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INDONESIA
Paediatrica Indonesiana
Published by Ikatan Dokter Anak Indonesia
ISSN : 00309311     EISSN : 2338476X     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Paediatrica Indonesiana is a medical journal devoted to the health, in a broad sense, affecting fetuses, infants, children, and adolescents, belonged to the Indonesian Pediatric Society. Its publications are directed to pediatricians and other medical practitioners or researchers at all levels of health practice throughout the world.
Arjuna Subject : -
Articles 2,118 Documents
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Systemic juvenile rheumatoid arthritis in an 11 year old boy: a case report I Wayan Gustawan; Ketut Dewi Kumara Wati; Hendra Santosa
Paediatrica Indonesiana Vol 49 No 2 (2009): March 2009
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (117.832 KB) | DOI: 10.14238/pi49.2.2009.119-123

Abstract

Juvenile rheumatoid arthritis (JRA) is the mostcommon rheumatic condition in childrenand a major cause of chronic disability. 1 JRAis defined as persistent arthritis in one oro e joints for at least six weeks, when certainexclusionary conditions have been eliminated.2·3The three major subtypes of JRA are based onthe symptoms at disease onset and are designatedas systemic onset, pauciarticular onset, andpolyarticular onset.2 Systemic onset juvenilerheumatoid arthritis (SoJRA) represents about10-20% of all forms of JRA.4The incidence of ]RA is approximately 13.9/100,000 per year among children 15 years old oryounger.1 In Finland, the incidence was 19.5/100,000of the population under 16 years of age. The incidencewas significantly higher than in earlier years (1980,1985, and 1990) in the same district.5 Different racialand ethnic groups appear to have varying frequenciesof the subtype of JRA.1The treatment of JRA is achieved usingcombinations of anti-inflammatory and immunomodulatorymedications in combination withphysical and occupational therapy, occasionalsurgery, nutritional support, and psychosocial andeducational partnerships with patients and parents.3,6It is widely thought that a comprehensive teamapproach is associated with a superior outcome. 7This paper reports a case of systemic JRA in an 11-year old boy.
Association between interleukin-8 and severity of dengue shock syndrome in children Suryadi N. N. Tatura; Dasril Daud; Irawan Yusuf; Sitti Wahyuni; Janno B. Bernadus
Paediatrica Indonesiana Vol 56 No 2 (2016): March 2016
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (531.028 KB) | DOI: 10.14238/pi56.2.2016.79-83

Abstract

Background Dengue hemorrhagic fever (DHF) remains a major health problem in tropical countries. The case fatality rate (CFR) can be reduced from 45% to <1%, if dengue shock syndrome (DSS) is treated early and adequately. Early biomarkers for DSS outcomes in children are needed. Interleukin-8 (IL-8) might be one of the molecule, as it plays a role in the pathophysiology of DHF in children.Objective To assess IL-8 levels in pediatric DHF patients at various stages of illness severity and to determine the correlation between serum IL-8 concentration on admission and DSS outcomes in children.Methods A prospective cohort study was done in children with DSS who were admitted to the Pediatrics Department of Kandou Hospital, Manado. We measured subjects’ serum IL-8 levels at the time of DSS diagnosis and followed-up subjects until there was improvement or deterioration. An association between IL-8 and DSS outcome was analyzed using univariable logistic regression test. An ROC curve and Chi-square test were used to analyze the prognostic value of serum IL-8 levels. Statistical significance was considered to be a P value of <0.05 (power 80, β=0.20)..Results Fifty-eight children with DSS were included in this study. Twenty-seven subjects had clinical deterioration (to recurrent shock, prolonged shock or died). There was a significant association between elevated IL-8 levels and clinical deterioration in DSS (OR 116.7; 95%CI 18.0 to 756.0; P=0.0001). The ROC curve revealed an IL-8 cut-off level of 194.9 pg/mL, AUC 0.982, with sensitivity 89.3%, specificity 93.3%, positive predictive value (PPV) 92.6%, negative predictive value (NPV) 90.3%.Conclusion There is an association between elevated early serum IL-8 level and a DSS deterioration. Further prognostic studies are needed to confirm the predictive ability of serum IL-8 level on DSS deterioration in children.
Rebound serum bilirubin levels after single vs. double phototherapy Widyastuti Widyastuti; Supriatmo Supriatmo; Guslihan Dasa Tjipta
Paediatrica Indonesiana Vol 54 No 5 (2014): September 2014
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (113.766 KB) | DOI: 10.14238/pi54.5.2014.260-5

