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Jurnal Bios Logos
Published by Universitas Sam Ratulangi
ISSN : 20889569     EISSN : 26563282     DOI : https://doi.org/10.35799/jbl.11.2.2020.28153
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology
JURNAL BIOS LOGOS is the journal published by Department of Biology, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University. The aims of the journal are to publish original research papers and article review in biology science i.e. botany, zoology, molecular biology, microbiology, ecology, diversity and conservation, taxonomy and biogeography. BIOS LOGOS is published two times per year (February and August)
Arjuna Subject : Ilmu Pertanian dan Biologi (Semua) - Ilmu Pertanian dan Biologi (Lain-Lain)
Articles 279 Documents
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HIIT vs MICT on Male Reproductive Function in a Diabetic Model: A Review of the Benefit-to-Volume Ratio Sipahutar, Natasha Novida
JURNAL BIOS LOGOS Vol. 15 No. 3 (2025): JURNAL BIOS LOGOS
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jbl.v15i3.65808

Abstract

Diabetes mellitus impairs male reproductive function through hyperglycemia-induced oxidative stress, hormonal disruption, and testicular damage. This structured literature review evaluated the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on reproductive outcomes in streptozotocin-induced diabetic rodents. Studies reporting sperm quality, testosterone, oxidative stress markers, and testicular morphology after exercise interventions were synthesized narratively. Across the included studies, HIIT was associated with rapid increases in testosterone and sperm motility, alongside reductions in lipid peroxidation and apoptosis, mainly through acute metabolic stimulation and enhanced Leydig cell responsiveness. In contrast, MICT produced slower but more stable improvements, characterized by better spermatogenesis and sustained enhancement of antioxidant capacity, consistent with exercise-induced hormesis and improved insulin sensitivity. These findings suggest that HIIT and MICT act through distinct yet complementary physiological pathways and can be tailored to therapeutic goals and disease severity. Nevertheless, conclusions should be interpreted cautiously due to heterogeneity in streptozotocin dose, training intensity, and intervention duration.
AMPK as a Bioenergetic Checkpoint in Neurons: Conditional Permission for Synaptic Plasticity Pollo, Gracia Alice Victoria
JURNAL BIOS LOGOS Vol. 15 No. 3 (2025): JURNAL BIOS LOGOS
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jbl.v15i3.65833

Abstract

Synaptic signaling and plasticity require a lot of energy. Those two pathways occurance differ based on energy availability. Synaptic signaling can occur rapidly but plasticity depends on sustained energy availability. This makes neurons need to assess whether sufficient energy is present to support plasticity. Adenosine monophosphate–activated protein kinase (AMPK) is a central cellular energy sensor, yet its role in determining the energetic permissibility of synaptic plasticity has not been clearly defined. This review proposes a conceptual framework in which AMPK functions as a bioenergetic checkpoint for synaptic plasticity. Evidence indicates that AMPK activity is tightly coupled to cellular energy status. Under high-energy conditions, low AMP and high ATP levels limit AMP binding to the γ subunit. This makes the β subunit remains non-myristoylated and the α subunit unphosphorylated thus maintaining AMPK in an inactive state. This results in permitted synaptic plasticity. During low energy condition, elevated AMP and reduced ATP promote AMP binding to the γ subunit. The binding then induce myristoylationn of β-subunit and phosphorylation of the α subunit at threonine 172 (Thr172). This cascade activate AMPK. Activated AMPK suppresses energy-consuming processes, thereby restricting synaptic plasticity. Through these mechanisms, AMPK converts fluctuations in cellular energy into a threshold-based decision that determines whether synaptic activity is permitted toward long-term plasticity in preserving bioenergetic homeostasis. This framework positions AMPK as a central bioenergetic checkpoint linking cellular energy status to the permission of synaptic plasticity.
Gene Editing with CRISPR-Cas9 Technology for Hepatitis B Virus: A Literature Review Rattu, Ferencia
JURNAL BIOS LOGOS Vol. 15 No. 3 (2025): JURNAL BIOS LOGOS
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jbl.v15i3.65836

