological thrombocytopenia. A literature search using the keywords PF4, CXCL4, macrophage M4, platelet macrophage M4, and induced immune thrombocytopenia was done using the following databases: Google Scholar, ProQuest, ScienceDirect, and Scopus for articles published from 2000 to 2023. The literature study was done to find the connection between platelet activation, macrophage modulation, and vascular problems such as atherosclerosis and thromboembolism in induced immune thrombotic thrombocytopenia. Several recent studies on PF4, macrophage modulation, and vaccine-induced thrombotic thrombocytopenia were carefully reviewed. This review concludes that macrophage polarization modulation is promising in managing vascular problems in patients with induced immune thrombotic thrombocytopenia.
Profile of multidrug-resistant bacteria causing urinary tract infections in inpatients and outpatients in Jakarta and Tangerang Rosana, Yeva; Herliyana, Lina; Krisandi, Grady; Anggraini Suwarsono, Erike
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.303-313

Abstract

Background Urinary tract infections (UTIs) caused by bacteria occupy the second highest rank of common infectious diseases in the world. Empirical use of antibiotics may give rise to multidrug-resistant (MDR) bacteria because of irrational prescription. Choice of antibiotics to treat UTIs is limited because of MDR bacteria. Thus, this study was conducted to investigate the bacterial antibiotic susceptibility patterns in inpatients and outpatients in Jakarta and Tangerang. Methods Bacterial isolates were obtained from midstream urine specimens from 43 inpatients and 43 outpatients with UTIs in Jakarta and Tangerang. Bacteria were isolated on blood and MacConkey agar media using colony count method. Isolate identification and their susceptibility patterns were performed using VITEK2 compact system according to manufacturers’ instructions. Data were analyzed using Chi-square test. Results A total of 89 bacterial isolates consisting of 15 bacterial species were successfully isolated from 86 specimens. Gram-negative bacteria were the most common etiology of UTIs in inpatients and outpatients. MDR bacteria were found in 52 of the 89 isolates. ESBL-producing E. coli was the most common MDR bacteria. ESBL-producing E. coli and other MDR bacteria showed good susceptibility to ertapenem, meropenem, amikacin, and tigecycline. There were no significant differences regarding the MDR bacterial count in inpatients and outpatients (p=0.521). Conclusion E. coli was found to be the most common MDR bacteria causing UTIs in inpatients and outpatients in Jakarta and Tangerang. Higher resistance to many antibiotics was found in MDR bacterial isolates in inpatients compared to outpatients. MDR bacteria in outpatient UTIs were highly resistant to commonly used antibiotics.
Protective role of melatonin in ultraviolet radiation- induced oxidative stress in human skin photoaging Suyanto, Maria Veronica Putri; Widianti, I Gusti Ayu
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.346-359

Abstract

The ultraviolet radiation of the sun that reaches the earth is made up of ultraviolet A (95%) and ultraviolet B (5%). Exposure to ultraviolet radiation (UVR) is the main factor in photoaging. Chronic exposure to sunlight acts as an environmental stressor, leading to oxidative damage or stress. Oxidative damage stimulates the accumulation of free radicals, such as reactive oxygen species (ROS) or reactive nitrogen species (RNS) that are responsible for premature skin aging. Photoaged skin is characterized externally by irregular pigmentation, wrinkles, and reduced skin elasticity, and internally by the breakdown of dermal collagen and elastin. Free radicals can be scavenged and the skin can be protected from further oxidative damage by antioxidants. Melatonin is a hormone produced mainly by the pineal gland, as well as many other organs, including the skin. One of the functions of melatonin is exerted by the antioxidative melatoninergic system to prevent ultraviolet (UV)-induced skin photoaging. The aim of this review was to study the protective effect of melatonin on skin photoaging resulting from UVR exposure. The references were tracked using various databases, such as Google Scholar and PubMed with regard to publications in English for the last 5 years (2019-2023). Melatonin inhibits UVR-induced aging in multiple ways, such as protecting skin cells, binding free radicals, accelerating the activity of antioxidant enzymes, preventing increased mitochondrial membrane permeability, and assisting electron transport efficiency in the mitochondrial respiratory chain. Exogenous application of melatonin is usually by the oral route, but for localized effects on the skin, topical administration is recommended, with consideration of preparations with a better half-life and bioavailability. Understanding the protective antioxidant function of melatonin in UV-induced skin photoaging helps to optimize its application. The protective properties of melatonin against UVR-oxidative stress-induced photoaging will be further explored in this review.
Trends in iron deficiency anemia research 2010 – 2023: a bibliometric analysis Santosa, Budi; Damayanti, Fitriani Nur; Suparman, Suparman
Universa Medicina Vol. 43 No. 1 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.114-127

