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Pharmacy Study Program, Faculty of Mathematics and Natural Science, Sam Ratulangi University, Manado, North Sulawesi, Indonesia, 95115
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Kota manado,
Sulawesi utara
INDONESIA
PHARMACON
Published by Universitas Sam Ratulangi
ISSN : 23022493     EISSN : 27214923     DOI : 10.35799
Core Subject : Health,
Medicine & Pharmacology
Pharmacon is the journal published by Pharmacy Study Program, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Indonesia (P-ISSN: 2302-2493 E-ISSN: 2721-4923). Pharmacon was established in 2012 and published four times a year. Pharmacon is an open access journal and has been indexed by main indexing Google Scholar, GARUDA, Crossref.
Arjuna Subject : -
Articles 1,131 Documents
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IDENTIFIKASI DAN PENETAPAN KADAR ASAM BENZOAT PADA KECAP ASIN YANG BEREDAR DI KOTA MANADO Sumarauw, Windy; Fatimawali, Fatimawali; Yudistira, Adithya
PHARMACON Vol 2, No 1 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.881

Abstract

ABSTRACT   The salty ketchup is one of the food additives commonly added to food. The purpose of this study was to identily and determine levels of use of benzoic acid compound as a preservative in salty ketchup turn in Manado. The samples used were four different ketchup brands produced locally in Manado. Sample identification is done by extracting the sample using diethyl ether solvent. Ether was evaporated to obtain dried ketchup extract. The extracted residue was reacted with 5 % FeCl3 resulting in brown precipitate which proves that it contains benzoic acid. Determination of the preservative (benzoic acid) was determined using UV-Vis spectrophotometer. The results showed that four samples of ketchup used benzoic acid as a preservative. Using preservative not weather threshold set out in Decree PERMENKES RI No 722/MenKes/Per/IX/88.   Keywords : benzoate, ketchup, Manado, UV-Vis spectrophotometer.
UJI EFEK EKSTRAK ETANOL DAUN LIDAH MERTUA (Sansevieria trifasciata Prain) TERHADAP PENURUNAN KADAR GULA DARAH TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus L.) YANG DIINDUKSI SUKROSA Laimeheriwa, Chornelia
PHARMACON Vol 3, No 3 (2014)
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.3.2014.5441

Abstract

ABSTRACT This study aimed to test the effect of ethanol extract Lidah Mertua leaves (Sansevieria trifasciata Prain) to decrease blood sugar levels of white male wistar (Rattus norvegicus L.) who induced sucrose. This type of research laboratory experiments using a Complete Randomized Design methods. Animal testing of this experiments is a white 15 rat males totaled are divided into 5 groups. The five groups which are a negative control group given a solution of CMC 0,5%, a positive control group was given 0,036 mg/kg body weight suspension of glibenklamid, then the treatment Group's was given ethanol ekstract 0,0083 g/kg body weight of Lidah Mertua leaves (Sansevieria trifasciata Prain) for the group treatment  first, group treatment second 0,041 g/kg body weight, and treatment group third 0,083 g/kg body weight. Data obtained from the examination of the fasting blood sugar levels, 30 minutes after induction with sucrose and at first hour, second hours, third hours and fourth hours after treatment was given. The data analysis statistics test using ANOVA and LSD to see the difference between the negative control group, positive control group and treatment group 1, 2 and 3. The statistical analysis showed a significant difference with negative control group.   Key words : Sansevieria trifasciata Prain, blood sugar levels, sucrose   ABSTRAK Penelitian ini bertujuan untuk menguji efek ekstrak etanol daun Lidah Mertua (Sansevieria trifasciata Prain) terhadap penurunan kadar gula darah tikus putih jantan galur wistar (Rattus norvegicus L.) yang diinduksi sukrosa. Jenis penelitian yaitu eksperimen laboratorium dengan menggunakan metode Rancangan Acak Lengkap (RAL). Hewan uji berupa tikus putih jantan berjumlah 15 ekor dibagi dalam 5 kelompok yaitu kelompok kontrol negatif diberikan larutan CMC 0,5%, kelompok kontrol positif diberikan suspensi glibenklamid dengan dosis 0,36 mg/kgBB, kemudian untuk kelompok perlakuan diberikan ekstrak etanol daun Lidah Mertua (Sansevieria trifasciata Prain) dengan dosis 0,0083 g/kgBB untuk kelompok perlakuan 1, kelompok perlakuan 2 dengan dosis 0,041 g/kgBB, kelompok perlakuan 3 dengan dosis 0,083 g/kgBB. Data diperoleh dari pemeriksaan kadar gula darah puasa (t0), 30 menit setelah diinduksi sukrosa (t1) dan pada jam ke 1(t2), jam ke 2(t3), jam ke 3(t4), dan jam ke 4(t5) setelah pemberian perlakuan. Data dianalisis statistik menggunakan uji ANOVA dan LSD untuk melihat perbedaan antara kelompok kontrol negatif, kelompok kontrol positif dan kelompok perlakuan 1, 2 dan 3. Hasil analisis statistik menunjukkan berbeda secara signifikan dengan kontrol negatif.   Kata kunci : Sansevieria trifasciata Prain, kadar gula darah, sukrosa
UJI AKTIVITAS ANTIOKSIDAN KARANG LUNAK (Nepthea sp.) DENGAN MENGGUNAKAN METODE DPPH (1,1-difenil-2-pikrilhidrazil) Langi, Priski; Yudistira, Adithya; Mansauda, Karlah L.R
PHARMACON Vol 9, No 3 (2020): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.9.2020.30028