Abstract

Background Hyperbilirubinemia is the most common clinicalphenomenon found in newborns. Phototherapy is the standardtreatment for lowering bilirubin levels in neonates. Whileintensive (double) phototherapy produces a more rapid declinein serum bilirubin levels than standard (single) phototherapy,greater rebound effects may occur.Objective To assess bilirubin levels in neonates with hyperbilirubinemiawho underwent single or double phototherapy, includingrebound bilirubin levels after phototherapy termination.Methods An open, randomized, controlled trial was con ductedat H. Adam Malik Hospital and Dr. Pirngadi Hospital, Medan,from August 2009 until January 2010. Subjects with indirecthyperbilirubinemia were divided into two groups. One groupreceived single phototherapy (n = 41) and other receiveddouble photo therapy (n = 40) . Measurements of total plasmabilirubin level were conducted at 12 hours and at 24 hoursof phototherapy, as well as at 24 hours after phot otherapytermination. Rebound bilirubin serum level was defined asan increment of about 1 - 2 mg/dL serum bilirubin afterphototherapy discontinuation.Results The decreases in serum bilirubin levels were significantlygreater in the do uble phototherapy group for observationsat 12 h ours , 24 h ours, and 24 hours after phototherapyt ermination (P = 0.0001). At the 24-hour observation afterterminationofphototherapy, only 1 neonate (2.7%) in the singlephototherapy group compared to 4 neonates (10.8%) in thedouble phototherapy group had serum bilirubin level increasesof 1 - 2 mg/dL. Fisher's exact test did not reveal a significantdifference in rebound serum bilirubin occurrence in the twogroups (P = 0.358).Conclusion Double phototherapy shows significantly greaterdecrease in bilirubin level compared to single phototherapywithin a same period of time. Rebound serum bilirubin levels aftersingle and double phototherapy may occur in some patients withhyperbilirubinemia, as bilirubin production continues. However,260 • Paediatr Irulones, Vol. 54, No. 5, September 2014there is no significant difference in rebound effects between singlevs. double phototherapy.
Childhood non-Hodgkin’s lymphoma in Cipto Mangunkusumo Hospital, Jakarta: Outcome of treatment 2000-2005 Djajadiman Gatot; Teny Tjitrasari; Novie Amelia Chozie
Paediatrica Indonesiana Vol 46 No 4 (2006): July 2006
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi46.4.2006.185-8

Abstract

Background Childhood non-Hodgkin’s lymphoma (NHL) is the thirdmost common solid tumor in Cipto Mangunkusumo, Jakarta. Since1992 there was no national report on the survival of children withNHL. To continue our observation on the result of treatment of chil-dren with NHL in our institution, we briefly report the outcome therapyof children with NHL who were admitted to our hospital during 2000-2005.Objective All patients who were diagnosed as non-Burkitt type NHLbetween January 2000-December 2005 were included in the study.Data collected retrospectively from the Oncology Registration ofHematology-Oncology Division, Department of Child Health, CiptoMangunkusumo Hospital, including age, sex, primary site of tumor,histopathology type, staging, treatment response, and outcome.Results A total of 24 patients were available. Male:female ratiowas 1.8:1. The age range was from 9 months to 11 years (median6 years). The histological type consisted of LL (3) and non-LL (11).Ten out of 14 patients were diagnosed as advanced stages (stagesIII and IV), while the rest were in stage II. Primary tumor site in LLtype were the head and neck (1), mediastinum (1), and testis (1),while the non-LL type patients had more varied site. Overall sur-vival of NHL was 78.6%+4.7%.Conclusion The overall survival of childhood NHL patients treatedwith protocol in our institution is in the range of survival that hadachieved in other centers worldwide, even with advanced stage ofdisease.
Comparison of SpO2/FiO2 and PaO2/FiO2 ratios as markers of acute lung injury Dewi Shandi Laila; Chairul Yoel; Hakimi Hakimi; Munar Lubis
Paediatrica Indonesiana Vol 57 No 1 (2017): January 2017
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (21.685 KB) | DOI: 10.14238/pi57.1.2017.30-4

