cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
-
Editorial Address
-
Location
Kab. sleman,
Daerah istimewa yogyakarta
INDONESIA
Indonesian Journal of Chemistry
Published by Universitas Gadjah Mada
ISSN : 14119420     EISSN : 24601578     DOI : -
Core Subject : Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry
Indonesian Journal of Chemistry is an International, peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. The journal is accredited by The Ministry of Research, Technology and Higher Education (RISTEKDIKTI) No : 21/E/KPT/2018 (in First Rank) and indexed in Scopus since 2012. Since 2018 (Volume 18), Indonesian Journal of Chemistry publish four issues (numbers) annually (February, May, August and November).
Arjuna Subject : -
Articles 1,956 Documents
 137   138   139   140   141 
Electrogenerated Chemiluminescence for Immunoassay Applications Isnaini Rahmawati; Irkham Irkham; Rahmat Wibowo; Jarnuzi Gunlazuardi; Yasuaki Einaga; Tribidasari Anggraningrum Ivandini
Indonesian Journal of Chemistry Vol 21, No 6 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.64596

Abstract

Electrogenerated chemiluminescence (ECL) has recently become one of the most prominent and well-established transducers for immunoassay techniques. ECL relates a luminophore concentration in solution with the emission of light triggered by an electrochemical stimulus. ECL immunoassay (ECLIA) performance depends on the parameters of its light generation, including the luminophore, the species that emit light called labels in ECLIA; co-reactants, which are added reagents that support the luminophore to undergo the excited state; electrodes, which are the place for the ECL reactions to take place; and the format of the immunoassay. This review discusses the behaviour of ECLIA parameters, the required instrumentations, and some important examples of detections based on ECLIA.
Adsorption of Pb(II) from Aqueous Solutions onto Humic Acid Modified by Urea-Formaldehyde: Effect of pH, Ionic Strength, Contact Time, and Initial Concentration Meidita Kemala Sari; Rahmat Basuki; Bambang Rusdiarso
Indonesian Journal of Chemistry Vol 21, No 6 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.64600

Abstract

Humic acid (HA) and urea-formaldehyde (UF) have been frequently reported as heavy metal adsorbents. However, the literature has never written HA modification by UF to improve the adsorbent’s performance. In this study, a new adsorbent of humic acid-urea formaldehyde (HA-UF) was synthesized. The reaction of the conducted the formation of HA-UF –COOH group of HA with the –NH2 group of UF was evidenced by decreasing total acidity from 549.26 cmol/kg (in HA) to 349.30 cmol/kg (in HA-UF). The success of HA-UF formation was characterized by attenuated total reflection-infrared (ATR-IR), energy dispersive X-Ray (EDX), and X-ray diffraction (XRD). The high stability of HA-UF was shown by 96.8% remaining in solid form at pH 12.4. Adsorption behavior of Pb(II) onto HA-UF was influenced by the ionic strength and pH, which were mainly driven by the ion exchange mechanism (EDR = 9.75 kJ/mol). The higher ionic strength will affect decreasing adsorbed Pb(II) at the optimum pH of 5.5. The effect of initial Pb(II) concentration (isotherm) shows that the data fitted well with the Langmuir-b isotherm model indicated the monolayer adsorption of Pb(II) onto homogenous surfaces of the HA-UF with the adsorption capacity of 2.26 × 10–4 mol/g (which is higher than its original HA of 1.12 × 10–4 mol/g). The Ho (pseudo-second-order) kinetics model represented the effect of contact time (kinetics) was represented by the Ho kinetics model. The synthesized adsorbent is also reusable, with 88.59% of adsorption capacity remaining in the fifth recycle run. Therefore, the adsorbent of HA-UF is suggested to be a promising candidate for adsorption applications.
Simple Method of 9,10-Anthraquinone Assay in Eleutherine americana (Aubl.) Merr. ex K. Heyne using High-Performance Liquid Chromatography Sophi Damayanti; Samuel Gunadi Tanusondjaja; Benny Permana; Rika Hartati; Dian Ayu Eka Pitaloka; Indra Wibowo
Indonesian Journal of Chemistry Vol 21, No 6 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.64701

