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Rachmat Kosman
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As-syifaa Jurnal Farmasi
Published by Universitas Muslim Indonesia
ISSN : 20854714     EISSN : 25029444     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
As-Syifaa Jurnal Farmasi receives manuscripts in Indonesian Language (Bahasa Indonesia) with abstracts in bilingual, both Indonesian and English. We’re open for various fields such as: Pharmacology and Toxicology, Pharmaceutical Microbiology and Biotechnology, Herbal Medicines, Pharmaceutics, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 397 Documents
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ANALISIS KADAR ARSEN (As) DAN TIMBAL (Pb) PADA MINYAK GORENG PEMAKAIAN BERULANG DENGAN METODE SPEKTROFOTOMETRI SERAPAN ATOM Aminah Aminah; Rahmawati Rahmawati; Tadjuddin Naid; Salma Salma
As-Syifaa Jurnal Farmasi Vol 9, No 1 (2017): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (226.96 KB) | DOI: 10.33096/jifa.v9i1.235

Abstract

This study aims to analyze the levels of arsenic (As) and lead (Pb) in frying oil usage over and over. This research was conducted at the Center for Health Laboratory Makassar. Samples obtained from merchants fried foods. To ensure the metal content of the samples prior didestruksi with HNO3P and heated for 16 hours to liberate arsenic and lead from the oil matrix, then measured using atomic absorption spectrophotometer (AAS) at a wavelength of 193.7 nm (Arsenic) and 283 nm (lead ). From the results obtained penilitian arsenic (As) in the three vendors that is <0.1 ppm (max 0.1 ISO ppm) and lead levels that merchants 1 (0.1503 mg / kg and 0.1940 mg / kg), traders 2 (0.3452 mg / kg and 0.4005 mg / kg), the merchant 3 (0.1111 mg / kg and 0.1788 mg / kg) respectively for the samples before and after frying (SNI max 0.1 mg / kg).
PROFIL BIOAUTOGRAM EKSTRAK FERMENTAT ISOLAT FUNGI ENDOFIT DARI DAUN GALING-GALING (Cayratia trifolia L) SEBAGAI ANTIBAKTERI Fitriana Fitriana; As Adi Abdullah; Annisa Almagfirah Achmar
As-Syifaa Jurnal Farmasi Vol 11, No 1 (2019): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (109.159 KB) | DOI: 10.33096/jifa.v11i1.494

Abstract

The research bioautogram profile of fermentate extract endophytic fungi from galing-galing (Cayratia trifolia L) leaf as an antibacterial has been to find the activity of the extract fermentat endophytic fungi isolates against bacterial test using TLC Bioautography. This research begins with the isolation of leaves galing-galing using Potato Dextrose Agar Chloramfenicol (PDAC) media, isolates do purification and macroscopic test. Subsquently isolates were followed by screening endophytic fungi isolates against test bacteria. Isolates that give the most excellent activity followed by fermentation with Maltose Yeast Broth (MYB) media using a shaker speed of 200 rpm at room temperature for 21 days. After the fermented liquid is separated to obtain fermentat and  mycelia. The fermented liquid was then extracted using a liquid-liquid extraction method using ethyl acetate solvents after which it was evaporated with a rotary evaporator until a thick extract was obtained. Extracts obtained followed by TLC Bioautography method using ethyl acetate : n-hexane (4: 1) eluent.  Endophytic fungi were obtained as many as 6 isolates and the best activity was endophytic fungi with IDGG-03 code against test bacteria. The results from the TLC Bioautography profile 2 Bioautography provide active spot with Rf values of 0.09 and 0.54 against the bacteria B. subtilis, V. cholerae and P. aeruginosa.
UJI AKTIVITAS IMUNOGLOBULIN M (IgM) EKSTRAK ETANOL HERBA RUMPUT MUTIARA (Hedyotis corymbosa) PADA MENCIT (Mus musculus) JANTAN DENGAN METODE HEMAGLUTINASI Safriani Rahman; Bayu Putra; Rachmat Kosman; Riska Mustika
As-Syifaa Jurnal Farmasi Vol 4, No 2 (2012): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (94.346 KB) | DOI: 10.33096/jifa.v4i2.79

