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Buletin Farmatera

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Published by Universitas Muhammadiyah Sumatera Utara

ISSN : 2528410X EISSN : 2528410X DOI : -

Core Subject : Health,

Medicine & Pharmacology

Arjuna Subject : -

Articles 242 Documents

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COMPARISON OF THE EFFECTIVENESS BETWEEN RED GALANGAL RHIZOME'S (Alpinia purpurata k.schum) EXTRACT AND KETOCONAZOL 2% TO INHIBIT GROWTH OF DERMATOPHYTE â€‹â€‹FUNGI IN VITRO Pangestuti, Dewi; Harris, Bilkes; Rahman, Tuti Khairani
Buletin Farmatera Vol 5, No 1 (2020)
Publisher : Universitas Muhammadiyah Sumatera Utara

Red galangal rhizome (Alpinia purpurata k. Scum) has a larger size and has more therapeutic properties. Red galangal has compounds that can inhibit fungal growth namely flavonoids and saponins which can interfere with the function of the fungal cytoplasmic membrane, besides that they can cause leakage and aggregation of the outer cell membrane, which can inhibit the growth of dermatophytes. This study is a laboratory experimental study, using antifungal activity test with diffusion method using paper discs to see the comparison of the red galangal extract effectiveness and ketoconazole 2% on the growth of dermatophytes fungi Microsporum canis, Microsporum gypseum, and Trichophyton metagrophytes by measuring the inhibition zone around the fungal colonies. The concentrations of red galangal extract used were 10%, 20%, 30%, 40%, and 50% and used 2% ketoconazole as control. The data was analyzed using the One Way Anova test. Result of this study shown that all concentrations without 10 % of red galangal have inhibited zones of Microsporum canis, Microsporum gypseum, and Trichophyton metagrophytes but not better than ketoconazole 2 % activities.

COMPARISON OF ANTIOXIDANT AND ANTI-TYROSINASE ACTIVITY BETWEEN BLACK SOYBEAN (GLYCINE MAX (L.) MERR.) AND DAIDZEIN Delken Kuswanto; I Nyoman Ehrich Lister; Ermi Girsang; Ali Napiah Nasution; Wahyu Widowati
Buletin Farmatera Vol 5, No 1 (2020)
Publisher : Universitas Muhammadiyah Sumatera Utara

Free radicals in the body will increase with excessive of ultraviolet (UV) light exposure, induce oxidative stress with the formation of Reactive Oxygen Species (ROS). A visible effect on skin tissue known as photoaging, including the process of melanogenesis catalyzed by the tyrosinase enzyme, risked for pigmentation or melanoma disorder.The use of natural ingredients has been widely used by the community to prevent the aging process. Natural compounds from a plant can be a source of antioxidants and have anti-aging abilities through inhibition of the tyrosinase enzyme. Black soybean (Glycine max (L.) Merr.) are high in isoflavone compound, one of which is daidzein.This study evaluates the antioxidant and anti-aging potential of black soybean extract with daidzein. Antioxidants using the DPPH method and anti-aging tests carried out, namely the inhibition of the tyrosinase enzyme, are very important in the aging process.Daidzein has an IC50 value of DPPH scavenging activity around 109.34±2.80 µg/mL lower than black soybean extract with 116.52±2.50 µg/mL. Results on tyrosinase enzyme inhibition activity, black soybean extract had an IC50 value of 70.71±1.83 µg/mL lower compared to daidzein with 72.65±2.81 µg/mL. In contrast to the better antioxidant activity of daidzein, the black soybean extract are more potential to inhibit the enzyme tyrosinase

The Relationship Between Body Mass Index and Urinary Creatinine in Adolescent Girls Nita Andriani Lubis; Geminsah Putra H Siregar; Mardan Ginting
Buletin Farmatera Vol 5, No 2 (2020)
Publisher : Universitas Muhammadiyah Sumatera Utara

Adolscent girls phase (12-21 years) is a very important individual development segment, beginning with the maturation of physical and reproductive organs that characterize women of childbearing age. Body mass index (BMI) is one of indicator used to see women of childbearing age status related to pregnancy. Kidney damage causes an increase in urinary creatinine but high urinary creatinine does not necessarily indicate kidney damage. Our objective is to determine the relationship between BMI and urine creatinine in adolscent girls in several Medan health schools. We performed an observasional study with cross sectional design of 56 participants 19-21 old girls. 24 hours urine creatinine concentration was measured using jaffe reaction method. The highest average BMI value (21.10 kg/m2 is the normal category (75%), mean urine creatinine concentration (1263,86 mg/24 hour) is also normal category. Data analysis with spearman correlation between BMI and 24-hour urine creatinine level was not statistically different (p = 0.140). High BMI values tend to have high 24-hour urine creatinine levels too, but statistically there was no significant relationship between 24-hour urine creatinine levels and BMI values in this study.

