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As-syifaa Jurnal Farmasi
Published by Universitas Muslim Indonesia
ISSN : 20854714     EISSN : 25029444     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
As-Syifaa Jurnal Farmasi receives manuscripts in Indonesian Language (Bahasa Indonesia) with abstracts in bilingual, both Indonesian and English. We’re open for various fields such as: Pharmacology and Toxicology, Pharmaceutical Microbiology and Biotechnology, Herbal Medicines, Pharmaceutics, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 397 Documents
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UJI EFEK HIPOGLIKEMIK EKSTRAK ETANOL BUAH SAWO MANILA (Manilkara zapota) PADA MENCIT JANTAN YANG DIINDUKSI ALOKSAN Aulia Wati; Safriani Rahman
As-Syifaa Jurnal Farmasi Vol 8, No 1 (2016): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (107.011 KB) | DOI: 10.33096/jifa.v8i1.165

Abstract

Diabetes mellitus is a metabolic disorder of carbohydrate, fat and protein that is characterized of hyperglycemia. Manila sapodilla (Manilkara zapota) empirically has been used by people as a traditional medicine. This study aims to determine the hypoglycemic effects and an effective concentration of ethanol extract manila sapodilla fruit as hypoglycemic on male mice induced by alloxan. The group of test animals consisted of 25 mice balb / c males were divided into 5 groups. Negative control group Na.CMC suspension 1% w / v, the comparison group glibenclamide 0.65 mg/kgbw, and group 3, 4, and 5 are a group of ethanol extract manila sapodilla fruit (EBSM) at a doses of 250 mg/kgbw, 500 mg/kgbw, and 750 mg/kgbw. Before treatment all test animals alloxan induced a dose of 150 mg/kgbw intraperitoneally (i.p). Given the test preparation is done orally once daily for 21 days. Blood collection from tail vein of mice on day 1 (h- 3rd), -3, -7, -11, -14, -17 and days 21 during treatment. Measurement of blood glucose levels is done before induction as early glucose levels, glucose levels after induction as diabetes mellitus, and after the end of therapy as glucose levels. The results were analyzed statistically by t-test and one-way ANOVA. Results showed EBSM a dose of 250 mg/kgbw showed no significant different compared to glibenclamide suspension. From this study it can be concluded that manila sapodilla fruit extract has hypoglycemic effects with an effective dose of 250 mg/kgbw. Keywords : Hyperglycemia, Manilkara zapota, male mice, alloxan.
PENELUSURAN POTENSI MIKROBA ENDOFIT DARI RIMPANG PAKU KEPALA TUPAI (Drynaria quercifolia J.Smith) SEBAGAI PENGHASIL SENYAWA ANTIBIOTIKA Rusli Rusli; Dian Rahmaniar
As-Syifaa Jurnal Farmasi Vol 5, No 2 (2013): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (168.775 KB) | DOI: 10.33096/jifa.v5i2.54

Abstract

This research object to obtain abd determine the activity of antibiotics microbial isolates from endophyticpakukepalatupai (Drynariaquercifolia J. Smith) as a producer of antibiotic compounds. Methods research is using the method in a medium cast nutrient agar and potato dextrose agar with a dilution of 10-1 to 10-5. Result showed that there were 5 active isolates on thosetwo medium, identification of isolates bacterial and fungi. Then, the bacteria and fungi isolates purified by quadrant method on nutrient agar and potato dextrose agar medium were in mikroskopic. To produce antibiotic compound fermentation carried out  by maltose yeast broth. The results of testing the activity of an antibiotic fermentation with agar diffusion method, results showed that the bacterial active against Bacillus subtilis, Pseudomonas aeruginosa, Streptococcus mutans, Escherichia coli and fungal isolates aktifagains candida albicans. Identification of endophyte microbe isolates carried out by gram staining. Result obtained showed that all isolates of the bacteria were negative Gram and coccus and bacil from.Key word : Antibiotic, Microbial Endophyte, Drynaria quercifolia J. Smith
PEMANFAATAN JAMUR ENDOFIT DARI DAUN MURBEI (Morus alba L.) SEBAGAI ANTIBIOTIK Sukriani Kursia; Alimuddin Ali; Fitriyanti Jumaetri Sami; Rabiatul Adhawiyah
As-Syifaa Jurnal Farmasi Vol 9, No 1 (2017): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (214.564 KB) | DOI: 10.33096/jifa.v9i1.254

