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BIOEDUSCIENCE

bioeduscience
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Published by Universitas Muhammadiyah Prof. Dr. Hamka

ISSN : 2614154X EISSN : 26141558 DOI : -

Core Subject : Science, Education, Agriculture,

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education

BIOEDUSCIENCE is an open access journal that publishes research in the field of Biology and Biosain Education such as: Applied and implemented in education and learning, Botany, Zoology, Microbiology, Ecology, Biotechnology, Molecular Biology, Genetics, Bioinformatics, Cell and Developmental Biology, Biodiversity and Bioconservation. BIOEDUSCIENCE is published by Biology Education Study Program, Universitas Muhammadiyah Prof. Dr. Hamka, Indonesia regularly in June and December. ISSN : 2614-1558; P-ISSN : 2614-154X.

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Articles 544 Documents

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Pengembangan Booklet Kelainan Sistem Peredaran Darah Disertai Pengayaan Uji Aktivitas Antidislipidemia Ekstrak Daun Salam Nur Dwi Handarsiputri; Titin Titin; Wolly Candramila
BIOEDUSCIENCE Vol 6 No 1 (2022): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Background: Media booklets are media used in the learning process that have advantages in supportive conditions. The booklet contains a summary of the material that is equipped with pictures and colors so that it is interesting. This study aims to develop a booklet with enriched information about the antidyslipidemic activity test of bay leaf extract (Syzygium polianthum (Wight) Walp.) as a learning medium in the Sub Material of Circulatory System Abnormalities for second grade of highschool. Methods: This development research uses the type of research and development (R&D). The development stages include potentials and problems, data collection, product design, design validation, design revision, and product. The media booklet was validated by 5 validators in terms of format, content, and language, all of which covered 9 criteria. Results: Validation obtained Content Validity Ratio (CVR) and Content Validity Index (CVI) values "‹"‹of 1 which meet the minimum criteria for content validity. Conclusion: Thus, the booklet enriched with the results of the antidyslipidemic activity test of bay leaf extract (Syzygium polianthum (Wight) Walp.) was declared content valid as a learning medium in the Circulatory System Abnormalities Submaterial.

Penanganan Epilepsi Grand Mal Sebagai Akibat dari Ketidaknormalan Kerja Neuron di Otak Menggunakan Metode Diet Ketogenik Nommensen Pangihutan Ompusunggu; Sabar Manampin Giawa; Wahyu Irawati
BIOEDUSCIENCE Vol 6 No 1 (2022): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Background: The nervous system is composed of a complex structure to support its highly organized work. Damage to the working mechanism of nervous systems can exert fatal impacts to the human body. One of the consequences of damage to the mechanism of action potentials is grand mal epilepsy. The purpose of this paper is to determine the structure, function, and mechanism of action of neurons, establish grand mal epilepsy as a result of damage to the working mechanism of neurons, and recognize the ketogenic diet as a non-pharmacological therapy for epilepsy patients. Methods: The research method used is descriptive qualitative research. Results: Nerve cells generally consist of dendrites for receiving stimuli, cell bodies for transmitting stimuli to the axon, and axons for transmitting stimuli to other nerve cells. Grand mal epilepsy is a nervous system disorder caused by the increased activity of sending electrical waves throughout the brain that can reach up to four times faster than normal. However, grand mal epilepsy patients suffer from an excessive number of seizures that may occur at any time. Conclusions: The ketogenic diet method is a high-fat and low-carbohydrate diet method that can reduce electrical activity in the brain. Ketone-containing fats have a stabilizing effect on the central nervous system, contributing to anticonvulsant and antiepileptic effects that may reduce the excessive number of seizures experienced by patients. The application of this diet should be balanced with the provision of additional intake of multivitamins, minerals, and fiber to balance the nutrients the body needs.

