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Rachmat Kosman
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As-syifaa Jurnal Farmasi
Published by Universitas Muslim Indonesia
ISSN : 20854714     EISSN : 25029444     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
As-Syifaa Jurnal Farmasi receives manuscripts in Indonesian Language (Bahasa Indonesia) with abstracts in bilingual, both Indonesian and English. We’re open for various fields such as: Pharmacology and Toxicology, Pharmaceutical Microbiology and Biotechnology, Herbal Medicines, Pharmaceutics, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 397 Documents
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IDENTIFIKASI MORFOLOGI dan PARAMETER SPESIFIK SIMPLISIA DAN EKSTRAK DAUN ROSELLA (Hibiscus sabdariffa L.) ASAL KAB. ENREKANG (SULAWESI SELATAN) A. Amalia Dahlia; Asni Amin; Rahayu Lestari
As-Syifaa Jurnal Farmasi Vol 4, No 2 (2012): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (116.334 KB) | DOI: 10.33096/jifa.v4i2.81

Abstract

Identification of morphology and spesific parameters from simplicia and rosella leaf's extract (Hibiscus sabdariffa L.). From regency of Enrekang, South Sulawesi. Identification of morphology and spesific parameters from simplicia and rosella leaf's extract have been done. The aim of this research is to know morphology and to get data of spesific parameters from simplicia and rosella leaf's extract (Hibiscus sabdariffa L.). Morphology test showed that rosella leaf's had spesific characteristic, i.e had red nervatio, had three palmatifidus leaf and their edge of leaf was serrated. Microscopic test of simplicia showed that the shape of their xilem was spiral and ladder, mesophyl, had thick trachoma, Ca.oksalat shaped sand, fibers sklerenkim, oil cells, epidermis and, diasitik stomata type, cortical parenchyma and lymph lysogen. Chemical identification of rosella leaf's powder showed that lignin, cathecol, aleuron, and flavanoid. Spesific parameters of extract showed that water soluble compound was 6,6203% and ethanol soluble acompund was 18,6992%. Identification of chemical group used Thin Layer Chromatography that sprayed by spesific reagent showed that the extract contained terpenoid and flavonoid.Key word : Identification, morphology, Hibiscus sabdariffa L
PENENTUAN WAKTU OPTIMUM PRODUKSI METABOLIT SEKUNDER ISOLAT BAKTERI ACTINOMYCETES DARI TANAH RHIZOSFER AKAR TANAMAN JARAK PAGAR (Jatropha curcas. L) TERHADAP BAKTERI PATOGEN Fitriana Fitriana; Rusli Rusli
As-Syifaa Jurnal Farmasi Vol 10, No 1 (2018): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (295.803 KB) | DOI: 10.33096/jifa.v10i1.331

Abstract

The study of optimum time determination of secondary metabolite production of Actinomycetes bacteria isolate from Jatropha curcas L root of the soil (Jatropha curcas (L) of pathogenic bacteria has been done with the aim to determine pathogen bacteria that can be inhibited by Actinomycetes bacteria and determine the optimum time in producing secondary metabolite to pathogenic bacteria. The first phase of this study is to isolate Actinomycetes purification IBPT 01. Then performed a screening test of activity against pathogenic bacteria. Furthermore, the timing of production of antibiotics or secondary metabolites with bacterial fermentation Actinomycetes IBPT 01 begins on the 1st day until the 28th day and carried out the activity of antibiotics for 28 days. The results obtained in the screening test Actinomycetes bacteria activity IBPT code 01 provides antibacterial activity with category which has a diameter of 20 mm 11- barriers against 8 bacteria while one bacterium with diameter> 20 mm including strong category. Optimization results showed that the isolated bacteria Actinomycetes capable of producing secondary metabolites on 9 day, 8 day, 7 day, 4 day and 26 day. From this research can be concluded that the bacterial isolates of Actinomycetes IBPT 01 can provide the optimum time to produce different secondary metabolites.
STUDI INTERAKSI OBAT PADA PENGOBATAN PASIEN STROKE YANG DISEBABKAN HIPERTENSI DI RSUP. Dr. WAHIDIN SUDIROHUSODO MAKASSAR Hendra Herman
As-Syifaa Jurnal Farmasi Vol 2, No 2 (2010): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v2i2.113

Abstract

This research concerning by means non-experimental with descriptive approach was to collect the data with retrospectively compared take from medical data then to search the drugs that interacting each other on strokes patient caused by hypertension at RSUP. DR. Wahidin Sudirohusodo in Makassar. The result of this research showed that strokes and hypertensions drug that interacting each other in 2007 and 2008 was the interaction between aspire and captopril where in 2007 was 48% and in 2008 was 54%, with pharmacokinetics interaction type is distributions interaction.Key Words : Drug Interacting, strokes, hypertensions.
UJI TOKSISITAS EKSTRAK ETANOL UMBI TALAS (Colocasia esculenta L. Schoot ) DENGAN METODE BRINE SHRIMP LETHALITY TEST TERHADAP Artemia Salina Leach Bayu Putra; Said Asrul Adjmi Assagaf
As-Syifaa Jurnal Farmasi Vol 7, No 1 (2015): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (153.46 KB) | DOI: 10.33096/jifa.v7i1.17