Abstract

ABSTRACTSoft corals (Nepthea sp.) are soft corals that have the ability to be antibacterial and anticancer. These chemical compounds are the result of secondary metabolites of living organisms that are often known as natural products, which are generally in the form of terpenoids. This study aims to analyze the antioxidant activity of Nepthea sp. Soft Coral (Nepthea sp.) Samples were obtained from Bangka Island waters, Likupang. This research is an experimental laboratory with maceration as method of extraction. Testing of ethanol extracts of soft corals (Nepthea sp.) was using the DPPH method (1,1-diphenyl-2-picrylhydrazy) with concentrations of 25, 50, 75, 100, 125, 150 mg / L to analyze antioxidant activity using a spectrophotometer. The greatest antioxidant level is found in Nepthea sp. with a concentration of 150mg/L. The results of this study showed that the antioxidant levels of Nepthea sp. from Bangka waters have antioxidant activity and the higher of the concentration the higher the antioxidant levels produced.  Keywords: Activity, Antioxidants, DPPH, Nepthea sp. ABSTRAK Karang lunak (Nepthea sp.) adalah karang lunak yang mempunyai kemampuan sebagai antibakteria dan antikanker. Senyawa kimia tersebut merupakan hasil metabolit sekunder organisme hidup yang sering dikenal dengan natural producty yang umumnya berupa terpenoid. Penelitian ini bertujuan untuk menganalisis aktivitas antioksidan dari Nepthea sp. Sampel Karang Lunak (Nepthea sp.) diperoleh dari perairan Bangka, Likupang. Penelitian ini merupakan eksperimental laboratorium dengan metode ekstraksi maserasi pengujian terhadap ekstrak etanol karang lunak (Nepthea sp.) menggunakan metode DPPH (1,1-difenil-2-pikrilhidrazi) dengan kosentrasi 25, 50, 75, 100, 125, 150 mg/L untuk menganalisis aktivitas antioksidan dengan menggunakan spektrofotometer. Kadar antioksidan yang paling besar terdapat pada Nepthea sp. dengan konsentrasi 150mg/L. Hasil penelitian ini memperlihatkan kadar antioksidan Nepthea sp. di perairan Bangka mempunyai aktivitas antioksidan dan semakin tinggi konsentrasi semakin tinggi pula kadar antioksidan yang dihasilkan. Kadar antioksidan yang paling besar terdapat pada Nepthea sp. dengan konsentrasi 150 mg/L.Kata Kunci  : Aktivitas, Antioksidan, DPPH, Nepthea sp.
UJI EFEKTIFITAS SALEP EKSTRAK ETANOL DAUN BAKAU HITAM (Rhizophora mucronata Lamk) DAN PENGUJIAN TERHADAP PROSES PENYEMBUHAN LUKA PUNGGUNG KELINCI YANG DIINFEKSI BAKTERI Staphylococcus aureus Paputungan, Fachrial
PHARMACON Vol 3, No 1 (2014)
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.3.2014.3891