Overview of The Incidence of Hyperprolactinemia Side Effects in Schizophrenia Patients With Antipsychotic Therapy Vivinia RA Putri; Dita Hasni; Nadia Purnama Dewi; Mutiara Anissa
Buletin Farmatera Vol 5, No 2 (2020)
Publisher : Universitas Muhammadiyah Sumatera Utara

Antipsychotic-induced hyperprolactinemia disorder affects the morbidity and quality of life of the patient, and can lower the patient's adherence to taking antipsychotics, thereby lowering the therapeutic success rate. This study aims to figure out the incidence of hyperprolactinemia side effects in schizophrenia patients receiving antipsychotic therapy. This descriptive research was conducted at HB Saanin Psychiatric Hospital Padang in January-June 2018. The population in this study is all schizophrenia patients in the HB. Saanin Psychiatric Hospital Padang Year 2018 and involved participants as many as 100 people recruited in consecutive sampling. Data were analyzed using a descriptive statistical method. The results showed that more than half of the patients were 59 people (59.0%) hyperprolactinemia. Patients with gynecomastia amounted to 16 people (16%). Patients with galactorrhea amounted to 3 people (3%). Patients with sexual dysfunction amounted to 19 people (19%). Male patients amounted to 60 people, 21 people (35%) The sexual dysfunction of female patients amounted to 40 people, 26 people (65%) Menstrual cycle changes. More than half of the Schizophrenia patients receiving antipsychotic therapy in this study suffer symptoms of hyperprolactinemia in the manifestation of galactorrhea, gynecomastia, menstrual disorders, and sexual dysfunction.

Effects of Corn Silk (Stigma Maydis) Against Blood Glucose Levels of Type 2 Diabetes Mellitus Patients Alimin, Laurencia
Buletin Farmatera Vol 5, No 2 (2020)
Publisher : Universitas Muhammadiyah Sumatera Utara

According to WHO, in 2017 there are an estimated 425 million sufferers of diabetes mellitus. Indonesia is placed in the seventh rank in the world in 2015, with an estimated 10 million sufferers. To reduce the prevalence of type 2 diabetes mellitus, improvements need to be made, such as lifestyle modification and treatment. Most anti-diabetic drugs have high side effects. Corn silk is one of the natural ingredients that contain flavonoids, which can reduce blood fat levels. The dose of corn silk of 500 mg/kg BW is the best substance against diabetic rats from excessive weight loss. Therefore, corn silk can be calculated to have an anti-diabetic effect by using lipids, eliminating free radicals, and increasing antioxidant capacity.Â

The Difference of Effectivity Between Nutmeg Seed Extract (Myristica Fragrans Houtt) and Diazepam Based on Sleep Induction Time on Swiss Webster Mice Arif Azhari Nasution; Debby Mirani Lubis
Buletin Farmatera Vol 5, No 2 (2020)
Publisher : Universitas Muhammadiyah Sumatera Utara

According to the National Sleep Foundation in America, more than one third (36%) of young adults aged 18-29 years reported having difficulty getting up early (compared to 20% at 30-64 years old and 9% over 65 years). The National Sleep Foundation also states that in Indonesia the prevalence of insomnia sufferers reaches 70% at least once a week and 30 million people have difficulty sleeping every night. This study is an experimental study with a post-test only control group design. The samples used were 27 male Swiss webster mice which were divided into three groups. The treatment group was given nutmeg seed extract at a dose of 7.5 mg / kgBW; the positive control group was given diazepam, and the negative control group was given aquabidest. The results showed the difference in the average value of sleep induction time in the treatment group was 2.97 minutes, positive control group 5.06 minutes, and negative control group 8.43 minutes with p = 0.00. Conclusion: There is a significant difference between the effectiveness of nutmeg seed extract 7.5 mg / kgBW with diazepam based on the time of sleep induction in Swiss webster male mice.

