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Journal of Applied Pharmaceutical Research
Published by Creative Pharma Assent
ISSN : -     EISSN : 23480335     DOI : 10.18231
Core Subject : Health,
Medicine & Pharmacology
Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Cosmetic Technology, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Herbal drugs/ formulations, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest) which publish quarterly. JOAPR also includes evaluation of pharmaceutical excipients & their practical application to research & industry based efforts. The aim of the scientific journal, JOAPR is to present a wide area for the current researchers to share their noble works and ideas in terms of the research papers, review articles and short communications. JOAPR only publish the original research works with a definite innovation and novelty after thorough reviewing. The paper must have a suitable and proper scientific background.
Arjuna Subject : -
Articles 459 Documents
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Pharmacological activities of pyrazolone derivatives Parajuli, Rishi Ram; Pokhrel, Priyanka; Tiwari, Amish Kumar; Banerjee, Janmajoy
Journal of Applied Pharmaceutical Research Vol 1 No 1 (2013)
Publisher : Creative Pharma Assent

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Abstract

Pyrazoline is a five member heterocyclic ring which is a versatile lead compound for designing potent bioactive agents. The review of the literature shows that the pyrazoline derivatives are quite stable and has inspired the chemists to synthesize the new pyrazoline derivatives. The past studies of pyrazoline derivative revealed that they are useful in pharmaceutical and agrochemical research. Pyrazoline derivatives display various pharmacological activities such as antitumor, antitubercular, antimicrobial, antibacterial, anti-inflammatory and antioxidant etc. and the pharmacological activities of different synthesized compound are reviewed in the present article.
A critical review on keeta visha: an ayurvedic approach Kumar, Parvesh; Goswami, Ashish B.
Journal of Applied Pharmaceutical Research Vol 4 No 2 (2016)
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Abstract

Indian system of medicine plays an important part in health care system all over India. Ayurveda is an ancient Indian system of medicine having eight important branches. Agad Tantra is among one of them which deals with toxicological conditions and their management. Sage Susruta in Kalpasthaana of his work Susruta Samhita, and Sage Vaagbhata in Uttaratantra of his work Ashtaanga Hrdaya, and in other classics and regional texts have narrated regarding the origin of Visha and Keeta Visha. There are several types of Keeta Visha described. Among animal poisoning, Acharayas have described different creatures (Sarpa, Keeta, and Luta) responsible for life threatening situations. The importance of Keeta Visha is more because it causes severe manifestations in the human being, even death also. Acharya Suhsruta described Keeta Visha under Jangama Visha and explained 67 varieties of Keeta under 4 groups. According to its variety diagnosis and treatment of Keeta Visha is found to be very difficult because these varieties are not yet correctly identified and besides, regional variations of these Keetas manifests very differently.
Development and characterization of topical phyto-formulation for antifungal activity Choudhury, Ananta; Verma, Reema; Sinha, Devnarayan; Sahu, Saurabh; Roy, Amit
Journal of Applied Pharmaceutical Research Vol 2 No 2 (2014)
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Abstract

The present study was aimed to develop a potent antifungal topical gel using Curcumin and fluconazole in suitable combination. In these studies we have prepared different gel formulations using polymer like carbapol, Hydroxy propylmethyl cellulose, as well as excepients like tri-ethanolamine, methanol, glycerin and purified water. The formulated gel were evaluated in context of different parameters like drug content, pH, spreadability viscosity , in-vitro drug release , anti-microbial effect etc. Candida albicans was used as a model fungus to evaluate the antifungal activity of the prepared formulations.
Liposomes in dermatological diseases Kamra, Manju; Diwan, A.
Journal of Applied Pharmaceutical Research Vol 5 No 2 (2017)
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Abstract

Liposomes are vesicles comprising of spherical phospholipids making them useful for topical applications of drugs. Liposome research has been expanded considerably and nowadays, it is possible to construct a wide range of liposomes varying in size, phospholipids composition and surface characteristics. In dermatological diseases, the topical application of liposomes has proven to be of high therapeutic value. Liposomes can be used as carriers for hydrophilic as well as lipophilic therapeutic agents because of their amphipathic character. They may improve stabilization of instable drugs by encapsulating them. They have the potential to target drugs into the pilosebaceous structures and hence have an advantage for treatment of hair follicle-associated disorders. Liposomal encapsulated drugs are found useful in the treatment of acne, atopic dermatitis, psoriasis, vitiligo, superficial vein thrombosis and hair removal etc
Evaluation of anxiolytic potential of Linum usitatissimum oil in wistar rats Satapathy, Trilochan; Kasture, S. B.; Kurrey, Shekhar Suman; Meher, Bibekananda
Journal of Applied Pharmaceutical Research Vol 2 No 3 (2014)
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Abstract

The objective of the present study was to evaluate the anxiolytic potential of the Linum usitatissimum (Flax seed) oil (5ml and 2.5ml/kg) in wistar rats by using Elevated plus maze (EPM) model and 5ml and 10 ml/kg in Lithium induced head twitches model. Experiments were carried out on white inbred Wistar rats (180-200 g). The efficacy of the oil at both the animal models was compared with the standard anxiolytic drugs Diazepam (0.5 mg/kg). The result showed that the oil significantly increased the number of entries and time spent in the open arm in the elevated plus maze. Similarly in Lithium induced head twitches model administration of oil decreases the no. of head twitches. Present study confirms that the extract showed significant anxiolytic activity at both dose levels which is comparable with standard anxiolytic Diazepam.
Review on natural gums and mucilage and their application as excipient Bahadur, Sanjib; Sahu, Uttam; Sahu, Dipesh; Sahu, Ghanshyam; Roy, Amit
Journal of Applied Pharmaceutical Research Vol 5 No 4 (2017)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/2348-0335.2017.0010

