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INDONESIA
Indonesian Journal of Chemistry
Published by Universitas Gadjah Mada
ISSN : 14119420     EISSN : 24601578     DOI : -
Core Subject : Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry
Indonesian Journal of Chemistry is an International, peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. The journal is accredited by The Ministry of Research, Technology and Higher Education (RISTEKDIKTI) No : 21/E/KPT/2018 (in First Rank) and indexed in Scopus since 2012. Since 2018 (Volume 18), Indonesian Journal of Chemistry publish four issues (numbers) annually (February, May, August and November).
Arjuna Subject : -
Articles 1,956 Documents
 123   124   125   126   127 
Structure of the Cyclic, Cationic Antimicrobial Peptide (KKWWKF) in Octanol Solution: in silico Approach Seyed Hassan Mortazavi; Mohammad Reza Bozorgmehr; Mohammad Momen Heravi
Indonesian Journal of Chemistry Vol 20, No 6 (2020)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.49190

Abstract

Understanding the mechanism of antimicrobial activity of cyclo-peptides helps to design new drugs based on these compounds. A common aspect of the mechanisms provided for the creation of antimicrobial activity of cyclo-peptides is their interaction with cell membranes. On the other hand, the octanol/water system is a good mimic of the water/membrane interface. Here, the conformational structure of the very short sequences cationic hexapeptide cyclo (Lys-Lys-Trp-Trp-Lys-Phe) has been studied in different concentrations of octanol by molecular dynamics simulation. The concentration of alcohol in the range of experimental concentrations of octanol was considered. The results obtained from calculating the radial distribution function show that the interaction of the peptide with octanol is a mixted of interactions between charged residues with octanol and the interaction of aromatic residues with octanol. These results are in agreement with experimental observations. Also, Lys5 plays a greater role than Lys1 and Lys2 in the interactions with octanol.
Comparative Study of Various Kinetic Models on Leaching of NCA Cathode Material Soraya Ulfa Muzayanha; Cornelius Satria Yudha; Luthfi Mufidatul Hasanah; Linggar Tungga Gupita; Hendri Widiyandari; Agus Purwanto
Indonesian Journal of Chemistry Vol 20, No 6 (2020)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.49412

Abstract

The kinetics study of NCA leaching in the HCl system was proposed. Various kinetic models such as shrinking core, logarithmic rate law, and Avrami equation were used to find out the most appropriate kinetic models for this process. The effect of HCl concentrations, leaching temperatures, solid to liquid (S/L) ratio, and leaching duration were observed. The optimum conditions of NCA leaching were at HCl concentration of 4 M, temperature of 80 °C, S/L ratio of 100 g/L, and leaching time of 1 h. The result shows that shrinking core model with diffusion control process of residue layer describes well the leaching mechanism in this research, which is indicated by the good fitting of coefficient values of correlation (R2) and confirmed by the activation energy values of Ni, Co, Al that were less than 40 kJ/mol.
Performance Improvement of Tetraethylorthosilicate Consolidated Andesite Rock by Adding Titanium Tetraisopropoxyde and Silica Particles Nahar Cahyandaru; Endang Tri Wahyuni; Nuryono Nuryono
Indonesian Journal of Chemistry Vol 21, No 1 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.49786

Abstract

A study to improve the performance of andesite mortar and rock consolidated with tetraethylorthosilicate (TEOS) sol and a solvent of ethanol in the presence of titanium tetraisopropoxyde (TTIP) and silica particles has been conducted. The improvements include minimizing the shrinkage using silica particles from rice husk ash, rheological property suitability of the consolidant, and mechanical properties of the consolidated mortar and rock. The effect of TTIP concentration, ethanol volume, and addition of the silica particles on rheological properties of TEOS-based consolidant, and also mechanical properties of the consolidated mortar and rock were evaluated. The results showed that the increase of TTIP content in the consolidant shortens the gelling time, and the weight percentage ratio of TTIP:TEOS:ethanol of 5%:55%:40% was the optimum composition for the consolidation. Consolidation of andesite block using that composition significantly increased the compressive strength up to 57.61% (0.58 kgf/mm2). The addition of 2% of silica particles into the consolidant decreased the gel shrinkage and increased the Young modulus of the mortar. The presence of water in the andesite matrix reduced the consolidation performance, and 0.5% was the maximum percentage of water content acceptable for the consolidation.
Imprinted Zeolite Modified Carbon Paste Electrode as a Selective Sensor for Blood Glucose Analysis by Potentiometry Miratul Khasanah; Alfa Akustia Widati; Usreg Sri Handajani; Muji Harsini; Bahrotul Ilmiah; Irene Dinda Oktavia
Indonesian Journal of Chemistry Vol 20, No 6 (2020)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.49820