Abstract

The objectives of this research are to find out the quality of 4%, 6%, 8%, and 10% ointments from black mangrove extract, and the healing effect of infected wound on rabbit back skin. Extraction of black mangrove was done by maceration. Ointments were tested by organoleptics, homogeneityt and pH. Test of healing effectivity was done using 5 categories, that is chloramphenicol ointments (positive control), basic ointments (negative control), black mangrove ethanol ointments extract 4%, black mangrove ethanol ointments extract 6%, black mangrove ethanol ointments extract 8%, black mangrove ethanol ointments extract 10% against infected wound of experiment rabbits, which done in 7 days. Data was analyzed using One Way ANOVA (Analysis Of Variance) and continued with LSD (Least Significant Different). The result shows that the basic ointments and the black mangrove ethanol ointments extract 4%, 6%, 8%, 10% meet the quality standard by homogeneity test, organoleptic test, pH test, but did not meet saturate requirements of dispersive power test. Black mangrove ethanol extract ointments 10% possess high activity of wound healing, followed with 8%, 6%, and 4% black mangrove ethanol ointments extract.   Key words : Rhizophora mucranata Lamk, ointments, infected wound, rabbit
EVALUASI PENGGUNAAN OBAT ANTITUBERKULOSIS PADA PASIEN TUBERKULOSIS PARU DI INSTALASI RAWAT INAP BLU RSUP PROF. DR. R. D. KANDOU MANADO PERIODE JANUARI – DESEMBER 2010 Simamora, Vethreeany; Tjitrosantoso, Heedy; Wiyono, Weny
PHARMACON Vol 1, No 1 (2012)
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.1.2012.442

Abstract

This study aims to examine the patterns of the use of antituberculosis drugs (OAT) and to evaluate thesuitability of the use of OAT based on the Guidelines for Tuberculosis Control 2009 by Ministry ofHealth RI, in hospitalized patients with pulmonary tuberculosis in BLU RSUP Prof. Dr. R. D. KandouManado period January to December 2010. This study is a descriptive survey research and datacollection carried out retrospectively. Data was analyzed with descriptive analysis. The resultsshowed patients with category 1 of an intensive phase is given the alloy HRZE or 4FDC andcontinoum phase patients is given the alloy HR. Category 2 patients, the 2-month intensive phase isgiven the alloy HRZES and for category 2 patients at 1-month intensive phase is given the alloyHRZE. A total of 97.7% of patients prescribed a single drug dosage OAT (generic) and 2.3% ofpatients prescribed OAT FDC. Based on the suitability of the selection of alloys OAT, for thetreatment of category 1 have met the suitability of 94.7% and category 2 is 66.7%, compliance withthe standards of the Guidelines for Tuberculosis Control 2009 by Ministry of Health RI.Keywords: OAT, pulmonary tuberculosis, hospitalized patients
UJI EFEKTIVITAS EKSTRAK KULIT BATANG JAMBU METE (Anacardium Occidentale L.) TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus) YANGT DIINDUKSI ALOKSAN Carolus, Fitri Prihartini
PHARMACON Vol 3, No 3 (2014)
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.3.2014.5371