Abstract

A Research About Activity of Ethanol of Pearl Grass (Hedyotis corymbosa) On The Imunoglobulin M (IgM) by Hemaglutination Method Had Been Conducted of Male Mice. This research purpose to established of activity imunoglobulin M (IgM) from ethanol extract of pearl grass (Hedyotis corymbosa). Mice is animal that used for this research,The mice was divided into 4 treatment groups, where each group consisted of 3 mice. The first group as negative control, and each group was given Sheel Red Blood Cell (SRBC) 2 % as many 0,1 ml intraperitonially, after that negative control group was administrated with air sulingt, and other group was administrated with ethanol extract  dose 26 mg, 78 mg, dan 130 mg for five days. The blood from all group was collected by intracardial after five days. The activity of imunoglobulin M (IgM) was measured by hemaglutination method based on titer of the imunoglobulin M (IgM) there was highest dilution of mice blood serum in which aglutination was showed. Research result showed   Ethanol extract of Pearl Grass (Hedyotis corymbosa) at 26 mg, 78 mg, and 130 mg dose, can increased imunoglobulin M (IgM) activity.Key words : Imunoglobulin M, Hedyotis corymbosa, Hemaglutination Method
FORMULASI SEDIAAN SABUN PADAT DARI MINYAK NILAM (Pogostemon cablin Benth) Nirwati Rusli
As-Syifaa Jurnal Farmasi Vol 10, No 1 (2018): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (58.995 KB) | DOI: 10.33096/jifa.v10i1.325

Abstract

Solid soap is a soap made from fat saponification reaction of solid sodium hydroxide, which is used to cleanse the body. Patchouli essential oil content of patchouli alcohol discount antibacterial and anti-inflammatory. One dosage appropriate to formulate patchouli essential oils to antibacterial soap is in the form of a solid. This research aims to create a solid soap preparation patchouli essential oils as antibacterial soap. Research conducted an experiment with solid soap making preparations to test a physical evaluation of solid soap include organoleptic test is the color, shape and scent, pH test, test foam height and stability test (cycling test). The results showed that the preparations are made which have different colors and scents are the same, because the process used for solid soap that is by the saponification reaction for 2 hours with temperature 70-800C, with the variation of patchouli essential oil 1%, 2%, 3% (b / b) as an ingredient additives and make use of the type of NaOH. From the result of the concentration of essential oils nilam varied, which makes different colors with the same scent, obtained pH between 7.77 to 9.70 with a height of 9 cm foam inside.
ANALISIS KANDUNGAN POLIFENOL DAN UJI AKTIVITAS ANTIOKSIDAN DARI BUAH MARKISA (Passiflora edulis) Aco Mappacanda
As-Syifaa Jurnal Farmasi Vol 2, No 2 (2010): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v2i2.111