Abstract

The research of toxicity assay of Ethanol Extracts of Taro tubers (Colocasia esculenta L. Schott) have been conducted with the aim of determining the effects of toxicity and anticancer potential of ethanol extract of tubers of taro (Colocasia esculenta L. Schott) by Brine Shrimp Lethality Test method against Artemia salina Leach. Ethanol extract, made with concentrations of 0.1, 1, 10, 100, 1000, and 10000 µg/ml and for comparison with the drugs vincristine concentrations of 0.01, 0.1, 1, and 10 µg/ml. Negative control using sea water made with the same concentrations. Furthermore, each concentration 10 ml of sea water and then put 10 shrimp larvae. The treatment is done by 10 replication at each concentration. Observations were made after 24 hours of treatment by counting the number of dead larva. The observations calculated using probit analysis program, showed LC50 values with 95% confidence level is 33,997 µg/ml (7,970 µg/ml-151,231 µg/ml). And the results of a comparison of data from drug vincristine showed LC50 value is 0,398 µg/ml (0,259 µg/ml-0,624 µg/ml).
SKRINING AKTIVITAS ANTIMIKROBA EKSTRAK HERBA BELIMBING TANAH (OXALIS CORNICULATA L.) SECARA KLT-BIOAUTOGRAFI DAN DIFUSI AGAR Herwin, Herwin; Nuryanti, Siska
Jurnal Ilmiah As-Syifaa Vol 4, No 1 (2012): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (43.169 KB)

Abstract

The screening studies have been carried out antimicrobial activity of herb Belimbing Tanah (Oxalis corniculata L.) extracts from Mamuju West Sulawesi that purpose to got data about activity of Belimbing Tanah (Oxalis corniculata L.) extract based on antimicrobial screening of some microbes in the Bioautography-TLC test and agar diffusion.The result screening of antimicrobial activity by Bioautography-TLC,showed that  dietil eter extract of belimbing tanah (Oxalis corniculata L.) give antimicrobial activity to bacteri Staphylococcus aureus, Streptococcus mutans, Staphylococcus epidermidis, Salmonella thypi, Escherichia coli, Vibrio sp, and fungus Candida albicans  with a profile chromatogram using the eluent n-hexane: ethyl acetate Rf value of 0.45 obtained. And the screening of antimicrobial activity of the juice belimbing tanah (Oxalis corniculata L.) at a concentration of 25%, 50% and 75% in the diffusion in order to obtain an average diameter of zone of resistance to the bacteria Staphylococcus aureus = 14:00 mm, Streptococcus mutans = 15.00 mm, Salmonella thypi = 24.66 mm, Escherichia coli = 19.99 mm, Vibrio sp = 17.77 mm, and fungus Candida albicans = 15.00 mm. Keyword : Oxalis corniculata L., Screening of antimicrobial, Mamuju
TOXICITY TEST DIETHYL ETHER EKSTRACT OXALIS CORNICULATA L. HERB ON BRINE SHRIMP LETHALITY TEST METHOD Herwin, Herwin; Kosman, Rachmat; Baits, Muzakkir
Jurnal Ilmiah As-Syifaa Vol 6, No 2 (2014): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (265.895 KB)

Abstract

Recearch toxicity effect of  standar dietil eter ekstract Oxalis corniculata L. herb at Artemia salina Leach with purpose  to determine toxicity potencial and LC50 value Oxalis corniculata L. herb on  brine shrimp lethality test method. The result of this research shows that diethyl ether ekstract Oxalis corniculata L. herb at concentration  100, 50, 5, 1, 0.5, 0.1, 0.05, 0.01 µg/ml and controler is diethyl ether. Presentation data of Artemia salina Leach larvae was analyzed with probit analysis to count LC50. Ekstract is toxic if LC50 value < 1000 µg/ml. So obtained that diethyl ether ekstrak Oxalis corniculata L. herb is toxit to Artemia salina Leach larvae with LC50 4,17± 2,59 µg/ml. Key words : Oxalis corniculata L, Toxicity, Brine Shrimp Lethality Test.
FORMULASI TABLET PARACETAMOL SECARA KEMPA LANGSUNG DENGAN MENGGUNAKAN VARIASI KONSENTRASI AMILUM UBI JALAR (IPOMEA BATATAS LAMK.) SEBAGAI PENGHANCUR Ani, Nur
Jurnal Ilmiah As-Syifaa Vol 8, No 2 (2016): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (160.145 KB)