Abstract

ABSTRACT Cashew (Anacardium occidentale L.) is one of the plant that used by native people as diabetics medicin. This research was intended to find out the effectiveness of cashew stem’s bark extract upon the reduction of blood  sugar levels on white male wistar which were inducted with aloxane. 30 mices were made to being diabetic by aloxan 130 mg/KgBB intravenously. Then they were devide into 5 treatment groups, they were dose extract 0,085 g/KgBB, dose 0,17 g/KgBB, dose 0,34 g/KgBB, as the comparison of Glibenklamid 0,63 mg/KgBB (positive control) and CMC 0,5 % (negative control) and 5 mices for normal control. The collected data were analyzed by Duncan test. analyzed Shows that there are significant difference (α <0.05) between dose of extract and the negative control but nothing significant difference with positive control. Based on this result, it can be concluded that the ethanol extract of stem’s bark of Anacardium occidentale L. has effect upon the reduction of blood sugar levels on white male wistar which are inducted with aloxane.   Key words : cashew stem bark, blood glucose, Rattus norvegicus       ABSTRAK Jambu mete (Anacardium occidentale L.) merupakan salah satu spesies tumbuhan yang dimanfaatkan masyarakat sebagai obat untuk penyakit kencing manis. Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak kulit batang jambu mete terhadap penurunan kadar glukosa darah pada tikus putih jantan galur wistar (Rattus norvegicus) yang diinduksi aloksan. Sebanyak 30 ekor tikus dibuat diabetes dengan menggunakan aloksan 130 mg/kgBB secara intravena. Kemudian dibagi menjadi 5 kelompok perlakuan, yaitu: ekstrak dosis 0,085 g/KgBB, dosis0,17 g/KgBB, dosis 0,34 g/KgBB, sebagai pembanding Glibenklamid 0,63 mg/KgBB (control positif) dan CMC 0,5% (control negatif) serta 5 ekor tikus untuk kontrol normal. Data yang diperoleh dianalisis dengan SPSS ver.20, uji one way ANOVA dan dilanjutkan dengan uji Duncan. Hasil analisa statistik menunjukkan terdapat perbedaan penurunan kadar gula darah yang signifikan antara kelompok perlakuan dosis ekstrak dengan kontrol negatif, tetapi tidak memiliki perbedaan secara signifikan dengan control positif. Berdasarkan hasil tersebut dapat disimpulkan ekstrak etanol kulit batang Anacardium occidentale L. memiliki efek terhadap penurunan kadar gula darah tikus putih jantan galur wistar yang diinduksi aloksan.   Kata kunci : kulit batang jambu mete, gula darah, Rattus norvegicus
FORMULASI DAN UJI EFEKTIVITAS ANTIOKSIDAN SEDIAAN KRIM EKSTRAK ETANOL DAUN BELIMBING WULUH (Averrhoa bilimbi L. ) DENGAN MENGGUNAKAN METODE DPPH (1,1-diphenyl-2-picrylhydrazyl) Ariem, Feiby; Yamlean, Paulina V.Y; Lebang, Julianri Sari
PHARMACON Vol 9, No 4 (2020): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.9.2020.31355

Abstract

ABSTRACTBelimbing wuluh leaves (Averrhoa bilimbi L.) Contains  flavonoids, phenols, alkaloids, tannins and coumarin. The aim of this research is formulated ethanol extract of Belimbing Wuluh leaves in the form of cream preparations, as well as test the effectiveness of antioxidants using the DPPH method. Extract was made by maceration method using ethanol 96% formulated into a cream with a concentration of 3%, 5%, 7%. The results of the cream preparations evaluation before and after cycling test meet the requirements of organoleptis, homogeneity, pH, adhesiveness, coverage. The test results of antioxidant activity with the DPPH method using the most effective UV-Vis spectrophotometer as the antioxidant cream of the leaves extract Belimbing Wuluh is 7% has a value of IC50 = 0.118 ppm and vitamin C as comparator has a value of IC50 = 0.0327 ppm. From this research can be concluded that Belimbing Wuluh leaves ethanol extract cream can be formulated as a stable cream and has a very strong antioxidant activity. Keywords: : Belimbing Wuluh Leaves,cream, antioxidant,DPPH ABSTRAK Daun Belimbing Wuluh (Averrhoa bilimbi L.)  mengandung senyawa flavonoid, fenol, alkaloid, tanin dan kumarin. Tujuan penelitian ini membuat formulasi ekstrak etanol daun Belimbing Wuluh dalam bentuk sediaan krim, serta menguji efektivitas antioksidan menggunakan metode DPPH. Pembuatan ekstrak dilakukan dengan metode maserasi menggunakan etanol 96 % diformulasi menjadi krim dengan konsentrasi 3%, 5% ,7%. Hasil evaluasi sediaan krim sebelum dan sesudah cycling test memenuhi persyaratan organoleptis, homogenitas, pH, daya lekat, daya sebar. Hasil uji aktivitas antioksidan dengan metode DPPH menggunakan spektrofotometer UV-Vis yang paling efektif sebagai krim antioksidan dari ekstrak daun Belimbing Wuluh adalah 7 % memiliki nilai IC50 = 0,118 ppm dan vitamin C sebagai pembanding memiliki nilai IC50 = 0,0327 ppm. Dari penelitian ini dapat disimpulkan bahwa krim ekstrak  etanol daun Belimbing Wuluh dapat diformulasikan sebagai sediaan krim yang stabil dan memiliki aktivitas antioksidan yang sangat kuat.  Kata kunci : Daun Belimbing Wuluh, Krim, Antioksidan, DPPH
UJI INVIVO EKSTRAK UMBI BAWANG HUTAN (Eleutherine americana Merr.) TERHADAP GAMBARAN MAKROSKOPIS ORGAN JANTUNG TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus) Rondonuwu, Greifen Triky; Simbala, Herny; Rumondor, Erladys
PHARMACON Vol 10, No 2 (2021): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.10.2021.34043

