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Jurnal Bios Logos
Published by Universitas Sam Ratulangi
ISSN : 20889569     EISSN : 26563282     DOI : https://doi.org/10.35799/jbl.11.2.2020.28153
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology
JURNAL BIOS LOGOS is the journal published by Department of Biology, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University. The aims of the journal are to publish original research papers and article review in biology science i.e. botany, zoology, molecular biology, microbiology, ecology, diversity and conservation, taxonomy and biogeography. BIOS LOGOS is published two times per year (February and August)
Arjuna Subject : Ilmu Pertanian dan Biologi (Semua) - Ilmu Pertanian dan Biologi (Lain-Lain)
Articles 273 Documents
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HIIT vs MICT on Male Reproductive Function in a Diabetic Model: A Review of the Benefit-to-Volume Ratio Sipahutar, Natasha Novida
JURNAL BIOS LOGOS Vol. 15 No. 3 (2025): JURNAL BIOS LOGOS
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jbl.v15i3.65808

Abstract

Diabetes mellitus impairs male reproductive function through hyperglycemia-induced oxidative stress, hormonal disruption, and testicular damage. This structured literature review evaluated the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on reproductive outcomes in streptozotocin-induced diabetic rodents. Studies reporting sperm quality, testosterone, oxidative stress markers, and testicular morphology after exercise interventions were synthesized narratively. Across the included studies, HIIT was associated with rapid increases in testosterone and sperm motility, alongside reductions in lipid peroxidation and apoptosis, mainly through acute metabolic stimulation and enhanced Leydig cell responsiveness. In contrast, MICT produced slower but more stable improvements, characterized by better spermatogenesis and sustained enhancement of antioxidant capacity, consistent with exercise-induced hormesis and improved insulin sensitivity. These findings suggest that HIIT and MICT act through distinct yet complementary physiological pathways and can be tailored to therapeutic goals and disease severity. Nevertheless, conclusions should be interpreted cautiously due to heterogeneity in streptozotocin dose, training intensity, and intervention duration.
AMPK as a Bioenergetic Checkpoint in Neurons: Conditional Permission for Synaptic Plasticity Pollo, Gracia Alice Victoria
JURNAL BIOS LOGOS Vol. 15 No. 3 (2025): JURNAL BIOS LOGOS
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jbl.v15i3.65833

Abstract

Synaptic signaling and plasticity require a lot of energy. Those two pathways occurance differ based on energy availability. Synaptic signaling can occur rapidly but plasticity depends on sustained energy availability. This makes neurons need to assess whether sufficient energy is present to support plasticity. Adenosine monophosphate–activated protein kinase (AMPK) is a central cellular energy sensor, yet its role in determining the energetic permissibility of synaptic plasticity has not been clearly defined. This review proposes a conceptual framework in which AMPK functions as a bioenergetic checkpoint for synaptic plasticity. Evidence indicates that AMPK activity is tightly coupled to cellular energy status. Under high-energy conditions, low AMP and high ATP levels limit AMP binding to the γ subunit. This makes the β subunit remains non-myristoylated and the α subunit unphosphorylated thus maintaining AMPK in an inactive state. This results in permitted synaptic plasticity. During low energy condition, elevated AMP and reduced ATP promote AMP binding to the γ subunit. The binding then induce myristoylationn of β-subunit and phosphorylation of the α subunit at threonine 172 (Thr172). This cascade activate AMPK. Activated AMPK suppresses energy-consuming processes, thereby restricting synaptic plasticity. Through these mechanisms, AMPK converts fluctuations in cellular energy into a threshold-based decision that determines whether synaptic activity is permitted toward long-term plasticity in preserving bioenergetic homeostasis. This framework positions AMPK as a central bioenergetic checkpoint linking cellular energy status to the permission of synaptic plasticity.
Gene Editing with CRISPR-Cas9 Technology for Hepatitis B Virus: A Literature Review Rattu, Ferencia
JURNAL BIOS LOGOS Vol. 15 No. 3 (2025): JURNAL BIOS LOGOS
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jbl.v15i3.65836

Abstract

Hepatitis B Virus (HBV) is a global problem with a significant impact on morbidity and mortality rates that are expected to continue to increase if no further treatment is carried out. HBV is caused by the Hepatitis virus type B, which until now has no medical therapy that can eliminate HBV. The latest developments referring to gene editing for genetic and non-genetic diseases are clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9. CRISPR-Cas9 appears with a promising approach with solutions to various disease disorders. CRISPR-Cas9 with DNA editing by Cas9 endonuclease, which is guided by the RNA sequence is able to pair with the target base sequence. The purpose of this paper is to examine the effectiveness and potential of the gene editing method with CRISPR-Cas9 as a therapy for Hepatitis B disease. The writing method is a Literature Review with databases obtained through Google Scholar, PubMed, and ScienceDirect. Various studies and methods have been developed to improve the success of CRISPR-Cas9. Off-target effects are detected to reduce the risk of CRISPR-Cas9. The results show that CRISPR-Cas9 can inhibit HBV replication in vitro and in vivo. Therefore, the technology shows much-needed potential for eradicating the hepatitis B virus. However, further studies are needed to determine its safety and effectiveness as a hepatitis B therapy.

Page 28 of 28 | Total Record : 273

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