Identifikasi Pemanfaatan Tanaman Obat Desa Kasiyan Kecamatan Puger sebagai Bahan Penyusun Booklet Dini Nurmawati; Diah Sudiarti; Haning Hasbiyati
BIOEDUSCIENCE Vol 6 No 1 (2022): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Background: Indonesia is a country that has many types of plants, one of which is medicinal plants, Kasiyan Village is a village located in the Puger district, Jember district, this village grows a lot of plants that are used as medicine by the local community, the purpose of this study is to identify the types of medicinal plants part of the population. as well as how to use it by the people of Kasiyan Village, it is hoped that this can enrich biology learning resources packaged in the form of booklets. Results: There are 47 species of medicinal plants from 25 families that are found in the family Euphorbiaceae. The part of the plant that is widely used is the leaf part with a percentage of 40%. How process plants that are often used is boiled with a percentage of 29%. Conclusions: Medicinal plants have properties that can be used as a treatment of diseases considering the many properties obtained from this medicinal plant for the body not only that this medicinal plant more natural and more efficient.

Pengaruh Penggunaan Zat Pengatur Tumbuh Alami terhadap Perkecambahan Biji Cabai Katokkon Reisky Megawati Tammu; Jessica Elfani Bermuli
BIOEDUSCIENCE Vol 6 No 1 (2022): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Background: Katokkon is a local red pepper that is widely cultivated in the North Toraja Regency and several surrounding areas within the scope of South Sulawesi Province, Indonesia. This pepper has a spicy taste and a unique fruit shape like paprika in small size and is rich in nutrients such as ascorbic acid, carotenoids, and capsaicin so that it benefits human health and serves as one of the commodities that improve the people's economy. Katokkon pepper is adapted to grow well in upland areas so that cultivation outside this habitat requires certain efforts to be optimal. Seed germination is an important step in plant cultivation. Coconut water and shallots extract were commonly used as sources of growth regulators substances to stimulate seed germination. Therefore, this study aims to determine the effect of natural growth regulators substances on the Katokkon pepper seed germination. Methods: This study was conducted by a factorial randomized block design with two factors and three replications. The Katokkon pepper seeds were soaked in the 25%, 50%, and 75% of coconut water and shallots solution for 24 hours. Results: The treatment of coconut water with a concentration of 75% (ZAK3) has a significant effect on the percentage and speed of seed germination of Katokkon pepper. Conclusions: The greater concentration of natural growth regulators used, the greater the percentage of seed germination obtained. However, the effect of coconut water treatment on seed germination of Katokkon pepper was more significant than the shallots extract.

Extraction and Identification Potent Antibacterial Bioactive Compound of Streptomyces sp. MB 106 from Euphorbia sp. Rhizosphere Dian Rachma Wijayanti; Almatin Puspa Dewi
BIOEDUSCIENCE Vol 6 No 1 (2022): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Background: Actinomycetes are groups of bacteria that play an important role in pharmacy and medicine in their ability to produce secondary metabolites in the form of bioactive compounds with various chemical structures and biological activities. The genus Streptomyces produces more than 70% of all described actinomycetes natural products. In particular, antibiotics represent the largest group. Through mutations, bacteria may survive chemotherapy. Thus its infection is hard to eradicate. Therefore the search for new potent bioactive compounds is important Methods: Isolate preparation, Production, and extraction bioactive compound, Crude extract antibacterial test, Identification of bioactive compound Results: There are antibacterial activities per 100 µl crude extract. Inhibition zone range from 11.5 to 13 mm. Various bioactive compounds detected in n-Butanol extract, There are nine bioactive compounds detected from Streptomyces sp. MB 106 crude extract. The highest was Naphthalene (43.89 %). The lowest was 3-Imino-3h,5h- [1,2,4] Thiadiazolo [3,4-1] Isoindole (1.70 %). Six compounds were reported to have antimicrobial activities butane, 1,1-dibutoxy, naphthalene, nonadecane, docosane, heneicosane, and eicosane Conclusions: Crude extract showed an average of 12 mm inhibition zone against Escherichia coli ATCC 8739. There are nine bioactive compounds from Streptomyces sp. MB 106. Six of them are promising drugs candidate. Further studies on these compounds are essential for future drugs candidate.

