Garuda - Garba Rujukan Digital

Article Per Year (5 Year)

All

Buletin Farmatera

buletin_farmatera
Website

Published by Universitas Muhammadiyah Sumatera Utara

ISSN : 2528410X EISSN : 2528410X DOI : -

Core Subject : Health,

Medicine & Pharmacology

Arjuna Subject : -

Articles 242 Documents

4 5 6 7 8

Karakteristik Gen Nrf2 ( Nuclear Respiratory Factor 2 ) Dan Gen Actn-3 (R577x) Siswa Sekolah Sepak Bola Di Kota Medan Karolina Surbakti; Martina Evelyn R.H; Gusbakti Rusip; Bintang Y.M Sinaga
Buletin Farmatera Vol 4, No 1 (2019)
Publisher : Universitas Muhammadiyah Sumatera Utara

Penelusuran genetik dapat menjadi salah satu metode talent profiling pada atlet sepak bola. Gen yang berhubungan dengan performa atletik adalah gen NRF2 dan ACTN3. Gen NRF2 dikenal juga GA-binding protein transcription factor sub unit β (GABPBI) gen ini terdapat pada DNA mitokondria dan merupakan faktor transkripsi pada biogenesis mitokondria. Gen ACTN-3 merupakan gen yang mengkode sebuah protein sarkomer yang hampir secara keseluruhan diekspresikan dalam serat otot cepat dan menghasilkan daya ledak. Tujuan penelitian ini untuk melihat variasi gen NRF2 dan gen ACTN3 pada siswa sekolah sepak bola yang berusia 11-14 tahun yang berjumlah 33 orang.Identifikasi gen NRF2 dan gen ACTN-3 diidentifikasi menggunakan PCR-RFLP dari sampel sel bukal. Hasil studi menunjukkan varian gen NRF2 secara mayoritas adalah genotip AA (homozygote) sebanyak 29 orang (87,90%) sebanyak 29 orang (87,90%), sedangkan genotip AG sebanyak 4 orang (12,12%) (heterozygote). Varian genotip GG tidak ditemukan dalam penelitian ini. Varian genotif ACTN-3 adalah genotip RX (heterozygote) sebanyak 14 orang (42,4%), sedangkan genotip XX sebanyak 13 orang (39,4%) (homozygote) danvarian genotip RR sebanyak 6 orang (18,2%) (homozygote)

Prevalensi Dermatitis Kontak di Satuan Medis Fungsional Kulit dan Kelamin RSUP. H. Adam Malik Periode Januari 2010 â€“ Desember 2010 Nopa, Ika
Buletin Farmatera Vol 4, No 1 (2019)
Publisher : Universitas Muhammadiyah Sumatera Utara

Contact dermatitis is a dermatitis caused by the material or substance that sticks to the skin. Data from NIOSH foundÂ from 372,000 work-related illness were reported 12% is a skin disease or disorder and 80% of occupational skin disease is contact dermatitis. To observe the progression of this disease, therefore a research was conducted to observe the latest prevalence of contact dermatitis.The purpose of this research is to find out the prevalence of contact dermatitis atÂ Dermatology Polyclinik of Haji Adam Malik General Hospital, Medan in January 2010 -December 2010. Â This is a descriptive study and the design is cross-sectional study. Population in this research was all medical records of contact dermatitis from January 2010 - December 2010, and samples were taken by simple random sampling method and 97 medical records sampled. All the collected data were calculated with SPSS and presented in distribution tables.Results showed the prevalence of contact dermatitis patients is 660 patients (11.65%) of the entire population, with the highest percentage found in the female as many as 62 patients (63.9%) of the sample. Based on age group, the highest prevalence found in 30-39 years old as many as 28 patients (28.9%) of the sample. Based on the type of work, the highest prevalence found in housewives as many as 31 patients (32%) of the sample. Based on the location of contact dermatitis, the highest prevalence found in the hands of the 35 patients (36.1%) of the sample. Based on the type of work, location of most lesions on housewives found on the hand, and that 18 of 31 patients.