Abstract

Background One of the diagnostic criteria for acute lung injury (ALI) is the PaO2/FiO2 (P/F) ratio. This measurement is obtained by blood gas analysis, which involves an invasive procedure (arterial blood draw). In order to reduce invasive procedures on critically ill patients, an alternative non-invasive marker for ALI is needed. The SpO2/FiO2 (S/F) ratio attained by pulse oximetry may be a suitable alternative.Objective To investigate for a correlation between S/F ratio and P/F ratio, in order to find an alternative non-invasive marker of ALI.Methods A cross-sectional study was conducted in the pediatric intensive care unit (PICU) at Haji Adam Malik Hospital, Medan from August 2012 to June 2013. Subjects (children aged 1 month – 18 years) underwent blood gas analysis when their pulse oximetry showed saturation of 80-97% within 24 hours of ventilator use. We measured PaO2, SpO2, and FiO2 and calculated S/F and P/F ratios. Data were analyzed by Spearman’s correlation and linear regression tests.Results Of 69 PICU patients, 39 children fulfilled the criteria for ALI. The S/F ratio and P/F ratio had a weak correlation (r=0.2; P=0.18). The linear regression equation was S/F ratio = 129.67 + 0.11 (P/F), with S/F ratio values of 162.67 and 151.67 correlating to P/F ratio values of 300 and 200, respectively.Conclusion  The S/F ratio has a weak correlation with P/F ratio for ALI in children.  
Sucrose Tolerance Test in Children With Diarrhoea Widiarto Widiarto; Teluk Sebodo; Irawan Irawan; Widayat Widayat; Ismangoen Ismangoen
Paediatrica Indonesiana Vol 22 No 7-8 (1982): July - August 1982
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi22.7-8.1982.126-31

Abstract

A study of Sucrose Tolerance Test has been done in 30 children with the ages ranging between 11!2 and 18 months suffering from diarrhoea who were admitted to the Department of Child Health, Gadjah Mada University Hospital, Yogyakarta during November 1979 until April 1980.Ten out of 30 children (33.33%) had blood sugar level increase more than 40 mg%, and one of them developed diarrhoea, while 20 out of 30 children (66.67%) had blood sugar level increase less than 40 mg%, one of them developed diarrhoea.
Quality of general movements: A valuable tool for the assessment of neurological integrity in young infants Alifiani H. Putranti; Mijna Hadders-Algra
Paediatrica Indonesiana Vol 47 No 6 (2007): November 2007
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (303.803 KB) | DOI: 10.14238/pi47.6.2007.290-4

Abstract

Brain development and its significance for neurological diagnosis in infancy.
Tuberculosis score chart signs and symptoms in children with positive tuberculin skin tests Finny Fitry Yani; Rizanda Machmoed; Marhefdison Marhefdison; Darfioes Basir
Paediatrica Indonesiana Vol 52 No 2 (2012): March 2012
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (120.271 KB) | DOI: 10.14238/pi52.2.2012.78-85