Abstract

Eleutherine americana (E. americana) is a medicinal plant commonly found on the island of Borneo, Indonesia. This plant is known to have several biological activities. However, anthraquinone residues are generally present as contaminants. This study was aimed to develop a method of determining the levels of 9,10-anthraquinone in plant extracts and fractions using High Performance Liquid Chromatography (HPLC). The research aims to optimize the mobile phase, the system suitability test, and the system validation. The optimal mobile phase was acetonitrile:distilled water 1:1 v/v with a flow rate of 1.25 mL/min. The validation result shows that the linearity was obtained with a correlation coefficient (r) of 0.9995 and an r2 coefficient of 0.9991. The estimated limits for detection and quantification values were 0.178 and 0.594 µg/mL, respectively. In the intraday and inter-day accuracy test, the coefficient of variance for reference was 0.627 and 0.774, while the results for the sample were 2.966 and 2.658. The percentage recovery rate for reference was between 98.976–101.452%, and for the sample, the result was 89.191–94.667%. The average 9,10-anthraquinone content in the acetate fraction of E. americana plant was 9.799 µg/g ± 5.243.
Ferrate(VI) Synthesis Using Fe(OH)3 from Waste Iron Electrolysis and Its Application for the Removal of Metal Ions and Anions in Water Gunawan Gunawan; Abdul Haris; Nor Basid Adiwibawa Prasetya; Eka Pratista; Azis Amrullah
Indonesian Journal of Chemistry Vol 21, No 6 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.64824

Abstract

Ferrate(VI) salt is an effective oxidant and coagulant for water treatment and removal of metal ions. This study demonstrates a new approach to processing metal ions and anions in water by Fe(VI) through Fe(III) obtained from the electrolysis of waste iron transformer. The electrolysis was successfully carried out in the Na2SO4 electrolyte using waste iron and zinc plates as anode and cathode, respectively. Fe(III) electrolysis results through the characterization of FTIR and XRD indicate compliance with Fe(OH)3 standards. Synthesis of ferrate was carried out by adding Fe(III) from electrolysis with NaOCl in alkaline conditions. The formed ferrate solution shows a purple color with a typical maximum wavelength of 505 nm. Furthermore, the ferrate obtained is used to remove metal ions (Fe(III), Cu(II), Zn(II), Mg(II), Pb(II)) and anions (sulfate, nitrate, and carbonate) in water with pH variations. Ferrate treatment filtrate was analyzed using AAS for metal ions, while sulfate, nitrate, and carbonate anions used UV-Vis spectrophotometry, turbidimetry, and titration methods. The results showed that ferrate effectively eliminates metal ions and anions in water with optimum pH 6. The mechanism of heavy metal removal by ferrate(VI) can be explained by ionic bonding and adsorption.
Utilization of Corn Oil through Water Degumming Process for Lecithin Emulsifier Production Fahmi Arifan; Muhammad Kelvin Nandita; Enrico Fendy Sapatra; Salsabila Salsabila
Indonesian Journal of Chemistry Vol 21, No 6 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.65195