Polymorphism TaqIA Gen Dopamine D2 Receptor In Men Aged Start From 40 Years Old With Metabolic Syndrome Compared To Non Metabolic Syndrome Syahputra, Muhammad Budi
Buletin Farmatera Vol 4, No 1 (2019)
Publisher : Universitas Muhammadiyah Sumatera Utara

Introduction : Metabolic syndrome involves heritability , genetic , bad diet and lack of physical activity . One cause of the Metabolic Syndrome is a genetic abnormality in the dopamine D2 receptor gene that causes " Reward Deficiency Syndrome ".Aim: To investigate the relationship between polymorphisms of the dopamine D2 receptor gene Taq1A in men starting from 40 years of age with metabolic syndrome compared to those without metabolic syndrome.Methods: This research was done as an unpaired analytical research using case control design . The research subject is stored DNA isolates originating from metabolic syndrome 21 and 21 are non metabolic syndrome . Thermal Cycle process performed on isolates DNA using PCR techniques with applications located on a 310 bp band with a 2 % agarose gel , then the application in digestion with enzyme Taq1A ( New England Biolabs Â®Inc ) and there are variant polymorphism ( T / C 310 bp , 180 bp , 130 bp ) , ( C / C 180 bp , 130 bp ) , ( T / T 310 bp ) and analyzed statistically using xÂ² test , odds ratio.Result: Based on the metabolic syndrome X Â² test was found genotype T / C at most ( 47.6 % ) , T / T ( 19.1 % ) , C / C ( 33.3 % ) with a value of p = 0.500 with a significance of p < 0 , 05 . In no metabolic syndrome T / C ( 61.9 % ) , T / T ( 9.5 % ) , C / C ( 28.6 % ) with a value of p = 0.457 with a significance of p < 0.05. Based on the distribution of allele no significant relationship.Conclusion: Based on the results of the study didnâ€™t relate to the frequency distribution of genotype and allele distribution Taq1A polymorphisms of the dopamine D2 receptor gene in men aged from 40 years with the metabolic syndrome than those without metabolic syndrome

Hubungan Beberapa Faktor Pengukuran Fungsi Paru Menggunakan Peak Flow Meter Pada Buruh Pabrik Aspal PT. Karya Murni Patumbak Deli Serdang Nanda Novziransyah; Faisal Balatif; Sinta Veronica
Buletin Farmatera Vol 4, No 1 (2019)
Publisher : Universitas Muhammadiyah Sumatera Utara

Kesehatan adalah faktor yang sangat penting bagi produktifitas dan peningkatan produktifitas tenaga kerja selaku sumber daya manusia. Tidak ada pekerjaan tanpa bahaya, tetapi dapat dihindari ketika para pekerja sadar akan resiko dan tahu cara menghilangkan atau meminimalkannya. Setiap pekerja harus memahami petunjuk kerja dengan menggunakan alat pelindung diri (APD) seperti ssarung tangan, safety shoes, atau masker. Salah satu faktor resiko yang dapat menurunkan fungsi paru adalah debu. Peak Flow Meter merupakan alat sederhana yang dapat digunakan untuk mengukur kecepatan aliran udara maksimal ketika paru pada keadaan inspirasi maksimal disebut dengan Peak Expiratory Flow Rate (PEFR). Tujuan penelitian ini untuk mengetahui hubungan beberapa faktor dengan pengukuran fungsi paru menggunakan Peak Flow Meter pada buruh pabrik aspal dii PT. Karya Murni Patumbak.Jenis penelitian yang digunakan adalah survei analitik dengan tujuan untuk mengetahui hubungan antar variabel melalui analisis statistik dengan pendekatan cross sectional. Populasi dalam penelitian ini adalah buruh pabrik aspal PT. Karya Murni Patumbak yang berjumlah 43 orang, metode total sampling digunakan untuk mengambil sampel pada penelitian ini sebanyak 43 orang. Data terdiri dari data primer yang diperoleh langsung dari hasil wawancara dan pemeriksaan fungsi paru. Teknik analisa data yang digunakan adalah analisis univariat dan bivariat.Pada hasil penelitian didapat bahwa (1) adanya hubungan antara umur dengan gangguan fungsi paru (RP=1,37); (2) adanya hubungan antara masa kerja dengan gangguan fungsi paru (RP=1,1); (3) adanya hubungan antara penggunaan APD dengan gangguan fungsi paru (RP=1,4); (4) adanya hubungan antara kebiasaan merokok dengan gangguan fungsi paru (RP=2,76) pada buruh pabrik aspal PT. Karya Murni Patumbak.Dari hasil penelitian ini disarankan kepada para buruh pabrik aspal PT. Karya Murni Patumbak agar tetap bekerja sesuai dengan SOP dan menggunakan APD sesuai pada tempatnya sehingga tercipta dunia kerja yang aman dan nyaman bagi diri sendiri, bagi rekan kerja dan lingkungan kerja. Mengurangi atau meminimalisir potensi bahaya di tempat kerja agar terhindar dari penyakit hubungan kerja dan penyakit akibat kerja. Disarankan kepada pihak manajemen PT. Karya Murni Patumbak ikut serta dan mendukung dalam menciptakan budaya K3 di tempat kerja dan lebih memperhatikan hak-hak para pekerja.