Abstract

Anemia is a health disorder marked by a reduction in hemoglobin concentration (Hb), hematocrit (Ht), and erythrocyte count. Iron deficiency anemia is marked by a reduction in hemoglobin synthesis, resulting in the production of hypochromic microcytic erythrocytes. The interest over time in the topic of iron deficiency anemia throughout the world is increasing. Many studies associated with iron deficiency anemia have been conducted by various authors and are increasing from year to year. The aim of the present review was to evaluate the literature on iron deficiency published between 2010 and 2023, with a focus on the trend in number of publications and citations, the trend of the link strength on the topic of iron deficiency anemia, and the low density of articles published from 2010 to 2023, to determine the trend and novelty of the topic of iron deficiency anemia. This review was a systematic study with the stages conforming to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) diagram. The data on scientific publications on the topic of iron deficiency anemia were collected using dimensions.ai from 2010 to 2023. The data were subsequently analyzed with the Vosviewer program. This review resulted in the following findings. First, the number of publications and citations on the topic of iron deficiency anemia increased exponentially from year to year. Second, there were 139 items, 3 clusters, and 5579 links, with a link strength of 18253 for the topic of iron deficiency anemia. Third, the recommended study topics connected with iron deficiency anemia are topics of low density, namely clinician, pathogenesis, and biofortification. The study findings may assist the interested researchers to know the trends and novelties of studies on iron deficiency anemia, and may recommend suggestions for further research.
Health insurance trends from 2004 to 2022: a bibliometric analysis Damayanti, Fitriani Nur; Santosa, Budi; Suparman, Suparman; Kusumawati, Erna; Istiana, Siti
Universa Medicina Vol. 43 No. 2 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.240-251

Abstract

The goal of health systems implemented at international, national, or regional level is to improve health effectively and efficiently by all available means, including community efforts, special education, military, and government, thereby improving public health at all levels. Health issues as national issues need top priority. Inequalities in mortality risk are inseparable from issues surrounding the health policy debate. Public health level is assessed through several indicators. Health Policy in law regulates the right to health. Proposed health system goals at international, national, or regional levels are usually not measured by human rights standards and instruments. Universal Health Insurance is expected to provide benefits. Health services are provided as medicines and treatments. This review aimed to determine trends in number of publications and visualize linkages of health insurance topics through bibliometric analysis. This was  a systematic review with steps following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) diagram using 661 scientific articles published between 2004 and 2022, followed by inclusion and exclusion criteria from Dimensions database. Review of articles was by means of  Vosviewer app. Our study results contributed to research roadmap development on health insurance. The limitation is that app.dimension.ai and google scholar databases are periodically updated, such that bibliometric analysis of health insurance should be repeated in the near future. Because this bibliometric analysis only extracted scientific article data from app.dimension.ai database, further research should add another database for broader and more comprehensive understanding of health insurance.
HIV-1 drug resistance-associated mutations in relation to viral load among HIV/AIDS patients at Dr. M. Djamil-Hospital Padang Nadia, Rizka; Elvira, Dwitya; Raveinal, Raveinal
Universa Medicina Vol. 43 No. 1 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.38-43

Abstract

BackgroundAccording to the WHO, 38 million people suffer from HIV worldwide and according to the HIV Drug Resistance Report, the prevalence of antiretroviral therapy (ART) resistance is 3-29%. Drug resistance-associated mutations (DRAMs) are the presence of one or more HIV mutations that reduce the ability of certain drugs to inhibit viral replication and that will increase viral replication and HIV RNA, which can lead to therapeutic failure. The objective of this study was to determine the prevalence of HIV-1 DRAMs among patients with chronic HIV-1 infections and to compare HIV RNA viral load between M184V and K103N mutations. Methods A cross-sectional was conducted involving 80 patients with HIV who met the inclusion criteria. The study subjects were examined for genotype and HIV RNA viral load, both using the polymerase chain reaction (PCR). Data were analyzed with the Kruskal-Wallis test. Results The overall drug resistance mutation prevalence was 10.0%. The most common mutations were M184V and K103N. There was a significant difference between the median HIV RNA viral load counts in patients with either M184V or K103N, and with both M184V and K103N mutations, the values being 45.420, 13.207, and 97.517 copies/mL, respectively (p<0.001). Conclusion The HIV RNA viral load count was higher in the mutation group than in the group without mutation. Long-term and ongoing surveillance of HIV DRAMs among these patients is necessary, which will help us to adjust the treatment regimen.