Abstract

This study aims to analyze and determine the levels of polyphenols content from passion fruit (Passiflora edulis) is particulary cultivated in the central region of Malino in South Sulawesi regencies of Gowa, and test the antioxidant activity compared with ascorbic acid (vitamin C) is also one of the body’s antioxidant. This research  was conducted by using UV-visible spektrophotometry and as reagents used Folin Ciocalteu solution and 15% Na2CO3 produces a blue color, read absorbtion at 670 nm wavelength. As a standard solution used with tannat acid concentration 0,5 ppm, 1,0 ppm, 2 ppm, 4 ppm and 8 ppm. To test the antioxidant activity is also using UV-visible spectrophomometry and used as reactant solution concentration of DPPH with 1 mM (milimolar), read absorbtion at 515 nm wavelength with color change from purple to yellow to dark brown. Used as a standard solution of ascorbic acid concentration 20 ppm, 40 ppm, 80 ppm and 160 ppm. The result showed that the 2 varieties of passion fruit (Passiflora edulis) contain levels of polyphenols with poliphenol content of the purple passion fruit (Passiflora edulis Sims var. Edulis) of 0.5768 mg/100 ml and the yellow passion fruit (Passiflora edulis L var. Flavicarpa Degener) 1.1278 mg/100 ml. To study the antioxidant activity of the test result is the percentage of resistance in purple  passion fruit (Passiflora edulis Sims var. Edulis)  of 90.65% and yellow passion fruit (Passiflora edulis  L var. Flavicarpa Degener) for 47.32%.Keyword : Polifenol, Passiflora edulis, Spectrofotometric UV-Vis 
PENGARUH VOLUME URIN TERHADAP PEMERIKSAAN SEDIMEN URIN PADA PASIEN INFEKSI SALURAN KEMIH (ISK) Tadjuddin Naid; Fitriani Mangerangi; Muldhaniah Arsyad
As-Syifaa Jurnal Farmasi Vol 7, No 1 (2015): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (206.981 KB) | DOI: 10.33096/jifa.v7i1.15

Abstract

The research about effect of urine volume to urine sediment examination in patient with Urinary Tract Infection (UTI) at Wahidin Sudirohusodo hospital was performed. This research aimed to find out the volume urine effect to urine sediment examination in Urinary Tract Infection (UTI) so as to improve the diagnostic a laboratory. This research used laboratorial eksperimental method with total samples are 30 consist of 13 male (43,3%) and 17 female (56,7%). Microscopically sample examination used Shih-Yung method with during urine with comparative volume 12 ml, 10 ml, and 8 ml. This research showed mean total urine sediment in volume 12 ml (leukocyte 37,75/μL; erythrocyte 7,77/μL; epithelial cells 7,96/lfv; bacteria 5,15/lfv) in volume 10 ml (leukocyte 22,67/ μL; erythrocyte 4,48/ μL; epithelial cells 4,35/lfv; bacteri 3,88/lfv) in volume 8 ml (leukocyte 12,20/μL; erythrocyte 2,16/μL; epithelial cells 2,50/lfv; bacteria 2,08/lfv) from One Way Anova statistic test get P value = 0,000 (
ISOLASI DAN IDENTIFIKASI KOMPONEN KIMIA FRAKSI n-HEKSANA DAUN TUMBUHAN JERINGAU (Acorus calamus Linn.) Ari Wahyuni; Abd Kadir; Ahmad Najib
As-Syifaa Jurnal Farmasi Vol 4, No 1 (2012): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (231.22 KB) | DOI: 10.33096/jifa.v4i1.143

Abstract

Isolation and identification of n-Hexane faction from Sweet Flag leaves (Acorus calamus Linn.) was done. The aim of research is determine the chemical compound on it leaf, which was commonly used as the traditional medicine. Sample from 250 grams of dried Sweet Flag leaf, macerate using methanol, produce 21.563 grams dried extract. Isolation of n-hexane faction  using  column  chromatography  method  with  various  mobile  phases.  The  isolate identified by UV and IR spectroscopy method. From the data result show that the isolate has a specific compound.Key words : Isolation, Acorus calamus, UV-Vis, IR
ISOLASI DAN IDENTIFIKASI KOMPONEN KIMIA EKSTRAK N-HEKSAN DAUN PALA (Myristica fragrans) Virsa Handayani
As-Syifaa Jurnal Farmasi Vol 6, No 2 (2014): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (122.756 KB) | DOI: 10.33096/jifa.v6i2.43

