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Journal of Applied Pharmaceutical Research
Published by Creative Pharma Assent
ISSN : -     EISSN : 23480335     DOI : 10.18231
Core Subject : Health,
Medicine & Pharmacology
Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Cosmetic Technology, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Herbal drugs/ formulations, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest) which publish quarterly. JOAPR also includes evaluation of pharmaceutical excipients & their practical application to research & industry based efforts. The aim of the scientific journal, JOAPR is to present a wide area for the current researchers to share their noble works and ideas in terms of the research papers, review articles and short communications. JOAPR only publish the original research works with a definite innovation and novelty after thorough reviewing. The paper must have a suitable and proper scientific background.
Arjuna Subject : -
Articles 459 Documents
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Inspection of a novel penetration enhancer for transungual drug delivery system: Pelargonium hortorum Singh, Vikram; Chandrul, Kaushal Kishore
Journal of Applied Pharmaceutical Research Vol 3 No 1 (2015)
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Abstract

This study was to search some natural penetration enhancer and formulate them in  a transungual drug delivery formulation. This natural penetration enhancer helps to overcome the main problem in front of success of transungual drug delivery system. We selected to formulate fluconazole as a model drug  for the nail fungal infection treatment with extracted penetration enhancer (PE). Model drug i.e. fluconazole was formulated with the natural extracted penetration enhancer with different deigned formula. The solvent for PE extraction was methanol and that extracts were air dried. 
Formulation and evaluation of transdermal delivery system of an anti-hypertensive drug Goswami, D. S.; Uppal, N.
Journal of Applied Pharmaceutical Research Vol 1 No 1 (2013)
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Abstract

The present study was aims to formulate and evaluate transdermal drug delivery for sustained release of an anti-hypertensive drug Captopril, it is considered as drug of choice in anti hypertensive therapy and is reported for potential administration through transdermal route. The investigation was carried out to study the effect of different proportion of ethyl cellulose and PVP a hydrophobic and hydrophilic polymer respectively. Transdermal patches were prepared using different combination of the two polymers by solvent evaporation technique. Polyvinyl alcohol was used to prepare the backing membrane and dibutyl phthalate as a plasticizer. Several Physicochemical parameter like moisture content, moisture loss, thickness, film folding endurance, tensile strength, flatness were studied. For all the formulations, in vitro drug release was studied using modified diffusion cell. Formulations with highest proportion of polyvinyl pyrolidone shows faster release whereas increasing proportion of ethyl cellulose produces a prolonged regimen of sustained drug delivery through transdermal route for a period of 24 hrs.
Concept of "AMA DOSHA" WSR to free radicals Kumar, Munish; Kumar, Parvesh
Journal of Applied Pharmaceutical Research Vol 4 No 4 (2016)
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Abstract

Ama is considered as root cause of all diseases in the body. It has tremendous capacity to vitiate the Doshas and disturbing the homeostasis (Dhatusamya).  Ama is the result of improper digestion or partially digestion of the food particle due to hypo function of Jatharagni and also due to accumulation of mala in the body. In modern physiology, Ama can be correlated with deadly Free radicals. Free radicals are atoms, ions or molecules that contain one or more unpaired electron, which requires neutralization by free radical scavengers. The majority of free radicals that damage biological systems are oxygen free radicals, and these are known as “Reactive oxygen species”. Thus it exists in incomplete metabolic state which is also the state of Ama described as Avipakam (incompletely metabolized).  This Ama is responsible for the production of various diseases. In the same way, free radicals are also found to be root cause of many diseases. The aim of present article is to understand the concept of Ama as well as free radicals as a root cause of diseases and its treatment.
Phytosome: a novel dosage form for herbal drug delivery Choudhury, Ananta; Verma, Swati; Roy, Amit
Journal of Applied Pharmaceutical Research Vol 2 No 2 (2014)
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Abstract

Phytosome is a complex of a natural active ingredient and phospholipids. The term ‘Phyto’ means plant while ‘some’ means cell like structure. It is claimed that phytosome increases absorption of "conventional herbal extracts" or isolated active principles both orally as well as topically. In this era phytosome gain popularity as a potential drug delivery device due to excessive demand and utility of herbs or herb based medicines. This advance technology offers amenities like improved absorption, enhanced delivery & increased bioavailability of herbal extracts. These drug-phospholipid complexes can be fabricated in the form of solution, suspension, emulsion, syrup, lotion, gel, cream, aqueous micro dispersions. Standardized plant extracts, mainly polar phytoconstituents like flavonoids, terpenoids, tannins, xanthones shall be introduced in form of phytosome.
Ethnomedicinal plants in Chhattisgarh origin Chandrakar, Kunal; Satapathy, Trilochan; Nayak, Manoj; Dhalendra, Ghanshyam; Kumar, Birendra
Journal of Applied Pharmaceutical Research Vol 2 No 3 (2014)
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Abstract

The survey on Ethano medicinal plant of Chhattisgarh origin has been carried out to gather information regarding potent medicinal plants and their uses. The survey report is focused on traditional practice ethnic natural resources for mitigation and cure from several ailments. Even today, these herbal medicines are in practice to cure variety of disease. The present investigation was conducted using questionnaire in rural areas situated around in Chhattisgarh. Traditional knowledge about plant wealth passes from generation to generation for conservation of the traditional medicine. 
Phyto-pharmacological review of Portulaca quadrifida Linn Das, Mrinimay; D, Ashok Kumar
Journal of Applied Pharmaceutical Research Vol 1 No 1 (2013)
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Abstract

