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Journal of Medicine and Health

jmh
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Published by Universitas Kristen Maranatha

ISSN : 24425227 EISSN : - DOI : -

Core Subject : Health, Science,

Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Journal of Medicine and Health (JMH) is an open access journal (OAJ), a periodic scientific publication biannually online published on February and August; using review and screening system by peer group reviewer. JMH receives original research articles which related to medicine, health, new developing therapy from traditional medicine or herbs and developing clinical therapy. JMH also receives otiginal review articles, case report, continuing medicine and health study. Articles should be written in good English or Indonesian language.

Arjuna Subject : -

Articles 264 Documents

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Subchronic Treatment of Combination Extract Detam 1 Soybean and Jati Belanda Leaves has No Toxic Effect on Function, Weight, and Histopathological of Wistar Rat Kidney Hidayat, Meilinah; Prahastuti, Sijani; Chikita, Vibiola; Safitri, Dewi; Rahmawati, Siti F.; Soemardji, Andreanus A.
Journal of Medicine and Health Vol. 1 No. 4 (2016)
Publisher : Universitas Kristen Maranatha

The combination of Detam 1 soybean and Jati Belanda leaves proved to have effect of weight loss. Since it will become longterm using, toxicity effectvresearch is needed.Â This study was conducted to determine the effect of subchronic combination of ethanol extract of soybean Detam 1 (EEDS) and Jati belanda (EEJB) on kidney function, with parameters: urea and creatinine, macroscopic and histopathological of kidney. This study were conducted on 120 Wistar rats (60 males, 60 females), 90 days (treatment group) and 120 days (satellite group). Rats were divided into six treatment groups. Test results of urea and creatinine levels of all treatment groups was lower than control group (p <0.05). The treatment turned out to have a good effect on kidney function. Kidney weight of all groups showed no significant difference with the control group (p> 0.05). Histopathological score interpretationâ€™s result of low dose group male and female kidney rats were not disturbed. In conclusion, the combination of EEDS and EEJBÂ have a good effect on kidney function, didÂ not lead to changes in organ weight and at low doses did not cause disturbance ofÂ renal histopathology.Â Key words: combination of soybean jati Belanda, subchronic treatment, kidney function, kidneyâ€™sÂ weight, kidneyâ€™s histopathology

Difficulty in Diagnosing Secondary Peripheral Chondrosarcoma: Radiology versus Anatomical Pathology Undang Ruhimat; Arie Hendarin
Journal of Medicine and Health Vol. 1 No. 4 (2016)
Publisher : Universitas Kristen Maranatha

Chondrosarcoma is a malignant tumor derived from bone cartilage. This tumor can be either primary or secondary. Secondary chondrosarcoma has some differences compared to the primary type i.e. the incidence is rarer, the younger age group, and many are low grade. The authors report a case of a 26-year-old man came to Hasan Sadikin Hospital with a chief complaint of a lump in the right thigh with mild pain since 5 months before consulation that is increasingly enlarging. After undergoing physical and radiological examinations, the patient was diagnosed with suspect chondrosarcoma in right thigh. Histopathologic examinations were performed 2 times, one of which used ultrasound guidance, giving a diagnosis of chondroma in right thigh. However the lesion was finally treated as chondrosarcoma. We suspected that the patient was more likely to suffer from secondary peripheral chondrosarcoma originating from malignant transformation of multiple osteochondromas. As widely known, it is almost impossible to differentiate between the low grade chondrosarcoma and chondroma with full certainty and this poses a classical problem in diagnostic medicine. Case described here was an example of the difficulty in distinguishing between these two diseases.Â Key words: secondary chondrosarcoma, peripheral chondrosarcoma, chondrosarcoma arising Â in osteochondroma

The Effect of Kinesio Taping on Quadriceps Femoris Muscle Power and Strength in Non-Athlete Adult Males Julia W Gunadi; Yenni Limyati; Jeanny E Ladi; Stela Clara; Hadrian M Sinaga
Journal of Medicine and Health Vol. 1 No. 5 (2017)
Publisher : Universitas Kristen Maranatha

