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Paediatrica Indonesiana
Published by Ikatan Dokter Anak Indonesia
ISSN : 00309311     EISSN : 2338476X     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Paediatrica Indonesiana is a medical journal devoted to the health, in a broad sense, affecting fetuses, infants, children, and adolescents, belonged to the Indonesian Pediatric Society. Its publications are directed to pediatricians and other medical practitioners or researchers at all levels of health practice throughout the world.
Arjuna Subject : -
Articles 2,118 Documents
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Risk factors for positive tuberculin tests in children Purnomo Sidhi; Dwi Wastoro Dadiyanto; Suhartono Suhartono
Paediatrica Indonesiana Vol 51 No 6 (2011): November 2011
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi51.6.2011.311-5

Abstract

Background Tuberculosis (TB) is a chronic infectious disease and a public health problem. The World Health Organization (WHO) declared TB to be a global emergency because of currently increasing rates of disease and drug resistance. Two million people die annually because of TB. Children are one of the highest groups at risk for TB infection. An effort to define risk factors is needed for effective intervention.Objective To identify risk factors for positive tuberculin tests in children.Methods This case control study was done in elementary school children aged 8–12 years in areas served by three community health centers in Semarang. Twenty-nine subjects were Mantoux positive and 29 others served as controls. Consecutive sampling was used for all negative Mantoux test results. Pulmonary TB was diagnosed using the TB scoring system, including the Mantoux test. Statistical bivariate and multivariate analyses were performed.Results History of household TB contact as a risk factor for positive tuberculin test in children resulted in an OROR of 3.76 (95% CI 1.059 to 13.342), P=0.040. History of illness at the time of testing resulted in an OR of 10.23 (95% CI 1.138 to 91.930), P=0.038. The probability of positive tuberculin testing was 90.7% if both these variables were positive.Conclusion History of household TB contact and the history of illness at the time of testing were risk factors for positive tuberculin tests in children.
A child with pheochromocytoma and malignant hypertension Abidin S.; Alatas H.; I. G. N Wila Wirya; Taralan Tambunan
Paediatrica Indonesiana Vol 21 No 11-12 (1981): November - December 1981
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi21.11-12.1981.240-9

Abstract

Herein we report a boy of 13 years old who suffered from pheochromocytoma with malignant hypertension. No metastasis was found and surgical approach was done successfully. Histopathologic examination showed pheochromocytoma of the left suprarenal gland with pleomorphism in the primary tumor.Postoperatively the blood pressure returned to normal within one month and remained so within 3 years follow up.
Diarrhoeal Disease of Children in Indonesia Sunoto Sunoto; Adnan S. Wiharta; J. Sulianti Saroso
Paediatrica Indonesiana Vol 18 No 11-12 (1978): November - December 1978
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1248.932 KB) | DOI: 10.14238/pi18.11-12.1978.332-58

Abstract

Diarrhoeal disease in infants and children up till now is still becoming a major problem with its high morbidity and mortality. There are too many factors which can play a role in causing this disease. But by giving Oral-glucose electrolyte Solution as soon as possible the case fatality rate can be reduced as low as possible. Whereas decreasing the morbidity still needs a very long time, since it has very multi-complex factors i.e. socio-economic condition, environmental and personal hygiene and sanitation, life style of people, belief, etc. The study on epidemiology, the influence of improvement of environmental sanitation and socio-anthropology is still very few, besides there is no satisfactory vaccin produced to prevent this disease. Meanwhile the worse of the case is that there is a tendency of decreasing breast-feeding in the big cities and to substiotute it with bottle-feeding.
Agreement of simplified Fencl-Stewart with Figge-Stewart method in diagnosing metabolic acidosis in critically ill children Rotua Sinaga; Abdurachman Sukadi; Dadang Hudaya Somasetia
Paediatrica Indonesiana Vol 47 No 4 (2007): July 2007
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (436.663 KB) | DOI: 10.14238/pi47.4.2007.144-9