Peningkatan Pemahaman Konsep Keanekaragaman Hayati melalui Model Pembelajaran Biologi Berbasis Lingkungan Nursidin Nursidin; Rusman Rusman; Laksmi Dewi
BIOEDUSCIENCE Vol 6 No 1 (2022): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Background: Indonesia has abundant biodiversity. The concept of biodiversity was chosen because there are still places that must be known that students can use as learning resources. The learning innovation carried out is the application of environment-based knowledge to improve students' understanding of the concept of biodiversity. Method: This study used a pretest-posttest group design, 105 students of class X SMA Negeri Asera. The research sample consisted of 2 classes, namely the experimental and control classes. The experimental class uses environment-based learning and the control class uses conventional learning. The data was obtained through a test of understanding the concept of biodiversity and interviews. Data analysis was carried out by descriptive analysis and inferential statistics. Hypothesis testing through t-test using SPSS 20.0 program. Result: There is a difference in values between the experimental and control classes, where the experimental class values are higher than the control class values with that = 10,899. Conclusion: The application of this environment-based learning can affect student learning outcomes of SMA Negeri Asera.

Pemanfaatan Pewarna Alami Kain Tenun Futus Sebagai Alternatif Pewarna Preparat Jaringan Tumbuhan Yolanda Getrudis Naisumu; Emilia Juliyanti Bria; Welli Herlince Kasse
BIOEDUSCIENCE Vol 6 No 1 (2022): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Background: Natural plant dyes can replace synthetic dyes to reduce the negative effects caused. This study aims to determine the types of color-producing plants, the process of using natural dyes as dyes for plant tissue preparations and the percentage of quality and feasibility of plant tissue preparations. Methods: experiments were carried out in the application of natural plant dyes on plant tissue preparations. Data analysis was carried out to calculate the percentage of quality and feasibility of the preparations. Results: there were eight plant species from four families namely Fabaceae, Zingiberaceae, Maliaceae, and Lamiaceae. The process of processing plant parts into natural dyes is by soaking, boiling, pounding, grated and applied to preparations of corn and spinach plants. The use of natural dyes on corn and spinach preparations with a percentage of preparation quality ranging from 33.33% - 75.00% and said to be poor to good, while the percentage of feasibility of preparations ranged from 67.08% - 87.50% and was said to be feasible to very suitable for use in the observation of plant cells and tissues. Conclusions: Natural dyes from futus fabrics can replace synthetic dyes in dyeing plant tissue preparations.

Anti-PD-L1 Therapy as a Solution for Non-Melanoma Skin Cancer Basal Cell Carcinoma Rahul Simon Situmeang; Gim Mi Kyong; Rosiva Betaria Purba; Wahyu Irawati
BIOEDUSCIENCE Vol 6 No 1 (2022): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Skin cancer is a disease that can cause the loss of the ability to regenerate and protect the skin normally. The types of skin cancer that are known are melanoma and non-melanoma skin cancer. Non-melanoma Basal cell carcinoma is a malignant neoplasm originating from non-keratinizing cells in the basal layer of the skin's epidermis. The treatment itself is carried out through the application of immunotherapy, namely the use of drug therapy Programmed Death Ligand 1 (PD-L1). This study aims to see the effectiveness of PD-L1 Therapy as a treatment for basal cell carcinoma. The focus of the study of the article is the integument system, skin cancer, non-melanoma basal cell carcinoma, and the effect of anti-PD-L1 use. The research method used is a literature review from various sources. Skin cancer Basal cell carcinoma attacks the basal cells of the epidermis, causing disruption. Attacks slowly, but when ignored will spread wider and more severe. Through PD-L1 therapy by binding to PD-1 receptors on immune cells, it causes the activation of T lymphocytes as anti-cancer cells in the body that suppress growth while actively controlling tumor cells. Through the use of PD-L1 therapy in treating cancer that attacks basal cells, it will suppress growth, destroy and shrink cancer cells, and increase the body's immunity against cancer cells.

