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All Journal bionature As-syifaa Jurnal Farmasi Jurnal Mandala Pengabdian Masyarakat JOMPA ABDI: Jurnal Pengabdian Masyarakat Pharmaceutical Reports Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan

Safriani Rahman

Faculty Of Pharmacy, Universitas Muslim Indonesia, Makassar 90231, Indonesia

Author-ID : 512348

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Public Health Social Sciences Veterinary Other

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Efek Ekstrak Etanol Daun Awar-Awar (Ficus septica Burm. F) terhadap Kemampuan Epitelisasi pada Tikus (Rattus novergicus) Safriani, Rahman; Rachmat, Kosman; Iva, Mukrima
bionature Vol 14, No 2 (2013): Oktober
Publisher : Fakultas MIPA UNM

Luka adalah suatu bentuk rusaknya jaringan sel akibatÂ adanya kontak dengan panas, zat kimia atau radiasi. Telah dilakukan penelitian efek ekstrak etanol daun awar-awar (Ficus septica Burm.F) terhadap kemampuan epitelisasi pada tikus (Rattus novergicus) yang diberikan secara topikal dengan tujuan untuk menentukan kemampuan epitelisasi dari ekstrak etanol daun awar-awar (Ficus septica. Burm.F) pada tikus (Rattus novergicus) putih, Na CMC 1% sebagai kontrol negatif. Sebanyak 12 ekor tikus putih yang dibagi dalam 4 kelompok, 1 kelompok kontrol diberikan suspensi Na CMC 1 % dan 3 kelompok perlakuan yang diberikan ekstrak etanol daun awar-awar dengan konsentrasi 0,5%, 1% dan 1,5 % secara topikal sebanyak 2 kali sehari. Luka bakar dibuat dengan menempelkan logam panas (100oC) selama 2 detik pada kulit punggung tikus.Â Pengamatan dilakukan pada hari ke 3, 7, 14 dan 15. Evaluasi luka bakar dilakukan dengan pengamatan lama waktu penyembuhan luka dengan indikator pengecilan diameter luka bakar. Hasil penelitian menunjukkan bahwa ekstrak etanol daun awar-awar pada konsentrasi 0,5%, 1% dan 1,5% rata-rata penurunanya masing-masing 2,17 cm, 2,25 cm dan 1,68 cm.Â Â HasilÂ uji statistik diperoleh ekstrak etanol daun awar-awarÂ memiliki kemampuan epitelisasi pada tikus putihÂ dan padaÂ konsentrasi 1.5 %Â sangat signifikan (p<0,05) sebagai obat untuk penyembuhan luka bakar.

UJI EFEK ANTIINFLAMASI EKSTRAK ETANOL DAUN SIRSAK (Annona muricata Linn.) TERHADAP MENCIT (Mus musculus) JANTAN YANG DIINDUKSI DENGAN KARAGEN Rahmawati Rahmawati; Safriani Rahman; Mustari Mustari
As-Syifaa Jurnal Farmasi Vol 4, No 1 (2012): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

The research about aniinflammatory effect of Sirsak leaves (Annona muricata Linn.) ethanolic extract in male mice (Mus musculus) was conducted, the aim to assay the anti-inflammatory effect of Sirsak leaves done extract based on decrease in oedema volume of foot palm male mice. It was used 15 male mices that evaluated and divided into 5 groups that each group has 3 mices given extract in dose 0f 0,182 g/kgBB, 0,546 g/kgBB and 0,91 g/kgBB, one group as the compore which administered diclofenac sodium, one negative control group which administered 1% Na.CMC. induction carried out by injection 1% w/v carrageen 0,05 ml subcutan in the feet palm of mice. One hour later each group administered the teste preparation orally 1 ml/30 gBW. Group 1 to 3 the series dose of the extract 0,182 g/kgBB, 0,546 g/kgBB and 0,91 g/kgBB. Group 5 diclofenac sodium suspension. The measurement of oedema volume carried out prior and after administration of the tested preparation 0, 30, 60, 90, and 120 minutes. The data correlation between oedema versus time analysed value with use SPSS 20.Result indicated variaties with ethanolic Extract of Sirsak leaves have the effect antiinflamatory at dose 0,182 g/kgBB, 0,546 g/kgBB, dan 0,91 g/kgBB and not differ the reality by Natrium Diklofenak.Keywords : Inflamation, Anona muricata’s leaf, Carageen.