The use of Kinesio Taping has been reported to increase muscle power and strength,especially quadriceps femoris muscle, the great extensor of the leg. This research examines theeffect of Kinesio Taping on quadriceps femoris muscle power and strength in non-athlete adultmales. This research is quasi experimental design, involving 30 non-athlete adult males aged18-22 years old . Muscle power is examined by using Margaria-KalamenPower Test, andmuscle strength by using Isometric Leg Strength Test before, 20 minutes and 24 hours afterusing Kinesio Taping. The data is analyzed by using paired t test. The result shows that musclepower difference between 20 minutes and before using KinesioTaping (196,62Â±150,67) watt arelower than muscle power difference between 24 hours and before using KinesioTaping(247,31Â±139,88)watt (p value <0,01). The result also shows that muscle strength differencebetween 20 minutes and before using KinesioTaping (26,74Â±10,26)kg shows lower than musclestrength difference between 24 hours and before using KinesioTaping(30,26Â±9,99)kg(p value<0,01). KinesioTaping increases quadriceps femoris muscle power and strength 24 hours afterbetter than 20 minutes after using in non-athlete adult males.Keywords: Kinesio Taping, quadriceps femoris, muscle power, muscle strength

Repair of Cerebrospinal Fluid Leak After Functional Endoscopy Sinus Surgery Mohamad I Sapta; Teresa L Wargasetia
Journal of Medicine and Health Vol. 1 No. 5 (2017)
Publisher : Universitas Kristen Maranatha

Cerebrospinal fluid (CSF) leak is one of Functional Endoscopic Sinus Surgery (FESS)complications. Since 2001, it was reported that there is one case of CSF leak as FESScomplication in ENT-HN Department, Faculty of Medicine, Maranatha Christian University -Immanuel Hospital in Bandung. The purpose of this case report is present clinical findings andmanagement of CSF leak as FESS complication. A-45 year old male with headache as chiefcomplain after undergone FESS five days before. There was a clear rhinorrhea running frompatientâ€™s right nose. In nasoendoscopic examination, it was showed there was a defect in laminacribrosa. The result of paranasal sinus computed tomography scanning showed an air columnin brain ventricular system. The defect in lamina cribrosa was repaired by transnasalendoscopic using materials such as surgicel, cartilages, and fat tissues. The conclusion is weroll out one case about repair of CSF leak as a FESS complication and it was done with a goodresult.Keywords: cerebrospinal fluid leak, functional endoscopic sinus surgery

The Effect of Tempe Dietary Intake on Plasma Glucose Level in Elderly Patients with Type 2 Diabetes Mellitus Grace Puspasari; Drupadi Dillon; Budiman Budiman
Journal of Medicine and Health Vol. 1 No. 6 (2017)
Publisher : Universitas Kristen Maranatha

The aim of the study was to investigateÂ the effect of daily intake of 100 grams tempe for four weeks on plasma glucose level in elderly patients with type 2 diabetes mellitus. This study was a parallel randomized clinical trial. Subjects were 30 diabetic elderly living in four nursing homes in Jakarta. In the study subjects were assigned to two groups using block randomization. All subjects had to take diabetic regiment with calorie and macronutrient following diabetic recommendation diet. The treatment group (n=16) received tempe, while control group (n=14) received legumes other than tempe. Fasting plasma glucose level (FPG) was assessed before and after intervention. Unpaired t test and Mann Whitney were used to analyzed data with the 5% significance level. There were 27 subjects completed the study: 15 of treatment group and 12 of control group. Both group were comparable in age, gender, BMI, calorie and macronutrient intake before treatment. Fat, fiber, and isoflavone intake were significantly higher in treatment group compare to control group. Decrease in FPG after intervention were observed but were statisticaly insignificant. In conclusion daily intake of 100 grams tempe for four weeks did not decrease FPG. Â Keywords: elderly, plasma glucose level, tempe, type 2 diabetes

Protective Effect of Ethanol Extract Tempuyung Leaf (Sonchus arvensis L.) Against Gentamicin Induced Renal Injury Viewed from Blood Ureum Level Imelda Imelda; Cherry Azaria; Teresa Lucretia
Journal of Medicine and Health Vol. 1 No. 6 (2017)
Publisher : Universitas Kristen Maranatha

Acute renal injury is characterized by decrement of glomerular filtration rate (GFR), resulting in nitrogen metabolic end product retention such as blood ureum. Aminoglycoside nephrotoxic injuries are common in elderly, with mortality rate 50-70%. Tempuyung has been empirically used in relieving renal problems as it contains several active antioxidants. This study aimed to analyze the protective effect of ethanol extract tempuyung leaf (EET) against gentamicin induced renal injury viewed from blood ureum level. The method used was true experimental laboratory, 16 wistar male rats, divided into 4 groups (n=4): negative control group (CMC), positive control group (Gentamicin 80 mg/kgBW), 1st treatment group (EET 100 mg/kgBW + Gentamicin), 2nd treatment group (EET 200 mg/kgBW + Gentamicin) for ten days. On the 11th day, blood serum were taken and the ureum level were analyzed. Data was analyzed by ANOVA and post hoc LSD test. Result showed positive control group had the highest blood ureum level (29.50 ï‚± 1.29 mg/dL) compared to negative control group (14.25 ï‚± 1.26 mg/dL), 1st treatment group (26.50 ï‚± 0.58 mg/dL), and 2nd treatment group (22.25 ï‚± 1.26 mg/dL) with significance difference (p<0,001). In conclusion, the result suggested the protective effect of EET against gentamicin induced renal injury.Keywords: acute renal injury, gentamicin, glomerular filtration rate, tempuyung, ureum

