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Journal of Applied Pharmaceutical Research
Published by Creative Pharma Assent
ISSN : -     EISSN : 23480335     DOI : 10.18231
Core Subject : Health,
Medicine & Pharmacology
Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Cosmetic Technology, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Herbal drugs/ formulations, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest) which publish quarterly. JOAPR also includes evaluation of pharmaceutical excipients & their practical application to research & industry based efforts. The aim of the scientific journal, JOAPR is to present a wide area for the current researchers to share their noble works and ideas in terms of the research papers, review articles and short communications. JOAPR only publish the original research works with a definite innovation and novelty after thorough reviewing. The paper must have a suitable and proper scientific background.
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Articles 8 Documents
 1 
Search results for , issue "Vol. 2 No. 1 (2014)" : 8 Documents clear
Novel 1, 1-dimethyl-3-phenyl-3-(5-phenyl-1, 3, 4- thiadiazol-2-yl) urea derivative has potential antiproliferative activity against human leukemia cell lines - K562 Ahirwar, Khemkaran; Jain, Sanmati K.; Tamrakar, Bholenath
Journal of Applied Pharmaceutical Research Vol. 2 No. 1 (2014)
Publisher : Creative Pharma Assent

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Abstract

Cancer is thought to be caused by the interaction between genetic susceptibility and environmental toxins. Based on the DNA changes in cells, proliferating cycle of tumor cells can be divided into 4 phases. Pre-synthetic phase (Gap 1 phase or G1 phase). Cells chiefly make preparations for the synthesis of DNA. Synthetic phase (S phase). Cells are synthesizing their DNA. Post-synthetic phase (Gap 2 phases or G2 phase). DNA duplication has been finished and they are equally divided to the two of future sub-cells. Mitosis phase (M Phase). Each cell is divided into two sub-cells. Some of these new cells enter the new proliferating cycle, the others become non-proliferating cells. G0 phase cells have proliferation ability but do not divide temporally. When proliferating cells are suffered heavy casualties, G0 phase cells will get into proliferating cycle and become the reasons of tumor recurrence.G0 phase cells are usually not sensitive to antineoplastic drugs, which is the important obstacle to tumor.chemotherapy. The antiproliferative activities of these compounds wee evaluated against a Cytotoxicity analysis of compounds against leukemia cell line -K562 organism homo sapiens(human) organ bone – marrow, tissue - lymphoblast, disease – chronic myelogenous leukemia(CML) one human tumor cell lines(K562) by applying the MTT colorimetric assay. The 1, 3-disubstituted urea derivatives show good antiproliferative activity against human cancer cell lines (K562). The hydroxyl groups on the phenyl ring reduced the antiproliferative activities.
Formulation design and in vitro evaluation of metformin hydrochloride transdermal film using hydrophilic polymer Sinha, Neman; Gupta, Suchita; Choudhury, Ananta
Journal of Applied Pharmaceutical Research Vol. 2 No. 1 (2014)
Publisher : Creative Pharma Assent

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Abstract

The purpose of the experimental study was to design a sustained release film formulation of metformin hydrochloride. In this study a transdermal film has been prepared by incorporating hydrophilic polymers like HPMC and PVA in combination of different ratios. The prepared film were subjected for different evaluation parameters like swelling index study, surface pH, drug content analysis, thickness of film, folding endurance study, drug release study. Results of evaluation of all the film was found satisfactory. Again further study needs to be conducted to stabilize the formulations
Design and evaluation of floating microspheres of amoxicillin trihydrate by ionotropic gelation method Chakrabotry, S.; Dey, B. K.; Saha, S.; Kar, A.; Saha, B.
Journal of Applied Pharmaceutical Research Vol. 2 No. 1 (2014)
Publisher : Creative Pharma Assent

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Abstract

The purpose of this investigation was to design and develop floating microspheres of Amoxicillin Trihydrate by ionotropic gelation method with combination of two polymers and to get the best possible formulation out of that with the various aspects. Floating drug delivery system have a bulk density less than gastric fluids and so remains buoyant in the stomach without affecting gastric emptying rate for a prolonged period of time. The floating microspheres were prepared using Ethyl cellulose and Hydroxy propylmethyl cellulose K4M as polymer to achieve an extended retention in upper GIT and there by improved bioavailability. The microspheres were evaluated for particle size analysis, Drug Entrapment Efficiency, Drug Loading Capacity, Floating efficiency, Swelling Study, Loose Surface Crystal Study , drug entrapment efficiency, drug- polymer compatibility study, Micromeritic properties like Bulk Density, Tapped Density, Carr’s Index, and Hausner’s Ratio, In-vitro release studies and surface morphology characterized by Scanning electron microscopy (SEM). The Microspheres have an average size range of 743.00±7.000 to 837.00±8.544μm. The entrapment efficiency was found to be in the range of 66.96±1.944 to 82.03±0.657 %. The In-vitro release studies of the drug from the best formulation F6 exhibited a sustained release of 93.46±0.684 % as studied over 10hrs. Release was best explained by zero-order kinetics model and it shows that the drug release follows diffusion mechanism. FT-IR data revealed that, compatible and there was no interaction between the drug and excipients added in the formulation. The data obtained in this study thus suggest that a floating microspheres of Amoxicillin Trihydrate are promising for sustained drug delivery which can reduce dosing frequency.
Investigation of novel penetration enhancer Lawsonia inermis for drug delivery through nail plate Singh, Vikram; Gupta, R. D.; Teotia, U. V. S
Journal of Applied Pharmaceutical Research Vol. 2 No. 1 (2014)
Publisher : Creative Pharma Assent