Abstract

Imprinted zeolite modified carbon paste (carbon paste-IZ) electrode had been developed as a sensor to analyze blood glucose content by potentiometry. The used zeolite was Lynde Type A (LTA) that synthesized with a mole ratio of Na2O, Al2O3, SiO2 and H2O of 4:1:1.8:270, respectively while non-imprinted zeolite was prepared with a mole ratio of glucose/Si of 0.0306. Glucose was then extracted from the zeolite framework using hot water (80 °C) to produce imprinted zeolite (IZ). The carbon paste-IZ electrode prepared from activated carbon, paraffin pastilles, and IZ with a mass ratio of 5:4:1 showed the best performance. The modified electrode demonstrated the measurement range of 10–4-10–2 M, the Nernst factor of 29.55 mV/decade, the response time less than 120 s, and the detection limit of 5.62 × 10–5 M. Ascorbic acid, uric acid, urea and creatinine did not interfere on the glucose analysis by potentiometry. Comparison test with spectrophotometry showed an accuracy of (90.7 ± 1.4)% (n = 5), while the application of the electrode to analyze five spiked serum samples showed recovery of (92.2 ± 1.3)% (n = 5). The electrode was stable for up to 9 weeks (168 times usage). Based on its performance, the developed electrode can be applied to analyze glucose in human serum sample and recommended for used in the medical field.
Synthesis, Characterization and Biological Efficacies from Some New Dinuclear Metal Complexes for Base 3-(3,4-Dihydroxy-phenyl)-2-[(2-hydroxy-3-methylperoxy-benzylidene)-amino]-2-methyl Propionic Acid Shatha Mohammed Hassan Obaid; Jasim Shihab Sultan; Abbas Ali Salih Al-Hamdani
Indonesian Journal of Chemistry Vol 20, No 6 (2020)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.49842

Abstract

The reaction of methyldopa with o-vanillin in refluxing ethanol afforded Schiff base and characterized through physical analysis with a number of spectra also the study of biological activity. The geometry of the Schiff base was identified through using (C.H.N) analysis, Mass, 1H-NMR, FT-IR, UV-Vis spectroscopy. Metal complexes of Cr3+, Mn2+, Co2+, Ni2+, Cu2+, Zn2+, Cd2+ and Hg2+ with Schiff base have been prepared in the molar ratio 2:1 (Metal:L), (L = Schiff base ligand) except Hg2+ at molar ratio 1:1 (Hg:L). The prepared complexes were characterized by using Mass, FT-IR and UV-Vis spectral studies, on other than magnetic properties and flame atomic absorption, conductivity measurements. According to the results a dinuclear octahedral geometry has been suggested for Cr3+, Mn2+, Co2+, Ni2+, Cu2+ and Zn2+ complexes, dinuclear tetrahedral for Cd2+ and mononuclear tetrahedral for Hg2+ complex. This work highlights the relevance of metal complexation strategy to stabilize the ligands and improve their bioactivity. Schiff base complexes have been screen for their antibacterial activity against Gram negative and positive bacteria and antifungal activity showing promising antibacterial and biological activity.
Design of Catechin-based Carbon Nanodots as Facile Staining Agents of Tumor Cells Yaung Kwee; Alfinda Novi Kristanti; Nanik Siti Aminah; Mochamad Zakki Fahmi
Indonesian Journal of Chemistry Vol 20, No 6 (2020)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.50327

Abstract

Carbon nanodots (CNDs) have widely received great attention as a result of favorable optical, electrical, optoelectrical, biocompatible, and non-toxic properties these nanoparticles possess. However, the exploration of nanoparticle from natural raw material was limited. In present work, the carbon dots were produced from catechin isolated from Uncaria gambir through a simple and facile process. Carbon nanodots were further produced by the pyrolysis process of catechin, which allowed it for carbonization. Owing to its unique properties such as photoluminescence with an emission peak at 500 nm (lex = 380 nm), average size diameter about 5 nm and non-toxic; Cat-CNDs were incredibly potential for staining targeted tumor cells. The staining ability by confocal microscopy observations showed their green fluorescence images which meant that the CNDs easily penetrated HeLa cells via endocytosis. The resulting CNDs which were analyzed using some significant techniques approved that the prepared Cat-CNDs were tremendously dispersible and water-soluble, good colloidal stability, excellent biocompatibility, favorable hydrophilicity, high photostability, and non-toxicity.
Antioxidant Activities and Identification of an Active Compound from Rambutan (Nephelium lappaceum L.) Peel Mistriyani Mistriyani; Sugeng Riyanto; Anjar Windarsih; Abdul Rohman
Indonesian Journal of Chemistry Vol 21, No 2 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.50421

