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Journal of Applied Pharmaceutical Research
Published by Creative Pharma Assent
ISSN : -     EISSN : 23480335     DOI : 10.18231
Core Subject : Health,
Medicine & Pharmacology
Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Cosmetic Technology, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Herbal drugs/ formulations, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest) which publish quarterly. JOAPR also includes evaluation of pharmaceutical excipients & their practical application to research & industry based efforts. The aim of the scientific journal, JOAPR is to present a wide area for the current researchers to share their noble works and ideas in terms of the research papers, review articles and short communications. JOAPR only publish the original research works with a definite innovation and novelty after thorough reviewing. The paper must have a suitable and proper scientific background.
Arjuna Subject : -
Articles 459 Documents
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Investigation of mindfulness & job of guardians in their child's oral prosperity & brushing framework Judder, Moidul Islam; Alam, Faruk; Islam, Mohidul
Journal of Applied Pharmaceutical Research Vol. 8 No. 2 (2020)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (192.088 KB) | DOI: 10.18231/j.joapr.2020.v.8.i.2.004

Abstract

Background: Childhood dental caries is a significant wellbeing worry in kids that keep on contrarily influence the oral wellbeing. Oral wellbeing in children’s assumes a key job as it sets out the establishment for sound lasting teeth. This investigation was done to evaluate the mindfulness level of guardians about the children's oral health. Methods: A cross-sectional survey study was directed among 150 guardians with children’s' answering to private dental school. In this examination, the guardians of kids’ children than 5–15 years were approached to fill the pre-tried questioner directed survey and the information were classified. Results: It was seen that constrained members knew about the oral soundness of preschool children. About 34% of guardians have information identified with brushing procedures and oral maladies. Just 36% of guardians have general mindfulness identified with children's oral wellbeing, significance of standard dental exam, and investigation of kid's oral hole. This examination unmistakably uncovers that there is an absence of information and mindfulness identified with significance of children's oral wellbeing. Conclusion: Our outcomes demonstrate that guardians who would be advised to information in regards to oral wellbeing, their children’s were having altogether lesser tooth rot. The job of guardians is exceptionally huge, however almost 50% of the guardians don't direct their children’s for brushing and keeping up great oral cleanliness. Ordinary dental exams by organizing dental camps in schools and teaching the children’s and guardians about oral cleanliness will improve the circumstance.
Method development and validation of aspirin and clopidogrel pharmaceutical dosage forms by developing new RP HPLC method Dharani Sai Sreekanth, Nellore; Adilakshmi, Nenavath
Journal of Applied Pharmaceutical Research Vol. 8 No. 3 (2020)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2020.v.8.i.3.38.47

Abstract

A simple and selective LC method is described for the determination of Aspirin and Clopidogrel in tablet dosage forms. Chromatographic separation was achieved on a c18 column along with mobile phase consisting of a combination of fifty five volumes of Mixed Phosphate Buffer and forty five volumes of Acetonitrile with detection of 235 nm. Linearity was observed in the range 20-60 μg/ml for Aspirin (r2=0.998) and 10-30 μg /ml for Clopidogrel (r2 =0.998) for the amount of drugs estimated by the projected ways was in smart agreement with the label claim. The proposed methods were validated. The accuracy of the methods was assessed by recovery studies at three different levels. Recovery experiments indicated the absence of interference from commonly encountered pharmaceutical additives. The method was found to be precise as indicated by the repeatability analysis, showing %RSD trials. All statistical data proves validity of the ways and may be used for routine analysis of pharmaceutical dosage form.
Overview of formulation & evaluation of fast dissolving tablet: A promising tablet dosage form Akash Babu; Akhtar, Md. Semimul
Journal of Applied Pharmaceutical Research Vol. 8 No. 3 (2020)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2020.v.8.i.3.1.9

Abstract

The science of drug delivery has been increasingly innovative and quick evolving with ever-increasing demand in the current scientific scenario. Fast dissolving tablet (FDT) is one of those forms of an advanced and special drug delivery system that is rapidly gaining a lot of attention in the rapid dissolution technology research sector. Fast dissolving tablets appear as one of the common and widely accepted dosage types, particularly for paediatric patients due to incomplete muscle and nervous system development and a form of geriatric patients with Parkinson's disease or hand shivering. The most popular administrative path for different medications has drawbacks such as first-pass metabolism, psychotic patients, bedridden and Uncollaborative patients, is the oral delivery type and oral path FDTs disintegrate or quickly dissolve in the saliva without requiring water. Within few seconds, FDT will dissolve within saliva for approximately 60 seconds and these comprises will dissolve even faster
Phytochemical investigations of Campsis radicans L. Islam, Mirazul; Kuddus, Md Ruhul; Rashid, Mohammad Abdur; Haque, Mohammad Rashedul
Journal of Applied Pharmaceutical Research Vol. 8 No. 3 (2020)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2020.v.8.i.3.55.59