Abstract

ABSTRACTForest onion bulbs (Eleutherine americana Merr.), Including the Iridaceae family, have been used for generations by the Dayak people as medicinal plants for various types of diseases such as breast and colon cancer, hypertension, diabetes mellitus, hypercholesterolemia and stroke. This study was conducted to evaluate the effect and side effects of extracts of forest onion bulbs to the macroscopic description of cardiac organ in rats. Thirty male white rats Wistar strain was used as research object, which is divided into three groups of dose that applied with the ethanol extract of Forest onion bulbs orally (5mg/ml, 10mg/ml, 15mg/ml)  and one group as controls for comparison. The tests were carried out for 15 days, with observations made against the body weight of rats, macroscopic observation of cardiac organ and observation of cardiac organ weights. The results showed that the provision of forest onion bulbs extract did not cause significant changes based on the graph of observations made on the macroscopic image of the heart organ and the weight of the rats. Keywords : Forest onion bulbs (Eleutherine Americana Merr.), cardiac macroscopic, white rat (Rattus norvegicus)  ABSTRAKUmbi bawang hutan (Eleutherine americana Merr.) termasuk familia Iridaceae, secara turun temurun telah dipergunakan oleh masyarakat dayak sebagai tumbuhan obat untuk berbagai jenis penyakit seperti kanker payudara dan kolon, hipertensi, diabetes mellitus, hiperkolesterol dan strok. Penelitian ini bertujuan untuk  melihat pengaruh yang ditimbulkan dari konsumsi ekstrak  Umbi bawang hutan terhadap gambaran makroskopis organ jantung pada tikus putih. Penelitian dilakukan menggunakan hewan percobaan  tikus putih jantan galur wistar berjumlah 30 ekor, yang dibagi dalam empat kelompok dosis yang diberi ekstrak etanol umbi bawang hutan secara oral yaitu (5mg/ml, 10mg/ml, 15mg/ml) dan satu kelompok kontrol sebagai pembanding. Masa pengujian dilakukan selama 15 hari, dengan pengamatan yang dilakukan berupa pengamatan berat badan tikus, pengamatan makroskopis organ jantung dan pengamatan berat organ. Hasil penelitian menunjukkan bahwa pemberian ektrak umbi bawang hutan tidak menimbulkan perubahan yang signifikan berdasarkan grafik pengamatan yang dilakukan pada gambaran makroskopis organ jantung serta penimbangan berat badan tikus. Kata kunci : Umbi bawang hutan (Eleutherine americana Merr.), makroskopis jantung, tikus putih (Rattus norvegicus)
PERSPEKTIF PELANGGAN DAN PERSPEKTIF PEMBELAJARAN DAN PERTUMBUHAN DALAM MENGUKUR KINERJA INSTALASI FARMASI RUMAH SAKIT ADVENT MANADO DENGAN METODE BALANCED SCORECARD Agow, Mikhael C.; Citraningtyas, Gayatri; Rumondor, Erladys M.
PHARMACON Vol 10, No 1 (2021): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.10.2021.32756

