cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
M. Widyo Wartono
Contact Email
widyo@mipa.uns.ac.id
Phone
-
Journal Mail Official
alchemymipauns@gmail.com
Editorial Address
-
Location
Kota surakarta,
Jawa tengah
INDONESIA
ALCHEMY Jurnal Penelitian Kimia
Published by Universitas Sebelas Maret
ISSN : 14124092     EISSN : 24434183     DOI : -
Core Subject : Science, Social, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Materials Science & Nanotechnology
ALCHEMY Jurnal Penelitian Kimia is a chemistry journal published by Sebelas Maret University, Surakarta. ALCHEMY Jurnal Penelitian Kimia publishes original research articles or review articles in organic chemistry, inorganic chemistry, analytical chemistry, physical chemistry, biochemistry, and environmental chemistry.
Arjuna Subject : -
Articles 281 Documents
 25   26   27   28   29 
Optimization Depolymerization of Tilapia Fish Scale Chitosan by Oxidative Degradation with H2O2 using Central Composite Design (CCD) Dhian Eka Wijaya; Afra Raeviana Putri; Intan Lestari; Edwin Permana; Munifilia Ekasari; Nur Ahniyanti Rasyid
ALCHEMY Jurnal Penelitian Kimia Vol 22, No 1 (2026): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.22.1.95765.95-105

Abstract

Tilapia fish scales are among the fishery wastes that have not been optimally utilized, even though they have economic potential when processed into chitosan. Chitosan is a poly(2-amino-2-deoxy-β-D-glucose) obtained by deacetylation of chitin, with a high molecular weight ranging from 100 to 1.200 kDa, making it difficult to dissolve in water. To increase its solubility, chitosan can be depolymerized into oligochitosan with a lower molecular weight, around 5 – 10 kDa. This depolymerization process is influenced by temperature, time, and concentration factors. This study aims to determine the optimal conditions for the depolymerization of chitosan from tilapia fish scales using a central composite design (CCD). The stages of chitosan production include demineralization, deproteinization, and deacetylation, yielding a white powder with a molecular weight of 264.214 kDa and a degree of deacetylation of 74.24%. Based on CCD optimization, the optimal conditions for the depolymerization of tilapia fish scale chitosan were 3.6 M H2O2, 50 °C, and 2 hours, yielding a molecular weight of 3093 kDa. Fourier transform infrared (FTIR) characterization showed a peak shift from wave number 3267 cm-1 to 3303 cm-1. Oligochitosan also showed 100% solubility in water at neutral pH
Preparation and Optimization of Coal Fly Ash-Based Geopolymer and Its Application as an Adsorbent for Basic Yellow 2 and Methylene Blue Dyes Eddy Heraldy; Edi Pramono; Yuniawan Hidayat; Khoirina Dwi Nugrahaningtyas; Angel Maydeleine; Intan Dwi Rahmadani
ALCHEMY Jurnal Penelitian Kimia Vol 22, No 1 (2026): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.22.1.98784.254-263

Abstract

The preparation of geopolymer from coal fly ash (CFA) solid waste of Jepara PLTU has been carried out by activating CFA using a 10 M NaOH solution and Na2SiO3. Characterization of CFA and geopolymer using X-ray fluorescence (XRF), X-ray diffractometer (XRD), Scanning Electron Microscopy (SEM), and Fourier Transform Infra-Red (FTIR) spectroscopy. The adsorption process was studied under parameters including pH, geopolymer mass, contact time, and initial adsorbate concentration. The optimum conditions for the adsorption process of basic yellow 2 dye with fly ash-based geopolymer were optimum at solution pH of 11; adsorbent mass of 0.15 g; contact time of 120 minutes; and initial concentration of 80 ppm, while methylene blue adsorption was at solution pH of 11; adsorbent mass of 0.15 g; contact time of 120 minutes; and initial concentration of 60 ppm. Coal fly ash, a solid waste product from the Jepara PLTU, can be used to produce geopolymers through geopolymerization in the presence of activators such as NaOH and Na₂SiO₃. The adsorption capacities of these geopolymers for basic yellow 2 and methylene blue dye solutions are 26.55 and 19.825 mg/g, respectively.
Free Radical Scavenging, Cytotoxic Activity, and Antioxidant-Targeted Molecular Docking Analysis of Akar Kusim Besar (Artabotrys sp.) Methanolic Extract from Ketambe, Indonesia Halimatussakdiah Halimatussakdiah; Ulil Amna; Vivi Mardina; Misdi Misdi
ALCHEMY Jurnal Penelitian Kimia Vol 22, No 1 (2026): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.22.1.108079.200-216