Abstract

Endophytic fungi are fungi colonize internally plant tissue, without giving detrimental effect to the host plant. They act as symbiont, mediated plant resistance against biotic stress i.e. pests and diasease and abiotic stress such as drought and extreme of temperature. Endophytic fungi are one of the most creative groups of secondary metabolite producers that play important biological roles for human life. Fungi are among the most important groups of eukaryotic organisms that are well known for producing many novel metabolites which are directly used as drugs or function as lead structure for modification.Mulberry (Morus alba L.) is one of the genus species known to have secondary metabolite compound that can be used as an antioxidant, antibacterial, antiviral, antidiabetic, antihypertensive, hypolipidemic, fever, flu, cough, antiemetic and gastrointestinal disorders. This research aimed to determine antibacterial activity of Mulberry Fungi from the leaves against the bacteria Escherichia coli and Staphylococcus aureus. Isolation of endophytic fungal carried by the direct isolation techniques. Isolates which produced as much as 3 isolates the MUR1, MUR2 and MUR3. Further isolates fermented using PDY medium and extracted using ethyl acetate. The ethyl acetate extract qualitative test the activity against bacteria Escherechia coli and Staphylococcus aureus. The result of the antibacteria activity, ethyl acetat extract from fermentation medium PDY of Mulbery (Morus alba L.) inhibited growth of Escherechia coli and Staphylococcus aureus at > 12 mm Keywords: Endophytic fungi, Mulberry (Morus alba L.), Antibiotic.
AKTIVITAS ANTIMIKROBA KOMBINASI EKSTRAK PROPOLIS Trigona sp DAN JAHE (Zingiber officinale ROSCOE) TERHADAP BAKTERI Salmonella thypimurium Muhammad Fadhlullah Mursalim; Abdul Wahid Jamaluddin
As-Syifaa Jurnal Farmasi Vol 11, No 1 (2019): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (154.816 KB) | DOI: 10.33096/jifa.v11i1.471

Abstract

This study aims to find the antimicrobial activity of a combination of extract propolis Trigona sp and gingger (Zingiber officinale var ROSCOE) against Salmonella thypimurium. The test was carried out by the method of diffusion disc with propolis and ginger test material. The study was conducted with 10 groups treatment, namely the combination of K1 (1mL ginger (30%)), K2 (1mL ginger (30)% & 1mL propolis (1%)), K3 (Ginger 1 mL (30%) & propolis 1 mL (5% ), K4 (1mL ginger (15%)) K5 (1mL ginger (15%) & 1mL propolis (1%)), K6 (1mL ginger (15%) & 1 mL propolis (5%)), K7 (1 mL propolis 1 %), K8 (1 mL propolis 5%), negative control K9 (DMSO 10%), and K10 (positive control amoxicillin). The results showed that the combination extract of propolis and ginger on K3 had the highest inhibition area of Salmonella thypimurium 12.26 mm. This study proves that various combinations of concentrations of propolis and ginger extract have antibacterial activity against the growth of Salmonella typhimurium.
UJI AKTIVITAS ANTIMIKROBA EKSTRAK DIETIL ETER AKAR ANTING-ANTING (Acalypha australis L.) SECARA KLT-BIOAUTOGRAFI A. Mumtihanah Mursyid
As-Syifaa Jurnal Farmasi Vol 4, No 2 (2012): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (179.477 KB) | DOI: 10.33096/jifa.v4i2.86