Volume 1 Topic Index (Indonesian) Team Editor
Journal of Medicine and Health Vol. 1 No. 6 (2017)
Publisher : Universitas Kristen Maranatha

Volume 1 Topic Index(Indonesian)

Expression of Ki-67 has Correlation with the Degree and Size of Endometriosis Cysts Ruswana Anwar; Muhammad Alif; Adhi Pribadi
Journal of Medicine and Health Vol. 1 No. 1 (2015)
Publisher : Universitas Kristen Maranatha

Endometriosis is one of the most common gynecological problem. Cells resulted in chronic inflammation and progressive, proliferative, invasive and even infiltrating an area that resembles the character of the malignancy. Ki-67 is an antigen on the cell nucleus that is found only in actively dividing cells. Expression of Ki-67 are associated with an aggressive tumor and metastasis. This study aims to determine the level of Ki-67 expression correlation with stage and size of the endometriosis cyst. Methods research is observational analytic cross cut method on 56 paraffin blocks of patients who have been diagnosed with endometriosis and had performed a laparotomy or laparoscopic surgery in Dr Hasan Sadikin Hospital. The results showed a significant relationship between the level of expression of Ki-67 with endometriosis cyst size (p <0.001) with a fairly strong relationship (0.55) according to statistics based on criteria Guilford. Moreover the results also showed a significant relationship between the level of expression of Ki-67 with endometriosis stage (p <0.001) with a fairly close relationship (0.564) according to statistics based on criteria Guilford. It can be concluded that the expression of Ki-67 associated with cyst size and stage of endometriosis.Â Keywords: Ki-67, endometriosis stage, endometriosis cyst

Effect of Lycopene on Peritoneal Fluid Malondialdehyde Level in Endometriosis Nanang W. Astarto; Tono Djuwantono; . Yelliantty
Journal of Medicine and Health Vol. 1 No. 1 (2015)
Publisher : Universitas Kristen Maranatha

Oxidative stress is a factor that contribute in pathogenesis of endometriosis. This condition could also implicated in infertility. Lycopene is a carotenoid that has antioxidant activity. Supplementation of lycopene can reduce oxidative stress in peritoneal fluid of women with endometriosis. This study aims to compare the effect of lycopene on malondialdehyde (MDA) levels in peritoneal fluid of women with endometriosis. It is an experimental study on peritoneal fluid from five women with endometriosis. The result show that lycopene supplementation affecting the MDA levels in peritoneal fluid. MDA levels in peritoneal fluid with lycopene is lower than without lycopene. It conclude that lycopene is proved lowering MDA levels in peritoneal fluid of women with endometriosis.Â Keywords: endometriosis lycopene, malondialdehyde

Phytochemical Features of Moringa oleifera Leaves as Anticancer Edwinanto, Ludovicus; Septiadi, Endry; Nurfazriah, Latifah R.; Anastasya, Karina S.; Pranata, Natallia
Journal of Medicine and Health Vol. 2 No. 1 (2018)
Publisher : Universitas Kristen Maranatha

Cancer is a disease that can threaten human life. Various methods of cancer therapy havebeen widely practiced, one of which is chemotherapy. But the cost used for the therapy is alsovery expensive. This difficulty led many researchers to conduct research to find activecompounds from natural materials. Moringa leaf (Moringa oleifera) has cytotoxic activity,because it contains a lot of flavonoids. Flavonoids are polyphenol compounds produced fromsecondary metabolism in plants. The most flavonoids that are anticancer active substances inthe Moringa leaf are quercetin, kaempferol and myricetin. Cytotoxic activity because theseactive substances can induce apoptosis through intrinsic pathways by inhibition of mitogen-activated protein kinase (MAPK), extracellular-signal-regulated kinase 1/2 (ERK 1/2), c-Jun N-terminal protein kinase 1 (JNK), and protein kinase C (PKC).Keywords: Moringa leaf, quersetin; kaempferol; myricetin; anticancer

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