UJI EFEK ANTIRHEUMATOID ARTRITIS EKSTRAK n-BUTANOL DAUN PETAI CINA (Leucaena leucocephala (Lam.) de Wit) PADA TIKUS JANTAN YANG DIINDUKSI COMPLETE FREUND`S ADJUVANT Sitti Amirah; Safriani Rahman; Rahmatia S Hi Amin
As-Syifaa Jurnal Farmasi Vol 13, No 1 (2021): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v13i1.763

Rheumatoid arthritis is an autoimmune disease characterized by chronic inflammation. The research animed to determine the effect of n-butanol extract of Leucaena leucocephala leaves and the effective dose as antirheumatoid arthritis. It used 15 male rats divided into 5 groups: group I (negative control) was given Na-CMC; group II (positive control) was given a suspension of Methylprednisolone; group III, IV dan V were give the extraxt with doses of 83,3 mg/kgBW, 166,6 mg/kgBW and 333,2 mg/kgBW. The treatment was started by inducing Complete Freund`s Adjuvant intraplantary of 0,1 mL and let it remain until day 16. The therapy was conduction for 14 days orally and the foot volume measurements and observation of the arthritis index were performed on day 17 and 31st. In conclusion, the n-butanol extract of Leucaena leucocephala leaves had the effect as antirheumatoid

UJI AKTIVITAS EKSTRAK ETIL ASETAT DAUN KAYU JAWA (Lannea coromandelic (Houtt.) Merr.) TERHADAP PENYEMBUHAN LUKA BAKAR PADA TIKUS PUTIH (Rattus norvegicus) Bayu Putra; Safriani Rahman
As-Syifaa Jurnal Farmasi Vol 12, No 2 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v12i2.720

Wound healing is a process of repairing skin and soft tissue when these organs are injured. One of the plants that are presumed to affect wound healing is Kayu Jawa (Lannea coromandelic (Houtt.) Merr.). This research aims to determine the healing effect of burns and the effective dose of ethyl acetate extract of Kayu Jawa’s leaves. The animal test that has been induced using a hot plate with temperature 100oC stuck at the back of mice were divided into 5 (five) groups. Group 1 Na.CMC as Negative control, Group 2 Lanakeloid-E as Positive control, Group III, IV, and V were extract ethyl acetate of Kayu Jawa’s leaves (Lannea coromandelic (Houtt.) Merr) with 3 dosage variations namely, 75 mg/kg, 150 mg/kg, and 300 mg/kg were given topically 2 times a day for 21 days. Then wound area measure using calipers. The group with 300 mg/kg dosage has the best effect for reducing wound area of burns, with statistical value not significantly different from the comparison group (Lanakeloid-E) with a percentage value of 84%.

UJI EFEK EPITELISASI EKSTRAK DAUN EKOR NAGA (Rhaphidophora pinnata (L.f) Schott.) PADA TIKUS Safriani Rahman; Andi Maulana Kamri
As-Syifaa Jurnal Farmasi Vol 11, No 1 (2019): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Burns are damage to the skin due to contact with sources of heat and radiation. The stage of handling burns involves several phases, namely the inflammatory phase, proliferation and maturation. This study aims to determine the effect of epithelialization of ethanol extract of dragon tail leaves (Rhaphidophora pinnata (L.f) Schott.) In the process of wound healing. This research was conducted in an experimental laboratory and used rat test animals. 15 animals were divided into 5 groups consisting of group I (control) given Na.CMC, group II were given bioplacenton ointment, group III, IV and V (group given) giving ethanol leaves Rhaphidophora pinnata extract. Giving is done twice a day for 14 days. The wound is made by inducing the back of a mouse with a hot plate of 100o C for 2 seconds.. The results of the study data are the average wound diameter and percent of wound reduction in statistics using oneway ANOVA and LSD follow-up test. Based on the results of the research that has been done, it can be concluded that the ethanol extract of dragon tail leaves has the effect of epithelialization in rats.