Abstract

Hepatitis B Virus (HBV) is a global problem with a significant impact on morbidity and mortality rates that are expected to continue to increase if no further treatment is carried out. HBV is caused by the Hepatitis virus type B, which until now has no medical therapy that can eliminate HBV. The latest developments referring to gene editing for genetic and non-genetic diseases are clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9. CRISPR-Cas9 appears with a promising approach with solutions to various disease disorders. CRISPR-Cas9 with DNA editing by Cas9 endonuclease, which is guided by the RNA sequence is able to pair with the target base sequence. The purpose of this paper is to examine the effectiveness and potential of the gene editing method with CRISPR-Cas9 as a therapy for Hepatitis B disease. The writing method is a Literature Review with databases obtained through Google Scholar, PubMed, and ScienceDirect. Various studies and methods have been developed to improve the success of CRISPR-Cas9. Off-target effects are detected to reduce the risk of CRISPR-Cas9. The results show that CRISPR-Cas9 can inhibit HBV replication in vitro and in vivo. Therefore, the technology shows much-needed potential for eradicating the hepatitis B virus. However, further studies are needed to determine its safety and effectiveness as a hepatitis B therapy.
Relationship Between Soil Density And Soil Organic Carbon Stock In Tembawang Agroforestry Area Of Semayang Village Sanggau Regency Wahyudi, Miki; Rafdinal; Turnip, Masnur
JURNAL BIOS LOGOS Vol. 16 No. 1 (2026): JURNAL BIOS LOGOS
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jbl.v16i1.63676

Abstract

Tembawang agroforestry is composed of tree vegetation that stores abundant carbon reserves both on the surface and in the soil. Soil organic carbon plays a role in increasing soil fertility so that plant productivity and the sustainability of plant life can increase. The purpose of this study was to determine organic carbon content, and organic carbon reserve and their relationship in the Tembawang Agroforestry of Sanggau Regency. This research was conducted from August 2024 to December 2024. Determination of sampling locations using purposive sampling method. Sampling was done at 5 points in each location. Determination of organic carbon content using the Walkey and Black method. Data were analyzed using the SPSS 30 program. The results of this study show that the soil density is 0,6615 g/cm3 to 0,7795 g/cm3. The highest organic carbon content was 7.08% then decreased to 2.89%. Soil organic carbon reserves were 2311,38 ton/ha to 6735,60 ton/ha. Soil density had a week negative correlation with organic carbon content (r = -0,240 < 0,05) and a moderate positive correlation with organic carbon stocks (r = 0,546 < 0,01). Organic carbon content had a strong negative correlation with organic carbon reserves (r = -0,681 < 0,01).  
Characterization of Thelenota ananas and Its Potential as a Natural Source of Antioxidants Budiarso, Fona; Sorisi, Angle; Fatimawali, Fatimawali
JURNAL BIOS LOGOS Vol. 16 No. 1 (2026): JURNAL BIOS LOGOS
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jbl.v16i1.63976

Abstract

The sea cucumber Thelenota ananas, commonly found in tropical waters, possesses significant biological potential. This study aims to assess the antioxidant potential of Thelenota ananas extract obtained from the Manado sea. The simplicia was analyzed for organoleptic properties, moisture content (9.8%), and ash content (23%). Bioactive compounds were identified through color and foam reactions, while antioxidant activity was measured using the DPPH method. The extract was found to contain saponins, terpenoids, and alkaloids. The antioxidant activity of the extract, with an IC50 value of 99.8 ppm, demonstrates strong antioxidant properties, though less potent than the control, vitamin C (IC50 of 45.5 ppm). These findings suggest that while Thelenota ananas extract exhibits substantial antioxidant activity, it is still less effective than vitamin C. This research highlights the potential of Thelenota ananas as a natural antioxidant source for the development of health products.
Density and Functional Role of Zooplankton in The Coastal Waters of Bahu and Meras, North Sulawesi Ali, Sitti Nur Haliszah; Koneri, Roni; Papu, Adelfia
JURNAL BIOS LOGOS Vol. 16 No. 1 (2026): JURNAL BIOS LOGOS
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jbl.v16i1.64781

Abstract

The city of Manado is surrounded by waters with a long coastline. Most of the coastline is used for human activities. These activities include tourist attractions, ports, and trade centres. The sustainability of these sectors is highly dependent on the health of the marine ecosystem. One organism that plays an important role in the aquatic ecosystem is zooplankton. This study aims to calculate the density of zooplankton and analyse its functional role. The method used was exploratory descriptive, which is a research pattern that describes in detail or comprehensively the condition or status of zooplankton phenomena. This study was conducted at Bahu Beach and Meras Beach, North Sulawesi. The density value at Bahu Beach is 307.35 ind/m3 and at Meras Beach is 222.4 ind/m3. Zooplankton identified from two sampling points belonged to the phyla Arthropoda, Foraminifera, Annelida, Mollusca, and Cilliophora. The total number of genera found was 22. There were 1,032 consumer I individuals, 798 consumer II individuals, and 193 consumer III individuals.
Identification of Potential PDE5 Inhibitors from Natural Sources for Erectile Dysfunction Therapy Through A Molecular Docking Approach Mantiri, Vic; Tendean, Lydia; Turalaki, Grace
JURNAL BIOS LOGOS Vol. 15 No. 3 (2025): JURNAL BIOS LOGOS
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jbl.v15i3.66648