Abstract

Nutmeg plant is a multi-purpose plant because each part can be utilized in the industry. Nutmeg  leaves contain essential oils and phenolic compounds. Essential oils are used as traditional medicine ingredients and as raw material for the manufacture of cosmetics, soaps, perfumes and others. This study aimed to isolate and identify the chemical components in the leaves of nutmeg (Myristica fragrans). Have done isolation and Identification of chemical components of the methanol extract of leaves pala (Myristica fragrans.) of 500 grams to determine the class of chemical components caontained in the leaf pala (Myristica fragrans.). The methanol extract which obtained by maseartion method 9,45 grams continued by solid liquid partition with n-hexane 4,61 grams extract. N-hexan extract isolated by column chromatography method obtained 37 bottles vials. Fraction D of the merger based on the appearance of spotting the chromatograms isolated by preparative thin-layer chromatography method, obtained 3 band. D.1 fractions isolated by TLC obtained a stain. In fractions spotting D.1 is obtained by testing a single two-dimentional TLC ang the elution system of multi eluen. Interpretation UV-Visible spectra data showed maximum  absorption at a wavelength 0f 273 nm and showed infrared fungtional group (OH) on the wave number (3927.78 cm-1, 3828.59 cm-1, 3743.30 cm-1, 3387.93 cm-1), group (CH) on the wave number (2925.93 cm-1, 2859.02 cm-1, 2364.17 cm-1), alken group (C = C) aromatik on the wave number (1642.54 cm-1, 1565.88 cm-1, 1516.65 cm-1, 1458.92 cm-1, 1114.33 cm-1), benzene group on the wave number ( 698.24 cm-1). Single spots obtained gave a positive reaction to spotting visualizer class of  flavonoids. Key words : Nutmeg , Isolation, Essential Oils.
UJI AKTIVITAS ANTIRADIKAL BEBAS FRAKSI DIETIL ETER BERUWAS LAUT (Scaevola taccada (Gaertn.) Roxb.) MENGGUNAKAN DPPH A. Amaliah Dahlia; Rachmat Kosman; Halija Halija
As-Syifaa Jurnal Farmasi Vol 5, No 1 (2013): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (47.242 KB) | DOI: 10.33096/jifa.v5i1.70

Abstract

Radical scavenging activity of diethyl ether fraction from sea lettuce tree (Scaevola taccada (Gaertn.) Roxb.) using DPPH.The of research aims is determine the radical scavenging activity of sea lettuce tree based on the binding of free radical DPPH. Was conducted the research on test radical scavenging activity of sea lettuce tree (Scaevola taccada (Gaertn.) Roxb.) and then compared with the radical scavenging activity Vitamin C. Five thousand grams of sea lettuce tree (Scaevola taccada (Gaertn.) Roxb.) extraced by maceration using ethanol. Dry ethanol extract was partitioned with solid-liquid partition, using diethyl ether and then tested for activity and was obtained radical scavenging IC50 value 27,06 µg/mL.Key Word : Radical Scavenging, Scaevola taccada, DPPH
POTENSI SENYAWA FLAVONOID DAUN AFRIKA (Vernonia amygdalina Del.) ASAL TERNATE SEBAGAI ANTIOKSIDAN Sukmawati Sukmawati; Harira Hadi; Aminah Aminah
As-Syifaa Jurnal Farmasi Vol 9, No 2 (2017): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (368.555 KB) | DOI: 10.33096/jifa.v9i2.278

Abstract

African Leaf (Vernonia amygdalina Del.) belonging Asteraceae family. The African leaf contain flavonoids, alkaloids, saponins, terpenoids, tannins, glycosides, indole alkaloids, anthraquinones and luteolin. This study aimed to measure the potencyl of flavonoid compounds of African leaf (Vernonia amygdalina Del.) origin Ternate using DPPH and FRAP. Extraction by maceration method using ethanol 96%. The compounds identification in African leaf extract contains flavonoids. The absorbance was measured at the maximum wavelength of 515 nm. DPPH scavenging showed that ethanol extract has weak antioxidant activity based on AAI 0.454 value. This potency is lower in comparasion with quersetin which has a value of AAI 6,315 and for FRAP methods, the absorbance was measured at the wavelength of 720 nm with the antioxidant capacity is 14,846 mgQE / gram.

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