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Buletin Farmatera
Published by Universitas Muhammadiyah Sumatera Utara
ISSN : 2528410X     EISSN : 2528410X     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Arjuna Subject : -
Articles 242 Documents
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Analisis Drug Related Problems Pada Pasien Benign Prostatic Hyperplasia (BPH) di RSUD Arifin Achmad Provinsi Riau Nugraha, Dimas Pramita; Afdal, Afdal; Pratama, Anggit Armedo; Kemala, Sandrina
Buletin Farmatera Vol 6, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i2.5528

Abstract

The prevalence of Benign Prostatic Hyperplasia (BPH) is progressive and increases linearly with age. In addition to the high prevalence of comorbid diseases in the elderly population, patients with BPH are more likely to be prescribed a variety of drugs, which leads to an increased risk of drug interactions, BPH patients are at risk of developing drug-related problems (DRP). This study aimed to analyze DRP-related factors in BPH patients. This research is a retrospective study conducted at Arifin Achmad Hospital, Riau Province, with data taken from January 2017 to December 2019. DRP classification uses Pharmaceutical Care Network Europe Classification Version (PCNE) 5.01. The relationship between categorical variables was analyzed using Pearson's chi-square. In this study, most of the patients were old age (73.9%), ethnic Malay (31.9%). Clinical characteristics of BPH patients 84.5% had a period of suffering from BPH less than 1 year, the most common BPH complications were hematuria at 34.3% and the most comorbid disease was hypertension 26.6%. Most of the patients used alpha-blocker monotherapy (89.3%). There were a total of 40 DRPs, the most common DRP category was interaction problems in the form of potential drug interactions (97.5%) followed by drug selection problems in the form of incorrect duplication in the therapy group (2.5%). Factors that were significantly associated with the occurrence of DRP in BPH patients were complications of BPH (p = 0.007, RR = 2.77), hypertension (p = 0.011, RR = 2.04), and polypharmacy (p = 0.00, RR = 4, 79). This study indicates that there is still DRP in BPH patients, especially concerning potential drug interactions. Undetectable DRP can cause drug-related morbidity and if not attended to or treated, it can lead to a drug-related death.
The Effect of Giving Red Dragon Fruit Juice on Changes in Leukocyte Levels and Fatigue Time in Maximum Intensity Physical Exercise Rianingsih, Rika; Rusip, Gusbakti
Buletin Farmatera Vol 6, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i2.5552

Abstract

Physical exercises contribute to oxidative tresses to cause fatigue and reduce the level of antioxidants in the body so that it affects physical fitness. Antioxidants are needed to neutralize free radicals and prevent damage to oxidative stress. This study aimed to determine the effect of red dragon fruit juice (Hylocereus polyrhizus) on leukocyte levels and tiring time in maximum intensity physical exercise. This research is the experimental research of the pre-test and post-test control group design. The research samples were divided into two groups, i.e. the control and treatment groups. Leukocyte levels were checked by using 2ml blood samples with hematology analyzers. Tiring time was determined by a treadmill test, in which the subject was asked to run until he/she reached maximum pulse. The minute the subject feels fatigued was documented as tiring time. This study showed significant results of leukocyte levels before and after treatment with a p-value of 0.005, tired time showed a p-value of 0.001, in which there was the lateness of tired time among the intervention group. Subjects who were given red dragon juice showed there was no increase in leukocyte levels and experienced lateness in the occurrence of tired time. That showed a better physical fitness level among the intervention group.
The Effect of Fasting Sunnah Mondays and Thursdays on Body Composition, Blood Pressure, and Blood Glucose Levels Bebasari, Eka; Sofian, Amru; Pratama, Bayu Fajar
Buletin Farmatera Vol 6, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i2.5500

