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Buletin Farmatera

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Published by Universitas Muhammadiyah Sumatera Utara

ISSN : 2528410X EISSN : 2528410X DOI : -

Core Subject : Health,

Medicine & Pharmacology

Arjuna Subject : -

Articles 242 Documents

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THE IMPACT OF LONGER WORKING TO MERCURY LEVEL (HG) IN BLOOD OF THOSE TRADITIONAL GOLD MINERS AT DESA PANTON LUAS KABUPATEN ACEH SELATAN Syafruddin Din
Buletin Farmatera Vol 4, No 3 (2019)
Publisher : Universitas Muhammadiyah Sumatera Utara

It is seen traditional gold mining workings where there use mercury to process out amalgamation has been done for more than 4 years already at Desa Panton Luas. This paper is to determine the impact of longer work with Mercury level existed in the blood of those mining workers with traditional gold miners on the location. This paper is descriptive research and found that the mercury level existed in blood for a working period of average a year noted 5.57 ppb, for 2 years average noted 6.52 ppb, in three years average 7.34 ppb, and for 4 years average noted 8.95 ppb. As has been conducted in statistical test analysis indicated that there is a difference between a long-time off work in a year to 4 years serving with p < 0.05. Still, an existing difference of increasing mercury level in blood with a long time of one, two, three and four years serving in the field but it is threshold value as recommended by WHO namely 5-10 ppb. Keywords: mercury blood level, long duration of working, gold mining

PREDICTORS OF IN-HOSPITAL LENGTH OF STAY IN NSTEMI PATIENTS Ahmad Handayani; Andika Sitepu; Faisal Habib
Buletin Farmatera Vol 4, No 3 (2019)
Publisher : Universitas Muhammadiyah Sumatera Utara

As our population grows older, the rate of NSTEMI patients is rising. Risk stratification is an important process for patients with Non-ST Elevation Myocardial Infarction (NSTEMI). Global Registry of Acute Coronary Events (GRACE) scores in the best to predict mortality and myocardial infarction in NSTEMI Patients. On the other hand, NSTEMI Patients trends to be older with more co-morbidity. In this scenario, we need to predict the length of stay as it correlates with the patient's prognostic and cost. This study aims to analyze factors influencing the in-hospital length of stay in survivor NSTEMI Patients in four different hospitals (Adam Malik Medan National General Hospital, Pirngadi Medan General Hospital, Grandmed Lubuk Pakam General Hospital, and Aceh Tamiang Public General Hospital). This was an observational study with prospective design conducted on 44 patients in four different hospitals from March to May 2017. We only included the patients that discharged alive from the. hospital Statistical analysis was performed to assess the routine clinical and laboratory variables relations with the length of stay. Prolong length of stay was defined as more than 5 days. As mentioned in the previous study, older age, heart failure will prolong the length of stay. The limitations of this study were we didn't analyze the effect of revascularization, the co-morbidities, and the method of patient’s payment. We should use GRACE and TIMI risk score routinely, optimizing therapy for heart failure and giving special attention to elderly patients in NSTEMI Patients.Keywords: NSTEMI, GRACE, Length of Stay

THE DIFFERENCE BETWEEN THE EFFECTS OF CONTINUOUS RUNNING AND INTERVAL RUNNING TRAINING METHODS ON MAXIMUM OXYGEN VOLUME (O2) OF FOOTBALL ATHLETES AT EDUCATION CENTERS AND STUDENT TRAINING (PPLP) ACEH PROVINCE Hadi, Amirul
Buletin Farmatera Vol 4, No 3 (2019)
Publisher : Universitas Muhammadiyah Sumatera Utara

