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Rachmat Kosman
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As-syifaa Jurnal Farmasi
Published by Universitas Muslim Indonesia
ISSN : 20854714     EISSN : 25029444     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
As-Syifaa Jurnal Farmasi receives manuscripts in Indonesian Language (Bahasa Indonesia) with abstracts in bilingual, both Indonesian and English. We’re open for various fields such as: Pharmacology and Toxicology, Pharmaceutical Microbiology and Biotechnology, Herbal Medicines, Pharmaceutics, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 397 Documents
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PENGEMBANGAN TARGET TERAPI PADA HEPATITIS C Ahmad Najib
As-Syifaa Jurnal Farmasi Vol 1, No 2 (2009): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v1i2.102

Abstract

For the development of new, specific anti-HCV drugs, an understanding of the HCV life cycle in particular the genomic organization and polyprotein processing, is essential. It has resulted in the development of several agents that target specific stages of the life cycle, the so-called specifically targeted antiviral therapy for HCV (STAT-C) drugs. Potential processes for viral inhibition include virus entry into the host cell, proteolytic processing, RNA replication, and the assembly and release of the new virions. Among the most promising new agents in development are the protease and polymerase inhibitors, as discussed below. RNA-targeted therapies, such as antisense oligonucleotides, ribozymes and small interfering RNA (siRNA)-targeting structures, have shown substantial success at inhibiting the HCV life cycle in vitro, but not in vivo. The structural viral envelope proteins E1 and E2, as well as their assembly, represent other potentialantiviral targets. Analogous to a recently developed HIV cell fusion inhibitor, detailed understanding of HCV cell fusion and cell entry could permit the development of specific HCV entry inhibitors.Key Word : HCV, Antiviral, Target Specific
UJI EFEKTIVITAS KOMBINASI SARI BUAH MERAH (Pandanus conoideus Lam.) DAN PERASAN DAUN KUMIS KUCING (Orthosiphon aristatus Mig.) SEBAGAI ANTIINFLAMASI PADA MENCIT (Mus musculus) SECARA TOPIKAL Sukriani Kursia; Besse Hardianti; Jeane Mega Tanna
As-Syifaa Jurnal Farmasi Vol 7, No 2 (2015): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (88.958 KB) | DOI: 10.33096/jifa.v7i2.6

Abstract

Inflammation is a protective response on the body from injury of cell. Edema is one of inflammation sign. It was reported that Pandanus conoideus Lam. and Orthosiphon aristatus Mig. empirically used as an antiinflammation. The aim of this research was determining the combination effect of Pandanus conoideus Lam. and Orthosiphon aristatus Mig. based on formation edema volume on sole of foot male mice againts carrageenan, inflammation that occurs is measured using the pletysmometer. In the research, we used sodium CMC as a negative control and sodium diclofenac as a positive control administered topically. While combination of Pandanus conoideus Lam. and Orthosiphon aristatus Mig. with a ratio of 2:1. The result showed decrease edema with percent of inhibition 76,92% Respectively, as a conclussion the result indicate Natrium diklofenak didn't showed significant effect compare with the testing data.
STUDI INTERAKSI OBAT PADA PENGOBATAN PASIEN DIABETES MELLITUS YANG DISERTAI TROMBOSIS DI RSUP. Dr. WAHIDIN SUDIROHUSODO MAKASSAR Rachmat Kosman
As-Syifaa Jurnal Farmasi Vol 3, No 2 (2011): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v3i2.134

Abstract

The aim of this study was to determine the interactions of drugs that used to treat the Diabetes Mellitus patiens espoused by Trombosis at RSUP. DR. Wahidin Sudirohusodo in Makassar. The research concerning by means non-experimental with descriptive approach was to collect the data with retrospectively compared take from medical data then to seach the drugs that interacting each other on Diabetes Mellitus patient espoused by Trombosis at RSUP. DR. Wahidin Sudirohusodo in Makassar. From determinable research result that in the year 2007 interaction  among drug of Diabetes Mellitus ( Sulfonylurea) with the drug antitrombosis ( Aspirin) that is equal to 61,6% while in the year 2008 equal to 38,4%, with the interaction type that is interaction pharmacokinetics in the form of distribution interaction, and effect generated by that is effect Pharmacodynamik.Key Words : Interaction, Diabetes mellitus, Thrombosis
PERAWATAN BEDAH FLAP PERIODONTAL PADA PERIODONTITIS KRONIS: SEBUAH LAPORAN KASUS Sri Oktawati; Lilies Anggarwati Astuti
As-Syifaa Jurnal Farmasi Vol 6, No 1 (2014): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (165.213 KB) | DOI: 10.33096/jifa.v6i1.38