Abstract

Fasting is a form of non-pharmacological intervention to improve health. One of the sunnah fastings that is often done is fasting Monday and Thursday. There is still little research on the benefits of this sunnah fasting. This study is a quasi-experimental study to determine the effect of sunnah fasting on Mondays and Thursdays on body composition, blood pressure, and blood glucose levels. The research subjects were 19 Riau University students who were willing to fast every Monday and Thursday for 4 consecutive weeks (8 days of fasting), were healthy, and did not smoke. Measurement of research parameters was carried out before and after fasting. The results of this study showed differences in the average values of body composition (weight, body mass index, upper arm circumference, waist circumference, waist-hip ratio), systolic blood pressure, diastolic blood pressure, and blood glucose levels before and after fasting. The results of statistical analysis with paired t-test there were significant differences in the average values of upper arm circumference, waist circumference, diastolic blood pressure, and blood glucose levels before and after fasting (p 0.05), but there was no significant difference in body weight, index body mass, waist-to-hip ratio, and systolic blood pressure before and after fasting (p 0.05). There is an effect of Monday and Thursday sunnah fasting on upper arm circumference, waist circumference, diastolic blood pressure, and blood glucose levels.
Antifungal Activity of Henna Leaf Extract (Lawsonia inermis linn.) Against Inhibition of Trichophyton rubrum Fungal Growth Cause Tinea Unguium Meutia, Nanda; Putra, Imam Budi; Jusuf, Nelva Karmila
Buletin Farmatera Vol 6, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i2.4768

Abstract

Tinea unguium is a common fungal nail infection. Most commonly caused by Trichophyton rubrum. It disturbs not only cosmetic figure, but also but also might have an impact on patients emotional, social and occupational functioning, lastly affecting the overall quality of life. The management of tinea unguium is still challenging. The therapy experienced many failures and recurrences. The aim of this research is to determine the presence of antifungal activity of Lawsonia inermis L. extract and to identify the extract concentration that can inhibit the fungal growth. This research is an experimental in vitro study with isolate from Microbiology Laboratory of Faculty of Medicine, Universitas Sumatera Utara. The Lawsonia inermis L. leaves extracted by maceration method. The antifungal assay was done using dilution method with various concentrations of (3,125%; 6,25%; 12.5%; 25%; 50%; 75% w/v). The mixtures of extract, suspension of Trichophyton rubrum and the media is incubated at 37C for 2-3 days. The mixture was streaked on SDA medium to determine the antifungal activity. The results indicates that Lawsonia inermis L. extracts has an antifungal effect, and with concentrations of 25%, 50% and 75% it can be use to inhibit the growth of Trichophyton rubrum qualitatively in vitro.
Potential of Flavonoids on Aortic Histopathological Improvement of ApoE-/- Mice With High-Fat Diet: A Systematic Literature Review Adyatma, Hilmi; Hardini, Niniek; Thadeus, Maria Selvester
Buletin Farmatera Vol 6, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i2.6358

Abstract

Non-communicable diseases account for more than 36 million deaths every year (63% of all deaths). Globally, non-communicable diseases (NCDs) that cause the most deaths each year are cardiovascular diseases. One of the cardiovascular diseases is coronary heart disease. The cause of coronary heart disease is acute coronary syndrome. More than 90% of acute coronary syndromes (ACS) are the result of atherosclerotic disorders. Therefore, research on the potential of flavonoids to improve histopathology of atherosclerosis needs to be carried out in order to provide information about alternative drugs that can be used by patients. The purpose of this research using a systematic literature review research methodology is to identify the potential of flavonoids to improve aortic histopathology in ApoE-/- mice with a high-fat diet. Systematic literature review by conducting a literature search using PubMed and Google Scholar. Literature that discusses flavonoids, ApoE-/- mice, high-fat diet, aorta, and atherosclerosis. There were 8 studies which concluded that flavonoids could inhibit or reduce the enlargement or further formation of aortic atherosclerotic plaques in ApoE-/- mice on a high-fat diet. Flavonoids have the potential to inhibit or reduce the enlargement or further formation of aortic atherosclerotic plaques in ApoE-/- mice on a high-fat diet.
Hubungan asupan diet dengan penanda inflamasi pada penyandang obesitas Martineta, Meriza; Sari, Dina Keumala; Tala, Zaimah Z; Lubis, Nenni Dwi Aprianti
Buletin Farmatera Vol 6, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i2.6460

