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INDONESIA
JURNAL BIOMEDIK
Published by Universitas Sam Ratulangi
ISSN : 20859481     EISSN : 2597999X     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions
JURNAL BIOMEDIK adalah JURNAL ILMIAH KEDOKTERAN yang diterbitkan tiga kali setahun pada bulan Maret, Juli, November. Tulisan yang dimuat dapat berupa artikel telaah (review article), hasil penelitian, dan laporan kasus dalam bidang ilmu kedokteran..
Arjuna Subject : -
Articles 499 Documents
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Hubungan antara Pengetahuan dan Sikap dengan Tindakan Pencegahan Penyebaran COVID-19 pada Perusahaan Produsen Air Minum Dalam Kemasan Soeratinoyo, Dewi K.; Doda, Diana V. D.; Warouw, Finny
Jurnal Biomedik : JBM Vol 13, No 3 (2021): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.13.3.2021.34512

Abstract

Abstract: The Covid-19 pandemic constitutes a major impact not only on health but also onithe economy include those in Indonesia. Currently, the prevention of COVID-19 in the workplace needs attention, since worker's safety and health may influence companies' productivity. Information and infrastructure as a preventive measure of Covid-19 must be provided by the company so that employees could apply health protocols. This study was conducted with the aim of analyzing the relationship between knowledge and attitudes as well as preventive measures for the spread of COVID-19 among employees at a Bottled Drinking Water Producer Company. This research is a cross-sectional study design. Sixty-one employees were recruited randomly at the Packaged Drinking Water Industry in Airmadidi, North Sulawesi. Chi-square test was used to test the data. The results showed that 78.7% of employees had good knowledge, 65.6% of employees are in the category of good attitude,iand 88.5% of employees are in the category of good actions. The bivariate result showed that there was no significant relationship between knowledge with the practice of Covid-19 prevention measures (ρ i= i0.624). However, it revealed a significant relationship between attitudes (ρ= 0.002) and Covid-19 prevention measures (ρ= 0.002). In conclusion, the good attitudes toward the prevention of Covid-19 were important to the practice of preventive actions taken by employees at Packaged Drinking Water Industry in Airmadidi North Sulawesi.Keywords: knowledge, iattitude, iprevention imeasures, iCovid-19  Abstrak: Pandemi Covid-19 berdampak besar tidak hanyaibagiisektor ikesehatan tetapi juga terhadap perekonomian termasuk di Indonesia. Saat ini pencegahan COVID-19 di tempat kerja perlu mendapat perhatian, karena keselamatan dan kesehatan kerja dapat mempengaruhi produktivitas perusahaan. Informasi dan infrastruktur sebagai langkah pencegahan Covid-19 harus disediakan perusahaan agar karyawan dapat menerapkan protokol kesehatan. Penelitianiini bertujuan untuk menganalisis hubungan antara pengetahuan dan sikap serta tindakan pencegahan penyebaran COVID-19 pada karyawan di Perusahaan Produsen Air Minum Dalam Kemasan. Penelitian ini merupakan penelitian kuantitatif dengan desain studi potong lintang. Sebanyak 61 karyawan diambil secara acak di Industri Air Minum Dalam Kemasan di Airmadidi, Sulawesi Utara. Uji Chi-square digunakan untuk menguji data tersebut. Hasil penelitian menunjukkan bahwa 78,7% karyawan memiliki pengetahuan baik, 65,6% karyawan dalam kategori sikap baik, i88,5% karyawan dalam kategori tindakan baik. Hasil uji dua variabel menunjukkan tidak ada hubungan yang berarti antara pengetahuan dengan tindakan pencegahan Covid-19 (ρ= 0,624). Namun, terungkap adanya hubungan yang signifikan antara sikap (ρ=i0,002) dan tindakan pencegahan Covid-19 (ρ=i0,002). Sebagai simpulan, sikap yang baik terhadap pencegahan Covid-19 penting untuk praktik tindakan preventif yang dilakukan oleh karyawan di Industri Air Minum Dalam Kemasan Airmadidi Sulawesi Utara.Kata kunci: pengetahuan, sikap, tindakan, Covid-19
Peran Vitamin dalam Penanganan Penyakit Parkinson Onibala, Aurelia R.; Mambo, Christi D.; Masengi, Angelina S. R.
Jurnal Biomedik : JBM Vol 13, No 3 (2021): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.13.3.2021.31956