UJI TOKSISITAS EKSTRAK ETANOL BUAH MERAH (Pandanus conoideus Lam) ASAL MANOKWARI PAPUA BARAT DENGAN METODE BRINE SHRIMP LETHALITY TEST Safriani Rahman; Riyan Wulansari Puspa Seruni
As-Syifaa Jurnal Farmasi Vol 3, No 2 (2011): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

A research on Toxicity assay of Extract Ethanol Red Fruit (Pandanus conoideus Lam) upon Brine Shrimp Lethality Test which intended to know the toxic effect of Red Fruit and supposed to determine Lc50 of the Red fruit by method Brine Shrimp Lethality Test. The ethanol ekstrak, was made in various concentration 10, 100, 1000 µg/ml. Mean while, for negative control was seawater which made by the same concentration. In each concentration has put in 10 brine shrimp. Each concentration has put 1 drop of yeast extract as source of food. The volume is added to 10 ml, observation is done after 24 hours treatment. Observation result in dead brine shrimp data. From the counted of probit analysis method obtained Lc50 value was that 52,844 ± 25,679 µg/ml. Mean while in negative compare there were not brine shrimp killed. Key words : Pandanus conoideus Lam, Brine Shrimp Lethality Test, Toxicity assay

EFEK ANTIINFLAMASI EKSTRAK ETANOL DAUN KAMBOJA (Plumeria rubra L.) PADA TIKUS PUTIH (Rattus norvegicus) Safriani Rahman; Aulia Wati; Ema Sukmawati
As-Syifaa Jurnal Farmasi Vol 10, No 1 (2018): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Inflammation is a body protective response against tissue injury which can be characterizet by the formation of edema. Frangipani Leaves contain flavanoids, saponins and alkaloids. The flavanoid compound is considered to have a useful effect for healing edema. This research aimed to examine the effects of anti-inflamatory and determined the dose of ethanol extract of the frangipani leaves (Plumeria rubra L.) as an anti-inflammatory in the rat. The test of anti-inflammatory effect was done by using the Rat Hind Paw Edema method in which test animals it used 15 rats divided into 5 groups: groups I (negative control) was given Na.CMC 1% w/v, group II (positive control) was given diclofenac sodium, group III, IV and V were given the ethanol extract of the frangipani leaves successive doses of 166,6mg/kgBW, 222,2 mg/kgBW, and 277,7 mg/kgBW, all groups were orally administered. The tested animals were induced carrageenan 1% w/v in intraplantar 0,5 mL and were meansured their foot edema volume before performed before induction as the intial volume (Vo), after induction, and 1 hour after the administration of the dosage form for 5 hours with the intervals of 1 hours using the pletismometer. The research result data were proccessed statistically using on-wey anova. Based of the data analysis showed that the ethanol extract of the frangipani leaves have the activity as the anti-inflammatory and statistically, the assay extract group showed the result not significantly different (p>0,05) against the diclofenac sodium group and a dose of 277,7mg/kgBW possessed the best activity compared to a dose of 166,6mg/kgBW and 222,2mg/kgBW.

EFEK HEPATOPROTEKTOR DARI EKSTRAK ETANOL DAUN JOHAR (Cassia siamea LAMK.) PADA TIKUS (Rattus norvegicus) Safriani Rahman; Rachmat Kosman; Andi Cassia Siamea
As-Syifaa Jurnal Farmasi Vol 9, No 2 (2017): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Johar leaf has been empirically used as malaria and hepatitis medicine. This research aims to determine hepatoprotective effect of ethanol extract of Johar leaves (Cassia siamea Lamk.) of rats liver. This research used 15 tested rats divided into 5 groups, group I was given Na.CMC 1% (negative control), group II ethanolic extract of Johar leaves of 50 mg/kgBB, group III ethanolic extract of Johar leaves of 250 mg/kgBB, group IV ethanolic extract of Johar leaves of 500 mg/kgBB, and group V as a comparison given suspension curliv® of 42,86 mg/kgBB. Giving suspension curliv® was orally done once a day for 7 days. On the 8th day, the experimental rats were given paracetamol suspension dosage of 2,5 g/kgBB. Measurements of SGPT content was done before therapy (normal), after therapy, and after administration of paracetamol. The results showed that the ethanolic extract of Johar leaves with the dose of 50; 250; 500 mg/kgBB have a hepatoprotective effect and dose is 500 mg/kgBB which was not statistically significantly different from curliv®.