Abstract

Background The traditional Henderson-Hasselbalch approach hasproven to be imprecise in critically ill patients. Stewart’s approachcan detect metabolic acidosis missed by traditional approach,including acidosis caused by increased unmeasured agreement(UA). The complexity of Stewart’s method leads to developmentof simpler modifications, simplified Fencl-Stewart and Figge-Stewart method. Agreement between both modifications isunknown.Objective This study aimed to measure the agreement of simplifiedFencl-Stewart with Figge-Stewart method in diagnosing metabolicacidosis in critically ill children.Methods The was performed in Hasan Sadikin General Hospital,Bandung from July to August 2006, involving <14 year-old criticallyill children. Blood samples for gas analysis, sodium, potassium,chloride and albumin measurement were taken simultaneously. Testresult was analyzed with simplified Fencl-Stewart and Figge-Stewartmethod and recorded with Excell spreadsheet. PASS was used forinterim analysis and DAG_Stat for raw agreement indices andKappa calculations.Results Forty-five (31 males, 14 females) children were enrolled.Acid base disturbances based on Stewart’s method were identifiedin 10 subjects with normal base excess and nine with normalbicarbonate. Significant increase of UA was detected in 11 of 45subjects with simplified Fencl-Stewart method, compared to thatof 12 subjects with Figge-Stewart method. Raw agreement indicesshowed 95.65% and 98.51% agreement for positive and negativeresult, Kappa was 0.94 (P=0.0000).Conclusions Excellent agreement is shown between simplifiedFencl-Stewart and Figge-Stewart method in diagnosing metabolicacidosis in critically ill children. Increased UA can be assessedwith both methods.
Renal manifestations in tuberous sclerosis patients: two case reports Oke Rina Ramayani; Rosmayanti Rosmayanti; Rafita Ramayati; Rusdidjas Rusdidjas
Paediatrica Indonesiana Vol 53 No 1 (2013): January 2013
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (134 KB) | DOI: 10.14238/pi53.1.2013.56-8

Abstract

Tuberous sclerosis (TS) is a neurocutaneous disorder, characterized bymental retardation, epilepsy, and facialangiofibromas. The incidence has beenestimated to be 1 case per 6000 live births.Although rare, this disorder is a cause of mentalretardation with severe epilepsy.1 Scientists havefound manifestations of this disorder not only inbrain and skin, but also in the eyes, heart, lungs, andkidneys, so it has been renamed tuberous sclerosiscomplex (TSC).
Periventricular leucomalacia in premature infants in neonatal ward, Cipto Mangunkusumo Hospital: A preliminary study Kemas Firman; Idham Amir; Nia Kurniati; Sudigdo Sastroasmoro
Paediatrica Indonesiana Vol 44 No 3 (2004): May 2004
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1274.925 KB) | DOI: 10.14238/pi44.3.2004.122-6

Abstract

Introduction Periventricular leucomalacia (PVL) is a major causeof neurodevelopment delay in premature infants, so early detec-tion of the preterm infant at high risk for the subsequent develop-ment of this lesion is critical.Objectives To determine the prevalence of PVL in premature in-fants hospitalized in neonatal ward, Cipto Mangunkusumo Hospi-tal using cranial ultrasound scans and define its characteristicsMethods Premature infants hospitalized in the neonatal ward fromJanuary to July 2003 were included in this study. Clinical featureswere retrieved from medical charts. Ultrasound scan was performedonce, after the age of 7 days and interpretations were read sepa-rately by two consultants of the radiology division.Results Fifty-one infants were included, 21 with <32-week gesta-tion, 30 with >32-week gestation; birth weight range were 1000 to2600 gram. Nineteen infants had cystic lesion and/or dilatation ofthe ventricle from the cranial ultrasound scan. The prevalence ofPVL in gestational age (GA) of <32 weeks was 6/21 and that in GAof >32 weeks was 13/30. Risk factors found in infants with PVLwere maternal infection, respiratory distress, sepsis and circula-tory failure.Conclusion The prevalence of PVL in preterm infants in CiptoMangunkusumo neonatal ward was higher than that was reportedin developed countries. Maternal infection, respiratory distress,sepsis, and circulatory failure which were commonly found in theseinfants were factors to be considered as risks for PVL
Prevalence and risk factors of overweight and obesity in adolescents Gary Adhianto; Soetjiningsih Soetjiningsih
Paediatrica Indonesiana Vol 42 No 9-10 (2002): September 2002
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi42.5.2002.206-11

Abstract

Background Overweight and obesity in adolescents is associated with persistent obesity and higher risk of morbidity and mortality in adulthood.Objective To determine the occurrence of overweight and obesity in adolescents and to identify the associated risk factors.Methods A cross sectional study was carried out on 600 dlildren aged from 11 to 17 years old. Anthropometric measurements induded body weight, height, and triceps skin fdd thickness. The nutritional status was dassified based on BMI using the WHO standard criteria. Three 24-hour dietary recalls were collected to assess the quality of food. A systematic random sampling was made according to school grade and sex.Results Five hundred and fifty two (92%) children met the indusion criteria, 46% were boys and 54% were girls. Most subjects (64%) had nonnal weight, 12% were underweight, 13% were overweight and 11% were obese. Among overweight group, 49% were boys, while among obese group, 53% were boys. On bivariate analysis, it was found that nutritional status had strong relationship with mother's education. On multivariate regression analysis, it was noted that energy expenditure and mother's education had significant negative correlation with the occurrence of overweight and obesity (8=- 0.235; p<0.001 and 8=-0.171; P=0.006) while energy intake and parental obesity had a significant positive correlation (8=0.498; P<0.001 and B=0.128; P<0.001).Conclusions Energy expenditure and mother's education were inversely related to overweight and obesity, while energy intake and parental obesity were proportionally related to overweight and obesity.
Treatment of Newborns and Infants in Japan suffering from Pneumonia with New Antibiotics Susumu Nakazawa
Paediatrica Indonesiana Vol 15 No 3-4 (1975): March - April 1975
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (887.804 KB) | DOI: 10.14238/pi15.3-4.1975.105-11