RISK FACTORS ANALYSIS OF HEARING DISORDERS DUE TO NOISE ON MACHINERY WORKERS AT UNIVERSAL STEEL FACTORY Elvira Kesuma; Muhammad Edy Syahputra Nasution
Buletin Farmatera Vol 4, No 2 (2019)
Publisher : Universitas Muhammadiyah Sumatera Utara

Abstract: Noise, being one of the threats towards occupational health, has exposed 600 million workers globally. The incidence of hearing loss caused by workplace noise is 16% in adults. There are various risk factors of hearing loss. The purpose of this study was to determine the effect of those risk factors on Universal Steel Factory’s workshop workers. This is an analytical study with a cross-sectional design. Data were collected through history taking, physical examination and pure tone audiometry for 30 workers. The data obtained were analyzed using Chi-square and Fisher's exact. There was a correlation between hearing loss with age (p = 0.001), working period (p = 0.001), noise intensity (p = 0.004), and smoking habits (p = 0.013). Therefore, age, working period, noise intensity, and smoking habits have influences to the occurrence of noise-induced hearing loss.Keywords: risk factors, noise-induced hearing loss, workshop workers

VITAMIN C PREVENTS STRESS INDUCED CARDIOMYOPATHY IN PRENATAL NOISE EXPOSED RODENTS Winnie Nirmala Santosa; Viskasari P. Kalajanti; Ni Wajan Tirthaningsih
Buletin Farmatera Vol 4, No 2 (2019)
Publisher : Universitas Muhammadiyah Sumatera Utara

Potency of oral vitamin C to prevent cardiomyopathy in prenatal noise exposed newborn Wistar rats was studied by comparing the cardiomyocyte numbers and the extracellular matrix expressions (ECM) to controls. Twenty-four newborns (NR) of 32 pregnant mothers were divided equally into 4 groups: K1 (distilled water [DW]), K2 (150 mg/kg of BW oral vitamin C once daily [VC]), P1 (4 hours daily of white noise at 95 dB [WN]+DW), and P2 (WN+VC). VC and WN were given from D1 till birth and from D15 till birth, respectively. The hearts of NR were harvested, and processed for histology slides (2 midsagittal 4 μ cut slides/ animal) stained with hematoxyllin-eosin and Masson trichrome for the cardiomyocytes and ECM quantification at the ventricles using Image Raster 3.0 and ImageJ, respectively. Pictures from 8 visual fields/ slide were taken and analyzed in duplicate (400x magnifications under a light microscope). Data were analyzed using SPSS 17; significance level of p<0.05. In P1, the cardiomyocite cell numbers was significantly lowest (p<0.001); whilst the ECM was significantly highest than K1, K2, P2 (p<0.001 and p<0.005, respectively). Here, vitamin C could prevent the adverse effect of prenatal noise exposures in the ventricle myocardium of newborn rats.Keywords: cardiomyopathy, hypertrophy, prenatal noise, vitamin C