Abstract

A research had been done of antimicrobial activity of Anting-anting (Acalypha australis L.). The preliminary research was done by screening test using Staphylococcus aureus, Salmonella typhi, Streptococcus mutans, Staphylococcus epidermidis, Pseudomonas aeroginosa, Escherichia coli, Vibrio sp, Bacillus subtilis and Candida albicans  toward extract of ethanol, dietyl eter and n-butanol of anting-anting (Acalypha australis L.) wich were use in 1 mg/ml.  The result showed that the dietil eter extract inhibit growth of bacteria, Staphylococcus aureus, Escherichia coli, Bacillus subtilis and Salmonella typhi. The test Antimicrobial activity toward dietil eter extract of Gamal (Glyricidia sepium (Jacq).Steud.) was done by using  the liquid dilution  methode to find out the MIC value in concentration 0,00625%, 0,025%, 0,1%, 0,4% and 1,6% continued by spreading on solid medium to find out the MKC value. The result showed that MIC toward to Staphylococcus aureus is 0,025%, Eschericia coli is 0,1%, Bacillus subtilis is 0,025%, and Salmonella thypii is 0,025%. While MKC  toward to Staphylococcus aureus is 1,6%, Escherichia coli is 0,4%, Bacillus subtilis is 0,025%, and Salmonella thypii is 0,1%. The TLC-Bioautography technique was used to predict the active constituents. The best result  has been obtained from separating by means TLC which used mixture of n-hexane : ethyl acetate (3:1). The result of TLC-Bioautografi showed that the spot in Rf 0,27 and Rf 0,36 given the activity antimkrobial toward Escherchia coli, Rf 0,36 toward Bacillus subtilis, and Rf 0,45 toward Staphylococcus aureus and Salmonella typhi. The identification result of the chemical component shown that the actif compound wich given positif result as fenol on spot in Rf 0,27 and 0,36 and the active compound wich given positif result as steroid on spot in Rf 0,45.Key word : Aktivitas antimikroba, Skrining, KLT-Bioautografi, Anting-anting (Acalypha australis L.)
PERBEDAAN DAYA HAMBAT ANTIBAKTERI ANTARA EKSTRAK DAUN SIRIH MERAH (Piper crocatum) DAN EKSTRAK DAUN SIRIH HIJAU (Piper betle L.) TERHADAP BAKTERI Streptococcus mutans Risnayanti Anas; Kurniawan Kurniawan; Yustisia Puspitasari
As-Syifaa Jurnal Farmasi Vol 10, No 1 (2018): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (255.657 KB) | DOI: 10.33096/jifa.v10i1.396

Abstract

Background: Red Betel (Piper crocatum) and green betel (Piper betle L.) is believed to have efficacy preventing dental caries disease caused by the bacterium Streptococcus mutans. Purpose: Research purpose is to review describes different inhibitory  extract of red betel leaf and leaf green betel Against bacteria Streptococcus mutans. Materials and Methods: Operations Research is an experimental  by design post test only group design. Sample Research : is a pure culture of Streptococcus mutans bacteria in the laboratory of Microbiology, Faculty of Pharmacy, University Muslim Indonesia. Analitical statistics to be done using One Way ANOVA. Furthermore, the Post Hoc multiple comparison test for review red betel Differences And green betel  inhibit bacteria. Results: Based on the statistical test showed that the zone of inhibition power of 4 Different the concentration (0.1%, 1%, 10%, 100%) As well as having a significant difference between the two TYPE betel leaf against bacteria Streptococcus mutans. Conclusion: The findings of the data analysis can be concluded that the green betel leaf showed inhibitory better than red betel leaf against bacteria Streptococcus mutans.
ANALISIS KANDUNGAN Β-KAROTEN PADA BEBERAPA VARIETAS CABAI MERAH (CAPSICUM ANNUUM) SECARA SPEKTROFOTOMETRI UV-VIS Harti Widiastuti
As-Syifaa Jurnal Farmasi Vol 3, No 1 (2011): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v3i1.118