Abstract

Abstrak: Penyakit Parkinson atau Parkinson’s disease (PD) merupakan penyakit neurodegeneratif yang bersifat kronis, progresif, dan tidak dapat disembuhkan sehingga penyakit ini memiliki dampak sosial yang besar. Pengobatan yang digunakan saat ini tidak dapat menghentikan perjalanan PD dan memiliki efek samping yang merugikan. Oleh sebab itu diperlukan terapi tambahan dengan risiko efek samping yang lebih rendah seperti vitamin. Penelitian ini bertujuan untuk mengetahui vitamin apa saja yang berperan dan bagaimana mekanisme peran vitamin tersebut dalam membantu penanganan PD. Penelitian ini dilakukan dengan menggunakan metode Literature Review. Berdasarkan artikel yang dianalisis, vitamin memiliki peran dalam penanganan PD. Vitamin A (9-cis-retinoic acid) bermanfaat melalui mekanisme neuroproteksi pada neuron dopaminergik. Vitamin B3 (niasin) berpotensi dalam mengurangi peradangan saraf. Vitamin B12 dalam penelitian in vitro berperan melalui  mekanisme inhibisi terhadap agregasi α-synuclein, menghambat aktivitas kinase leucine-rich repeat kinase 2 (LRRK2), dan mencegah neurotoksisitas. Vitamin C (asam askorbat) efektif untuk menurunkan stres oksidatif. Vitamin E memiliki efek antiinflamasi dan antioksidan serta dapat meningkatkan kapasitas antioksidan total, dan meningkatkan GSH. Penggunaan vitamin A (9-cis-retinoic acid), vitamin B3, vitamin B12, vitamin C (dalam dosis dan jangka waktu tertentu), dan vitamin E bermanfaat untuk agen terapeutik PD. Vitamin B12, berdasarkan literature review perlu penelitian lebih lanjut namun tampaknya dapat menjadi terapi pendukung PD.Kata kunci: Vitamin, Penyakit Parkinson, Stres Oksidatif, Peradangan Saraf  Abstract: Parkinson's disease (PD) is a chronic, progressive, and incurable neurodegenerative disease that has a major social impact. The medications currently used cannot stop the course of PD and have adverse side effects. Therefore additional therapy with a lower risk of side effects such as vitamins is needed. This study aims to determine which vitamins play a role and how the mechanism of the role of these vitamins in helping treat PD. This research was conducted using the Literature Review method. Based on the articles analyzed, vitamins have a role in the management of PD. Vitamin A (9-cis-retinoic acid) is beneficial through neuroprotection in dopaminergic neurons. Vitamin B3 (niacin) has the potential to reduce nerve inflammation. Vitamin B12 in in vitro studies plays a role through inhibitory mechanisms of α-synuclein aggregation, inhibits the activity of leucine-rich repeat kinase 2 (LRRK2), and prevents neurotoxicity. Vitamin C (ascorbic acid) is effective for reducing oxidative stress. Vitamin E has anti-inflammatory and antioxidant effects and can increase the total antioxidant capacity and increase GSH. The use of vitamin A (9-cis-retinoic acid), vitamin B3, vitamin B12, vitamin C (in certain doses and for a certain time), and vitamin E are beneficial for the therapeutic agent of PD. For vitamin B12, based on the literature review, further research is needed but seems to be a supportive therapy for PD.Keywords: Vitamins, Parkinson's Disease, Oxidative Stress, Neuroinflammation
Ambliopia anisometropia Rares, Laya
Jurnal Biomedik : JBM Vol 8, No 2 (2016): JURNAL BIOMEDIK : JBM Suplemen
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.8.2.2016.12704