SUDDEN DEATH DUE TO RESPIRATORY TRACT DISEASES Abdul Gafar Parinduri
Buletin Farmatera Vol 4, No 2 (2019)
Publisher : Universitas Muhammadiyah Sumatera Utara

Sudden death is death that occured within 24 hours since of the onset symptoms. Forensic cases, most occur within minutes or even the first seconds of appearance. Sudden death causes can be applied according to the body system, there are central nervous, respiratory, gastrointestinal, haemopoietic, and the endocrine system. Sudden death from respiratory illness is one of the causes of sudden and natural deaths worldwide. Incidence of sudden death in developing countries has a higher frequency. One of the respiratory ailments that causes sudden death is tuberculosis. Case report:a 35 year-old female has been carried out outside examination and in (autopsy) on the corpse. Autopsy was found that lung attachment with chest cavity. Right and left lung was full of foam mixed with pus. This verification supports that the cause of sudden death was due to chonic lung disease.Keywords: Corpse autopsy, pulmonary tuberculosis, sudden death, respiratory disease

EFFECTS OF METHANOL EXTRACT AND N-HEXANE EXTRACT OF PAPAYA LEAVES (CARICA PAPAYA L) ON TOTAL AND DIFFERENTIAL WHITE BLOOD CELL COUNTS IN MALE WISTAR RATS AFTER CARRAGEENAN INDUCTION Okto P.E Marpaung; Datten Bangun; Syafruddin Ilyas
Buletin Farmatera Vol 4, No 2 (2019)
Publisher : Universitas Muhammadiyah Sumatera Utara

As one of the countries producing medicinal plants, Indonesia has the potential to develop medicinal plants in the future. The anti-inflammatory effects of methanol and n-hexane extract from papaya leaves were seen in this study using a pretest-posttest control group design using 36 male adult Wistar rats divided into 6 groups. All rats received 1 week acclimatization, then blood specimens were taken from the tail, after which they were treated, and intraplantar injections were carried out with 1% carrageenan solution as much as 0.1 ml. Then retrieval of blood specimens from rats' tails at 3 hours and 6 hours afterwards. Then an examination of the number and type of leukocytes was performed on all blood specimens obtained. It was found that the number of male Wistar rat leukocytes after getting methanol extract of papaya leaves was lower but not significant (p> 0.05) compared to those who did not. The increase in the number of leukocytes cannot be restrained significantly by the administration of n-hexane extract. It was found that changes in leukocyte counts in acute inflammatory conditions with the administration of methanol extract and n-hexane extract of Papaya Leaves. The increase number of neutrophils and monocytes in acute inflammatory conditions can be significantly suppressed by the administration of methanol extract of papaya leaves. Key words: inflammation, carrageenan, papaya, Carica papaya l

ASSOCIATION OF DISEASE HISTORY WITH RHEGMATOGENOUS RETINAL DETACHMENT AMONG PATIENTS IN DEPARTMENT OF OPHTHALMOLOGY AT DR. MOHAMMAD HOESIN ACADEMIC GENERAL HOSPITAL PALEMBANG Amin, Ramzi; Septadina, Indri Seta; Putri, Dwi Octaverina
Buletin Farmatera Vol 4, No 2 (2019)
Publisher : Universitas Muhammadiyah Sumatera Utara

Abstract. Retinal detachment is the detachment of neuroretina from pigmented retinal epithelial layer which supplying it. Retinal detachment which is untreated could lead into permanent visual impairment. According to its etiology, retinal detachment can be classified into rhegmatogenous and non-rhegmatogenous, where rhegmatogenous cause is more common that the other. Rhegmatogenous retinal detachment is associated with many previous disease history. Research was to determine the association between previous disease history and rhegmatogenous retinal detachment in the patient in Department of Ophthalmology at Dr. Mohammad Hoesin Academic General Hospital, Palembang. This was an analytical observational study using cross sectional design. Population of study was patients which had been diagnosed as having retinal detachment at the study site. One hundred and fifty-five of 267 patients were taken as study sample by using consecutive sampling technique. Data was obtained from patientsâ€™ medical records from 1 January 2015 to 31 August 2018. Analysis of association showed the following results: previous cataract surgery (p=0,038; PR=1,309), high degree myopia (p=0,014; PR=1,400) and trauma history (p=0,036; PR=1,350). There were significant associations between previous cataract surgery, high degree myopia and trauma history with rhegmatogenous retinal detachment.Keywords: Previous cataract surgery, myopia, trauma, rhegmatogenous retinal detachment.

