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Buletin Farmatera
Published by Universitas Muhammadiyah Sumatera Utara
ISSN : 2528410X     EISSN : 2528410X     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Arjuna Subject : -
Articles 10 Documents
 1 
Search results for , issue "Vol 7, No 3 (2022)" : 10 Documents clear
Article Review: Antioxidant Activity of Some Plants Found In Garut Arboretum Asman Sadino; Hesti Renggana; Saepul Nurohman
Buletin Farmatera Vol 7, No 3 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i3.10707

Abstract

Abstract: Free radicals in the form of atomic molecules do not have partners with high reactivity, free radicals can come from within the body in the form of metabolic waste products and from outside the body such as ultraviolet light, food, beverages, smoke and pollutants. The role of antioxidants is needed to reduce these free radicals. This article review aims to find out and examine scientific information from research that has been carried out regarding plants, especially in the Garut Arboretum which have antioxidant activity. The method of writing this article review uses a literature study through search engines such as Google Scholar, Pubmed, and NCBI. It is known that from 56 plant species found in the Garut Arboretum, 27 plant species have been studied to have antioxidant activity, including 15 plants with very strong antioxidant activity, 9 plants with strong antioxidant activity, and 3 plants with moderate antioxidant activity. Secondary metabolites that are responsible for antioxidant activity include flavonoids, alkaloids, saponins, and tannins.
Salivary Microflora and Its Diagnostic Importance Dina Rahmi Solihad Nasution; Zulham Yamamoto
Buletin Farmatera Vol 7, No 3 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i3.12199

Abstract

Saliva as a source of DNA has several advantages over blood. These advantages include easier sample collection, the sampling process can be carried out independently by participants, and stability. The study of the normal microflora of human saliva is increasingly in demand because it is related to the oral health status of each individual. Several studies explain microflora associated with diabetes, cancer, rheumatic heart disease, and others. Other things that affect the composition of the microflora of each individual include living habits, hygiene, age, and smoking. The microflora in saliva are protozoa, bacteria, yeast, and viruses. In healthy people, the characteristics of normal oral microflora found are dominant Gram-positive cocci and rods such as Actinomycetes spp and Streptococcus spp. Protozoa commonly found in saliva are Entamoeba gingivalis and Trichomonas tenax, while from the yeast Candida albicans group, the viruses most commonly found in saliva are herpes and retrovirus. Identification of normal salivary microflora can be done through microbiological and biomolecular approaches. Identification of microflora using a biomolecular approach, currently the most commonly used markers are 16S rRNA (bacteria) and ITS rDNA (fungi).
Anti-Cervical Cancer Study of a Labdane-type Diterpene Obtained from Legundi Fruit (Vitex triolia L.) Targeting the Bcl-2 Gene Humairah Medina Liza Lubis; Emni Purwoningsih; Nurfadly Nurfadly
Buletin Farmatera Vol 7, No 3 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i3.11728

Abstract

Abstract: The development and induction of cervical cancer carcinogenesis are linked to sexually transmitted Human Papillomavirus (HPV) infection, and can affect human genes, particularly those involved in the apoptotic process, one of which is the Bcl-2 gene. Several synthetic compounds, including pyrimidineylpiperazine, phenylpyrazole, kendomycin, and navitoclax, have been shown to be effective in inhibiting the antiapoptotic activity of Bcl-2, but it is the labdane-type diterpene content of the natural legundi fruit plant (Vitex trifolia L.) that has anticancer bioactivity, particularly in the process of genetic mutations, Apoptotic inhibition and therapeutic failure have yet to be discovered, particularly in cervical cancer. The study's goal was to investigate the mechanism of interaction (molecular docking) of labdane type-diterpene compounds with the antiapoptotic protein Bcl-2. In silico (docking molecular) research was used to determine the interaction between legundi fruit ligands and the Bcl-2 target protein in cervical cancer. The docking analysis results will then be visualized with the Discovery Studio 4.1, LigPlot+, and Ligand Scout 3.1 software. The interaction of proteins and ligands was studied to determine the number and type of bonds formed, such as hydrogen and hydrophobic bonds. The results were as follows: Gibbs energy -7.8, pKi 1.91 m, 10 hydrophobic bonds, and hydrophobic residues Leu80, Leu82, Thr83, Thr86, Ala87, Cys90, Met118, Glu121, Ser122, and Leu130. The findings presented here suggest that labdane-type diterpenes are powerful anticancer agents capable of inducing apoptosis and inhibiting the antiapoptotic action of the Bcl-2 gene, which should be investigated further in (pre)clinical studies.
Description of Types of Wounds on Living Victims Due to Persecution who Come to the Emergency Installation of Drs. H. Amri Tambunan Hospital, Deli Serdang, in 2020-2021 Abdul Gafar Parinduri; Muhammad Reza Restu Fauzi
Buletin Farmatera Vol 7, No 3 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i3.12137

