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Rachmat Kosman
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Fakultas Farmasi UMI, Kampus II, Universitas Muslim Indonesia, Jl. Urip Sumohardjo Km.5, Makassar
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As-syifaa Jurnal Farmasi
Published by Universitas Muslim Indonesia
ISSN : 20854714     EISSN : 25029444     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
As-Syifaa Jurnal Farmasi receives manuscripts in Indonesian Language (Bahasa Indonesia) with abstracts in bilingual, both Indonesian and English. We’re open for various fields such as: Pharmacology and Toxicology, Pharmaceutical Microbiology and Biotechnology, Herbal Medicines, Pharmaceutics, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 397 Documents
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IDENTIFIKASI MAKROSKOPIK DAN MIKROSKOPIK SEDIAAN JAMU ASAM URAT YANG BEREDAR DI KOTA MAKASSAR Handayani, Virsa
Jurnal Ilmiah As-Syifaa Vol 3, No 1 (2011): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v3i1.125

Abstract

Was done research about pharmacognostic identification from muscle acid medicinal herbs that circulating at Makassar city., with aim to get pharmacognostic’s data from medicinal herbs of muscle acid that circulating at Makassar, for security in consuming. This research covers macroscopic and microscopic. On microscopic test medicinal herbs powder A, B dan C there are endosperm, parenkim with sekresi cell, fiber and calsium oksalat. From both offabove sample,really contains Zingiberis Rhizoma, Phaleria macrocarpa andyy `Piper nigrumKey word : Makroskopic, mikroskopic, muscle acid medicinal herbs
STABILITAS KIMIA DAN USIA SIMPAN SIRUP PARASETAMOL PADA BERBAGAI SUHU PENYIMPANAN Zulkarnain, Iskandar
Jurnal Ilmiah As-Syifaa Vol 6, No 1 (2014): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (203.511 KB) | DOI: 10.33096/jifa.v6i1.29

Abstract

Paracetamol syrup used to treat the symptoms of an illness and is often used as a stock. Chemical stability during storage is important to know. This study aims to determine the half-life of paracetamol syrup and store age. Stability testing performed on 4 kinds of paracetamol syrup that is Generic A and B, and C and D. Each issued its contents syrup 30 ml and stored at room temperature and refrigerator temperature. For comparison there are also groups syrup without treatment. After that stability testing. The method of testing is done by an accelerated stability test that samples stored at 40oC, 50oC, and 60oC for 4 days and then determined the concentration of paracetamol syrup every day. Age store (t90) obtained from the results of the study for paracetamol syrup A generic product without treatment, room temperature and the temperature in the refrigerator is 3.44237, 2.42564 in, 0.66226 years. For paracetamol syrup generic product B without treatment, room temperature and the temperature in the refrigerator is 2.38027, 1.52801 in, 0.34438 years. For paracetamol syrup product patent C without treatment, room temperature and refrigerator temperature is 4.98265 in, 4.09024 in, 3.59095 years. For paracetamol syrup patent product D without treatment, room temperature and refrigerator temperature is 4.14238 in, 3.44643 in, 2.70283 years. So it can be known that paracetamol syrup stored at room temperature more stable.
PERBANDINGAN MUTU BERDASARKAN PROFIL DISOLUSI TABLET GLIBENKLAMID PATEN DAN GENERIK YANG BEREDAR DI MAKASSAR Mursyid, A. Mumtihanah; Hasyim, Nursiah; Jauhari, Evy Fajrianti
Jurnal Ilmiah As-Syifaa Vol 8, No 1 (2016): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (121.561 KB) | DOI: 10.33096/jifa.v8i1.158

Abstract

A research of dissolution testing of patent and generic glibenclamide tablet have been done. The purpose of this research is to determine quality of patent and generic glibenclamide tablet that circulated in Makassar. Glibenclamide tablets patent and generic dissolution have been tested with paddle methode in 500 ml posfat buffer pH 7,4, medium was accomplished at 37 oC±0,5 the speed of 75 rpm. Aliquot retaken as much 5 ml is done at time intervas of 10, 20, 30, 45, and 60 mnutes and then, the concentrations is confiruxed by spektrofotometer UV-VIS at the 299 nm wavelength. Based on the dissolution experiment result, the acquired glibenclamide percentage that was dissolute from glibenclamide tablets generic A = 85,686 %, generic B = 81,336 % and paten = 126,665 % have fulfill the dissolution the condition according to British Pharmacphea 2008. That is the dissolute is not less than 75 % within 45 minutes. And the average of Dissolution value efficiency (ED) rate each glibenclamide tablet paten = 115,29 %, generic B = 72,409 % and generic A = 77,352 %.
ANALISIS KADAR ALKOHOL PRODUK KOMBUCHA DAUN PERMOT (Passiflora foetida L.) ASAL MAKASSAR SULAWESI SELATAN SECARA KROMATOGRAFI GAS Herwin Herwin; Rachmat Kosman; Fitriani Fitriani
As-Syifaa Jurnal Farmasi Vol 5, No 2 (2013): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (101.241 KB) | DOI: 10.33096/jifa.v5i2.52