Abstract

Akar Kusim Besar (Artabotrys sp.), a vine from the Annonaceae family and an orangutan food source in Ketambe (Indonesia), is known to contain diverse bioactive metabolites. This study evaluated the phytochemical profile, antioxidant activity, cytotoxicity, and molecular docking of its methanolic leaf extract. Phytochemical screening confirmed the presence of alkaloids, steroids, terpenoids, saponins, flavonoids, phenolics, and tannins. The extract showed strong radical scavenging activity (IC50 = 100.816 µg/mL) and cytotoxicity against Artemia salina larvae (LC50 = 57.702 µg/mL), indicating potential bioactivity attributable to flavonoids and phenolic compounds. Gas Chromatography-Mass Spectrometry (GC-MS) analysis detected 30 compounds, of which 12 were subjected to molecular docking against human glutathione peroxidase 7 (2P31). Stigmasta-3,5-diene exhibited the strongest binding affinities, while several compounds complied with Lipinski's Rule of Five, supporting their potential druglikeness. Together, these findings suggest that Artabotrys sp. exhibits promising antioxidant and cytotoxic activities, and that molecular docking provides mechanistic insight into its anticancer potential.
The Effect of Co-Processed Excipient and Mannitol on Physical Properties and Release Test of Flavonoid Total of Bajakah Root (Spatholobus littoralis Hassk.) Water Extract in Effervescent Granule Dian Eka Ermawati; Nur Cahyo Fajar Trihantono; Ulfa Afrinurfadhilah Darojati; Nindita Claurisa Amaris Susanto; Sholichah Rohmani; M. Fiqri Zulpadly; Annisa Diyan Meitasari; Diyah Tri Utami; Anif Nur Artanti; Heru Sasongko; Meta Kartika Untari
ALCHEMY Jurnal Penelitian Kimia Vol 22, No 1 (2026): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.22.1.94157.148-156

Abstract

Bajakah root is traditionally used in herbal medicine and exhibits notable antioxidant activity (IC₅₀ = 0.155 mg/mL) with a total flavonoid content of 32.49 ppm. However, conventional consumption by boiling is limited by poor taste, odor, and low stability. To overcome these limitations, this study developed effervescent granules to enhance acceptability and absorption. The effect of combining co-processed excipients (lactose–manihot starch in a ratio of 64.32:35.68) with mannitol on granule characteristics and flavonoid release was investigated. Bajakah root extract was prepared by hot water infusion (90 °C, 15 min; ratios 1:10 and 1:20) followed by freeze-drying. Phytochemical contents were analyzed using UV–Vis spectrophotometry. Co-processed excipients were prepared via wet granulation and characterized by SEM. Formulations with co-processed excipient–mannitol ratios of 3:1, 2:2, and 1:3 were evaluated for physicochemical properties and flavonoid release. Results showed total flavonoid and tannin contents in the extract of 2.19% and 9.04%, respectively. Excipient ratios significantly affected flow rate, angle of repose, moisture content, and disintegration time (p < 0.05), but not pH. All formulations met pharmacopoeial requirements for ≥80% flavonoid release within 60 min. The optimal formulation (1:3) demonstrated excellent properties, supporting its potential as an effective herbal delivery system.
Synthesis, Characterization, and DFT Computational Study of Cu(II) Complex with 3-Hydroxybenzoate Fastabiqul Khoirot; Muhammad David Julian Syach; Sentot Budi Rahardjo; Triana Kusumaningsih
ALCHEMY Jurnal Penelitian Kimia Vol 22, No 1 (2026): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.22.1.114305.106-116

Abstract

This study focuses on the synthesis, characterization, and density functional theory (DFT) computational study of Cu(II) complexes with 3-hydroxybenzoic acid ligands. The synthesis process was carried out by reacting CuCl₂·2H₂O with 3-hydroxybenzoic acid ligands in methanol, refluxing for 3 hours, and allowing the mixture to stand until complex precipitation formed. The complex formula was determined by atomic absorption spectrometry (AAS), thermogravimetric analysis (TGA), and molar conductivity measurements (41 S·cm2·mol-1), indicating that Cl⁻ acts as a counterion and that the complex formula is [Cu(3-hydroxybenzoate)2]Cl2·4H2O. The complex exhibits a single electronic absorption peak at 914 nm, indicating ligand-metal charge transfer (LMCT) and d-d transitions, consistent with a distorted square-planar geometry. The infrared spectrum shows a phenolic –OH band, indicating that –OH is not deprotonated. Computational methods were used to reveal the electronic structure and molecular geometry, and to verify the experimental data. This complex forms a distorted square planar structure.
Phytochemical Examination, GC-MS Analysis, and Antibacterial Activity of Methanol Extract of Dadap Leaves (Erythrina variegata L.) Against Staphylococcus aureus and Escherichia coli Bacteria using Disc Diffusion Method Yulia Theodora Situmorang; Halimatussakdiah Halimatussakdiah; Ulil Amna; Vivi Mardina
ALCHEMY Jurnal Penelitian Kimia Vol 22, No 1 (2026): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.22.1.99255.264-273