Abstract

Abstract: Anisometropic amblyopia is blurred vision due to refractive anomaly without any anatomical disorders of the eyes. It is frequently found among children in their growth and development periods. The prognosis depends on the ambylopia severity, management, patient’s obedience to the management, and age. We report a case of anisometropic amblyopia in a 8-year-old boy with his main complaint was blurred vision of both eyes. The ophthalmological examination showed the visual acuity of both eyes 6/40, PH 6/9. Several tests that showed normal results were as follows: eyeball movements to all directions; pupil responses to light; Hischberg test; cover test dan cover uncover test at near and far distance fixation; alternate cover test; and worth four dots and Maddox rod tests. Cyclopegical refraction with streak retinoscopy at 50 cm distance resulted in right eye S-4.00 C-3.00 x1800 6/9 and left eye S-1.25 C-3.25 x1800 6/7.5; autorefraction of right eye S-4.50 C-3.25 x70 and of left eye S-1.25 C-4.25 x1710. Anterior and posterior segments of both eyes were normal. Conclusion: In this case, the diagnosis was confirmed as anisometropic amblyopia and compound myopic astigmatism of the right and left eyes. The prognosis was dubia ad bonam. The patient was treated with maximal correction glasses and observed for the first four weeks, and then would be evaluated continuously untill the vision was normal. Keywords: amblyopia anisometropia, vision, refraction anomalyAbstrak: Ambliopia anisometropia merupakan gangguan penglihatan akibat kelainan refraksi tanpa disertai adanya kelainan anatomik pada mata yang sering terjadi pada masa perkembangan anak. Prognosis sangat tergantung pada derajat ambliopia, penanganan, kepatuhan pasien terhadap penanganan, dan usia pasien. Kami melaporkan kasus ambliopia anisometropia pada seorang anak berusia 8 tahun, dengan keluhan utama penglihatan kedua mata kabur. Dari pemeriksaan oftalmologik didapatkan visus ODS 6/40, PH 6/9. Beberapa pemeriksaan yang dilakukan memperlihatkan hasil normal, yaitu: pergerakan bola mata ke segala arah; respon pupil terhadap cahaya; Hischberg test; cover test dan cover uncover test pada fiksasi jarak dekat dan jauh; alternate cover test; serta worth four dots test dan Maddox rod test. Pemeriksaan refraksi sikloplegik dengan streak retinoscopy pada jarak 50 cm didapatkan mata kanan S-4,00 C-3,00 x1800 6/9 dan mata kiri S-1,25 C-3,25 x1800 6/7,5 dan pemeriksaan autorefraksi mata kanan S-4,50 C-3,25 x70 dan mata kiri S-1,25 C-4,25 x1710. Pemeriksaan segmen anterior dan posterior mata kanan dan kiri dalam batas normal. Simpulan: Diagnosis pada kasus ini ialah ambliopia anisometropia ODS dan astigmatisma miopikus kompositus ODS, dengan prognosis dubia ad bonam. Terapi yang diberikan ialah kacamata koreksi maksimal dan diobservasi selama 4 minggu pertama, dan akan dievaluasi terus sampai ketajaman penglihatan normaL. Kata kunci: ambliopia anisometropia, ketajaman penglihatan, kelainan refraksi
HIPERURISEMIA DAN RESPONS IMUN Manampiring, Aaltje E.
Jurnal Biomedik : JBM Vol 3, No 2 (2011): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.3.2.2011.865

