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INDONESIA
Majalah Farmaseutik
Published by Universitas Gadjah Mada
ISSN : 1410590x     EISSN : 26140063     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Majalah Farmaseutic accepts submission concerning in particular fields such as pharmaceutics, pharmaceutical biology, pharmaceutical chemistry, pharmacology, and social pharmacy.
Arjuna Subject : -
Articles 534 Documents
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Target Fishing and Molecular Docking Study Identify 6-Shogaol as Potential Agent for Insulin Resistance Overcoming through ALOX5 Modulation Laura Sonya Viega De Ariesta Supusepa; Triana Hertiani; Soni Siswanto
Majalah Farmaseutik Vol 22, No 3 (2026): IN PRESS
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v22i3.117168

Abstract

Insulin resistance underlies major metabolic disorders and is driven by chronic low-grade inflammation and oxidative stress that impair insulin signalling in peripheral tissues. Natural compounds with anti-inflammatory properties represent promising strategies to modulate this pathological axis, yet the molecular targets mediating these effects often remain unclear. This study employed an integrative in silico approach combining target fishing and molecular docking to elucidate the potential molecular mechanisms of 6-shogaol, a bioactive constituent of Zingiber officinale, in insulin resistance. Target prediction analysis identified arachidonate 5-lipoxygenase (ALOX5) as the highest-probability molecular target of 6-shogaol. Physicochemical profiling indicated favourable oral bioavailability and drug-likeness properties. Molecular docking analysis against ALOX5 (PDB ID: 6N2W), validated by redocking (RMSD 1.1 Å), demonstrated that 6-shogaol binds effectively within the enzyme active site and exhibits a more favourable binding affinity than the reference inhibitors zileuton and masoprocol. The predicted interaction supports 6-shogaol's ability to suppress leukotriene-mediated inflammatory signalling implicated in insulin resistance. Collectively, these findings suggest that 6-shogaol may act as a multi-target natural modulator of inflammation and oxidative stress, with ALOX5 emerging as a key therapeutic node in insulin resistance.
PENGARUH DISREGULASI EPIGENETIK TERHADAP PATOLOGI PENYAKIT ALZHEIMER DAN TARGET TERAPI MELALUI JALUR EPIGENETIK Iradatul Ikhtiari; Marlyn Dian Laksitorini; Nunung Yuniarti
Majalah Farmaseutik Vol 22, No 3 (2026): IN PRESS
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v22i3.117661

Abstract

The increase in life expectancy is directly proportional to the increasing prevalence of Alzheimer's disease. By 2050, it is estimated that 152 million people will be living with Alzheimer's disease. Alzheimer's disease is a disease caused by progressive neuronal damage, characterized by a decline in cognitive functions such as memory, concentration, and communication impairments. Molecularly, this disease is characterized by the presence of beta-amyloid (Aβ) plaques and tau protein neurofibrillary tangles (NFTs). The pathogenesis of Alzheimer's disease is associated with changes in epigenetic mechanisms, namely changes in DNA expression without involving changes in DNA sequence. Epigenetic mechanisms may contribute to the pathology of Alzheimer's disease through increased activity of the Bace1 and psen1/2 genes, which cleave APP. APP cleavage will predispose to the amyloidogenic pathway, producing toxic Aβ and facilitating tau protein NFTs. The role of epigenetic mechanisms is not limited to the pathology of Alzheimer's disease; several studies have assessed their potential as promising therapeutic targets. Through epigenetic reprogramming, several studies have shown encouraging results. This article reviews the role of epigenetic mechanisms in driving the development of Alzheimer's disease pathology and explores the potential of epigenetic reprogramming as a therapeutic strategy. Through this in-depth approach, it is hoped that this article will open new perspectives on the role of epigenetic mechanisms in Alzheimer's disease pathology and therapeutic targets.
Computational Design and Evaluation of Modified AEW-1 Chalcone Derivatives as Potential Anti-Inflammatory Agents Fitriana Nur Hanifah; Ratna Asmah Susidarti; Niko Prasetyo
Majalah Farmaseutik Vol 22, No 3 (2026): IN PRESS
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v22i3.118375

Abstract

Long-term therapy of inflammation is limited by gastrointestinal, cardiovascular, and renal side effects, motivating the search for safer, multi-target anti-inflammatory agents. The chalcone derivative AEW-1, which exhibits in vivo anti-inflammatory activity comparable to ibuprofen, was selected for rational optimization. Three new AEW-1 derivatives were designed by introducing trihydroxy substitutions on the A ring and evaluated in silico using target prediction, molecular docking, and pharmacokinetic/drug-likeness prediction. Target prediction indicated iNOS as the most probable target for AEW-1 and all its derivatives, supporting iNOS as an additional anti-inflammatory target alongside COX-2. For docking to COX-2, compound 1 exhibited the best binding profile and showed a binding affinity comparable to that of the native ligand, with key interactions involving Ser530. For docking to iNOS, compound 1 also demonstrated the most favorable profile among the derivatives and formed a hydrogen bond with Glu377, a key residue. However, its binding affinity was lower than that of the native ligand. All AEW-1 derivatives satisfied drug-likeness criteria and exhibited improved pharmacokinetic profiles compared to AEW-1. Overall, compound 1, consistent with the 2,4,6-trihydroxy substitution pattern, emerged as the most promising candidate as a dual COX-2/iNOS inhibitor, warranting further validation through molecular dynamics simulations and in vitro enzyme inhibition assays.
Pengaruh intervensi Apoteker terhadap Kepatuhan Terapi dan Kualitas Hidup Pasien Diabetes Melitus Tipe 2 di Apotek Komunitas: Tinjauan Naratif Annisa Rayan; Djoko Wahyono
Majalah Farmaseutik Vol 22, No 3 (2026): IN PRESS
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v22i3.118426

Abstract

Diabetes Melitus tipe 2 merupakan penyakit yang saat ini keberhasilan pengobatannya masih rendah tetapi prevalesinya setiap tahun terus meningkat. Intervensi pelayanan kefarmasian yang dipimpin oleh apoteker sangat penting dalam mencapai keberhasilan pengobatan yang optimal. Narrative review bertujuan penelitian ini untuk menelusuri berbagai literatur tentang intervensi yang dipimpin oleh apoteker untuk meningkatkan kepatuhan minum obat dan kualitas hidup pasien diabetes melitus tipe 2. Metode yang digunakan adalah narrative review dengan pencarian literatur melalui database PubMed dan Google Scholar. Narrative review ini dilakukan melalui tinjauan artikel  terbaru dari  tahun  2019 sampai 2025 dan didapatkan  sebanyak 608 artikel. Pemilihan artikel berdasarkan kriteria inklusi dan eksklusi, sebanyak 5 artikel yang memenuhi syarat untuk dianalisis secara deskriptif. Hasil dari kajian ini menunjukkan bahwa berbagai intervensi apoteker seperti pemberiaan layanan home pharmacy care , konseling ,  peningkatan edukasi pada pasien, penggunaan paltform digitalisasi dan monitoring pengobatan secara signifikan dapat meningkatkan kepatuhan minum obat dan kualitas hidup pasien. Kesimpulannya adanya berbagai intervesi apoteker dapat meningkatkan kepatuhan minum obat dan meningkatakan kualitas hidup pasien Diabetes Melitus tipe 2 lebih stabil.

Page 54 of 54 | Total Record : 534

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