Abstract

The global prevalence of erectile dysfunction has increased in recent decades, and despite various treatment modalities, including phosphodiesterase-5 (PDE5) inhibitors, side effects and contraindications necessitate alternative therapies. This research explores the potential of active compounds present in aphrodisiac plants as PDE5 inhibitors using a molecular docking approach. Eight test compounds evaluated, namely quercitrin, quercetin, garcinoic acid, ellagic acid, catechin, and kaempferol, exhibited high affinity towards PDE5. Receptor-ligand analysis revealed interacting residues supporting PDE5 inhibition. Pharmacokinetic analysis demonstrated similarities, particularly in terms of bioavailability and toxicity, among these ligands, except for quercitrin when compared to the control ligand, sildenafil. This study found that compounds derived from herbal sources show potential as PDE5 inhibitors, with pharmacokinetic profiles comparable to sildenafil. Experimental validation is required to verify the efficacy of these ligands.
Identification of Mangrove using DNA Barcoding and Vegetation Analysis at the Sarawet Mangrove Ecotourism Site, North Minahasa Regency Rondonuwu, Sendy B; Maabuat, Pience; Kamu, Vany; Pujiastuti, Dwi Rahayu
JURNAL BIOS LOGOS Vol. 16 No. 1 (2026): JURNAL BIOS LOGOS
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jbl.v16i1.67260

Abstract

This study aims to identify the diversity of mangrove species in the Mangrove Ecotourism area of Sarawet Village, Likupang, North Minahasa Regency, using a molecular taxonomy approach based on DNA barcoding and an ecological approach through vegetation analysis. Vegetation data collection was conducted descriptively and qualitatively using transect and plot methods. Molecular analysis included DNA extraction from mangrove leaf samples, amplification of the matK and rbcL genes using Polymerase Chain Reaction (PCR), followed by sequencing and nucleotide base comparison using the Basic Local Alignment Search Tool (BLAST). The morphological vegetation analysis found six mangrove species at the research site, namely Rhizophora mucronata, Rhizophora apiculata, Bruguiera sp., Sonneratia alba, Aegiceras corniculatum, and Ceriops tagal. Meanwhile, the molecular identification results of DNA barcoding showed that the matK gene sequence in the SRA sample had a 99.98% similarity with Sonneratia alba, and the rbcL gene sequence in the SRC sample had a 100% similarity with Aegiceras corniculatum. The combination of molecular identification and vegetation analysis provides accurate data on mangrove species composition, which is highly essential as a foundation for monitoring, sustainable management, and conservation of the mangrove ecotourism area as a buffer zone.
Anti-inflammatory and Insulin-sensitizing Effects of Combined Pandanus amaryllifolius and Syzygium polyanthum Extracts in HFD-STZ Induced Diabetic Rats Meilinda, Selvia; Lim, Hadyanto; Anto, Endy Juli; Siahaan, Jekson M; Tarigan, Menang B
JURNAL BIOS LOGOS Vol. 16 No. 1 (2026): JURNAL BIOS LOGOS
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jbl.v16i1.66731

Abstract

Type 2 Diabetes Mellitus (T2DM) is a global health crisis characterized by insulin resistance and pancreatic -cell failure, largely driven by chronic low-grade inflammation. Elevated pro-inflammatory markers, particularly TNF- and IL-6, disrupt insulin signaling. While conventional oral hypoglycemics are effective, their long-term use is often hindered by adverse effects. Pandanus amaryllifolius and Syzygium polyanthum are polyphenol-rich medicinal plants with significant antioxidant potential. This study evaluates the in vivo efficacy of a combined ethanolic extract of these plants in reducing TNF-, IL-6, and HOMA-IR levels, alongside in silico validation of their bioactive compounds. An experimental posttest-only control group design was employed using HFD-STZ-induced male Wistar rats. Key parameters included blood glucose, HOMA-IR, inflammatory cytokines, and pancreatic histopathology. Molecular docking was conducted to analyze the interaction between bioactive compounds and glucose metabolism receptors. The combined extracts significantly suppressed systemic inflammation, marked by a substantial reduction in TNF- and IL-6. This correlated with improved insulin sensitivity and lower HOMA-IR values. Histopathologically, the 200 mg/kg BW dose showed the most significant recovery of the islets of Langerhans. In silico analysis confirmed that flavonoids like quercetin exhibit strong binding affinities to target proteins. The combination of P. amaryllifolius and S. polyanthum acts as a potent anti-inflammatory and insulin sensitizer, offering a promising adjuvant therapy for T2DM management.

Page 28 of 28 | Total Record : 279

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