Abstract

Abstract: Hyperuricemia, a highly prevalent condition in adult population, is associated with hemodynamic and metabolic disturbances. Albeit, pathophysiological aspects of hyperuricemia are still not clearly understood. Uric acid plays an essential role in immunity by induction of some cytokines and chemokines, such as TNFα, Il-1β, IL-6, CXCL8 (IL-8), and CXCL1 (growth-related oncogene α). Deposits of monosodium urate crystals in joint cavities and periarticular tissues  are related to an autoinflammatory disturbance, namely gout. Keywords: hyperuricemia, monosodium urate crystal, immune responsse.   Abstrak: Hiperurisemia merupakan suatu keadaan yang umum dijumpai pada populasi dewasa dan berhubungan dengan kelainan metabolik dan hemodinamik. Aspek patofisiologik dari hiperurisemia belum sepenuhnya dipahami dengan jelas. Asam urat berperan penting dalam imunitas dengan menginduksi berbagai sitokin dan kemokin, antara lain TNFα, Il-1β, IL-6, CXCL8 (IL-8) dan CXCL1 (growth-related oncogene α). Deposit kristal monosodium urat di dalam rongga sendi dan jaringan periartikuler berkaitan dengan gangguan autoinflamasi yang dikenal sebagai gout. Kata kunci: hiperurisemia, kristal monosodium urat, respons imun.
Besaran Neutrofil dan Kadar C-reactive Protein sebagai Faktor Prognostik Multi Organ Failure pada Pasien Multi-trauma ., Candy; Sapan, Heber B.; Kalesaran, Laurens T. B.; Kalitouw, Ferry
Jurnal Biomedik : JBM Vol 9, No 3 (2017): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.9.3.2017.17341

Abstract

Abstract: Trauma is the leading cause of death among people under 50 years old worldwide. Severe trauma will trigger systemic inflammatory response syndrome (SIRS) which can worsen into multiple organ failure MOF). This study was aimed to evaluate whether there was a correlation between neutrophil count and C reactive protein concentration in multi-traumatic patients and whether both variables could become predictors of the occurence of MOF. This was a correlation study with a cross sectional design. There were 71 multitraumatic patients enrolled in this study, obtained from Surgery Emergency Unit of Prof. Dr. R. D. Kandou Hospital Manado; 31 of them were associated with SIRS, MODS, and MOF. The regression analysis showed that the higher the neutrophil count was, the greater the chance of the patient to suffer from MOF (P < 0.001), as well as the higher the CRP concentration, the greater the chance of the patient to suffer from MOF (P < 0.001). The cut-off point of neutrophil to MOF was 17121.7 and the specifity was higher than the sensitivity. Morover, the cut-off point of CRP to MOF was 169.7 and the specifity was higher than the sensitivity. Conclusion: There were significant correlations between the neutrophil count and MOF as well as between CRP concentration and MOF. Neutrophil count and CRP concentration could become predictors of the occurence of MOF and were significant in sensitivity and specifity in acute multi-traumatic patients.Keywords: multiple trauma, MOF, neutrophil, CRPAbstrak: Trauma merupakan penyebab kematian nomor satu pada orang berusia kurang dari 50 tahun. Trauma berat akan memicu timbulnya respons inflamasi sistemik berat (Systemic Inflammatory Response Syndrome, SIRS) yang dapat memburuk menjadi kegagalan multi-organ. Penelitian ini bertujuan untuk mengetahui ada tidaknya korelasi antara besaran neutrofil dan kadar CRP pada pasien multi-trauma, dan apakah keduanya dapat digunakan sebagai faktor prediktor dalam mendeteksi terjadinya multi-organ failure (MOF). Jenis penelitian ialah korelasi dengan desain potong lintang. Hasil penelitian mendapatkan 71 pasien multi-trauma yang dirawat di Instalasi Gawat Darurat Bedah RSUP Prof. Dr. R. D. Kandou Manado; 31 di antaranya disertai SIRS, MODS dan MOF. Hasil analisis regresi menyatakan bahwa makin tinggi besaran neutrofil maka makin besar peluang pasien untuk terjadi MOF (P < 0,001), dan makin tinggi CRP maka makin besar peluang pasien untuk terjadi MOF (P < 0,001). Cut-off point neutrofil terhadap MOF ialah 17121,7 dengan nilai spesifisitas lebih besar dari sensitivitas sedangkan cut-off point CRP terhadap MOF ialah 169,7 dengan nilai spesifisitas lebih besar dari sensitivitas. Simpulan: Terdapat hubungan bermakna antara besaran neutrofil dan MOF serta antara CRP dan MOF. Besaran neutrofil dan CRP merupakan prediktor terjadinya MOF yang mempunyai signifikansi dalam sensitivitas dan spesifisitas pada pasien dengan multi- trauma akut.Kata kunci: multi-trauma, MOF, neutrofil, CRP
Hubungan antara pemberian kompensasi, gaya kepemimpinan, dan sarana-prasarana dengan motivasi kerja karyawan cleaning service di RSUP Prof. Dr. R. D. Kandou Manado Porotu’o, Lely I.; Porotu’o, John P.; Mandey, Lucia C.
Jurnal Biomedik : JBM Vol 9, No 1 (2017): JURNAL BIOMEDIK : JBM Suplemen
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.9.1.2017.15385