Page 51 of 61 | Total Record : 602

 49   50   51   52   53 

Filter by Year

2007 2026


Reset
Filter By Issues
All Issue Vol. 45 No. 1 (2026): Aheaf Of Print Vol. 44 No. 3 (2025) Vol. 44 No. 2 (2025) Vol. 44 No. 1 (2025) Vol. 43 No. 3 (2024) Vol. 43 No. 2 (2024) Vol. 43 No. 1 (2024) Vol. 42 No. 3 (2023) Vol. 42 No. 2 (2023) Vol. 42 No. 1 (2023) Vol. 41 No. 3 (2022) Vol. 41 No. 2 (2022) Vol. 41 No. 1 (2022) Vol. 40 No. 3 (2021) Vol. 40 No. 2 (2021) Vol. 40 No. 1 (2021) Vol 39, No 3 (2020) Vol. 39 No. 3 (2020) Vol. 39 No. 2 (2020) Vol 39, No 2 (2020) Vol 39, No 1 (2020) Vol. 39 No. 1 (2020) Vol 38, No 3 (2019) Vol 38, No 2 (2019) Vol 38, No 2 (2019) Vol 38, No 1 (2019) Vol 38, No 1 (2019) Vol 37, No 3 (2018) Vol 37, No 3 (2018) Vol. 37 No. 2 (2018) Vol 37, No 2 (2018) Vol 37, No 2 (2018) Vol 37, No 1 (2018) Vol 37, No 1 (2018) Vol 36, No 3 (2017) Vol. 36 No. 3 (2017) Vol 36, No 3 (2017) Vol 36, No 2 (2017) Vol 36, No 2 (2017) Vol 36, No 1 (2017) Vol 36, No 1 (2017) Vol 35, No 3 (2016) Vol 35, No 3 (2016) Vol 35, No 2 (2016) Vol 35, No 2 (2016) Vol 35, No 1 (2016) Vol 35, No 1 (2016) Vol. 35 No. 1 (2016) Vol 34, No 3 (2015) Vol 34, No 3 (2015) Vol. 34 No. 2 (2015) Vol. 34 No. 1 (2015) Vol. 33 No. 3 (2014) Vol. 33 No. 2 (2014) Vol. 33 No. 1 (2014) Vol. 32 No. 3 (2013) Vol. 32 No. 2 (2013) Vol. 32 No. 1 (2013) Vol. 31 No. 3 (2012) Vol. 31 No. 2 (2012) Vol 31, No 1 (2012) Vol. 31 No. 1 (2012) Vol 31, No 1 (2012) Vol 30, No 3 (2011) Vol 30, No 3 (2011) Vol 30, No 2 (2011) Vol 30, No 2 (2011) Vol 30, No 1 (2011) Vol 30, No 1 (2011) Vol 29, No 3 (2010) Vol 29, No 3 (2010) Vol 29, No 2 (2010) Vol 29, No 2 (2010) Vol 29, No 1 (2010) Vol 29, No 1 (2010) Vol 28, No 3 (2009) Vol 28, No 3 (2009) Vol 28, No 2 (2009) Vol 28, No 2 (2009) Vol 28, No 1 (2009) Vol 28, No 1 (2009) Vol 27, No 4 (2008) Vol 27, No 4 (2008) Vol 27, No 3 (2008) Vol 27, No 3 (2008) Vol 27, No 2 (2008) Vol 27, No 2 (2008) Vol 27, No 1 (2008) Vol 27, No 1 (2008) Vol 26, No 4 (2007) Vol 26, No 4 (2007) Vol 26, No 3 (2007) Vol 26, No 3 (2007) Vol 26, No 2 (2007) Vol 26, No 2 (2007) Vol 26, No 1 (2007) Vol 26, No 1 (2007) More Issue