Abstract

ABSTRACTPerformanced measurement used Balanced Scorecard with customer perspective and learn and growth perspective offers comprehensive solution to found how customers value products or services and how companies improved the resources of human quality become competent workers and  able to produce excellent performance for the organization. This studied aims to determine the performance of Pharmacy Installation at Manado Advent Hospital based on the customer perspective and learning and growth perspective. The typed of research was non-experimental research with descriptive evaluative design. Data were obtained prospectively and retrospectively. The criteria of data were qualitative and quantitative. Qualitative data form an observation data and interviews. Quantitative data form questionnaire. The results customer perspective has 83.45% of patient satisfied to performanced of Pharmacy Installation at Manado Advent Hospital. Learning and growth perspective got results the employees has high satisfaction of job and spirit worked with value 3.05 and 3.06. The employee training of Pharmacy Installation at Manado Advent Hospital was never been implemented. The conclusions good performanced on patient satisfaction based on costumer perspective. Learn and growth perspective has good performance from work spirit and employee job satisfaction but poor performance that must be improved was employee trained.Keywords : Performance, Pharmacy Installation, Balanced Scorecard, Customer Perspective, Learning and Growth Perspective.ABSTRAKPengukuran kinerja menggunakan Balanced Scorecard dengan perspektif pelanggan dan perspektif pembelajaran dan pertumbuhan menawarkan solusi menyeluruh untuk mengetahui bagaimana pelanggan menilai produk atau jasa serta cara perusahaan meningkatkan kualitas sumber daya manusia untuk menjadi pekerja yang kompeten dan mampu menghasilkan kinerja yang prima bagi organisasi. Penelitian ini bertujuan untuk mengetahui kinerja Instalasi Farmasi Rumah Sakit Advent Manado berdasarkan perspektif pelanggan dan perspektif pertumbuhan dan pembelajaran. Penelitian ini merupakan jenis penelitian non eksperimental dengan rancangan deskriptif evaluatif. Data diperoleh secara prospektif dan retrospektif. Kriteria data berupa data kualitatif dan data kuantitatif. Data kualitatif berupa data observasi dan wawancara langsung. Data kuantitatif berupa kuesioner.  Hasil penelitian yang diperoleh yaitu kinerja perspektif pelanggan yaitu 83,45 % pasien menyatakan puas terhadap kinerja Instalasi Farmasi Rumah Sakit Advent Manado. Perspektif pembelajaran dan pertumbuhan memperoleh hasil karyawan memiliki semangat kerja dan kepuasan kerja yang tinggi yaitu 3,05 dan 3,06. Pelatihan karyawan Instalasi Rumah Sakit Advent Manado belum pernah dilakukan. Kesimpulan yang diperoleh yaitu kinerja yang baik pada kepuasan pasien, semangat kerja dan kepuasan kerja karyawan. Kinerja kurang baik yang harus diperbaiki yaitu pelatihan karyawan.Kata kunci : Kinerja, Instalasi Farmasi, Balanced Scorecard, Perspektif Pelanggan, Perspektif Pertumbuhan dan Pembelajaran
EVALUASI SENYAWA BIOAKTIF EKSTRAK UMBI TEKI (Cyperus rotundus L.) SEBAGAI IMUNOMODULATOR MENGGUNAKAN PENAMBATAN MOLEKUL Hotmian, Ellen; Tallei, Trina; Suoth, Elly J.
PHARMACON Vol 10, No 2 (2021): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.10.2021.34034

Abstract

ABSTRACTBulbs (Cyperus rotundus L.) is a plant that is believed by the public to cure several diseases. According to a study conducted in vivo, the extract has many potentials such as anti-cancer, anti-inflammatory, antibacterial, etc. However, there are no studies that have examined its properties as an immunomodulator. This study aims to determine the polar bioactive compounds extracted from the tuber and to analyze the prediction of potential bioactive compounds against the TNF-α, IL-1β, IL-6, and NO receptors using theapproach in silico. The method used was the extraction of nut tuber dry powder using methanol as a solvent by maceration process and then analyzed using gas chromatography - mass spectrometry (GC-MS) to obtain information on the content of the tubers. The results of the analysis of this study indicate that there are 177 possible components of the compound in methanol solvent Keywords: Cyperus rotundus L., Immunomodulator, GC-MS, Molecular Docking   ABSTRAKUmbi Teki (Cyperus rotundus L.) merupakan tumbuhan yang dipercayai masyarakat dapat menyembuhkan beberapa penyakit. Menurut sebuah penelitian yang dilakukan secara in vivo, ekstrak umbi teki memiliki banyak potensi seperti antikanker, antiinflamasi, antibakteri, dll. Namun belum ada penelitian yang meneliti khasiatnya sebagai imunomodulator. Penelitian ini bertujuan untuk mengetahui senyawa-senyawa bioaktif polar yang diekstrak dari umbi teki dan menganalisis prediksi potensi senyawa bioaktif terhadap reseptor TNF-α, IL-1β, IL-6, dan NO dengan menggunakan pendekatan in silico. Metode yang digunakan dengan ekstraksi serbuk kering umbi teki menggunakan pelarut metanol dengan proses maserasi kemudian dianalisis menggunakan kromatografi gas – spektrometri massa (GC-MS) untuk mendapatkan informasi kandungan dalam umbi teki. Hasil analisis dari penelitian ini terdapat kemungkinan 177 komponen senyawa pada pelarut metanol. Kata kunci      : Cyperus rotundus L., Imunomodulator, GC-MS, penambatan molekul

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