Abstract

This study examines the antibacterial activity of a methanol extract from the leaves of Dadap (Erythrina variegata L.) against Staphylococcus aureus and Escherichia coli. Bacterial infections are a major health issue in Indonesia, so the development of plant-based natural medicines is being pursued. The Dadap plant has the potential to treat bacterial infections. This study aims to identify the types of secondary metabolites in the methanol extract of Dadap leaves, analyze the active compounds using Gas Chromatography-Mass Spectroscopy (GC-MS), and evaluate their antibacterial activity. Extraction was performed by maceration with methanol, and antibacterial testing was conducted by disk diffusion on Mueller-Hinton Agar with extract concentrations of 5, 10, 20, and 40% (w/v). The extracts were diluted in sterile distilled water. The results exhibited antibacterial activity against S. aureus and E. coli, with inhibition zones of 14 mm (strong) and 8.8 mm (moderate) at a 40% concentration, respectively. These activities might be linked to the active compounds found in the Dadap leaves extract using phytochemical and GC-MS analysis. The phytochemical analysis showed that the E. variegata L. leaf extract contains alkaloids, steroids, terpenoids, saponins, flavonoids, phenols, and tannins. Furthermore, the GC-MS chromatogram identified 11 compounds, including 7 with antibacterial activity, such as neophytadiene, 3,7,11,15-tetramethyl-2-hexadecen-1-ol, hexadecanoic acid, methyl ester, n-hexadecanoic acid, phytol, methyl stearate, and stigmasterol. Overall, the crude extract of Dadap leaves showed a potential candidate for development as an antibiotic.
Phloroglucinol Compounds and Their Derivatives: Comparison of FTIR, NMR, and Bioactivity Characterization as Antibacterial, Antioxidant, and Anticancer Agents Sevi Dwi Cahyani; Triana Kusumaningsih; Maulidan Firdaus; Wahyu Eko Prasetyo
ALCHEMY Jurnal Penelitian Kimia Vol 22, No 1 (2026): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.22.1.109425.1-39

Abstract

Research on phloroglucinol (PG) and its derivatives has been extensively pursued over the past three decades. PG compounds are found in many plants, such as in the genus Callopyillum, the genus Hypericum, Eucalyptus kino, and brown algae. PG compounds have a symmetrical compound structure and contain many electrons distributed across three active sites, making them very advantageous for electrophilic aromatic substitution. PG has biological activities, such as antibacterial, antioxidant, anticancer, antiviral, anti-inflammatory, and others. PG bioactivity can be increased by synthesizing PG derivatives using various synthetic methods. The addition of an active group to PG can affect its bioactivity, properties, and characteristics, as well as its polarity and lipophilicity. This study aims to collect data on (1) Comparison of Fourier transform infrared (FTIR) and nuclear magnetic resonance (NMR) characterization of various PG derivative compounds, (2) Comparison of PG bioactivity and its derivatives as antibacterial, antioxidant, and anticancer compounds. PG compounds and their derivatives have been shown to exhibit antibacterial effects against several bacteria, including Staphylococcus aureus, Escherichia coli, and MRSA. Furthermore, PG derivatives exhibit antioxidant properties, as evidenced by their low IC50 values, and have demonstrated anticancer activity against cancer cell lines such as A549, MCF-7, and HTC-116. The findings of this study have the potential to assist researchers in developing new drugs.
Identification of Antioxidant Compounds using the DPPH Radical Scavenging Method from Ethanol and Methanol Extracts of the Leaves and Fruits of the Renggak Plant (Ammomum dealbatum R.) Rahmawati Rahmawati; Meliana Meliana; Lestia Furnapasta; Syarifa Wahidah Al Idrus; Baiq Fara Dwirani Sofia; Sya’ban Putra Adiguna; Jono Irawan
ALCHEMY Jurnal Penelitian Kimia Vol 22, No 1 (2026): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.22.1.108082.217-227