Abstract

Preliminary research permot leaf (Passiflora foetida L.) used Acetobacter xylinum bacterial culture and Sacharomyces cerevisiae yeast fermentation in determined the alcohol content of kombucha with the purpose of determined the alcohol content of kombucha products permot leaf (Passiflora foetida L.) from Makassar in South Sulawesi gas chromatography. Based on result of research fermentation of kombucha product from permot leaf by add glucose 100 gram and inoculum kombucha 10 % obtaired content by gas chromatography as big as 0,0627292 %.                                                                                     Keyword : Permot leaf, kombucha, alcohol, gas chromatography
EFEK ANTIINFLAMASI EKSTRAK ETANOL DAUN KERSEN (Muntingia calabura L.) PADA MENCIT (Mus musculus) Safriani Rahman; Aulia Wati; Eka Mega Asariningtyas
As-Syifaa Jurnal Farmasi Vol 9, No 1 (2017): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (48.17 KB) | DOI: 10.33096/jifa.v9i1.244

Abstract

Leaf cherry (Muntingia Calabura L) empirically been used by the public as an anti-inflammatory drug. Cherry leaf contains flavonoids are thought to have antioxidant effects. This study has been tested antiinflammatory effect of ethanol extract of leaves of cherry (Muntingia Calabura L) in mice (Mus musculus). A total of 15 mice were divided into 5 groups of 3 animals. Group I (control) are given Na.CMC 1% w/v, Group II, III, and IV (treatment) were given cherry leaf extract ethanol concentration of 1% w / v, 3% w / v, and 5% w / v, as well as groups V (comparison) given Diclofenac Sodium 0.195 mg / 30 gBW. Before treatment all groups karagen induced with 1% w / v in intraplantar. Antiinflammatory effect was measured using pleytismometer. The results were analyzed statistically by one-way ANOVA method. The results showed that the ethanol extract of cherry leaf has anti-inflammatory effects and the concentration of 3% and 5% w / v has an effect no different to that diclofenac sodium.
FORMULASI DAN EVALUASI SALEP EKSTRAK DAUN GULMA SIAM (Chromolaena odorata L.) DENGAN VARIASI BASIS SALEP Hasrawati, A.; Famir, Yasir; Aztriana, Aztriana; Mursyid, A. Mumtihanah
Jurnal Ilmiah As-Syifaa Vol 11, No 1 (2019): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (149.872 KB) | DOI: 10.33096/jifa.v11i1.514

Abstract

Siam weed leaves are one of the plants that function as wound medicine. This study aims to produce a stable ointment dosage form. Siamese weed leaf extract is formulated in the form of ointment with a variety of bases consisting of a hydrocarbon base, absorption, water soluble and emulsion. Evaluation of physical stability includes organoleptic testing, homogeneity, pH, dispersion, viscosity and flow properties carried out before and after forced conditions. Forced conditions were carried out with stock storage for 10 cycles at 50 and 350. The results of the analysis showed that the viscosity of the preparations in all formulas changed after storage at 50 and 350 for 5 days. However, the statistical results show that all formulas did not experience significant changes between before and after the stress condition treatment.
UJI TOKSISITAS FRAKSI n-HEKSAN DAUN BERUWAS LAUT (Scaevola taccada (Gaertn.) Roxb.) DENGAN METODE BRINE SHRIMP LETHALITY TEST Rahmawati Rahmawati; Sitti Amirah; Andi Sulfika
As-Syifaa Jurnal Farmasi Vol 4, No 2 (2012): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (99.444 KB) | DOI: 10.33096/jifa.v4i2.84

Abstract

Research of effect toksisitas of n-heksan faction of the beruwas laut (Scaevola taccada (Gaertn.)Roxb.) leaf at prawn larva of Artemia salina Leach have been done as a mean to determine potency of toksisitas and value of LC­­­50 beruwas laut (Scaevola taccada (Gaertn.)Roxb.) leaf. As control used n-heksan. Before treatment, prawn egg of Artemia salina Leach incubated at some stage and after 48 hours prawn larva of Artemia salina Leach are ready to given treatment. Hereinafter n-heksan faction of beruwas laut (Scaevola taccada (Gaertn.)Roxb.) leaf with concentration 0,1 ; 1 ; 10 ; 100 µg/ml in sea water enhanced 10 prawn larvas. For control, done same treatment. Perception done after 24 hours treatment by counting dead prawn larva. Result of perception indicate that value of LC50 n-heksan faction of beruwas laut (Scaevola taccada (Gaertn.)Roxb.) leaf 4,17 ± 2,59 µg/ml. So that can be expressed that n-heksan faction of beruwas laut (Scaevola taccada (Gaertn.)Roxb.) leaf have potency as anticancer, this matter is based by standard of Meyer (1982) expressing that a natural materials compound have potency of anticancer if value of LC50 <1000 µg/ml.   Key word : Toksisitas Test, Scaevola taccada (Gaertn.)Roxb, Brine Shrimp Lethality Test
Uji Daya Hambat Ekstrak Kulit Buah Manggis (Garcinia mangostana L.) Terhadap Pertumbuhan Candida albicans Secara In Vitro (Studi Eksperimen di Laboratorium Mikrobiologi Farmasi Universitas Muslim Indonesia 2017) Chusnul Chotimah; Diah Wahyuni; Nurasisa Lestari
As-Syifaa Jurnal Farmasi Vol 10, No 1 (2018): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (288.166 KB) | DOI: 10.33096/jifa.v10i1.355