Abstract

Petroleum ether, dichloromethane and ethyl acetate soluble fractions were obtained through partitioning the crude methanolic extract of the leaves of Campsis radicans L. (Family. Bignoniaceae) followed by the chromatographic separation of secondary metabolites from them. A total of five triterpene compounds i.e., corosolic acid methyl ester (1), β-amyrin (2), arjunolic acid (3), maslinic acid (4) and 28-O-[β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl]-2α,3α,19α-trihydroxy-12-en-28-ursolic acid (5) were isolated from the dichloromethane fractions and their structures were characterized by 1H NMR spectroscopy and compared the NMR data with published values.
Traditional and medicinal use of Barbaloin: potential for the management of various diseases Singh, Navdeep; Goyal, Kamya; Sondhi, Shivi; Jindal, Shammy
Journal of Applied Pharmaceutical Research Vol. 8 No. 3 (2020)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2020.v.8.i.3.21.30

Abstract

Barbaloin is the phytoconstituent which is obtained from the plant known as aloe vera.  As we all know aloe vera is the main curative medicinal plants, has been traditionally used as alternative treatment against the many skin diseases. Barbaloin extracted from the aloe vera plant which is physically light yellow colored powder. Extraction of barbaloin from the plant Aloe barbadensis Miller had been accomplished by the Soxhelt extraction, Batch extraction experiment and Ultrasound assisted extraction method (UAE). Barbaloin showed various kinds of therapeutic and medicinal properties like anti-diabetic, antioxidants, anti-cancer, anti-inflammatory and and anti-microbial. It also has good effect on cardiovascular system, test perception, enzyme or metabolism and bioavailability. Our Skin plays an important role in the development of skin diseases because there are many types of skin disorders are developed and the variety of disorders may result to dermatitis or they affect the social wellbeing of a person. Due to their good pharmacological activities, Barbaloin have great potential to treat the different type of skin disorders like Eczema, Psoriasis, Burns and wound, Acne, Dandruff, Frostbite, Rashes, Cold sores, Razor burn and Sunburn. To access the effective use of barbaloin there are various attempts have been experimented on the subject of their Pharmacological activities to check their effect on skin disease and the steps regarding the Isolation of barbaloin also has been made. We can examine their effects on chronic skin diseases. In this review article we discuss about the potential of barbaloin on skin disorders, medicinal importance or Pharmacological activities and their methods of extraction.
A review on characteristics and analytical methods of atovaquone – a potent antimalarial agent Sharma, Sanyam; Sharma, Rahul; Devi, Arti; Jindal, Shammy; Goyal, Kamya
Journal of Applied Pharmaceutical Research Vol. 8 No. 3 (2020)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2020.v.8.i.3.31.37

Abstract

Drugs used in the treatment of malaria that is caused by various plasmosium species i.e. P. falciparum, P. vivax are most irresistible disease throughout the world. The different medications are utilized in the treatment of malaria incorporated the Aryl aminoalcohol mixes: Quinine, Quinidine, Chloroquine, Mefloquine; Antifolate compound: Pyrimethamine, Proguanil, Chlorproguanil, Trimethoprim and Atovaquone. Atovaquone is most effective drug utilized in the treatment of malaria. It must be given in single or in mixture with different antimalarials. An enormous number of methodologies including High Performance Liquid chromatography (HPLC), UV–Visible spectroscopy and Liquid Chromatography-Mass Spectroscopy (LC-MS) are utilized for the determination of atovaquone. Various analytical methods are used for the analysis of pharmaceutical products and these methods were validated according to ICH guidelines (Q1A R2). Thus, this technique can be safely used for the standard quality control analysis of atovaquone.
Development and validation of novel method for simultaneous estimation of Atovaquone and Mefloquine hydrochloride in bulk drug using RP-HPLC Sharma, Sanyam; Ankalgi, Amar Deep; Sharma, Rahul; Devi, Arti; Jindal, Shammy; Goyal, Kamya
Journal of Applied Pharmaceutical Research Vol. 8 No. 3 (2020)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2020.v.8.i.3.48.54