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Abstract

Nail fungus infections may be very painful and can seriously harm through systemic circulation if untreated. In this study we try to find out and formulate the natural penetration enhancer(PEs). Lawsonia Inermis leafs were used as a penetration enhancer. To extract the penetration enhancer extraction was done with methanol and dried, which shows hundred percent penetrations across the nail plate. Human cadaver nail plate (dry weight 45.8 mg, thickness 220 µm) defatted with chloroform: methanol (2:1) was used for penetration study. Diffusion study with the help of franz diffusion cell with phosphate buffer saline. The transungual film F32 evaluated for the physical properties – %Drug Content 97.1±0.03, Weight variation 180±2.10, Thickness 0.21±0.01, Flatness 99%, Folding endurance 180±3, WVTR 3.143±0.436, %Moisture content3.823±0.23. The drug moved across the nail plate in near to first order manner and support by the pepass “n” value i.e. 0.87. The formulation with the Lawsonia Inermis’s extract penetrates the 2.09% more drug through nail plate. The present study can claim that the Lawsonia Inermis as a potent penetration enhancer for transungual delivery for which the penetration is a limiting factor.
Effect of solubilization technique on dissolution Das, Sujoy; Bahadur, Sanjib; Choudhury, Ananta; Saha, Suman
Journal of Applied Pharmaceutical Research Vol. 2 No. 1 (2014)
Publisher : Creative Pharma Assent

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Abstract

More than 40 percent of newly discovered drugs have little or no water solubility thus the present research aimed at the study of improvement of solublisation on dissolution by addition of different solublising agents and modification of methods. Irbesartan is the drug of choice. Effect of Solubility on dissolution was studied with some solubilizing agents like β-Cyclodextrins, PEG-6000, Polysorbate-80, Cremophore and Resins (Doshion). It was seen that Irbesartan give 90 percent release in 1hr with polysorbate-80 where cremophore containing tablets showed 97 % release in 1 hr in case of solid dispersion technique and in case of complexation technique respectively. Thus the present study concluded that, dissolution rate of poorly soluble drug can be increases by using solubilizing agent as well as using different techniques
Curcumin: a review Chauhan, Monika; Saha, Suman; Roy, Amit
Journal of Applied Pharmaceutical Research Vol. 2 No. 1 (2014)
Publisher : Creative Pharma Assent

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Abstract

The main objective of this review article is to overcome or to improve the problems related with curcumin with the help of new technologies or modifications to make a promising therapeutic agent which gives a good therapeutic response. Curcumin, a known natural polyphenolic compound obtained from dietary spice turmeric, possesses pharmacologic effects including anti-inflammatory, antioxidant, and many other activities. Clinical trials on curcumin have shown its safety and efficacy even at high doses in humans. But inspite of that it shows poor bioavailability (oral bioavailability) which is one of the major problems regarding curcumin. There are other reasons contributing to the low plasma and tissue levels of curcumin appear to be due to poor absorption, rapid metabolism, and rapid systemic elimination. To improve the bioavailability of curcumin, numbers of approaches have been undertaken. These approaches involve, first, the use of adjuvant like piperine that interferes with glucuronidation; second, the use of liposomal curcumin; third, curcumin nanoparticles; fourth, the use of curcumin phospholipids complex; and fifth, the use of structural analogues of curcumin.
Antihyperlipidemic potential of herbals Yadav, Swati; Satapathy, Trilochan; Roy, Amit; Prasad, Pushpa
Journal of Applied Pharmaceutical Research Vol. 2 No. 1 (2014)
Publisher : Creative Pharma Assent

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Abstract

One of the most widespread diseases in the world is Coronary Heart Disease (CHD). It is also one of the most preventable. This review explores the management of CHD through changes in dietary modifications, lifestyle, and the use of dietary supplements and botanicals
A short glimpse on promising pharmacological effects of Begenia ciliata Pokhrel, Priyanka; Parajuli, Rishi Ram; Tiwari, Amish Kumar; Banerjee, Janmajoy
Journal of Applied Pharmaceutical Research Vol. 2 No. 1 (2014)
Publisher : Creative Pharma Assent

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Abstract

Bergenia ciliata is a potent indigenous folk medicine that has been proved fruitful in the treatment of various adverse conditions of the body. The major chemical constituents of plant include tannic acid, gallic acid, glucose, metarbin, albumen, bergenin, (+)-catechin, gallicin. Bergenia ciliata was subjected to bioactivity analysis. The plant has antitussive, antiulcer, antioxidant, antibacterial, hypoglycemic, toxicological activity. It was observed that root and leaves extract were promising as antifungal agent. The root and leaves extract were effective against Microsporum canis, Pleuroetus oustreatus and Candida albicans. All the extracts except chloroform extract of root and leaves of Bergenia ciliata were found to possess hypoglycemic activity in Streptozotocin (STZ) treated rats. The methanolic extract exhibited significant anti-tussive activity in a dose-dependent manner. B. ciliata bear potent anti-neoplastic activities that may have prospective clinical use as precursor for preventive medicine. Methanolic and aqueous B. ciliata rhizome extracts were found to possess antioxidant activity, including reducing power, free radical scavenging activity and lipid peroxidation inhibition potential. Bergenia ciliata extracts exhibit a narrow spectrum antibacterial activity. The results obtained thus suggest that extracts of B. ciliata have promising therapeutic potential and could be considered as potential source for drug development by pharmaceutical industries.

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