Abstract

Lecithin is an emulsifier that plays an active role in reducing surface tension in making emulsions. The production of lecithin from other vegetable oils allows the use of other types of vegetable oil as a source of lecithin production to replace soy-based oil, which has begun to be used as a bioenergy raw material. This study aims to find an alternative source of new lecithin derived from corn oil by knowing the characteristics of lecithin and applied to mayonnaise. The resulting lecithin was used in mayonnaise with a 2 factorial randomized block design method consisting of 3 levels. Based on the results obtained, the characteristic of corn oil lecithin is that the largest content is hexadecanoic acid which is 44.79%, and the strongest vibration band is CH2 vibration with stretching modes of symmetry and asymmetry at 2922 and 2853 cm–1 and the terminal CH3 group in the 1374 cm–1. L3C3 treatment was the best result with 60% fat content, 4% emulsion stability, 2.12 cP viscosity, and 1.42 × 10–3 N/m surface tension and organoleptic showed a preference value, namely color 4.4 (like), taste 3.2 (sufficient like), smell 4 (like), and texture 3.80 (like it).
Synthesis of SO42–/ZrO2 Solid Acid and Na2O/ZrO2 Solid Base Catalysts Using Hydrothermal Method for Biodiesel Production from Low-Grade Crude Palm Oil Sri Setyaningsih; Maisari Utami; Akhmad Syoufian; Eddy Heraldy; Nasih Widya Yuwono; Karna Wijaya
Indonesian Journal of Chemistry Vol 22, No 1 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.65404

Abstract

Biodiesel is a renewable energy source that can be produced through esterification as well as transesterification reactions. This work presents a series of zirconia catalysts synthesized by hydrothermal method on various concentrations in acidic (H2SO4 0.3, 0.5, and 0.7 M) and basic (NaOH 1, 2, 3, and 4 M) solution to get a catalyst with the highest acidity or basicity. Characterizations of the catalysts were performed by FTIR, XRD, SEM-EDX, surface area analysis, acidity, and basicity test. The most active acid catalyst activity was evaluated for the esterification of low-grade crude palm oil (LGCPO), while the solid base catalyst was utilized for the transesterification reaction. The solid acid catalyst of 0.7 M SO42–/ZrO2 60 °C; 24 h was denoted as the most active acid catalyst with a total acidity of 1.86 mmol g–1, while 4 M Na2O/ZrO2 60 °C; 24 h catalyst was considered as the solid base catalyst with the highest total basicity of 3.75 ± 0.12 mmol g–1. The optimized acid catalyst exhibited a 31 times higher acidity than commercial ZrO2. The concentration of free fatty acids (FFA) decreased to 68.87% in the esterification reaction. The solid base catalyst of 4 M Na2O/ZrO2 60 °C; 24 h successfully converted LGCPO into biodiesel by 68.55% through a transesterification reaction.
Novel Benzo[f]coumarin Derivatives as Probable Acetylcholinesterase Inhibitors: Synthesis, In Vitro, and In Silico Studies for Evaluation of Their Anti-AChE Activity Zaizafoon Nabeel; Qassim Abdul-Hussein Jaber; Nabeel Abed Abdul-Rida
Indonesian Journal of Chemistry Vol 22, No 1 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.65663

Abstract

Novel benzo[f]coumarin derivatives bearing pyrimidine unit were successfully synthesized. The target is to develop novel acetylcholinesterase inhibitors. The benzo[f]coumarin chalcone 4 was prepared via Claisen-Schmidt condensation between 3-acetyl-5,6-benzocoumarin and 4-hydroxybenzaldehyde in the alkaline medium. Then, the cyclocondensation of chalcone 4 with urea, thiourea, and guanidine HCl in the presence of glacial acetic acid led to the formation of various pyrimidines. Structures of the newly synthesized compounds were characterized by FT-IR, 1H-NMR, 13C-NMR spectra, and elemental analysis. The acetylcholinesterase (AChE) inhibitory activity tests were carried out using Ellman's assay and donepezil as a reference drug. The biological activity results revealed that the derivatives 6 and 7 inhibit AChE activity in healthy samples showed that the greater inhibition percentage was found respectively at concentrations of 10–4 and 10–10 M while low inhibition percentage was obtained at 10–12 and 10–4 M. AChE showed inhibition constant Ki in the range of 10–4-10–12 M in the presence of maximum and minimum inhibitor concentrations, probably due to variant types of inhibition from non and uncompetitive. In addition, molecular modeling simulations of targeted compounds revealed their mechanism of action as potent inhibitors for the AChE enzyme.
The Biotransformation and Biodecolorization of Methylene Blue by Xenobiotic Bacterium Ralstonia pickettii Adi Setyo Purnomo; Asranudin Asranudin; Didik Prasetyoko; Yulinar Dwi Nur Azizah
Indonesian Journal of Chemistry Vol 21, No 6 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.65806