Abstract

Despite the recent development of a high state of chemotherapy in Japan, there has not necessarily been an improvement in the prognosis of pneumonia in infants and newborns. Upon bacteriological examination, relevant causative organisms such as pathogenic staphylococci, pneumococci, streptococci, and gram-negative bacteria have been detected as causing mixed infection. Suitable chemotherapeutic agents which diffuse well to the lung and show high bactericidal action against such organisms must be selected to combat the infection. A combination of two synthetic penicillins, ampicillin, effective against gram-negative as well as gram-positive bacteria and cloxacillin effective against resistant staphylococci, was used for the treatment of many cases of pneumonia in infants and newborns and satisfactory results were obtained. The results of this study and an appraisal of penicillin combination therapy will be discussed.
Immunogenicity of Low Dose Recombinant DNA Hepatitis B Vaccine in Children Ten Years Old and Younger Wiharta A.S.; Purnawati S.P.; Zuraida Z.; Julfina B.
Paediatrica Indonesiana Vol 37 No 3-4 (1997): March - April 1997
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi37.3-4.1997.76-85

Abstract

To evaluate the usefulness of low dose hepatitis-B vaccine, we recruited 70 healthy children of both sexes aged ten years or less. To be included in the study a child must have been clinically healthy and gave negative results for hepatitis-B virus infection (HBsAg, anti-HBs, anti-HBc), and with seerum glutamic oxaloacetic acid transaminase less than 50 mU/1. Subjects with intercurrent infection and those with chronic disease or moderate to severe malnutrition were excluded from the study. They were given 3 injections of 2,5 ml rDNA hepatitis B vaccine intramuscularly on month 0, month 1, and month 6. The seroconversion rate after the third injection in all subjects was 92.3%; this was slightly different between the well-nourished and under-nourished children (93.9% vs. 87,5%), and between girls and boys (96.7% vs 88.6%). The only side effect noted was fever encountered in 1 subject. We conclude that three intramuscular injections of 2.5 mg of rDNA hepatitis B vaccine give good anti-HBs titer, so that this method may be considered to be used in the mass immunization program.
Sodium channels of SCNIA gene mutations in generalized epilepsy with febrile seizure plus (GEFS+) spectrum related to autism Elisabeth Herini; Yudha Patria; Gunadi Gunadi; Surini Yusoff; Indra SAri Kusuma Harahap; Sunartini Sunartini; Sutaryo Sutaryo; Satoshi Takada; Hisahide Nishio
Paediatrica Indonesiana Vol 50 No 3 (2010): May 2010
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (438.04 KB) | DOI: 10.14238/pi50.3.2010.125-32

Abstract

Background Mutations in the a-subunit of the first neuronalsodium channel gene SCNIA have been demonstrated forgeneralized epilepsy \\lith febrile seizures plus (GEFS+), severemyoclonic epilepsy in infancy (SMEI), and borderline SMEI(SMEB). SCNIA mutations are also described in patients 'Withpsychiatric disorders such as autism.Objective To identify the mutations of SCNIA gene in patientswith GEFS+ spectrum which may be related to autism.Methods We examined four patients v.ith autism and GEFS+spectrum who were admitted to the Department of Child Health,Sardjito Hospital, Yogyakarta, Indonesia. Diagnosis of autism wasbased on DSM􀁟IV;ICD X criteria. Mutations in SCNIA wereidentified by PCRamplification and denaturing high􀁟performanceliquid chromatography analysis, Mth subsequent sequencing.Results There were four patients, all boys, aged 1.8 year to 7 years.The phenotypes of epilepsy were GEFS+ in one patient, SMEBin one patient and SMEI in two patients. Sequencing analysisrevealed a G􀁟to􀁟A heterozygous transition which was detectedat nucleotide c.4834G>A (p.V1612I ) in exon 25. Other singlenucleotid polymorphisms (SNPs) were c.383 +66T>C in intron 2,c.603-91G>A and c.603-1060> T in intron 4, c.965-21C> T inintron 6, c.1028+21T>Cin intron 7, c.2173G>A in exon 12 andc. 2177-38C>A, c.2177-12delT, c.2176+44C> T in intron 12.Conclusion In this study, we reported the first cases Mth mutationin SCNIA gene in GEFS+ spectrum related to autistic patientsin Indonesian population, which showed a missense mutationp.V16121. [Paediatr lndones. 2010;50:125-32].

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