Abstract

Atovaquone and Mefloquine hydrochloride are well known anti-malarial drugs. Literature survey reveals that there was no method available for the selected drug combination. In this way, here an endeavour has been made to develop simple, precise, fast method for simultaneous estimation of atovaquone and mefloquine hydrochloride in bulk drug by using RP-HPLC method. The method was carried out by using gradient HPLC on C18 column using Shimadzu prominence LC 20 AD and mobile phase comprised of Methanol:ACN:Water in the ratio of 85:7.5:7.5 (pH 2.9 was adjusted with OPA). The method was performed with 10µl injection volume. The UV detection was done at 231nm.The retention times of atovaquone and mefloquine hydrochloride were 7.6 and 2.6 min respectively.  The proposed method was validated according to ICH guidelines. The validation parameters were linearity, accuracy, precision (inter-day, intra-day and repeatability) and robustness etc. Linearity was in the range of 80-120µg/ml for atovaquone and 40-60µg/ml for mefloquine hydrochloride. The percent recoveries of both drugs were 99.99-100% and 92.05-99.09%. This method is suitable for the routine analysis of atovaquone and mefloquine hydrochloride in bulk drugs either individually or in mixture
A review on novel COVID-19: background, etiology, pathogenesis, transmission, prevention and management R, Kalyani.; Padmasri B.; Anilkumar V.; Prasanth. D.
Journal of Applied Pharmaceutical Research Vol. 8 No. 3 (2020)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2020.v.8.i.3.10.20

Abstract

Mankind's history is watching a bizarre time battling an imperceptible adversary, the novel COVID-19 Coronavirus. At first seen in the Wuhan province of China, presently limitlessly spreading all over world. How the COVID 19 has been made on the globe become Pandemic needs no depiction. The virus has been accounted for affecting the lungs and related respiratory tracts promoting harm of the alveoli. It has been accounted that the respiratory sickness is the prevailing Clinical symptom of COVID-19. This review article discusses an easily understanding of the causes, different type of Human viruses regarded of Coronavirus, clinical diagnosis of RT-PCR, FET, Primary prevention and control of the virus. Therefore, this review article main theme is to provide more reliable and valid information to control and manage public emergency in both acute and chronic conditions of coronavirus
A review on global threat corona virus disease: COVID-19 Barbhuiya, Samia begam; Vicky Bareh; Caroline Malsawmtluangi; Parikshit Das
Journal of Applied Pharmaceutical Research Vol. 8 No. 4 (2020)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2020.v.8.i.4.10.15

Abstract

Corona virus disease is a kind of viral disease caused by Severe Acute Respiratory Syndrome- CoV 2, which is first witnessed in Wuhan city, China and it can be transmit from human to human. Coronavirus size ranges from (65-125 nm) in diameter and contain a single stranded RNA as nucleic acid material, size ranging from 26 to 32 kbps in length. The sub group of coronaviruses family is Alpha (α) Beta (β) Gama (γ) and delta (δ) coronavirus. Coronavirus disease is a kind of respiratory disease which mainly affects the lower respiratory tract of human body. Initially interferon α normalisation, broad spectrum antibiotic and antiviral drugs was used to reduce the viral load. There may be different kind of mode of transmission of this virus for example Respiratory transmission, Aerosol transmission, Contact transmission and Hospital acquired transmission. There is a well explained safety measures is provided to inhibit the COVID-19 spread which should be followed properly. There are some testing processes also developed to determine the presence of this virus. Till now not even a single vaccine is developed for the treatment of this COVID-19 but more than 12 countries across the globe are undergoing trial for more than 150 vaccine candidates.
Quality of life in total knee replacement (TKR) patients – A review M. Ranga Priya; M. Karthika; Meril Lucy Shibu; B. Kowsalya; Lini Jacob
Journal of Applied Pharmaceutical Research Vol. 8 No. 4 (2020)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2020.v.8.i.4.16.23

Abstract

Worldwide, severe pain and disability are caused to patients by Osteoarthritis, which is a common condition of the joints. A need for knee replacement had become a great option for patients when conventional treatment fails in granting appropriate relief in them, especially in elderly patients. Like all joint replacement surgeries, a total knee replacement procedure is also a quite painful and risky procedure that requires sufficient postoperative rehabilitation and therapies to prevent further complications. Post-surgical pain had a great influence on the patients' quality of life and a need to measure pain intensity had become a basic requirement. Measuring pain intensity can be done using traditional pain scales like a visual analogue scale (VAS), and a numerical rating scale (NRS). A risk assessment and predictor tool (RAPT) determines the discharge accuracy in patients. The WOMAC scale which is the abbreviated form of the questionnaire for checking the health status of the patients known as the Western Ontario and McMaster University Osteoarthritis Index.  This questionnaire is used to assess the quality of life of the osteoarthritis patients after a surgery for the total knee replacement. The results of the assessment show that pain had become a significant factor in the reduction in quality of life. In conclusion, a well-designed multimodal analgesic regimen should be incorporated into the patient's rehabilitation care, which in turn will intensify the patient's quality of life, lessen the hospital stay, and minimize the socio-economic burden

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