Abstract

The biotransformation and biodecolorization of methylene blue (MB) dye using the bacterium Ralstonia pickettii was investigated. This experiment was conducted in a nutrient broth (NB) medium after adding MB at 100 mg L–1 concentration. Approximately 98.11% of MB was decolorized after 18 h of incubation. In addition, the metabolic products detected by LC-TOF/MS were Azure A (AA), thionine, leuco-MB, and glucose-MB, which indicated the MB degradation through a reductase that attacked the heterocyclic central chromophore group present in the structure. Moreover, azure A and thionine fragments resulted from the N-demethylase enzyme that attacked the auxochrome group. Thus, this research was assumed to be the first scientific report suggesting the potential to use R. pickettii in the biodecolorization and biotransformation of dye waste, particularly MB.
Development of an Analytical Method for Kasugamycin Residue in Herbal Medicine, Achyranthes japonica Nakai Jeong Yoon Choi; Hun Ju Ham; Min-woo Kim; Abd Elaziz Sulieman Ahmed Ishag; Jang-Hyun Hur
Indonesian Journal of Chemistry Vol 22, No 1 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.65970

Abstract

This study developed a suitable analytical method for kasugamycin residues in Achyranthes japonica using LC/MS/MS equipped with an amide column for polar substances. Extraction and cleanup processes were done at pH 4.5–5. Purification efficiency was assessed and confirmed step by step by selecting silica, hydrophilic-lipophilic balance (HLB), strong cation exchange (SCX), and double (HLB and SCX) cleanup SPE cartridges. The results indicated that silica SPE cartridge exhibited overloading tendency, while HLB SPE cartridge had low cleaning efficiency. Among SPE cartridges used, double cleanup and SCX were found sufficient with respective matrix effects of –15% and +14%, respectively. The LOD and LOQ were 0.008 ng and 0.04 mg/kg, respectively. The correlation coefficient (R2) was higher than 0.99, recovery rate ranges were 86.3–97.2%, and the RSD was below 8.8%. All methods are consistent with the Codex guidelines criteria. This study developed an appropriate LC/MS/MS analytical method for kasugamycin residue analysis in A. japonica with optimized, efficient extraction and purification conditions using a single SCX SPE cartridge, which is simple and time-efficient. In addition, the HLB and SCX SPE cartridges of the double cleanup methods were identified as primary methods that can be applied for the cleanup of other medicinal herbs.
Synthesis and Molecular Docking Studies of New Dispiropyrrolidines on West Nile Virus NS2B-NS3 Protease Nadia Mohamed Yusoff; Hasnah Osman; Mohd. Zaheen Hassan; Mohamed Ashraf Ali; Yeong Keng Yoon; Ezatul Ezleen Kamarulzaman; Muhammad Solehin Abd Ghani; Unang Supratman; Mohamad Nurul Azmi Mohamad Taib
Indonesian Journal of Chemistry Vol 21, No 6 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.66017

Abstract

West Nile virus (WNV) is among the other four flavivirus genus, rapidly spreading worldwide. The number of cases increases globally as there are no clinically available approved drugs and vaccines against this disease. Based on our previous finding related to a flavivirus, a series of spiropyrrolidine derivatives were regioselectively synthesized via [3+2]-cycloaddition reaction of three components between isatins, sarcosine, and (E)-3,5-bis (arylidene)-4-piperidones. The yield of synthesized compounds was in a range between 81–95%. The structures of all the synthesized compounds were characterized using FT-IR, 1D- and 2D-NMR, and HRMS. Molecular docking studies of spiropyrrolidines on NS2B-NS3 protease were done to understand and explore the ligand-receptor interactions and hypothesize the drug's refinements. The inhibition of NS2B-NS3 protease has been considered a promising strategy because this enzyme is responsible for the viral replication process. Among them, compound 5c shows an excellent binding affinity with ‒7.71 kcal/mol free binding energy and an inhibition constant of 1.73 μM. It also showed the binding orientation into the active site of WNV NS2B-NS3 protease on Asn84, Tyr1161, Gly1151, and Gly1153.