The increase in aerobic exercise is influenced by cardiovascular performance, so to improve aerobic exercise it is necessary to increase the VO2 Max value. The purpose of this study is to prove the differences in the effect of continuous running and interval running exercises on VO2 Max in soccer athletes in PPLP Aceh Province. This study used analytic experimental with pre-test and post-test design. The study was conducted at the Harapan Bangsa Stadium in Banda City with a sample of 52 soccer athletes. Data analysis using Independent Sample T-Test. The result is there was an overall difference between continuous running practice and interval running for VO2 max PPLP soccer athletes in Aceh Province. The average VO2 max with the continuous running method exercise is 61.9 better than the running interval is 54.9. Sig value (2-tailed) VO2 max data is 0.001 This means that there was a difference between continuous running and interval running exercises. From these results, it can be concluded that to improve the VO2 max of a professional soccer athlete, training with the continuous running method is recommended compared to the interval running training method.Keywords: Continuous running, Interval running, and VO2 Max

MODULATION OF BONE TISSUE HISTOMORPHOMETRY AND MALONDIALDEHYDE EXPRESSION LEVELS BY VITAMIN C IN RODENTS AFTER PRENATAL NOISE EXPOSURE Taya Elsa Savista; Viskasari Pintoko Kalanjati; Abdurachman Abdurachman
Buletin Farmatera Vol 4, No 2 (2019)
Publisher : Universitas Muhammadiyah Sumatera Utara

Abstract: Vitamin C is proposed as an antioxidant to combat the oxidative stress of prenatal noise exposure in bone tissue of newborn Wistar rats. Thirty-two Wistar mothers were administered oral vitamin C 150 mg/kg BW/day from D1 of pregnancy until delivery; white noise exposure of 95 dB, 4 hr/day was given from D15 of pregnancy until delivery. Newborn rats were divided into 4 groups equally (n=24): K1 (distilled water), K2 (vitamin C), P1 (distilled water + WN), P2 (vitamin C + WN). The osteoblast and osteoclast mean cell numbers, the osteoid volume, and an oxidative stress expression level marker of malondialdehyde (MDA) were calculated from two adjacent longitudinal slices of newborn rats’ tibiae using Cell Sense and ImageJ softwares (4 μ; 400x of light microscope magnification). Data were analyze using either ANOVA and LSD post-test or Brown-Forsythe and Games Howell post- test; significance level if p<0.05. In P2, the mean number of the osteoblast was significantly higher than in P1 (p<0.001); whilst the osteoclast mean number was significantly lower compared to other groups (p=0.03). In P2, the osteoid volume was significantly higher than in P1 (p=0.021); with lower MDA levels than P1 (p=0.074). From this study, vitamin C could protect the newborn rat bones exposed by prenatal noise as an oxidative stressor.Keywords: vitamin C, prenatal noise, osteogenesis, malondialdehyde

EFFECTIVENESS OF PREEMPTIVE ANALGESIA IBUPROFEN 10 MG / KGBB PER ORAL FOR POSTOPERATIVE PAIN MANAGEMENT IN CHILDREN UNDERGOING MASS CIRCUMCISION Muhammad Jalaluddin Assuyuthi Chalil
Buletin Farmatera Vol 4, No 3 (2019)
Publisher : Universitas Muhammadiyah Sumatera Utara

Management of post-mass circumcision pain is often overlooked and not optimal because the administration of analgesia will be given when circumcision is complete. This study aims to determine the effectiveness of oral 10 mg / KGBB ibuprofen as preemptive analgesia for the management of post mass circumcision pain. After obtaining permission from the ethics commission of the FK UMSU clinical research, a prospective double-blind randomized controlled clinical trial was conducted on 28 children in consecutive sampling who met the inclusion and exclusion criteria. Samples were randomized into 2 groups, A was given ibuprofen 10 mg/kg BW orally 1 hour before incision and B was given ibuprofen 10 mg/kg BW orally at the time immediately after the circumcision was completed. Pain scale measurements were performed using FPR-S (Faces Pain Scale-Revised) at the 1st, 2nd, 4th, 6th and 8th postoperative hours. Monitoring of the 1st to 4th hours is carried out at the location of the activity, while the 6th to 8th hours are carried out by telephone. There was a significant decrease in pain scale at the 1st hour (p = 0.031) in group A. At the second to eighth-hour monitoring, the effectiveness of the two methods was the same. In conclusion, the method of preemptive analgesia is effective for the management of post-mass circumcision pain.Keywords: preemptive analgesia, post-circumcision pain