Abstract

Background. About 50-70% of cases that come to the Emergency Installation are cases of injury or trauma. Injuries to these patients can occur as a result of accidents, abuse, attempted suicide, disasters, and terrorist attacks. Aim: This study aims to describe the types of injuries to living victims due to abuse who came to the Emergency Installation of drs. H. Amri Tambunan Hospital, Deli Serdang from January 1, 2021 to December 31, 2021. Method: The research design is an observational study using analytical descriptive methods and a retrospective approach using the data from visum et repertum report of survivors as a result of persecution who came to the Emergency Installation of drs. H. Amri Tambunan Hospital, Deli Serdang. Results: Out of 273 survivors of abuse, 69.6% involved mechanical trauma and the majority of mechanical trauma occurred to females (52.6%) and the most common pattern of injury was abrasions (58.2%). Conclusion: Based on the results of this study, the most common type of wound encountered was mechanical trauma with a pattern of abrasions.
Perception of Pharmacists as Agents of Change About the Use of Traditional Medicines by Indonesian Society Sri Suwarni; Aris Widayati; Nurista Dida Ayuningtyas
Buletin Farmatera Vol 7, No 3 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i3.11424

Abstract

Abstract: Pharmacists, as one of the professional health workers, have a big responsibility related to the use of traditional medicines, especially pharmacists in the community who deal directly with consumers, starting from choosing to use, ensuring the safety of use, and providing education about traditional medicines. This study aims to explore the perception of pharmacists as agents of change (AoC) and whether they are ready to take an active role in Indonesian society in the use of traditional medicines. Exploratory observation is used to deepen knowledge and seek new ideas about a particular phenomenon with non-participatory observation steps. The results of this study show that many people still use traditional medicine because of the suggestions and beliefs of the community from generation to generation. Pharmacists have been able to play an active role as a source of information on conventional medicines in the community. The conclusion is that people have used a lot of traditional medicine for curing disease or trying to increase stamina, even with information on the efficacy and dosage of use according to hereditary information.
Sholat Dhuha May Reduce The Risk of Knee Osteoarthritis in The Elderly: Preliminary Research Elman Boy; Des Suryani; Debby Mirani Lubis; Balemun Kaisar Harahap
Buletin Farmatera Vol 7, No 3 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i3.11939

Abstract

Abstract: Osteoarthritis is one of the most common degenerative diseases that attack the joints and cause deformity in the elderly. The purpose of this study was to investigate the link between dhuha prayer and the risk of knee osteoarthritis (kOA). Methods: cross-sectional and purposive sampling, with inclusion criteria including Muslim women cured in the Government Binjai Senior Care, age greater than or equal to 60 years, communicative, signing informed consent, and providing complete answers to the WOMAC questionnaire to assess kOA risk. The interview form was used to count the number of rak'ahs of dhuha prayer that are usually performed every day. SPSS was used to analyze the data, and the Spearman Rank test was used. The research criteria were met by 30 of 101 prospective respondents. The respondents ages range from 60 to 85 years old, 68% are at risk of mild kOA, and there is a link between the number of rak'ahs of dhuha prayer and a lower risk of kOA. Conclusion: The more rak'ahs of dhuha prayer that are performed on a daily basis, the lower the risk of KOA.
The Relationship of Environmental Factors to the Incidence of Malaria in Different Countries: Systematic Review Muhammad Aandi Ihram; Hamzah Hasyim; Hilda Zulkifli; Didit Haryanto
Buletin Farmatera Vol 7, No 3 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i3.11609