Abstract

Obesity is a body condition caused by an energy imbalance that is closely relatedto diet. Obese people experience chronic low-grade inflammation in the body that can lead tochronic disease due to the production of inflammatory markers from adipose tissue, one ofwhich is the acute phase protein C-reactive protein (CRP), which is closely related to diet.The purpose of this study was to determine the relationship between dietary intake andinflammatory markers (high sensitivity C-reactive protein, hs-CRP) in obese people. Therewere 34 men and women aged 19-59 years with BMI 25.0 kg/m2 tested for hsCRP blood andassessed dietary intake using the food frequency questionnaires (FFQ) method. Therelationship between dietary intake and hsCRP was assessed using the Spearman correlation.Intake of calories, protein, fat, carbohydrates, fiber, PUFA, and cholesterol did not have asignificant relationship with hsCRP (p 0.05). Dietary intake is not associated with hsCRP.
Factors that Influencing Sputum Conversion at the End of Intensive Phase on TB-DM Patients at Medical Health Service in Medan Pertiwi, Vani Gita; Sinaga, Bintang YM; Lindarto, Dharma
Buletin Farmatera Vol 6, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i2.4767

Abstract

Tuberculosis and type 2 DM are the main problems of health in the world, including Indonesia. Many sputum conversion failures are found in TB-DM patients. This study aims to know about the factors that influence sputum conversion at the end of the intensive phase on TB-DM patients at the Medical Health Service in Medan. This research was carried out in a Specialized Lung Hospital and eight Health Centers in Medan. The Design of this study is observational analytic with a Cross-Sectional approach that took place in October-December 2019. Of 76 patients, there were 65 subjects (85.5%) with sputum conversion and 11 subjects (14.5%) without sputum conversion, the number of male patients was 48 subjects (63.2%), elderly were 51 subjects (67.1%), the normals BMI were 54 subjects (71.0%), patients with smoking were 4 subjects (5.3%), previous alcohol consumptions were 6 subjects (7.9%), current blood sugar levels 200 mg/dl are 23 subjects (30.2%) and the patients which using the anti-diabetes medication regularly were 62 subjects (81.6%). This study found that there was a significant relationship between alcohol, current blood sugar levels, and regularity using anti-diabetes medication with sputum conversion (p=0.036, p=0.001, p=0.001), while the factors that influence sputum conversion are alcohol and regularity using anti-diabetes medication (p=0.032, dan p=0.001).
HUBUNGAN POLIMORFISME GEN ANGIOTENSIN CONVERTING ENZYME DENGAN PERBAIKAN FRAKSI EJEKSI VENTRIKEL KIRI PADA PASIEN GAGAL JANTUNG KRONIK Handayani, Ahmad; Thristy, Isra; Andina, Meizly
Buletin Farmatera Vol 6, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i2.5549

Abstract

Angiotensin-converting enzyme (ACE) is a circulating and membrane-bound enzyme in the renin-angiotensin system. Polymorphism is the presence of two or more alleles at a locus in a population. In patients with heart failure with impaired systolic function, the RAA system is activated. One of the main therapies in heart failure is the administration of angiotensin-converting enzyme blockers. This study aims to examine the relationship between angiotensin-converting enzyme gene polymorphisms with improvement in left ventricular ejection fraction (FEVK).This research is a prospective observational study using a convenient sampling technique, carried out at Mitra Medika Hospital Bandar Klippa, Deli Serdang. The number of samples in the study was 37 people. Each patient was examined for initial echocardiography and at least 1 month after treatment when clinical improvement was seen. All patients received treatment according to the standard guidelines for the management of chronic heart failure according to the European Society of Cardiology (ESC)/Indonesian Cardiovascular Specialist Doctors Association (PERKI). The majority of research subjects were male as much as 81% and the average age of the patients was 56 years. ACE gene polymorphism was dominated by gene II as much as 57%. The average FEVK value in the first measurement was 25.8% and in the second measurement, it increased to 34.4%. There was a significant change between FEVK I measurements by an average of 25% to 34% in the next measurement (p 0.05). In the analysis of the relationship, it was seen that the ACE gene polymorphism did not affect the improvement of the FEVK value.Treatment of chronic heart failure with a decrease in ejection fraction was seen to have a significant effect in increasing FEVK. There is no relationship between angiotensin-converting enzyme gene polymorphisms on response to therapy in patients with chronic heart failure in this study.
Correlation between Ascaris Lumbricoides Infection and The Results of Skin Prick Test using Allergen from Ascaris Worms in Students of Koto Baru 047/XI Elementary School with Atopic History in Pesisir Bukit Sub-District Sungai Penuh City Jambi Province Rachman, Faisal; Depari, Aman A.P.; Arrasyid, Nurfida Khairina
Buletin Farmatera Vol 6, No 3 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i3.3965