Abstract

The consumption of rambutan fruit resulted in a vast amount of peels and seeds waste. Therefore, the exploration of active compounds having beneficial effects on human health, such as antioxidants, is very lucrative. This research was aimed to isolate and to identify the active compound as an antioxidant from rambutan peel. The powdered rambutan peel was extracted with a maceration technique using methanol then fractionated using petroleum ether, chloroform, and ethyl acetate to get the corresponding fractions. The extract and fractions were determined for its antioxidant activities in vitro using 2,2’-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and metal-chelating assay. The ethyl acetate fraction exhibited the highest antiradical activity with an IC50 value of 26.22 μg/mL and metal-chelating activity, accounting for 12.32%. The antioxidant activities of extract and fractions correlated with its phenolics and flavonoid contents. Identification of active compounds using FTIR, GC-MS, and NMR resulted in the chemical formula of C7H6O4, identified as 3,4-dihydroxybenzoic acid.
Hydrotreatment of Cellulose-Derived Bio-Oil Using Copper and/or Zinc Catalysts Supported on Mesoporous Silica-Alumina Synthesized from Lapindo Mud and Catfish Bone Fahri Swasdika; Wega Trisunaryanti; Iip Izul Falah
Indonesian Journal of Chemistry Vol 21, No 2 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.50558

Abstract

Catalysts comprising copper and/or zinc supported on mesoporous silica-alumina (MSA) with a high Si/Al ratio were prepared by wet impregnation method. This study investigated the preparation, characterization, and catalytic application of the prepared catalysts for hydrotreatment cellulose-derived bio-oil. The wet impregnation was performed by directly dispersing Cu(NO3)2·3H2O and/or Zn(NO3)2·4H2O aqueous solution into MSA, followed by calcination and reduction under H2 gas stream. The acidity test revealed that metal addition on MSA support increases the acidity of catalysts. During hydrotreatment of cellulose-derived bio-oil CuZn/MSA with total acidity, copper loading, zinc loading, and specific surface area of 24.86 mmol g–1, 5.23 wt.%, 3.15 wt.%, and 170.77 m2 g–1, respectively, exhibited the best performance compared to other prepared catalysts with 90.49 wt.% conversion of liquid product.
Docking-Guided 3D-QSAR Studies of 4-Aminoquinoline-1,3,5-triazines as Inhibitors for Plasmodium falciparum Dihydrofolate Reductase Radite Yogaswara; Maria Ludya Pulung; Sri Hartati Yuliani; Enade Perdana Istyastono
Indonesian Journal of Chemistry Vol 20, No 6 (2020)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.50674

Abstract

Mutations in Plasmodium falciparum dihydrofolate reductase (PfDHFR), together with other mutations, hinder malaria elimination in Southeast Asia due to multiple drug resistance. In this article, molecular docking-guided three-dimensional (3D) quantitative structure-activity relationship (QSAR) analysis of 4-aminoquinoline-1,3,5-triazines as inhibitors for the wild-type (WT) PfDHFR to identify the molecular determinants of the inhibitors binding are presented. Compounds 4-aminoquinoline-1,3,5-triazines were reported promising to be developed as the non-resistant drugs. The 3D-QSAR analysis resulted in the best model with the R2 and Q2 values of 0.881 and 0.773, respectively. By correlating the molecular interaction fields (MIFs) of the best model to the docking pose employed to guide the 3D-QSAR analysis, S108 residue of the WT-PfDHFR was unfortunately recognized as one of the molecular determinants. Since the S108 residue is one of the mutation points of the PfDHFR mutants, the subsequent design strategy should modify the morpholine moiety to avoid the interaction with the S108 residue of the WT-PfDHFR.
Isotope and Geochemistry Characterization of Hot Springs and Cold Springs of Sembalun – Rinjani Area, East Lombok, West Nusa Tenggara – Indonesia Satrio Satrio; Rasi Prasetio; Boy Yoseph Cahya Sunan Sakti Syah Alam; Teuku Yan Waliyana Muda Iskandarsyah; Faizal Muhammadsyah; Mohamad Sapari Dwi Hadian; Hendarmawan Hendarmawan
Indonesian Journal of Chemistry Vol 20, No 6 (2020)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.50790

Abstract

The presence of several hot springs in Sembalun – Rinjani, East Lombok, West Nusa Tenggara is an indicator of geothermal potential in the area. This study aims to determine the characteristics of hot springs and cold springs and also the geothermal potential in Sembalun – Rinjani area using isotopes and geochemistry methods. The result of d18O and d2H stable isotopes analysis shows that most of the hot springs are meteoric water. Except for Kalak hot spring, other hot springs are a mixing product of meteoric water and andesitic water, with meteoric water composition between 64 to 87%. While 14C radioisotope suggests that the age of hot springs in the Sembalun area is about 10,000–12,000 years BP, the surrounding cold springs are mostly Modern except Jorong cold spring. The results of gas analysis (He, Ar, and Ne) also suggest the same origin of geothermal fluid, i.e., meteoric water origin. Based on chemical composition, Kalak hot spring is plotted as sulfate type water, while Sebau hot spring is plotted near mature water composition but not representing reservoir fluid due to its relatively low temperature and high Mg content. Na/K geothermometer calculation from Sembalun area shows that subsurface temperature is varied between 111-161 °C, while from Rinjani hot springs indicates higher subsurface temperature, i.e., 250-260 °C. It is estimated that reservoir fluid has high TDS with chloride content up to 4000 mg/L.

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