Abstract

Comparison of Covid-19 Vaccine Hesitancy in Healthy Adult Populations and Patients with Anxiety Disorders Annisa Annisa; Nanda Sari Nuralita; Yulia Afrina Nasution
Buletin Farmatera Vol 7, No 3 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i3.11949

Abstract

Vaccine hesitancy is one of the world's health problems that poses a threat to global health. This condition is influenced by various things, one of which is a mental condition. Willingness to receive vaccines, especially during the Covid-19 pandemic is very important. This study is a cross-sectional study involving 73 patients with anxiety disorders and 63 healthy adults. About 80% of the subjects were willing to be vaccinated. Based on the level of confidence in the vaccine, 90% of the subjects (66.20%) believed in the usefulness of the vaccine. A total of 39 people (28.7%) lacked confidence in vaccines. There were 28 subjects who refused vaccination, of which 26 were anxiety sufferers. The most common reasons for reluctance to vaccinate are fear of side effects (29.4%) and fear of injections (13.2%). In this study, 80% of the subjects had been vaccinated, according to the government's vaccination target. However, to maintain the success of long-term vaccination programs in populations with certain diseases, a more specific approach is needed.
Gambaran Penerima Transfusi Darah Pada Ruang Rawat Pediatrik di Rumah Sakit Umum Cut Meutia (RSCM) Aceh Utara 2019 2020 Teuku Ilhami Surya Akbar; Syifa Chairunnisa; Vera Novalia
Buletin Farmatera Vol 7, No 3 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i3.11575

Abstract

Abstract: Giving blood or blood components from a healthy person (donor) to another person is known as blood transfusion. A blood transfusion is intended to save a person's life. The number of blood donors has increased in the last decade, but it is still insufficient to meet the demand for blood. According to WHO guidelines, at least 2% of the total population requires blood, but the use of blood in hospitals is currently very limited. Adults receive blood transfusions more frequently than children and neonates. In adults, it is most commonly used in internal medicine, and in children, it is most commonly used in cases of thalassemia. The purpose of this study is to identify the characteristics of patients receiving transfusions in the pediatric ward at Cut Meutia General Hospital in North Aceh in 2019-2020. The descriptive method was used in the research. Total sampling was used in this study, thedata taken from the patient's medical records at the North Aceh Hospital in 2019-2020 obtaining 89 samples. The study's results for transfusion recipients were frequently found in male sex (55.1%), at 5 years - 11 years (38.2%), blood type O (51.7%) frequentlywith rhesus positive (98.9%). Thalassemia patients received the majority of blood transfusions (50.0%), and blood components were almost always PRC (98.9%). The conclusions in this study were male blood transfusion recipients, aged 5-11 years, blood type O rhesus positive, diagnosis of thalassemia and blood components used by PRC.
Intra Articular Injection of Mesenchymal Stem Cells in Osteoarthritis of the Knee Joint: A Systematic Review Ilham Hariaji
Buletin Farmatera Vol 7, No 3 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i3.11981

Abstract

Abstract: Treatment of osteoarthritis in the knee joint is carried out by sharing efforts. In addition to pharmacological therapy, it is also carried out therapy with the method of intra-articular injection of mesenchymal stem cells directly into the knee joint. This systematic study aims to find out the extent to which this method has been studied as well as the benefits of intra-articular knee joint by means of mesenchymal stem cells. This study was conducted as a systematic study by searching journal literature through the Google Scholar application with the keyword intra articular injection mesenchymal stem cells on knee osteoarthritis in the last 5 years, using a prism diagram classification system in article selection. The results of the selection found 41 articles that were included in the inclusion criteria. The results of the study found that there have been many studies of intra-articular injection therapy of mesenchymal stem cells from various sources. Research was carried out both pre-clinical and clinical, and assessment methods were carried out with various methods to see the results of the therapy given, and 90% showed the results of structural, functional, and clinical improvement of the knee joint. From the results of these studies, it is concluded that there have been many studies conducted and most have shown that this method provides benefits.

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