Abstract

Infectious diseases, intestinal worms that are transmitted through the soil (Soil-transmitted helminthiasis) is common infection that involves many people in the world. Estimates suggest Ascaris lumbricoides infect over one billion people. The number of most worm infections apply to sub-Saharan Africa, the Americas, China, and East Asia. The prevalence of asthma and other atopic diseases in children has increased worldwide in recent years, but the reason behind the increase in prevalence is unknown. Most epidemiologic data derived from research centers in the west while in Indonesia have not been many reports on the prevalence of allergies, especially when associated with parasitic infections. Ascaris lumbricoides infections induce immune responses that lead to the production of immunoglobulin type E (IgE) in large numbers. Atopy can be diagnosed by an individual or a family history that confirmed the presence of allergen-specific IgE or skin prick test results were positive. Conducted this study to compare the proportion of atopy in children infected with Ascaris lumbricoides were not infected with the cross-sectional method and determine the relationship between Ascaris lumbricoides infection of the skin prick test results with the allergen of Ascaris on elementary school children 047/XI Koto Baru with a history of atopy in the Coastal Hills District Full River City Jambi Province. Of 258 students overall, as many as 220 students and are willing to meet the requirements of the study examined stool. On a stool examination, 220 students found that Ascaris lumbricoides infections by 67 students and non-patient infection of Ascaris lumbricoides at 153 students. There is a relationship between Ascaris lumbricoides infection of a positive skin prick test results with the allergen of Ascaris on elementary school children 047/XI Koto Baru with a history of atopy in the Coastal Hills District Full River City Jambi Province namely in children infected with Ascaris lumbricoides was 67 (100% ) significantly different compared with uninfected children Ascaris lumbricoides 153 (100%) (p=0.0001)
Distribusi Polimorfisme Gen Transforming Growth Factor Beta-1 (T869C) Pada Pasien Psoriasis Di Kota Medan, Sumatera Utara Rahmiwita, Rahmiwita; Siregar, Yahwardiah; Ichwan, Muhammad
Buletin Farmatera Vol 6, No 1 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i1.3981

Abstract

Psoriasis is a chronic inflammatory skin disease with a prevalence in the world around 2-3%. TGF-?1 is a growth factor that has a polymorphism in its genes. The TGF-?1 gene polymorphism plays a role in the pathogenesis of psoriasis. This is a descriptive study with a simple random sampling technique. This study was conducted on the strored of DNA specimens collected from 62 psoriasis patients comprising 33 women and 29 men. This study aims to determine the frequency distribution of the TGF-?1 gene polymorphism (T869C) in patients with psoriasis. The TGF-?1 gene polymorphism (T869C) was determined using PCR-based restricted fragment length polymorphism (PCR-RFLP). TC genotype was the most prevalent (50%) of TGF-?1 (T869C) gene polymorphism in psoriasis patients, followed by TT genotype (6.5%) and CC (43.5%). TC variant is the most variant of TGF-?1 (T869C) gene polymorphism in psoriasis sufferers in Medan

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