Abstract

Chronic periodontitis is an inflammatory disease in periopdontal tissue. Subgingiva specific organisms are to be responsible for this gingiva inflammatory reaction. Gingiva attachment loss would occurred along with alveolar bone destruction, periodontal pocket formation, pathological migration and mobility of teeth. Case: A 48-year-old male was referred to the Departement of Periodontology RGSM Kandea Makassar. On clinical examination, tooth mobility in relation to teeth 31,32,33,34,41,42,43,44 was noticed. Chewing difficulty was reported by the patient. There was no routine control by dentists. Methode: Presurgery examination of teeths 31,32,33,34,41,42,43,44 showed mean pocket depths >5mm, there was gingiva recession and º3 teeth mobility. The patients was managed by an open flap debridement under local anesthesia. All subgingiva deposits were removed using curettes. The tissue was sutured and periodontal pack was put in place. Result: The patient was recalled after 3 weeks for suture removal and reevaluation. His results shows normal gingiva tissue with good tissue attachment. Teeth mobility was decreased by º1. Conclusion: This case report emphasizes the importance of routine dental examination for early intervention of chronic periodontitis.
TINGKAT PENGETAHUAN DAN KEPATUHAN MASYARAKAT DALAM PENGGUNAAN AMOXICILLIN UNTUK PENGOBATAN SENDIRI DI WILAYAH KELURAHAN LOLU SELATAN KECAMATAN PALU SELATAN Firdawati Amir Parumpu
As-Syifaa Jurnal Farmasi Vol 8, No 2 (2016): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (152.111 KB) | DOI: 10.33096/jifa.v8i2.206

Abstract

This study was aimed to determine the Society’s Levels of Knowledge and Compliance in Using Amoxicillin to Self-Medicate in South Lolu Urban Village, South Palu Sub-District. The basis of this study was descriptive survey and descriptive analytical approach aided by frequency table and percentage. Data and material collection was performed using observation, interview accompanied by questionnaire or list of question. The samples in this study were 75 adults in South Lolu Urban Village, South Palu Sub-District who were considered to know the research object, representing a population of 772 households. Based on the research result, it was determined that quite a lot of people in South Lolu Urban Village, South Palu Sub-District didn’t have any knowledge on Amoxicillin, influencing people’s level of compliance to rules of taking amoxicillin. It’s also due to other reasons, such as trying based on people’s recommendation, recovery after self-medicating, and unwillingness to take medicine for a long time. Therefore, socialization was required to support the knowledge of the people of South Lolu Urban Village, South Palu Sub-District to reduce resistance.
FORMULASI EMULSI ORAL MINYAK JINTAN HITAM (Nigella sativa) DENGAN BAHAN PENGENTAL Tomagola, M. Ilham
Jurnal Ilmiah As-Syifaa Vol 5, No 2 (2013): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (162.782 KB) | DOI: 10.33096/jifa.v5i2.61

Abstract

The aim of this research was to determine the type and thickening agent variation which of result stable emulsion. There were three thickening agent, they are CMC sodium, Acacia gum and xanthan gum used in formula. Those three formula then evaluated by accelarated condition method by which the parameter were organoleptic, type of emulsion, creaming volumen, viscosity and type of flow, dispersed globule observation before and after the condition. Organoleptic result showed that there were nothing different in formula II. Type of emulsion showed that those three formula were o/m emulsion. There were nothing creaming volume in formula I and II. Statistic analyze in viscosity measurement and yield value, rheogram curve showed close each other, dispersed globule there were not undergo aggrregation in formula I and II before ad after accelarated condition. Of those parameter the conclusión was formula II is stable one.Key word : Formulation, Emulsion, Nigella sativa,  Agent Variation
STUDI PENGGUNAAN OBAT DIARE PADA ANAK PASIEN RAWAT INAP DI RSUD ANDI DJEMMA MASAMBA KABUPATEN LUWU UTARA PERIODE JANUARI-DESEMBER 2014 Santi, Irma; Herman, Hendra; Aninditia, Dian Dwi
Jurnal Ilmiah As-Syifaa Vol 9, No 2 (2017): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (137.108 KB) | DOI: 10.33096/jifa.v9i2.277