ASSOCIATION OF PPARΑ INTRON 7 G/C (RS4253778) POLYMORPHISMS WITH MUSCULAR ENDURANCE AMONG SOCCER SCHOOL STUDENTS IN MEDAN Roy Wilson Sihaloho; Yahwardiah Siregar; Maya Savira
Buletin Farmatera Vol 4, No 3 (2019)
Publisher : Universitas Muhammadiyah Sumatera Utara

Peroxisome proliferator-activated receptor alpha (PPARα) is the transcription factor gene that regulates lipid metabolism and glucose homeostasis of energy within the mitochondria. PPARα gene Intron 7 variation is associated with the phenotype of human performance. Homozygous GG is more often found among athletes concerning muscular endurance. This study aims to investigate the association of PPARα polymorphism with muscular endurance. Samples from buccal cells were collected from 77 boys (aged 11-16 years). PPARα Intron 7 polymorphism was examined using PCR-RFLP with restriction enzyme TaqI. Meanwhile, the Curl-Up test has been performed to determine the muscular endurance of the subjects. The relationship between PPARα Intron 7 polymorphism with muscular endurance was assessed by using Fisher’s Exact test. The study found the genotype GG and GC of 97.4% and 2.6%, respectively. Muscular endurance was shown among categories of poor (66.2%) and fair (15.6%). Statistical analysis established no association between PPARα polymorphism with muscular endurance (p = 0,564). Keywords: PPARα polymorphisms, muscular endurance, Curl-Up test

PROFILE OF MICROORGANISMS CAUSING VAGINAL DISCHARGE IN REPRODUCTIVE WOMEN AT DR. PIRNGADI HOSPITAL IN MEDAN Iqrina Widya Zahara; Irma Damayanti Roesyanto; Sri Amelia
Buletin Farmatera Vol 5, No 1 (2020)
Publisher : Universitas Muhammadiyah Sumatera Utara

Leucorrhoea or Fluor albus or leukorrhea vaginal discharge is the discharge of fluid other than blood from the vaginal canal out of the ordinary, either smelling or not, and accompanied by local itching. There are two factors that cause leucorrhoea, namely endogenous factor such as abnormalities in the vagina and exogenous factor which are infection and non-infection. The aim of this study is to find the profile of microorganisms causing vaginal discharge in reproductive women. This is a descriptive study with cross-sectional method conducted at the Skin and Genital Polyclinic of the Sexually Transmitted Infectious Disease Division and the Obstetrics and Gynecology Clinic of Pirngadi Hospital, Medan. Populations that have met the inclusion and exclusion criterias were included in the study. Vaginal discharge samples will be sent to the microbiology laboratory and the parasitology laboratory of faculty medicine of University of North Sumatera to examine the gram staining, KOH staining, bacterial and fungal cultures and wet preparations for parasites. Out of a total of 50 people, the majority of the sample are in aged 31-40 years, with a history of high school education and working women. The most types of vaginal discharge are pathological (84%) and the most common cause of vaginal discharge is a fungal infection by Candida sp (90%) followed by bacterial infection by Staphylococcus aureus (64.8%) and Klebsiella (20.3%)

ANTIHIPERGLICEMIC THERAPY COMPLIANCE WITH HbA1C LEVELS IN TYPE 2 DIABETES MELLITUS PATIENTS AMONG PEKANBARU PROLANIS PARTICIPANTS Dimas Pramita Nugraha; Eni Karmila Asni; Ligat Pribadi Sembiring Pribadi Sembiring
Buletin Farmatera Vol 5, No 1 (2020)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v5i1.4203