Abstract

Background The Indonesian Pediatrics Respirology WorkingGroup (IPRWG) developed the tuberculosis (TB) scorechart to assist in diagnosing TB in community health centers(Puskesmas).Objectives To document signs and symptoms of the IPRWG TBscore chart, to analyze various combinations of these signs andsymptoms, and to compare these combinations in children withTB to those without TB, based on a TB score chart.Methods We performed a cross-sectional study from July toOctober 2008, in Padang, Bukittinggi and Pasaman. We recruitedchildren with known positive tuberculin skin tests (TST) from a2006 tuberculin survey. Questionnaires on signs and symptoms(IPRWG TB score chart) were completed and chest radiographswere obtained for all children. Subjects fulfilling a total score ofsix or more were considered to have a diagnosis of TB.Results We diagnosed TB in 78/285 (27.3%) subjects. A scorevalue of3 for the category of household contact (HHC) positivesmears was added in 21/78 subjects. However, the highest risk forTB disease was found in those diagnosed with no clear history ofHHC (58.9%; OR 192, 95% CI 22 to 1679). The highest riskfactors for TB were suggestive chest X-ray (34.6%; OR 9.2, 95%CI 3.6 to 23 .4) and fever lasting > 2 weeks (17.9%; OR 8, 95%CI 2.2 to 29.1), respectively. Of 46 children with TB diagnosisbut without HHC, the combination of undernourishment, lymphnode enlargement and suggestive chest X-ray was highest (28.2%).Individual or dual combination signs and symptoms were alsofound in children without TB diagnosis.Conclusion Various combinations of signs and symptoms couldlead to fulfillment of scoring for TB diagnosis. [Paediatr lndones.2012;5 2: 78-85].
Cardiac arrest in a child during a combined general epidural anesthesia procedure Soenarjo Soenarjo; Yudhi Prabakti; Edwin MP Siahaan; A Soemantri; M Sidhartani
Paediatrica Indonesiana Vol 45 No 3 (2005): May 2005
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi45.3.2005.132-6

Abstract

An increased risk of perioperative cardiac arrestin children, in comparison to adults, has beenrecognized. A number of factors associatedwith perioperative cardiac arrest have been identified,including young age, comorbidities, and emergencysurgery. Since anesthesia-related cardiac arrest isuncommon, a multi-related database is required tounderstand the mechanisms of cardiac arrest and todevelop preventive strategies. Most cardiac arrestsoccur during induction (37%) or maintenance (45%)of anesthesia, usually following one or more of thefollowing antecedent events, i.e., bradycardia (54%),hypotension (49%), abnormality of oxygen saturationas measured by pulse oximetry (48%), inability tomeasure blood pressure (25%), abnormality of end-tidal CO 2 (21%), cyanosis (21%), or arrhythmia(18%). In 11% of cases, cardiac arrest occurredwithout recognized warning. There are only fewreports in the literature, and in Kariadi Hospital, nonehas ever been reported. The aim of this report is toidentify and discuss possible causes of cardiac arrestand to anticipate its complications.
Comparison of serum aminotranferases in overweight and obese children Ayu Shintia Shanti; I Gusti Lanang Sidiartha
Paediatrica Indonesiana Vol 56 No 6 (2016): November 2016
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (342.398 KB) | DOI: 10.14238/pi56.6.2016.350-5

Abstract

Background Obesity has become a global issue. Non-alcoholic fatty liver disease is a metabolic complication of obesity, and indicated by elevated serum aminotransferases.Objective To compare serum aminotransferase levels in overweight and obese children.Methods This cross-sectional study was conducted from August to October 2015. A total of 82 subjects aged 6-10 years met the study criteria. Blood specimens and data concerning lifestyle and family history using questionnaires were collected. Subjects were divided into three groups based on BMI: overweight, obese, and severely obese. Comparisons of serum aminotransferase levels were analyzed by Kruskal-Wallis and post hoc tests, with P values < 0.05.Results The median serum alanine aminotransferase (ALT) levels in overweight, obese, and severely obese subjects were 14 (IQR 6-42) U/L, 15 (IQR 11-44) U/L, and 23 (IQR 9-59) U/L, respectively (P=0.031). The median serum aspartate aminotransferase (AST) levels in overweight, obese, and severely obese subjects were 22 (IQR 17-36) U/L, 22 (IQR 16-32) U/L, and 24 (IQR 15-41) U/L, respectively (P=0.049). Post hoc analysis revealed that median serum ALT levels were significantly higher in the severely obese group than in the overweight group [-8.982 (95% CI -14.77 to -3.20; P=0.003)], as well as in the obese group [-5.297 (95% CI -10.58 to -0.02; P=0.049)]. In addition, the median serum AST level was significantly higher in the severely obese group than in the obese group [-2.667(95% CI -5.27 to -0.07; P= 0.044)].Conclusion Median serum ALT and AST levels are significantly higher in severely obese children than in obese and overweight children. 

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