Abstract

Latar Belakang: Kesehatan gigi dan mulut penting untuk diperhatikan. Berdasarkan provinsi tahun 2013 yang mempunyai masalah gigi dan mulut yang cukup tinggi (>35%) adalah provinsi Sulawesi Selatan, Kalimantan Selatan dan Sulawesi Tengah dengan EMD 10,3%, 8%, dan 6,4%. Candida albicans merupakan flora normal yang dapat ditemukan dalam rongga mulut yang sehat, tetapi dapat menjadi pathogen apabila didukung oleh kondisi penurunan respon imun. Kulit buah manggis memiliki efek sebagai antifungi karena mempunyai kandungan aktif berupa alkaloida, saponin, flavonoid, tanin, triterpenoid dan steroid. Tujuan: Mengetahui daya hambat ekstrak kulit buah manggis (Garcinia mangotana L.) terhadap pertumbuhan Candida albicans secara in vitro. Metode: Penelitian ini adalah Eksperimental Laboratoris dengan desain post test only control group design. Sampel penelitian adalah biakan murni jamur Candida albicans di Laboratorium Mikrobiologi Farmasi UMI. Hasil: Hasil ekstrak kulit buah manggis konsentrasi 0,1% 0,5% 2,5% dan 12,5% mempunyai daya antifungi terhadap Candida albicans. Hasil uji One Way Anova didapatkan nilai p=0,000 (p
EFEKTIVITAS SEDIAAN OBAT KUMUR MINYAK BIJI JINTAN HITAM (Nigella sativa L.) TERHADAP MIKROBA Streptococcus mutans Faradiba Faradiba
As-Syifaa Jurnal Farmasi Vol 2, No 2 (2010): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v2i2.116

Abstract

Telah dilakukan penelitian formulasi minyak biji jintan hitam (Nigella sativa L.) sebagai obat kumur dengan tujuan untuk memperoleh formula sediaan obat kumur yang  memiliki aktivitas antimikroba yang paling efektif dalam menghambat pertumbuhan bakteri Streptococcus mutans. Pada penelitian ini dirancang formula dengan menggunakan tiga variasi konsentrasi minyak biji jintan hitam (Nigella sativa L.) yaitu 0,75%, 1,5%, dan 2,25% kemudian dilanjutkan dengan pengujian aktivitas antimikroba terhadap bakteri Streptococcus mutans dengan menggunakan metode difusi agar. Hasil analisis statistika dari setiap perbandingan antara formula dengan minyak biji jintan hitam (Nigella sativa L.) diperoleh zona hambatan untuk konsentrasi 0,75%, 1,5%, dan 2,25% memberikan hasil yang tidak berbeda nyata. Hasil penelitian menunjukkan bahwa ketiga formula tersebut memiliki aktivitas antimikroba yaitu dapat menghambat bakteri Streptococcus mutans dengan daya hambat terbesar pada konsentrasi 2,25%.Kata kunci :  Minyak biji jintan hitam, obat kumur
OPTIMASI BAHAN POLIMER PEMBENTUK MATRIKS TABLET SUSTAINED RELEASE Na. DIKLOFENAK Audia Triani Olii; Aztriana Aztriana
As-Syifaa Jurnal Farmasi Vol 7, No 1 (2015): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (167.657 KB) | DOI: 10.33096/jifa.v7i1.20

Abstract

Sustained release tablet is one of drug delivery system with an extended release drugs which use polymer  to control the release of drug from its dosage form. The advantages of this dosage form is can produce fixed blood levels are without repeat the administration of the unit dose. The aim of this study is to obtain the most optimum  polymer as a matrix in sustained release tablets of Diclofenac Sodium. Sustained release tablets made by direct compression  method from a mixture of three types of polymer combinations. F1 consists of a combination of HPMC polymer: Etilsellulosa, F2 is the combination of HPMC: Xanthan Gum and F3 consists of a combination of HPMC polymer: Na. Alginate. Each combination of polymer use the same ratio is 1: 2. Tablet evaluations include the  weight uniformity of tablet, size,drug content and dissolution test. Result showed  that the most optimum combination of polymer as a sustained release tablet matrix is F1 even F2 have an optimum dissolution.

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