Gastropoda Diversity in Polyculture Agricultural Ecosystem of Nansean Village, Insana District, North Central Timor Regency- East Nusa Tenggara Province (NTT) Blasius Atini; Aloysius Rusae
BIOEDUSCIENCE Vol 6 No 1 (2022): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Background: The research was carried out in the polyculture area of Nansean Village, North Central Timor Regency. This study aims to determine the diversity of Gastropoda species and also to determine the influence of environmental factors on the Gastropoda life in the polyculture agricultural ecosystem of Nansean Village. Methods: The method used in this research is the quadratic method by placing plots along the transect line. The data analysis technique for Gastropoda diversity was using the Shannon-Winner diversity formula. Results: From the results of the study, it was found that 6 types of Gastropoda namely Achatina fulica with a diversity index (H') of (3.51) were classified as high. Laevicaulis alte Bowd with a diversity index (H') of (1,15) was classified as moderate. Felicaulis sp with a diversity index (H') of (1,25) was classified as moderate, Bradybaena similaris Frussac with a diversity index (H') of (1,26) was classified as moderate. Achatina variegata Bowd with diversity index (H') of (0.92) is low. Doraceras leave sp with a diversity index (H') of (0.87) is low. Species diversity shows the pattern of adaptation to ecosystem conditions is quite good, and vice versa if the type of Gastropoda is low. Conclusions: the environment has a role in diversity variations in Nansean Village, Insana District, and North Central Timor Regency.

Konsentrasi Logam Berat Cd, Hg, Pb pada Produk Pangan Olahan Berbahan Dasar Pterygoplichthys pardalis (Castelnau, 1855) asal Sungai Ciliwung Wilayah Jakarta Dewi Elfidasari; Haninah Haninah; Handhini Dwi Putri; Irawan Sugoro
BIOEDUSCIENCE Vol 6 No 1 (2022): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Backgrounds: Heavy metal that pollutes the river area affects living organisms which reside in it. Contamination of heavy metal in Ciliwung River leads to the presence of heavy metal elements (Cd, Hg, and Pb) inside the body of the plecos (Pterygoplichtys Pardalis) which inhabits that area. Hence, the utilization of plecos flesh and bones as a raw material in processed food products (e.g. shredded fish, shumai, and fish flour) might be harmful for human. Accumulated load of heavy metal in human's body would likely trigger health problems. Insufficient data on heavy metal concentration in Ciliwung River plecos-based food products underlies this research, with the aim to calculate the concentration of heavy metal Cd, Hg, and Pb on the previously mentioned plecos-based shredded fish, shumai, and flour. Methods: Heavy metal Cd, Hg, and Pb concentration analysis using X-Ray Fluoresence (XRF) methods conducted on PAIR Batan. Results: Value of Cd on shredded fish <0.5 mg/kg, shumai 0,7 mg/kg, head+tailbone and body skeleton flour <0.3 mg/kg. Value of Hg on shredded fish and shumai <0.7 mg/kg, head+tailbone flour 0.3 mg/kg, body skeleton flour 0.4 mg/kg. Value of Pb on shredded fish 1.3 mg/kg, shumai 0.8 mg/kg, head+tailbone flour 2.3 mg/kg, body skeleton flour 1.6 mg/kg. Conclusions: Heavy metal concentration on Ciliwung River plecos-based processed food products (shredded fish, shumai, and flour) has exceed maximum limit of Cd, Hg, and Pb determined by SNI, BPOM, and FAO.

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Contact Name
Susilo

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aru_palaca@yahoo.com

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Journal Mail Official
rantimouri@gmail.com

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Kota adm. jakarta timur,

Dki jakarta

INDONESIA