Resistance Test of Aedes aegypti Mosquito Larvae Against Organophosphate Insecticides at Medan Selayang Zahir Husni Lubis; Nurfadly Nurfadly
Buletin Farmatera Vol 5, No 2 (2020)
Publisher : Universitas Muhammadiyah Sumatera Utara

Aedes aegypti is the main vector in several diseases such as Dengue Hemorrhagic Fever (DHF).Various types of efforts to control Aedes aegypti were carried out to terminate the transmission chain by spraying (organizing) the organophosphate insecticide. The use of irrational insecticides causes an increase in esterase enzymes, giving rise to the resistance of Aedes aegypti to insecticides. The purpose of this study is to determine the resistance status of Aedes aegypti larvae to organophosphate insecticides in Medan Selayang. The type of research used in this study is descriptive research with cross-sectional methods, using 276 larvae of Aedes aegypti. The results of this study are mosquito larvae that are susceptible (sensitive) to organophosphate insecticides by 66.3%, while mosquito larvae that are tolerant (moderate resistance) of organophosphate insecticides are 33.7% and resistant (high resistance) mosquito larvae were not found. There is 33.7% of Aedes aegypti larvae are tolerant (moderate resistance) to organophosphate insecticides and resistant (high resistance) mosquito larvae were not found.

Role of Breastfeeding and Onset of Atopic Dermatitis in Children Patient: a Cross Sectional Study Arridha Hutami Putri; Sri Wahyuni Purnama; Irma Damayanti Roesyanto
Buletin Farmatera Vol 5, No 2 (2020)
Publisher : Universitas Muhammadiyah Sumatera Utara

Abstract: Atopic dermatitis (AD) is a multifactorial disease belongs to the "burden disease" in childhood. It needs to be prevented to reach their optimal growth. Exclusive breastfeeding given during the first six months of life provides nutritional benefits and is thought to protect children from allergic or infectious diseases, such as AD. This study aims to determine the relationship between breastfeeding and onset of atopic dermatitis. This was an observational analytic study using cross-sectional method. Samples were taken consecutively at the Dermatovenereology Polyclinic of referral hospital and Puskesmas in Medan. This study included all pediatric patients aged 6 months to <18 years diagnosed with AD and were interviewed with informed consent. Children who didn’t get breastmilk were excluded. There result was a significant relationship between breastfeeding (exclusively to partially) and AD onset. There was no relationship between breastfeeding (exclusively to prelacteally) and AD onset. Polyunsaturated fatty acids, sIgA, and TGF-β2 in the breast milk of mothers with atopy is lower than mothers without atopy. Breastfeeding exclusively has a protective effect on AD. Further research is needed to analyzes various factors by comparing genetic predisposition.

The Relationship of Cognitive Function to Nutritional Status and Blood Pressure in the Tegal Sari Mandala Village, Medan City Nuralita, Nanda Sari; Damayanti, Amelia Eka
Buletin Farmatera Vol 6, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i2.3316

Cognitive function is an intellectual function that plays a role in carrying out daily activities. The main risk factor for impaired cognitive function is hypertension. In addition, nutritional status also influences cognitive function disorders. Currently, in Indonesia, people with increased blood pressure and unbalanced nutritional status are often found, and without realizing it can have a bad influence on cognitive function. This is a categorical analytic study with a cross-sectional method, the sampling method is non-probability sampling with consecutive sampling types, with a sample of 40 people. There is a significant difference between the difference in blood pressure on cognitive function and there is also a significant difference between nutritional status on cognitive function with a P-value = 0.001. There is a significant difference between cognitive function on blood pressure and weight gain

Correlation of 25 Hydroxyvitamin D3 Levels with Blood Pressure and Lipid Profile, in Healthy Individuals Sari, Mutiara Indah; Sanny, Sanny
Buletin Farmatera Vol 6, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i2.6892

Vitamin D is a prohormone and its level correlated with several cardiovascular diseases (CVD) biomarker such as blood pressure (systolic and diastolic) and lipid profile (total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C). This study aim to analyze correlation of serum 25-hydroxyvitamin D/ 25(OH)D levels with blood pressure and lipid profile in healthy subjects. This cross-sectional study was conducted on 39 healthy subjects from gym in Medan city. Measurement of vitamin D levels using Enzyme Linked Immunosorbent Assay (ELISA). Blood pressure was measured twice after 10 minutes rest using mercury sphygmomanometer. Lipid profile were measured by Cobas 6000 (C510+E610). Correlation of 25(OH)D with blood pressure and lipid profile were analyzed using Spearman correlation test. There was a significant correlation between of 25(OH)D levels and diastolic blood pressure (p = 0.047, r = -0.272), but not in systolic blood pressure and the lipid profile: TC, TG, HDL, and LDL, respectively. (p = 0.159, p = 0.290, p = 0.425, p = 0.492, p = 0.156). This study concluded that 25(OH)D levels was correlated with diastolic blood pressure with low correlation, in that decreasing of 25-hydroxyvitamin D levels will increased diastolic blood pressure.

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