Abstract

Diarrhea is generally caused by the bacteria contamined in food and drink. If the bacteria are not the right treatment, it can be fatal and cause death. This research aimed to present the drug use on the diarrhea patient of hospitalized children ar RSUD Andi Djemma Masamba North Luwu district. This research used descriptive method  by collecting data retrospectively. The data were collected by searching the treatment  records given by doctors to diarrhea patient of hospitalized children. The data obtained included patient medical record number, sex, age, body temperature, therapy (drug name, dose, frequency, route of administration) and length of stay.  The result showed that the diarrhea drug use on children included antibiotic drugs(cotrimoxazole 4,3%, amoxicillin 2,9%, gentamicin 4,3%, cefotaxime 1.4%) antimicrobial (metronidazole 14,5%) zinc supplements 30,4%,probiotics 2,9%, antipyretics (paracetamol 34,8%) antiemetic (methoclopramide 1,5%) and antidispepsia (omeprazole 2,9%).
EFEKTIVITAS GEL EKSTRAK KASAR BROMELIN KULIT NANAS (Ananus comosus L. Merr) HASIL OPTIMASI FORMULA PADA TIKUS YANG DIBUAT LUKA MEMAR Anang Setyo Wiyono; Dian Mustofani
As-Syifaa Jurnal Farmasi Vol 11, No 2 (2019): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (356.872 KB) | DOI: 10.33096/jifa.v11i2.569

Abstract

Pineapple (Ananus comosus L. Merr) peel contains a protease enzyme, it was called bromelain. The purpose of this study was to develop a crude extract of bromelain of pineapple peel to be formulated into a gel and to determine the effects of crude extract of bromelain of pineapple peel gel on injury healing of rats skin contusion. Fresh pineapple peel carried out in order to get a crude extract of bromelain using the Herdyastuti’s method (2006) then formulated into a gel preparations with variations in the concentration of gelling agent and humectant. The evaluation of the quality of gel preparations were carried out, which included organoleptic test, homogeneity test, dispersion test, pH test, and viscosity test. The results of the evaluation of the quality of gel preparations were optimized using Simplex Lattice Design (SLD) to applied into 3 (three) dosage variations of the crude extract of bromelain of pineapple peel, namely 150 mg / KgBB, 300 mg / KgBB, and 450 mg / KgBB. The results showed that there was an effect of the concentration of carbopol 940 and glycerin on the organoleptic test, dispersion test, pH test and viscosity test, and there was no effect of the concentration of carbopol 940 and glycerin on homogeneity tests. The 3 (three) dosage variations of the optimum gel formula have healing activity on rats skin contusion.
FORMULASI PASTA GIGI EKSTRAK ETANOL KULIT BUAH COKLAT (Theobroma cacao L.) dengan VARIASI BAHAN PENGIKAT Faradiba Faradiba; Ermina Pakki; Nurlela Djalal
As-Syifaa Jurnal Farmasi Vol 1, No 1 (2009): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v1i1.93

Abstract

A study has been done on the formulation of ekstract etanol pericarpium cacao as tooth paste with various binder agent.  the aim was to determined a stable tooth paste formulation of ekstract etanol pericarpium cacao (Theobroma cacao L.) physically satble. Two formula have been made use different binder agent, they were Natrium Carboxymetylcellulosa and Tragakan. Then the evalution of physics stability made before and after accelerated storing at 5oC – 35oC in which the parameters were organoleptic, pH, viskosity and flow type. The result of organoleptic and pH test from both formula showed no different before and after accelerated storing. The statistic analysis of viscosity’s result on formula I not shown a significant difference, but formula II shown a significant difference. Rheogram’s result of formula I and II shown dilatan flow type. So we concluded that the most stable formula was formula I used Natrium Carboxymetylcellulosa binder agent because had nothing changed before and after accelerated storing. Key words : pericarpium cacao,tooth paste
AKTIVITAS EKSTRAK DAUN SIRSAK (Annona muricata L.) SECARA IN VIVO TERHADAP SCABIES PADA KAMBING KACANG (Capra hircus). Risyani, Risna; Jamaluddin, Abdul Wahid; Mursalim, Muhammad Fadhlullah
Jurnal Ilmiah As-Syifaa Vol 10, No 2 (2018): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (252.315 KB) | DOI: 10.33096/jifa.v10i2.353

Abstract

The research was purposed to determine the activity of the leaf extract of soursop (Annona muricata L.) in dealing with scabies on Indonesian Native Kacang Goat (Capra hircus). There were 25 samples of scabies wounds used in this research. The samples were selected by examining the skin scrapings microscopically on goat which showed clinical symptoms of scabies to ensure mite infestion, Sarcoptes scabiei. Goat scabies are grouped into five treatment groups which consist of the positive control group, the negative control group, the group which was given the extract of soursop leaf of 10% concentration, the group which was given the extract of soursop leaf 20% concentration, and the group which was given the extract of soursop leaf extract 30% concentration. The treatment was given every day for seven days. The observation and the success assessment of scabies healing using a scoring method based on parameters of skin clinical changes consist of hair growth, scab, thickening, and skin folds. The conclusion of this research is the soursop leaf extract has an activity in healing scabies on Indonesian Native Kacang Goat (Capra hircus). 

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