Page 139 of 196 | Total Record : 1956

 137   138   139   140   141 

Filter by Year

2001 2025


Reset
Filter By Issues
All Issue Vol 25, No 5 (2025) Vol 25, No 4 (2025) Vol 25, No 3 (2025) Vol 25, No 2 (2025) Vol 25, No 1 (2025) Vol 24, No 6 (2024) Vol 24, No 5 (2024) Vol 24, No 4 (2024) Vol 24, No 3 (2024) Vol 24, No 2 (2024) Vol 24, No 1 (2024) Vol 23, No 6 (2023) Vol 23, No 5 (2023) Vol 23, No 4 (2023) Vol 23, No 3 (2023) Vol 23, No 2 (2023) Vol 23, No 1 (2023) Vol 22, No 6 (2022) Vol 22, No 5 (2022) Vol 22, No 4 (2022) Vol 22, No 3 (2022) Vol 22, No 1 (2022) Vol 22, No 2 (2022) Vol 21, No 6 (2021) Vol 21, No 5 (2021) Vol 21, No 4 (2021) Vol 21, No 3 (2021) Vol 21, No 2 (2021) Vol 21, No 1 (2021) Vol 20, No 6 (2020) Vol 20, No 5 (2020) Vol 20, No 4 (2020) Vol 20, No 3 (2020) Vol 20, No 2 (2020) Vol 20, No 1 (2020) Vol 19, No 4 (2019) Vol 19, No 3 (2019) Vol 19, No 2 (2019) Vol 19, No 1 (2019) Vol 18, No 4 (2018) Vol 18, No 3 (2018) Vol 18, No 2 (2018) Vol 18, No 1 (2018) Vol 17, No 3 (2017) Vol 17, No 2 (2017) Vol 17, No 1 (2017) Vol 16, No 3 (2016) Vol 16, No 2 (2016) Vol 16, No 1 (2016) Vol 15, No 3 (2015) Vol 15, No 2 (2015) Vol 15, No 1 (2015) Vol 14, No 3 (2014) Vol 14, No 2 (2014) Vol 14, No 1 (2014) Vol 13, No 3 (2013) Vol 13, No 2 (2013) Vol 13, No 1 (2013) Vol 12, No 3 (2012) Vol 12, No 2 (2012) Vol 12, No 1 (2012) Vol 11, No 3 (2011) Vol 11, No 2 (2011) Vol 11, No 1 (2011) Vol 10, No 3 (2010) Vol 10, No 2 (2010) Vol 10, No 1 (2010) Vol 9, No 3 (2009) Vol 9, No 2 (2009) Vol 9, No 1 (2009) Vol 8, No 3 (2008) Vol 8, No 2 (2008) Vol 8, No 1 (2008) Vol 7, No 3 (2007) Vol 7, No 2 (2007) Vol 7, No 1 (2007) Vol 6, No 3 (2006) Vol 6, No 2 (2006) Vol 6, No 1 (2006) Vol 5, No 3 (2005) Vol 5, No 2 (2005) Vol 5, No 1 (2005) Vol 4, No 3 (2004) Vol 4, No 2 (2004) Vol 4, No 1 (2004) Vol 3, No 3 (2003) Vol 3, No 2 (2003) Vol 3, No 1 (2003) Vol 2, No 3 (2002) Vol 2, No 2 (2002) Vol 2, No 1 (2002) Vol 1, No 3 (2001) Vol 1, No 2 (2001) Vol 1, No 1 (2001) ARTICLE IN PRESS Article in press More Issue