Abstract

Abstract: As one of health care organizations, a hospital comprehensively covers promotive, preventive, curative and rehabilitative services for the society, therefore, it often faces problems related to the quality of hospital services which is considered inadequate or unsatisfactory. The hospital has medical staff and non-medical staff such as employees at the finance section, cleaning service, front office, and marketing. These non-medical employees have very important responsibilities and they also manage the operational systems of the hospital. This sudy was aimed to assess the relationship between compensation, leadership style, and infrastructure with work motivation of the cleaning service employees at Prof. Dr. R. D. Kandou Hospital, Manado. This was a quantitative study with a cross sectional design conducted from December to February 2017. Respondents were all cleaning service employees as many as 125 people. Analysis of the data consisted of univariate, bivariate, and multivariate analyses using SPSS. The results showed that the significant values of the variables were as follows: compensation provision (P = 0.000), leadership style (P = 0.000), and infrastructure (P = 0.102) in relation with the work motivation of the cleaning service employees. Conclusion: There were significant relationships between the compensation and leadership style with work motivation of cleaning service employees, meanwhile infrastructure had no relationship with that work motivation.Keywords: compensation, leadership style, infrastructure, work motivationAbstrak: Rumah sakit sebagai salah satu organisasi pelayanan kesehatan yang komperhensif mencakup layanan promotif, preventif, kuratif, dan rehabilitatif bagi seluruh lapisan masyarakat, sering menghadapi permasalahan mutu pelayanan yang dianggap kurang memadai atau memuaskan. Rumah sakit memiliki tenaga medis dan non-medis yaitu antara lain karyawan yang bekerja di bagian keuangan, cleaning service, front office dan pemasaran. Tenaga non-medis juga memiliki tanggung jawab yang sangat penting dalam mengelola sistem operasional rumah sakit. Penelitian ini bertujuan untuk mengetahui hubungan antara pemberian kompensasi, gaya kepemimpinan, dan sarana-prasarana dengan motivasi kerja karyawan cleaning service di RSUP Prof. Dr. R. D. Kandou. Jenis penelitian ini ialah kuantitatif dengan desain potong lintang yang dilaksanakan pada bulan Desember-Februari 2017. Respoden ialah seluruh karyawan cleaning service sebanyak 125 orang. Analisis data terdiri dari univariat, bivariat, dan multivariat dengan menggunakan SPSS. Hasil penelitian menunjukkan bahwa nilai signifikansi pemberian kompensasi (0,000), gaya kepemimpinan (0,000), dan sarana-prasarana (0,102) terhadap motivasi kerja karyawan cleaning service. Simpulan: Terdapat hubungan antara pemberian kompensasi dan gaya kepemimpinan dengan motivasi kerja karyawan cleaning service di RSUP Prof. Dr. R. D. Kandou Manado, sedangkan sarana-prasarana tidak berhubungan dengan motivasi kerja tersebut. Kata kunci: kompensasi, gaya kepemimpinan, sarana-prasarana, motivasi kerja
SEPSIS NEONATAL PADA KASUS DEFEK SEPTUM VENTRIKEL Wangko, Loretta C.; Kaunang, Erling D.
Jurnal Biomedik : JBM Vol 4, No 3 (2012): JURNAL BIOMEDIK : JBM Suplemen
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.4.3.2012.1211