Abstract

This study aims to screen antioxidant compounds from the renggak plant (Amomum dealbatum R.). Screening of phytochemicals was carried out on the leaves and peel of the renggak fruit by the extraction method using ethanol and methanol solvents. Extraction was carried out by maceration, and the antioxidant potential test was carried out by measuring the extract's scavenging activity against DPPH radicals. In the fruit peel, both ethanol and methanol extracts tested positive for all phytochemicals, while in the leaves, ethanol extract was positive only for tannins and alkaloids, and methanol extract for flavonoids, saponins, tannins, and alkaloids. The difference in results was caused by differences in solvent polarity. The results of the antioxidant test showed that the leaf extract had an IC₅₀ value of 44.31 µM, while the fruit peel extract had an IC₅₀ value of 144.57 µM. The lower IC₅₀ value in the leaf extract indicates that the bioactive compounds contained therein have higher antioxidant potential than the fruit peel, as they can inhibit 50% of free radical activity at lower concentrations. The results of this study provide additional phytochemical and antioxidant sources from plant sources, for use as raw materials in the pharmaceutical and cosmetic industries.
Recent Developments of Biopolymer-Based Composite Membranes as Sustainable Separators for Lithium-Ion Batteries Tian Puspita Sari; Fitri Khoerunnisa; Asep Kadarohman
ALCHEMY Jurnal Penelitian Kimia Vol 22, No 1 (2026): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.22.1.114118.40-59

Abstract

The increasing adoption of electric vehicles and large-scale energy storage systems has intensified demand for high-performance and sustainable lithium-ion battery separators. This review summarizes recent progress in biopolymer-based separators as environmentally friendly alternatives to conventional polypropylene/polyethylene membranes. Fourteen research articles published between 2020 and 2026 are analyzed, focusing on biopolymers such as bacterial cellulose, chitosan, lignin, alginate, silk fibroin, and poly(L-lactic acid). The discussion covers material classification, membrane fabrication techniques, and modification strategies, including composite formation and crosslinking. Overall, the reviewed studies indicate that biopolymer-based separators generally exhibit improved electrolyte wettability, enhanced ionic conductivity, and adequate thermal stability, leading to competitive electrochemical performance and good cycling stability. In addition to performance benefits, the use of biomass-derived materials and water-based fabrication processes offers sustainability and potential biodegradability advantages. This review highlights current research trends and outlines key challenges related to testing standardization and manufacturing scalability for future lithium-ion battery applications.
The Influence of Solvent and Heating Time Toward the Percent Yield of Sumbermanjing Pyrophyllite-Polyethylene Glycol (PEG) 6000 Composites Siti Mutrofin; Ekantoro Ekantoro; Rurini Retnowati; Hanisah Kamilah
ALCHEMY Jurnal Penelitian Kimia Vol 22, No 1 (2026): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.22.1.104024.228-240

Abstract

The synthesis of clay-polymer composites has attracted considerable interest due to their promising potential properties. The composites were prepared from Sumbermanjing pyrophyllite and polyethylene glycol (PEG) 6000. This research aims to evaluate the influence of solvent and heating time on the percent yield of the composites. Pyrophyllite-PEG composites were synthesized via the casting and sol-gel methods with variations in solvent (demineralized water, methanol, acetone) and heating time (1, 1.5, and 2 hours). The highest yield (37.7239%) was achieved by a composite synthesized with acetone and a 2-hour heating treatment. The composite prepared with demineralized water showed poorer PEG diffusion into the pyrophyllite structure than did those prepared with methanol or acetone. A 2-hour treatment produced a more uniform, relatively smaller porous structure, despite subtle differences across various heating conditions. Statistical analysis revealed a significant difference among solvent treatments, but no significant difference among heating times. The melting points of the 1-hour and 2-hour composites were 120.7667 °C and 116.0333 °C, respectively, suggesting a successful composite synthesis. The successful composite synthesis was further confirmed by Fourier Transform Infrared (FTIR) spectra, which showed characteristic functional groups (O–H stretching, 3673.92 cm-1; C–H stretching, 2882.37 cm-1; Al–OH stretching, 1146.67 cm-1).

Page 27 of 29 | Total Record : 281

 25   26   27   28   29 

Filter by Year

2014 2026


Reset
Filter By Issues
All Issue Vol 22, No 1 (2026): March Vol 21, No 2 (2025): September Vol 21, No 1 (2025): March Vol 20, No 2 (2024): September Vol 20, No 1 (2024): March Vol 19, No 2 (2023): September Vol 19, No 1 (2023): March Vol 18, No 2 (2022): September Vol 18, No 1 (2022): March Vol 17, No 2 (2021): September Vol 17, No 1 (2021): March Vol 16, No 2 (2020): September Vol 16, No 1 (2020): March Vol 15, No 2 (2019): September Vol 15, No 1 (2019): March Vol 14, No 2 (2018): September Vol 14, No 1 (2018): March Vol 13, No 2 (2017): September Vol 13, No 1 (2017): March Vol 12, No 2 (2016): September Vol 12, No 1 (2016): March Vol 11, No 2 (2015): September Vol 11, No 1 (2015): March Vol 10, No 2 (2014): September Vol 10, No 1 (2014): March More Issue