Abstract

It has been conducted a research about paracetamol tablet formula with kempa  technique directly using various concentration of parsnip creeps amylum (Ipomea batatas Lamk.) as dissolver.  The result observation shows that all tablet qualifies to test tablet physical character of  that.  Cover wight uniformity, size uniformity, crispness, and violence, flohat are indicated accord with in Indonesian Pharmacopoeia.  Based on analysis of variance quiz f that there is no significant formula among uniformity, size uniformity, crispness and violence. All formula qualifies to test at dissolution.
ANALISIS KANDUNGAN LOGAM BERAT TIMBAL (Pb) Dan KADMIUM (Cd) PADA UDANG WINDU (Penaeus monodon) DI PERAIRAN BENIUNG TARAKAN KALIMANTAN TIMUR DENGAN METODE SPEKTROFOTOMETRI SERAPAN ATOM Rais Razak; Siti Masyitah
As-Syifaa Jurnal Farmasi Vol 5, No 1 (2013): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (37.036 KB) | DOI: 10.33096/jifa.v5i1.72

Abstract

The research have done to analysis of metal weigth lead (Pb) and Cadmium (Cd) at Windu Prawn (Penaeus monodon) in Beniung territorial water Tarakan East Kalimantan by Atomic Absorbtion Spectrophotometry (SSA). The research enwrap qualitative and quantitative analysis. Before to be analised, first to do destruction of Windu Prawn (Penaeus monodon) later on disolved in HNO3 and HCl. Qualitative analysis used reactant specific and quantitative analysis used atomic absorbtion spectrophotometry (SSA) at wave length of 217,0 nm and 228,8 nm for lead and cadmium respectively. Result of research find average rates of Pb metal  and cadmium letal in Beniung territorial water Tarakan East Kalimantan is 0,7636 ppm and is 0,4730 ppm. From result of research to showing that average rates Pb and Cd metal to Beniung territorial water Tarakan East Kalimantan, it is not over from sill limit and according to DIRJEN POM regulation.Key Words : Analysis, Pb, Cd, Penaeus monodon, Atomic Absorbtion Spectrophotometry
KOMBINASI EKSTRAK ETANOL DAUN KEMANGI (Ocimum bacilicum L.) DAN DAUN SALAM (Syzygium polyanthum (Wight) Walp) SEBAGAI ANTIINFLAMASI PADA TIKUS (Rattus norvegicus) JANTAN YANG DIINDUKSI KARAGEN sukmawati sukmawati; Rachmat Kosman; Nurwasi Saharuddin
As-Syifaa Jurnal Farmasi Vol 10, No 1 (2018): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (476.497 KB) | DOI: 10.33096/jifa.v10i1.314

Abstract

Inflammation is a normal protective response to tissue injury caused by physical trauma that could damage characterized by symptoms such as pain (dolor), heat (kalor), redness (rubor), swelling (tumor) and functional changes (fungsiolaesa). This research aimed to determine the anti-inflammatory effects of the ethanol extract combination of kemangi folium (Ocimum bacilicum L.) and salam folium (Syzygium polyanthum (Wight) Walp) in male rats (Rattus norvegicus) induced carrageen. This research used 15 rats divided into 5 groups: group I Na CMC (Naïve), group II Sodium Diclofenac (negative), group III was administered the ethanol extract of kemangi folium  and salam folium with dose 125:125 mg/kgBW, group IV with dose of 125:75 mg/kgBW and group V with dose 250:75 mg/kgBW. The entire of administration was done orally. The measurement of male rat foot was performed every 30 minutes to 150 minutes. The data were statistically analyzed using One Way ANOVA followed by Post Hoc LSD test. The results showed that the ethanol extract of Kemangi folium with dose of 250 mg/kgBW and the ethanol extract of Salam folium with dose of 75 mg/kgBW had the effect of decreasing the edema volume of the rat foot effectively the same as anti-inflammatory drugs NSAID where the results of statistical analysis were obtained significance (p>0.05).
STANDARISASI SIMPLISIA DAUN HANTAP (Sterculia coccinea JACK) ASAL KABUPATEN DONGGALA PROPINSI SULAWESI TENGAH SEBAGAI BAHAN BAKU SEDIAAN FITOFARMAKA Nurmaya Effendi
As-Syifaa Jurnal Farmasi Vol 2, No 1 (2010): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v2i1.104

Abstract

On morphological examination showed that hantap leaf plants including dicotyledoneae class with woody stems and roots heels. Transverse slices of the anatomy of the leaf stomata indicate anomositik type, sliced crosswise rod carrier file types are radial. Physical determination powders include determining the total ash content, ie 9.74%, ash content of the water soluble and 5.21% ash content that does not dissolve in acid 3.62%. Determination of levels of leaf extract hantap covering levels of water soluble extract, which is 18.89% and levels of ethanol-soluble extract: 14.17%. Identification with chemical reagents contain tannins, steroids and alkaloids. Thin-layer chromatography profiles obtained by the number of spots with more in n-butanol extract with polar eluen chloroform : methanol (20 : 1) diethyl ether extract compared with non eluen polar heksan : ethyl acetate (8 : 2).Key Words : Standaritation, Leaf Hantap, Tanin, Alkaloids, steroids

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