Abstract

Natural mucilage’s are included in novel drug delivered (NDDS) to multitask functions and in any cases directly or indirectly control the increase and rate of drug release. Substantial research efforts have been directed towards develop safe and efficient natural based mucilage particulate drug delivery systems., natural gums and mucilages and their isolation, purification, standardization and characterization characteristics along with their applications are covered. Recent trend towards the use of plant based and natural products demands the replacement of synthetic additives with natural ones. Today, the whole world is increasingly interested in natural drugs and excipients. These natural mucilages have advantages over synthetic ones since they are chemically inert, nontoxic, less expensive, and widely available.
A validated reverse phase HPLC method for the simultaneous estimation of clopidogrel bisulfate and rivaroxaban in pharmaceutical application Sajjanwar, Rupali; Bhaskaran, Shyamala; Kakati, Kulesh; Jha, Shailendra Kumar
Journal of Applied Pharmaceutical Research Vol 3 No 3 (2015)
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Abstract

A simple, sensitive and precise reverse phase high performance liquid chromatographic method has been developed for the simultaneous estimation of Clopidogrel bisulfate and rivaroxaban in pharmaceutical dosage forms. The combination drug was analyzed on BDS hypersil C18, 250mm × 4.6mm, 5µ, Thermo scientific. Mobile phase consisted of  buffer (0.05M KH2PO4 pH 4.0) : methanol in the ratio of 30:70 v/v delivered at a flow rate of 1.0 ml / min and wavelength of detection at 220 nm. The retention times of Clopidogrel bisulfate and Rivaroxaban were 2.39 min and 4.04 min respectively. The developed method was validated according to ICH guidelines. The proposed method can be used for the determination of these drugs in combined dosage forms.
Formulation design and in vitro evaluation of metformin hydrochloride transdermal film using hydrophilic polymer Sinha, Neman; Gupta, Suchita; Choudhury, Ananta
Journal of Applied Pharmaceutical Research Vol 2 No 1 (2014)
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Abstract

The purpose of the experimental study was to design a sustained release film formulation of metformin hydrochloride. In this study a transdermal film has been prepared by incorporating hydrophilic polymers like HPMC and PVA in combination of different ratios. The prepared film were subjected for different evaluation parameters like swelling index study, surface pH, drug content analysis, thickness of film, folding endurance study, drug release study. Results of evaluation of all the film was found satisfactory. Again further study needs to be conducted to stabilize the formulations. 
Bioelectrode based chitosan-nano copper oxide for application to lipase biosensor Bodade, A. B.; Taiwade, Minal Anil; Chaudhari, G. N.
Journal of Applied Pharmaceutical Research Vol 5 No 1 (2017)
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Abstract

Chitosan (Chit)-nanocrystalline CuO composite prepared from Chitosan and CuO nanoparticles by a spin coating method. CuO nanoparticles (45 nm) synthesized by Sol-gel citrate method and characterized by X-Ray diffraction (XRD), Raman spectroscopy, UV-visible spectroscopy, Fourier transform spectroscopy (FTIR) and Scanning electron microscopy (SEM). The electrochemical studies revels that these Chit-nano CuO electrode provide favorable condition for immobilization of enzyme lipase [LIP] specific enzyme for triglyceride detection, resulting in enhanced electron transfer at the interface. The prepared bioelctrode (LIP/Chit-nano CuO/Au bioelectrode) is utilized for triglyceride [TG] sensing using cyclic voltammetry (CV) with hexacyanoferrate as mediator. The electrochemical response studies shows on improved sensing performance of bioelectrode exhibit high sensitivity, low detection limit and good linearity of tributyrin concentration with fast response time. The low value of Michallis-Menten constant indicates high affinity of LIP towards the analyte (tributyrin). The Redox behavior of nano CuO makes an efficient matrix with chitosan for triglyceride [TG] biosensor
Evaluation of phytochemical parameters, antibacterial and antihelminthic activity of leaves and bark extracts of plant Bombax ceiba Shah, Suyogya; Ghimire, Kamana; Gupta, Amit Kumar; Pokhrel, Priyanka; Banerjee, Janmonjoy; Khanal, Hemanta; Pradhananga, Mahalaxmi
Journal of Applied Pharmaceutical Research Vol 5 No 3 (2017)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/2348-0335.2017.0006

Abstract

Bombax ceiba, commonly known as the red silk-cotton tree, is a large, briefly deciduous tree occurring in warm monsoon forests in southern Asia. Various phytochemical constituents present in different plant parts has been already reported earlier to possess many biological activities, here in this work extraction was performed by mixture of solvent (distilled water: ethanol) as well as the individual solvents (water) and (ethanol). The phytochemical screening of the leaves and barks was found to exhibit the presence of carbohydrates, glycoside, saponin, phytosterol phenol, tannins, flavonoid, proteins and diterpenes and negative result for alkaloids in all the solvent extracts. The ethanolic extract of leaves was subjected to antihelmenthic activity and the result was found to be moderate.

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