UJI EFEK ANTIINFLAMASI EKSTRAK n-HEKSAN DAUN BERUWAS LAUT (Scaevola taccada (Gaertn.) Roxb) PADA MENCIT JANTAN (Mus musculus) YANG DIINDUKSI DENGAN KARAGEN Sitti Amirah; Rahmawati Rahmawati; Safriani Rahman; Franita Achmad
As-Syifaa Jurnal Farmasi Vol 6, No 2 (2014): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

This research about antiinflammation effect from n-hexane extract of Beruwas Laut leaves (Scaevola taccada (Gaertn.) Roxb.) in male mice (Mus musculus) was conducted, the aim was assay the antiinflammation effect of Beruwas Laut leaves done extract based on decrease in edema volume of foot palm male mice. This research using 15 male mice that evaluated and divided into 5 groups that each group has 3 mice. In group I, diclofenac sodium as the compare administrated. In groups II, III, dan IV, n-hexane Extract of Beruwas Laut leaves in concentration of 2,5%, 5% and 7,5% administrated. In group V, 1% Na-CMC as negative control administrated. Induction carried out by injection 1% w/v carrageen 0,1 ml subcutan on the feet palm of mice. One hour later each group administered the preparation test 1 ml/30 gBW orally. The measurement of edema volume carried out prior and after administration of the tested preparation 0, 30, 60, 90, and 120 minutes. The data correlation between induction and antiinflammation effect analysed. Result indicated variety with n-hexane extract of Beruwas Laut leaves have the antiinflammation effect at concentration 7,5%. Key Word : Antiinflammation, Scaevola taccada (Gaertn.) Roxb, Mice, n-Hexane.

EFEK ANTIINFLAMASI EKSTRAK ETANOL DAUN KERSEN (Muntingia calabura L.) PADA MENCIT (Mus musculus) Safriani Rahman; Aulia Wati; Eka Mega Asariningtyas
As-Syifaa Jurnal Farmasi Vol 9, No 1 (2017): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Leaf cherry (Muntingia Calabura L) empirically been used by the public as an anti-inflammatory drug. Cherry leaf contains flavonoids are thought to have antioxidant effects. This study has been tested antiinflammatory effect of ethanol extract of leaves of cherry (Muntingia Calabura L) in mice (Mus musculus). A total of 15 mice were divided into 5 groups of 3 animals. Group I (control) are given Na.CMC 1% w/v, Group II, III, and IV (treatment) were given cherry leaf extract ethanol concentration of 1% w / v, 3% w / v, and 5% w / v, as well as groups V (comparison) given Diclofenac Sodium 0.195 mg / 30 gBW. Before treatment all groups karagen induced with 1% w / v in intraplantar. Antiinflammatory effect was measured using pleytismometer. The results were analyzed statistically by one-way ANOVA method. The results showed that the ethanol extract of cherry leaf has anti-inflammatory effects and the concentration of 3% and 5% w / v has an effect no different to that diclofenac sodium.

Co-Authors A Hasrawati Anak Agung Istri Sri Wiadnyani Andi Cassia Siamea Andi Emelda Andi Maulana Kamri Andi Nur Alam Amaliah Andi Salmah Rahmah Annisa Amaliah Aulia Wati Aulia Wati Ayyub Harly Nurung Aztriana Aztriana, Aztriana Bayu Putra Bayu Putra Bayu Putra Eka Mega Asariningtyas Ema Sukmawati Fitriana Fitriana Fitriana Fitriana Fitriana Fitriana Fitriana Fitriana Franita Achmad Hardianti Hardianti Inda Rahmaniar Kosman Rachmat, Kosman Mukrima Iva, Mukrima Mustari Mustari Rachmat Kosman Rachmat Kosman Rachmat Kosman Rahmatia S Hi Amin Ririn Ririn Riska Mustika Riyan Wulansari Puspa Seruni Sitti Amirah Vina Purnamasari M Virsa Handayani

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