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Farmasains : Jurnal Ilmiah Ilmu Kefarmasian
Published by Universitas Muhammadiyah Prof. Dr. Hamka
ISSN : 20866968     EISSN : 26219816     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Farmasains: Jurnal Ilmiah Ilmu Kefarmasian is an national journal published by Faculty of Pharmacy and Science University of Muhammadiyah Prof. DR. HAMKA. Farmasains: Jurnal Ilmiah Ilmu Kefarmasian is aimed at being a medium for research results dissemination and scientific paper exchanges on the pharmaceutical field among academics, practitioners, regulators, and public. Farmasains: Jurnal Ilmiah Ilmu Kefarmasian is issued two times annually, i.e., in April, and October.The Editor receives rigorous research manuscripts that have not been offered for publication elsewhere. Since its first issue published in 2010. Farmasains: Jurnal Ilmiah Ilmu Kefarmasian has become a CrossRef Member since 2019. Therefore, all articles published by Farmasains: Jurnal Ilmiah Ilmu Kefarmasian will have unique DOI number with p-ISSN 2086-6968 dan e-ISSN 2621-9816
Arjuna Subject : -
Articles 5 Documents
 1 
Search results for , issue "Vol. 12 No. 1 (2025)" : 5 Documents clear
FORMULASI SERUM MINYAK ATSIRI TIMI DAN CENGKEH SERTA UJI AKTIVITAS ANTIOKSIDAN DENGAN METODE DPPH Liem, Marcella; Monica, Eva; Yanuar, Michael Resta
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 12 No. 1 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v12i1.16087

Abstract

Essential oils from thyme (Thymus vulgaris) and clove (Syzygium aromaticum) are natural antioxidants with significant potential to neutralize free radicals. This study aims to evaluate the antioxidant properties of a serum containing a blend of these essential oils using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. It also aims to determine which serum formulation meets the required physical quality standards. The assessment includes organoleptic analysis, pH measurement, viscosity, homogeneity, spreadability, adhesiveness, globule size distribution, stability, emulsion type, hedonic evaluation, and antioxidant activity. The results indicate that the serum is in liquid form, with a pH between 5.149±0.227 and 5.447±0.109, viscosity ranging from 817.1±3.8 to 2083±0.00 cPs, adhesiveness lasting 5.45±0.26 to 11.210±0.09 minutes, and spreadability between 2.32±0.016 and 2.71±0.053 cm. Hedonic testing revealed that F1 was the most preferred formulation. Antioxidant activity analysis showed moderate to very weak effects, with IC50 values of 145.628 ppm (F1), 413.658 ppm (F2), and 536.529 ppm (F3).  F1, which contains 4.5% clove essential oil and 1.5% thyme essential oil, demonstrated the best balance of physical properties and antioxidant activity among the tested formulations.
Ekstrak Daun Kersen (Muntingia calabura L.) Meningkatkan Konsentrasi GLUT 4 pada Tikus Jantan yang Diinduksi Streptozotosin-Nikotinamida Ramadhiani, Aninditha Rachmah; Tari, Mayang; Pratiwi, Galih; Janadia, Putri Eka; Pratiwi, Jessica Wahyu
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 12 No. 1 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v12i1.16948

Abstract

Diabetes Mellitus (DM) is a group of metabolic diseases characterised by hyperglycaemia, resulting from abnormalities in insulin secretion, insulin action, or both. Kersen (Muntingia calabura L.) leaves contain bioactive compounds, namely flavonoids, tannins, terpenoids, saponins, and polyphenols, which exhibit antioxidants and anti-diabetics. Glucose transporter (GLUT) 4 is an insulin-responsive glucose transporter in muscle and adipose tissue. This study aimed to examine the effect of Kersen leaves extract on GLUT 4 concentration in male rats induced by Streptozotocin-Nicotinamide. Diabetic rats were induced by Streptozotocin 45 mg/kg BW-Nicotinamide 110 mg/kg BW intraperitoneally, and the extract was administered orally for 14 days. Blood glucose level was measured using the Glucose Oxidase-Phenol 4-Aminoantipyrine (GOD-PAP) method, and GLUT 4 activity was assessed using the ELISA method. Statistical results showed significant differences (p<0.05) at 200, 400, and 600 mg/kg BW doses on the glucose and GLUT 4 levels. The 600 mg/kg BW group dose showed the best result with a blood glucose level of 88.22±2.31 mg/dL and a GLUT 4 level of 37.21±0.81 ng/mL. These findings demonstrate that Kersen leaves ethanol extract effectively lowers blood glucose levels and enhances GLUT 4 activity, with the most effective dose being 600 mg/kg BW.
Optimasi Formula Facial Wash Gell Antipolutan Ekstrak Bunga Rosella Ungu (Hibiscuss sabdariffa L. Var. Roselindo2) Anisa Fitri, Hidayah; Falahdin, Fadita Iza; Astuti, Ika Yuni
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 12 No. 1 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v12i1.17127