One of the pillars in the management of Type 2 Diabetes Mellitus (DM) is pharmacotherapy, i.e. the use of antihyperglycemic drugs. Success in DM management is influenced by patient compliance to the pharmacotherapy given. One indicator of controlling Type 2 DM is HbA1c levels. This study aimed to analyze the relationship between antihyperglycemic therapy compliance and the HbA1c levels in Type 2 DM patients in the Chronic Disease Management Program in Pekanbaru. Method. This was a cross-sectional study. Samples were taken by consecutive sampling method. Laboratory examination was carried out to obtain HbA1c levels, the value of which was categorized controlled if <7%. The compliance with the use of antihyperglycemic drugs was assessed using Medication Possession Ratio (MPR). Patients were considered compliant if they had an MPR of ≥80%. Data were analyzed using the Fisher Exact test. Results. Most of the 48 patients had uncontrolled HbA1c levels (87,5%). The level of non-compliant patients was also very high (91,7%). This study showed a significant relationship between pharmacotherapy compliance and HbA1c levels (p <0.05). Discussion. There was a relationship between pharmacotherapy compliance and the level of HbA1c in Type 2 DM patients. Physicians should pay more attention to patients with low compliance as it may increase the risk to a high HbA1c level

CORRELATION OF NUTRITIONAL STATUS WITH THE INCIDENCE OF ACUTE DIARRHEA IN ONE TO THREE YEARS CHILDREN AT AMPLAS HEALTH CENTER IN 2015 Ashry Ramadhana Ginting; Amelia Eka Damayanty
Buletin Farmatera Vol 5, No 1 (2020)
Publisher : Universitas Muhammadiyah Sumatera Utara

Nutritional status is a body condition as a result of food consumption and infection status. Nutritional status can be a risk factor of diarrhea. The aim is to determine the correlation of nutritional status with the occurrence of acute diarrhea in children beetween one to three years old at Puskesmas Amplas in 2015. This research is an analytic method of cross sectional and analysis of Chi Square. Using a secondary data from medical records of Puskesmas Amplas. All of bad-nourished respondence often suffering an acute diarrhea within one month. A well-nourished respondence who often suffer from acute diarrhea is 16,7%, and all of obese respondence often suffering an acute diarrhea. There is a correlation between the nutritional status with the occurrence of acute diarrhea with p value is 0,000 (p<0,05) in this research

THE EFFECT OF WORK STRESS ON NURSE PERFORMANCE IN THE INPATIENT WARDS TANJUNG PURA HOSPITAL ON 2016 Nopa, Ika; Zulfendri, Zulfendri; Fauzi, Fauzi
Buletin Farmatera Vol 5, No 1 (2020)
Publisher : Universitas Muhammadiyah Sumatera Utara

Nursing care in a hospital is an integral part of health service. A nurse has constant contact with patients within 24 hours, and her work demands can potentially cause stress. The main purpose of the research was to find out the influence of work stress on nurses' performance in the Inpatient Wards.The research was a survey with an explanatory research method to find out the influence of work stress on nurses' performance in the Inpatient Wards of RSUD (Regional General Hospital) Tanjung Pura. The population was 63 nurses in the Inpatient Wards, and all of them were used as the samples since their numbers were relatively small. The data were gathered by conducting in-depth interviews and reporting data were obtained from the hospital. The gathered data were analyzed by using a linear regression statistic test.The result of the research showed that 77.8% of the respondents had moderate performance, 14.3% of the respondents had a good performance, and 7.9% of the respondents had a bad performance. It was also found that the variable of work stress influenced the performance at p-value = 0.00001.It is recommended that the hospital management pay attention to the nurses? condition in each Inpatient Ward. On the other hand, the hospital management should give special attention to the work stress undergone by the nurses in the Inpatient Wards

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