Abstract

A have applied of research about content of β-carotene in three quality of cabai namely cabai merah besar (Capsicum annuum L. Var. Abreviata Einger huth), cabai merah keriting (Capsicum annuum L. Var. Longum sendt) and cabai rawit (Capsicum frustescens L). For to Analysis and senelles content β-carotene in cabai.                Cabai sample to be extraction in demarcation by acetone. The result of extraction to extract again with petroleum eter and applied safonification with KOH 15%. Qualitative analysis applied with Chromatography method in thin layer using petroleum eter : Benzen (9:1).The result it showing there are spot which same on three samples and β-carotene pure as the compere. While Quantitative analysis with spectrofotometri visible using β-carotene pure as compere showing that the content of β-carotene cabai merah besar 154,32 mg/g, cabai merah keriting 181,41 mg/g and cabai rawit 146,85 mg/g.A have applied of research about content of β-carotene in three quality of cabai namely cabai merah besar (Capsicum annuum L. Var. Abreviata Einger huth), cabai merah keriting (Capsicum annuum L. Var. Longum sendt) and cabai rawit (Capsicum frustescens L). For to Analysis and senelles content β-carotene in cabai.                Cabai sample to be extraction in demarcation by acetone. The result of extraction to extract again with petroleum eter and applied safonification with KOH 15%. Qualitative analysis applied with Chromatography method in thin layer using petroleum eter : Benzen (9:1).The result it showing there are spot which same on three samples and β-carotene pure as the compere. While Quantitative analysis with spectrofotometri visible using β-carotene pure as compere showing that the content of β-carotene cabai merah besar 154,32 mg/g, cabai merah keriting 181,41 mg/g and cabai rawit 146,85 mg/g.
FORMULASI SEDIAAN BALSEM DARI EKSTRAK DAUN KEMANGI (Ocimum SanctumLinn) DAN PEMANFAATANNYA SEBAGAI OBAT TRADISIONAL Wahyuddin Jumardin; Safaruddin Amin; Nurhidayati M. Syahdan
As-Syifaa Jurnal Farmasi Vol 7, No 1 (2015): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (88.885 KB) | DOI: 10.33096/jifa.v7i1.22

Abstract

The research has conducted to produce balm basil leaf extract which aims to discover how to formulating preparations balm from basil leaf extract (Ocimum sanctum Linn) as a tradisional medicine. The results of research that basil leaf extract can be made in the preparation as a balm. This is indicated through organoleoptic observation and the homogeneity of the preparation is stable.
PENELUSURAN FUNGI ENDOFIT SEBAGAI PENGHASIL SENYAWA ANTIBIOTIKA DARI DAUN NANAS (Ananas comosus (L) Meer) Fitriana Fitriana; St. Maryam; Tadjuddin Naid; Maryana Maryana
As-Syifaa Jurnal Farmasi Vol 8, No 1 (2016): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (105.917 KB) | DOI: 10.33096/jifa.v8i1.152

Abstract

A search endophytic fungi from the leaves of pineapple (Ananas comosus (L) Merr) as a producer of antibiotic compounds will be carried out in order to obtain the endophytic fungi that have the ability to produce bioactive compounds useful as antibiotics.. Results of endophytic fungi isolates obtained six fungal isolates (IJA 1, IJA 2, IJA 3, IJA 4, IJA IJA 5 and 6), which have a different macroscopic characterization of forms, edge and elevation colonies. Isolates pure microbial fermentation results in the test antibiotic activity against some bacteria using agar diffusion test. All isolates pure fermentation results showed inhibitory activity against all bacteria in test as Bacillus subtilis, Esherichia coli, Pseudomonas aeruginosa, Salmonella thypi, Shigella dysenteriae, Staphylococcus aureus, Streptococcus mutans, and Vibrio cholerae. The inhibition of fungi isolates shown in (IJA 4) with a 26 mm zone of inhibition against Esherichia coli bacteria.
IDENTIFIKASI AKTIVITAS EKSTRAK ETANOLIK BUAH MANGGA (MANGIFERA INDICA L.) PADA MENCIT JANTAN (MUS MUSCULUS) SEBAGAI PRODUK IMUNOGLOBULIN (IGM) Herwin, Herwin; Meilani, Meilani
Jurnal Ilmiah As-Syifaa Vol 8, No 2 (2016): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (102.106 KB)

Abstract

Mango fruit (Mangifera indica L) is a plant which grow in Indonesia and contain antioxidant as carotenoid (Vitamin A), vitamin C and also various phenolic compound.  The aim of the investigation was to find out the activity of ethanol extract of mango fruit on male guinea pig (Mus musculus) as an immunoglobulin product. The test of immunomodulator was using hemagglutination antibody titer. The extracts were in concentration of 2%,4%,6%,8% and 10% administered orally 1 mL/30 g BW of the mouse which pre-immunized with 2% v/v red blood cells of the lamb. The results showed that the activity of the IgM in day seventh was raised in concentration extract 6% and 8% w/v while concentration extract 2% and 10% were the same to the control and the averages titer of immunoglobulin was 1/8, on the other hand concentration of the extract 4% was low in IgM activity was 1/4.

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