Abstract

Exposure to Particulate Matter (PM) and other airborne pollutants can lead to various skin issues. The anthocyanin compounds in purple roselle flower extract exhibit antipollution activity, making the extract a promising candidate for the development of a facial wash gel formulation, optimised with carbopol 940 and triethanolamine (TEA). These two ingredients were selected due to their influence on the physical properties of the formulation, which is expected to help maintain the physicochemical stability of anthocyanins. This study aimed to determine the optimal concentrations of these components as gel base-forming agents, such as viscosity, pH, and spreadability. The optimum formula was designed using Design Expert 13 software with a Simple Lattice Design (SLD) model, while statistical analyses were conducted using one-way ANOVA and T-test to verify the predicted and actual optimum formula. The physical evaluation results confirmed that the optimum formula met the required viscosity (3826±28.67 cPs), dispersibility (6.07±0.45 cm), and exhibited an acidic pH (6.53±0.07) suitable for a facial cleansing gel. Based on the conducted tests and analyses, the optimum formula contained 2% carbopol 940 and 2% TEA, with a desirability value of 0.993. Verification testing indicated no significant differences between the predicted and actual optimum formula.
Asam mefenamat Efek Rekristalisasi Konvensional dan Dengan Bantuan Ultrasonik terhadap Karakteristik Kristal Asam Mefenamat Rasydy, La Ode Akbar; Damayanti, Hilda; Femalda, Adefia; Yuniarto, Ari; Arrahman, Ikhsan Nazar; Wahid, Rifki Saldi A.
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 12 No. 1 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v12i1.17164

Abstract

Mefenamic acid is classified as a Biopharmaceutical Classification System (BCS) Class II drug. Crystallisation techniques can significantly influence the critical properties of mefenamic acid crystals, an essential consideration in the pharmaceutical industry. This study investigates the effect of recrystallisation on the morphology and particle size of mefenamic acid crystals using ethyl acetate as the solvent.  Recrystallisation was conducted using both conventional and ultrasonic-assisted methods. The yield was calculated, and characterization was performed to determine the crystal properties, shape, and particle size using polarized microscopy, X-ray Diffraction (XRD), and Fourier Transform Infrared Spectroscopy (FTIR). The results showed that conventional recrystallisation yielded 25.078%, while ultrasonic-assisted recrystallisation at 50 W, 60 W, 70 W, and 80 W yielded 43.47%, 47.71%, 51.90%, and 50.20%, respectively. Skewness and kurtosis values for the average crystal length and width indicated a normal distribution. XRD analysis revealed that the diffraction peak intensity of conventionally recrystallised crystals became narrow. In contrast, the diffraction peak intensity of ultrasonically assisted crystals broadened. FTIR results demonstrated that the recrystallisation process did not alter the fundamental chemical structure of mefenamic acid. Recrystallisation methods influence crystal shape and size, with ultrasonic-assisted techniques producing crystals of smaller average size than those obtained through conventional methods.
Pengujian Sifat Anti-Inflamasi Ekstrak Bunga Chamomile dalam Nanopartikel Kristal Cair Lyotropik Secara In Vitro Widyan Muchzadi Akbar; Muhammad Dzakwan; Fransiska Leviana
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 12 No. 1 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v12i1.17402

Abstract

Chamomile is renowned for its anti-inflammatory properties. Lyotropic Liquid Crystal Nanoparticle (LLCN) offers better enhancement of the bioavailability and efficacy of natural products. This study evaluated the LLCN system’s effectiveness in improving chamomile extract’s anti-inflammatory activity and compliance with nanoparticle standards. Chamomile 70% ethanol extract was prepared, and the total phenolic and flavonoid content was measured. The extract was formulated into LLCN, and the particle size, polydispersity index, zeta potential, stability, and entrapment efficiency were evaluated. Anti-inflammatory activity was tested in vitro using the protein denaturation inhibition method. The extract showed high phenolic and flavonoid content. The characterisation results demonstrated that the LLCN system met the required specifications, exhibiting particle size values of 230.366±3.412 nm, polydispersity index of 0.217±0.034, a zeta potential of -23.763±0.756 mV, and an entrapment efficiency of 84.060%±0.100. Stability testing indicated that storage at 4°C was more effective than room temperature, preserving a smaller particle size and improving overall stability. The LLCN system significantly enhanced the extract’s anti-inflammatory activity, as demonstrated by a lower IC50 value than the viscous extract. In conclusion, the LLCN system enhances the therapeutic potential of chamomile extract and represents a promising strategy for developing phytochemical-based anti-inflammatory formulations.

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