Abstract

Abstract: Neonatal sepsis is a clinical syndrome characterized by signs and symptoms of infection, with or without bacteriemia, that occurs in the first month of life. Neonatal sepsis is still a main factor of morbidity and mortality in newborns. We reported a case of a male newborn with septic risks: viscous amniotic fluid with a bad odour, maternal intrapartum fever (≥380C), urinary tract infection, and fluor albus. A chest x-ray showed some infiltration in the left paracardial region and a normal heart; and was interpreted to be pneumonia. A working diagnosis was an aterm neonatus with neonatal sepsis and neonatal pneumonia. Ventricle septal defect (VSD) without congestive heart signs was diagnosed by using an echocardiography. The patient was treated for a neonatal sepsis and given antibiotics from the first day of admission due to the neonatal septic signs. During observation, the patient was getting better, and his activities and reflexes improved without dyspnea. Conclusion: Based on all the tests performed, the diagnosis of this patient was neonatal sepsis, VSD, and pneumonia neonatal. The prognosis related to neonatal pneumonia in this case was good due to the early use of antibiotics. The prognosis of a small perimembrane VSD is dubia ad bonam because in 50% of cases it can spontaneously oclude in the second year. Keywords: newborn, sepsis, pneumonia, ventricle septal defect.   Abstrak: Sepsis neonatal ialah suatu sindrom klinis yang ditandai oleh gejala dan tanda-tanda infeksi dengan atau tanpa diikuti oleh bakteremia yang terjadi pada bulan pertama kehidupan. Sepsis neonatal masih merupakan penyebab utama morbiditas dan mortalitas pada bayi-bayi baru lahir. Kami melaporkan kasus bayi laki-laki baru lahir dengan resiko sepsis yaitu:cairan ketuban kental dan berbau busuk, demam intrapartum maternal (>38oC), infeksi saluran kencing, dan keputihan. X-foto toraks memperihatkan adanya infiltrat di parakardial kiri, jantung dalam batas normal, dan diinterpretasi sebagai pneumonia. Diagnosis kerja ialah neonatus cukup bulan, sepsis neonatal, dan pneumonia neonatal. Diagnosis defek septum ventrikel (DSV) ditegakkan melalui ekokardiografi tanpa tanda-tanda gagal jantung kongestif. Pasien diberikan penanganan sepsis dan pemberian terapi antibiotik empiris sejak hari pertama perawatan karena secara klinis telah ditemukan tanda-tanda sepsis neonatal. Selama observasi, pasien memperlihatkan perbaikan yang nyata dimana aktivitas dan refleks membaik tanpa disertai sesak napas. Simpulan: Berdasarkan hasil pemeriksaan yang dilakukan, diagnosis yang ditegakkan ialah sepsis neonatal disertai DSV dan pneumonia neonatal. Prognosis pneumonia neonatal kasus ini baik oleh karena pemakaian antibiotika sejak dini. Prognosis DSV kecil perimembran ialah dubia ad bonam karena 50% dapat menutup spontan pada usia dua tahun. Kata kunci: bayi baru lahir, sepsis, pneumonia, defek septum ventrikel.
GANGGUAN MANSET ROTATOR SENDI BAHU Suatu tinjauan anatomik Tanudjaja, George N.
Jurnal Biomedik : JBM Vol 6, No 3 (2014): JURNAL BIOMEDIK : JBM Suplemen
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.6.3.2014.6332

Abstract

Abstract: Rotator cuff of glenohumeral joint is a group of muscles and their tendons which surrounds and protects the wholeness of the glenohumeral joint and functions as a shoulder rotator. Shoulder pain is commonly found and is mostly caused by tendinitis of the rotator cuff or subacromial bursitis. There are four important muscles of this rotator cuff: supraspinatus, infraspinatus, teres minor, and subscapularis (SITS) muscles. Among them, the most troublesome is the tendon of supraspinatus muscle that functions as a sheet as well as the abductor of glenohumeral joint. Therefore, tendinitis of this muscle is associated with spontaneous pain and disturbance in lifting the superior extremity. This cuff structure shows that tendons of the SITS muscles together with the capsule of genohumeral joint and the joint structure itself enable a very wide range of motion with a consequence of being troubled easily.Keywords: glenohumeral, rotator cuf, tendon, jointAbstrak: Manset rotator sendi bahu adalah sekelompok otot dan tendonnya yang mengelilingi dan menjaga keutuhan articulatio genohumerale dengan fungsi lain sebagai rotator brachium. Nyeri bahu sering ditemukan dan umumnya disebabkan oleh tendinitis manset rotator atau bursitis subacromiale. Di antara keempat tendines, yang tersering mengalami gangguan yaitu tendon m. supraspinatus yang selain sebagai pembungkus juga berfungsi sebagai abduktor articulatio glenohumerale sehingga selain nyeri spontan juga ditemukan kesulitan mengangkat membrum superior. Struktur manset ini menunjukkan bahwa tendines keempat otot tersebut bergabung dengan capsula articularis genohumerale dengan struktur sendinya yang memungkinkan pergerakan bahu yang sangat luas tetapi dengan konsekuensi akan lebih mudah terjadi gangguan.Kata kunci: sendi bahu, manset rotator, tendon, articulatio
PATOGENESIS DAN DIAGNOSIS SINDROM KOLON IRITABEL Jim, Edwin
Jurnal Biomedik : JBM Vol 4, No 3 (2012): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.4.3.2012.792