THE EFFECTIVITY OF THE ETHANOL EXTRACT OF EGGPLANT (SOLANUM MELONGENA L.) PEELS AS ANTIMALARIAL TO MONOCYTE IN MICE (MUS MUSCULUS) INDUCED BY PLASMODIUM BERGHEI Ari Widiyantoro
Buletin Farmatera Vol 4, No 3 (2019)
Publisher : Universitas Muhammadiyah Sumatera Utara

Malaria is a disease caused by Plasmodium that is transmitted to humans by the bite of the female Anopheles mosquito. Malaria can be treated with antimalarial drugs such as chloroquine and artemisinin, but in some endemic areas, it is reported that parasitic resistance to chloroquine was reported so that malaria eradication becomes increasingly difficult. The occurrence of this resistance causes the need for new antimalarial findings. Eggplant (Solanum melongena L.) has many secondary metabolites, one of which is solanidine which is toxic to bacteria, fungi, viruses, and protozoa. Eggplant peel was extracted by maceration method using 70% ethanol. The analysis of secondary metabolites from the ethanol extract of eggplant peels used tube test and thin-layer chromatography. The level of parasitemia and the number of monocytes were calculated from blood smear of mice (Mus musculus) which were treated with extracts at a dose of 0.075 mg/20 g of body weight; 0.15 mg/20 of body weight; and 0.3 mg/20 g of body weight. 3.744 mg/20 g of body weight Dihydroartemisinin-Piperaquine (DHP) was used as positive control and distilled water was used as the negative control. Ethanol extract of the eggplant peels contains groups of alkaloids, flavonoids, terpenoids, steroids, phenolic, and saponins. 0.075 mg/20 g body weight of ethanol extract of the eggplant peels effectively reduces parasitemia and 0.3 mg/20 g body weight of ethanol extract of the eggplant peels effectively increases the number of monocytes in mice. There is no correlation between an increase in the number of monocytes and a decrease in the level of parasitemia. Keywords: antimalarial, eggplant, monocyte, Plasmodium berghei, Solanum melongena L.

Page 6 of 25 | Total Record : 242

4 5 6 7 8

Filter by Year

2016 2026

Filter By Issues

All Issue Vol 12, No 1 (2027) Vol 11, No 3 (2026) Vol 11, No 2 (2026) Vol 11, No 1 (2026) Vol 10, No 3 (2025) Vol 10, No 2 (2025) Vol 10, No 1 (2025) Vol 9, No 3 (2024) Vol 9, No 2 (2024) Vol 8, No 2 (2023) Vol 8, No 1 (2023) Vol 7, No 3 (2022) Vol 7, No 2 (2022) Vol 7, No 1 (2022) Vol 6, No 3 (2021) Vol 6, No 2 (2021) Vol 6, No 1 (2021) Vol 5, No 3 (2020) Vol 5, No 2 (2020) Vol 5, No 1 (2020) Vol 4, No 3 (2019) Vol 4, No 2 (2019) Vol 4, No 1 (2019) Vol 3, No 3 (2018) Vol 3, No 2 (2018) Vol 3, No 1 (2018) Vol 3, No 1 (2018): Buletin Farmatera Vol 2, No 3 (2017) Vol 2, No 2 (2017) Vol 2, No 1 (2017) Vol 1, No 2 (2016) Vol 1, No 1 (2016) More Issue

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
-

Contact Email
-

Phone
-

Journal Mail Official
-

Editorial Address
-

Location
Kota medan,

Sumatera utara

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name -

Contact Email -

Phone -

Journal Mail Official -

Editorial Address -

Location Kota medan, Sumatera utara INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
-

Contact Email
-

Phone
-

Journal Mail Official
-

Editorial Address
-

Location
Kota medan,

Sumatera utara

INDONESIA