Portulaca quadrifida Linn. (Family: Portuleacea), commonly known as “Chicken Weed”, a traditional medicinal plant has been used in the Ayurvedic system of medicine for centuries, valued for its benefits in the management of urinary and inflammatory disorders. The juice of leaves is applied to abscesses and decoction is given in dysentery. The decoction of the plant can act as anthelminthic and used in the treatment of stomach complaints and gonorrhoea. Portulaca quadrifida has been reported to possess antifungal activity. The effect of ethanolic extract of Portulaca quadrifida on central and peripheral nervous system were studied by using spontaneous motor activity, in vivo muscle relaxant activity (Grip strength) and anticonvulsant activity and it is also found to have good effect on central nervous system. In this review, we have explored the Phyto-pharmacological properties of the Portulaca quadrifida plant and compiled its vast pharmacological applications to comprehend and synthesize the subject of its potential image of multipurpose medicinal agents.
An Overview of Tuberculosis Chemotherapy - A Literature Review Sarangi, Manoj Kumar; Padhi, Sasmita
Journal of Applied Pharmaceutical Research Vol 4 No 1 (2016)
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Abstract

Tuberculosis (TB) is a major global health threat. The emergence of human immunodeficiency virus (HIV) and also multi drug resistant (MDR) and extremely drug resistant (XDR)-TB poses a vital challenge to the control of the disease. For the last 50 years, no new anti-TB drug has been discovered. This literature review provides a brief discussion of existing drugs and emerging drug targets, and also of the advantages of incorporating modern drug delivery systems and immune modulators in order to improve the existing treatment regimen in terms of better efficacy, reduced drug administration frequency, shortened period of treatment and reduced drug related toxicity. The investigation for a new drug target is essential to continue the battle against MDR and XDR-TB. However, owing to the enormous cost and time involved in new drug development, improvement of the existing treatment regimen is seen to be a valid alternative. Â 
In-situ gel: a study of dental diseases Bisht, Neha; Goswami, Laxmi; Kothiyal, Preeti
Journal of Applied Pharmaceutical Research Vol 2 No 2 (2014)
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Abstract

In-situ forming polymeric gelling systems has become prominent among novel drug delivery system (NDDS) in recent years due to advantages such as sustained and prolonged drug action, improved patient compliance and reduced frequency of administration of the drug in comparison to conventional drug delivery system (DDS). This is a type of mucoadhesive DDS where the polymeric formulation is in sol form before administration and once comes in contact with body fluids; it undergoes gelation to form a gel. The formulation of gel depends upon factors like temperature modulation, pH changes, presence of ions and ultraviolet irradiation from which drug gets released in sustained and controlled manner. Conventional formulation for the treatment of dental diseases has certain drawbacks. A new concept of in situ gel was develop to overcome the shortcoming of conventional formulation which deals with dental diseases. Conventional oral formulations like solution, suspension, and ointments have many disadvantages which result into poor bioavailability of drug in the buccal cavity. In-situ forming polymeric formulation drug delivery systems is in sol form before administration in the body, but once administered, undergoes gelation in-situ to form a gel.
Development and validation of RP HPLC method for determination of metformin and sitagliptin in bulk and pharmaceutical dosage form Sahoo, S. K.; Kavitha, D.; Rao, P. Venkateswara; Nagamani, M.; Chowdhari, Bhagyalaxmi
Journal of Applied Pharmaceutical Research Vol 5 No 2 (2017)
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Abstract

A simple and rapid reversed phase-high performance liquid chromatographic method was developed for simultaneous determination of Metformin and Sitagliptin in Tablet Dosage form. The elution was done with a mobile phase of Water: Methanol (60:40) on Intersil-BDS C18 column (250 × 4.6 mm, 5 μm particle size). The wavelength detector was set at 258 nm. Retention times for Metformin and Sitagliptin were around 2.869 min, 3.942 min respectively. The reliability and analytical performance of the proposed HPLC procedure were statistically validated according to the respect of linearity, ranges, precision, accuracy, repeatability, reproducibility, detection and quantification limits. Linear ranges were established between 20 – 80 μg/mL for both the drug. The LOD and LOQ for Metformin were found to be 0.663, 1.92 and for Sitagliptin were found to be 0.405, 1.228 respectively. The described High Performance Liquid Chromatography method was successfully employed for the analysis of pharmaceutical formulations containing combined dosage form
Antimicrobial activity study of ethanolic extract of Alternanthera sessilis linn. aerial parts D, Ashok Kumar; Das, Mrinmay; P, Mohanraj; Das, Arup
Journal of Applied Pharmaceutical Research Vol 2 No 3 (2014)
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Abstract

The ethanolic extract of Alternanthera sessilis Linn. was evaluated for antimicrobial activity study against medically important gram-positive bacteria such as Staphylococcus aureus, Bacillus subtilis, Bacillus polymexia & Streotococcus faecalis, gram negative bacteria such as Pseudomonas aerugenosa, Salmonella typhii, Shigella dysenteriae & Escherichia coli and fungi like Penicillum notatum, Aspergillus niger & Candida albicans. The in-vitro antimicrobial activity, minimum inhibitory concentration (MIC) of ethanolic extract was performed by broth dilution method and the zone of inhibition was studied by agar disc diffusion method at concentrations of 2, 5 and 10mg/ml in DMSO. Ciprofloxacin (5µg/ml) and Cotrimazole (25µg/ml) were used as reference control for the antibacterial and antifungal studies respectively. The results of MIC study revealed the antimicrobial activity of the extract against the tested strains of microorganisms between concentration range of 50 and 400 µg/ml. The results of zone of inhibition study revealed concentration dependant nature of the extract with better effectiveness against gram-positive bacteria than gram-negative bacteria. The present study indicates the potential usefulness of Alternanthera sessilis Linn. aerial parts in the treatment of various pathogenic diseases as mentioned in the ayurvedic literature.

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