Abstract

Abstract: Irritable bowel syndrome (IBS) is a chronic functional bowel disorder characterized by abdominal pain or discomfort and alterations in bowel habits. Many factors play some important roles in the development of the IBS including abnormal motility, visceral hypersensitivity, and enteric infection. Diagnosis of IBS is based on Rome III criteria.Keywords: irritable bowel syndrome, pathogenesis, diagnosisAbstrak: Sindrom kolon iritabel (SKI) adalah penyakit gastrointestinal fungsional kronik yang ditandai oleh nyeri perut atau rasa tidak enak di perut dan gangguan kebiasaan defekasi. Banyak faktor yang menyebabkan terjadinya SKI antara lain gangguan motilitas, hipersensitivitas viseral, dan pasca infeksi usus. Saat ini kriteria diagnosis yang digunakan untuk SKI ialah kriteria Roma III.Kata kunci: sindrom kolon iritabel, patogenesis, diagnosis
Hubungan Kadar Interleukin-10 Serum dan Kadar Leukosit Darah Perifer pada Pasien Cedera Otak Berat Akibat Trauma Suyanto, Edih; Prasetyo, Eko; Oley, Maximillian Ch.
Jurnal Biomedik : JBM Vol 10, No 2 (2018): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.10.2.2018.20090

Abstract

Abstract: This study was aimed to prove that in severe traumatic brain injury (TBI) there was an elevation in serum IL-10 level as well as in peripheral blood leukocyte level, and a correlation between both of them. This was an analytical correlational study. All patients had IL-10 level above normal value (18 pg/ml). There were three patients with normal blood leukocyte level. The correlation between IL-10 and blood leukocyte level was tested by using simple linear regression analysis and Pearson correlation coefficient analysis which obtained r = 0.045 with a P of 0.426 (>0.05). These results indicated a positive relationship between IL-10 and leukocytes levels, but not statistically significant. Conclusion: Interleukin-10 was consistantly elevated following severe traumatic brain injury and was a better TBI biomarker than the peripheral leukocyte level.Keywords: IL-10, leukocytes, TBIAbstrak: Penelitian ini bertujuan untuk membuktikan bahwa pada cedera otak akibat trauma (COT) berat terdapat peningkatan kadar serum IL-10 dan kadar leukosit darah perifer serta korelasi antara keduanya. Jenis penelitian ini ialah analitik korelasional. Hasil penelitian mendapatkan 20 pasien dengan COT berat berusia 16-65 tahun. Semua pasien memperlihatkan kadar Il-10 di atas nilai normal (18 pg/ml). Terdapat 3 pasien dengan kadar leukosit dalam batas normal Hubungan antara IL-10 dan leukosit diuji dengan analisis regresi linier sederhana dan analisis koefisien korelasi Pearson dan mendapatkan r = 0,045 dengan P = 0,426. Hasil ini menunjukkan hubungan positif antara IL-10 dan leukosit, tetapi tidak bermakna secara statistik (P = 0,426 >0,05). Simpulan: IL-10 secara konsisten meningkat setelah COT dan sebagai biomarker COT yang lebih baik daripada leukosit perifer.Kata kunci: IL-10, leukosit, COT

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