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INDONESIA
Indonesian Journal of Chemistry
Published by Universitas Gadjah Mada
ISSN : 14119420     EISSN : 24601578     DOI : -
Core Subject : Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry
Indonesian Journal of Chemistry is an International, peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. The journal is accredited by The Ministry of Research, Technology and Higher Education (RISTEKDIKTI) No : 21/E/KPT/2018 (in First Rank) and indexed in Scopus since 2012. Since 2018 (Volume 18), Indonesian Journal of Chemistry publish four issues (numbers) annually (February, May, August and November).
Arjuna Subject : -
Articles 1,956 Documents
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Tyrosinase-Based Paper Biosensor for Phenolics Measurement Fretty Yurike; Dyah Iswantini; Henny Purwaningsih; Suminar Setiati Achmadi
Indonesian Journal of Chemistry Vol 22, No 5 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.72607

Abstract

Environmental pollution resulting from various industrial activities is still a problem for developing countries. The high content of phenolics such as phenols, polyphenols, bisphenol A, catechol, m- and p-cresol from industrial activities are discharged into surface water, soil, and air. Periodic monitoring of the impact of these toxic pollutants is needed for proper control and handling. These detrimental chemicals are usually measured using conventional methods with many drawbacks such as expensive analysis costs, long measurement times, requiring competent analysts, and complicated instrument maintenance. However, the presence of tyrosinase-based paper biosensors is now considered the most promising tool in overcoming the challenges mentioned earlier because they can detect these components quickly, precisely, accurately, inexpensively, and can be measured in situ. The working principle of this biosensor sees optical changes such as dyes, redox processes, and physicochemical properties (aggregation or dispersion) due to the presence of analytes accompanied by the occurrence of color changes that appear. This biosensor uses a layer-by-layer electrostatic method, which causes the deposition of multi-layered films on solid surfaces. In this paper, we review the development of the tyrosinase-based paper biosensor method for phenolic measurement in water, air, and food that gives better results than the conventional methods.
3,4,5-Trimethoxychalcones Tubulin Inhibitors with a Stable Colchicine Binding Site as Potential Anticancer Agents Maadh Jumaah; Tutik Dwi Wahyuningsih; Melati Khairuddean
Indonesian Journal of Chemistry Vol 22, No 5 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.72790

Abstract

The development of microtubule perturbing drugs is one of the most promising anticancer therapeutic methods. Unfortunately, limitation such as drug resistance, adverse side effects, complex formulations and synthesis, and limited bioavailability of these microtubule perturbing drugs has aroused the search for a new molecule of the tubulin system. Different substituents of chalcone were designed, synthesized, and determined for inhibition of tubulin assembly and toxicity in human cancer cell lines based on conventional colchicine site ligands and a computer model of the colchicine binding site on tubulin. A molecular docking study indicated that the chalcone scaffold could fit the colchicine site on tubulin in a similar orientation to the natural product. The 3,4,5-trimethoxyphenyl ring, which occupies the same sub-cavity as the equivalent molecule in colchicine, appeared to benefit the ligand of α,β-tubulin interaction. Several 3,4,5-trimethoxychalcone compounds demonstrated improved cytotoxicity against MCF-7 cells and inhibited tubulin assembly in vitro as potently as colchicine. The most active chalcone 1 with the IC50 of 6.18 ± 0.69 μM prevented the proliferation of human cell lines at micromolar concentrations, causing microtubule destabilization and mitotic arrest in humans inhibiting breast cancer cells.
Heavy Metals Concentration in Muscle Tissue of Threatened Sharks (Rhizoprionodon acutus, Sphyrna lewini, and Squallus hemipinnis) from Binuangeun, Lebak Banten, Indonesia Suratno Suratno; Dwi Siswanta; Satriyo Krido Wahono; Nurul Hidayat Aprilita
Indonesian Journal of Chemistry Vol 22, No 4 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.72795

Abstract

Metals accumulation in threatened sharks’ meat represents a global health issue. The objective of the current study was to measure the concentration of six metals (Li, Ti, Ni, Cd, As, and Pb) using ICP-MS in threatened sharks’ meat of Rhizoprionodon acutus, Squalus hemipinnis, and Sphyrna lewini from Binuangeun Fish Auction in Lebak, Banten, Indonesia. The results showed that the concentration of Ni, Li, Cd, and Pb was below the acceptable levels for food sources for human consumption, except for As concentration (more than 30 fold higher). This study showed high levels of Ti concentration in all threatened sharks' meat. Overall, this study shows that an accumulation of Ti in sharks' meat should be considered a risk to the health of seafood consumers.
Optimization of Aptamer-Based Electrochemical Biosensor for ATP Detection Using Screen-Printed Carbon Electrode/Gold Nanoparticles (SPCE/AuNP) Rahmaniar Mulyani; Nida Yumna; Iman Permana Maksum; Toto Subroto; Yeni Wahyuni Hartati
Indonesian Journal of Chemistry Vol 22, No 5 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.72820

Abstract

Electrochemical biosensors are used to detect adenosine triphosphate (ATP) levels, which are involved in a variety of biological processes, such as regulating cellular metabolism and biochemical pathways. Therefore, this research aims to develop an aptamer-based electrochemical biosensor with Screen Printed Carbon Electrode/gold nanoparticles (SPCE/AuNP) and collect data as well as information related to ATP detection. The modification of SPCE with AuNP increased the analyte’s binding sensitivity and biocompatibility. The aptamer was selected based on its excellent bioreceptor characteristics. Furthermore, aptamer–SH (F1) and aptamer-NH2 (F2) were immobilized on the SPCE/AuNP surface, which had been characterized using SEM, EIS, and DPV. Also, the ATP-binding aptamers were electrochemically characterized using the K3[Fe(CN)6] redox system and Differential Pulse Voltammetry (DPV). According to the optimization results using the Box-Behnken experimental design, the ideal conditions obtained from the factors influencing the experiment were the F1 concentration and incubation time of 4 µM and 24 h, respectively, as well as F1/F2/ATP incubation time of 7.5 min. Meanwhile, for the range of 0.1 to 100 µM, the detection (LoD) and quantification (LoQ) limits were 7.43 and 24.78 µM, respectively. Therefore, this aptasensor method can be used to measure ATP levels in real samples.
Inhibition of Carbon Steel Corrosion by Some New Organic 2-Hydroselenoacetamide Derivatives in HCl Medium Alaa Abdel Khaleq Khalib; Hanan Abdul Jaleel Al-Hazam; Attared Fadhel Hassan
Indonesian Journal of Chemistry Vol 22, No 5 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.72852

Abstract

This study aims to prepare 2-hydroselenoacetamide derivatives (5-8) to use some of these compounds as corrosion inhibition for carbon steel in 1 M HCl. The compound C10H10NO2Cl 1 was prepared by reacting between p-aminoacetophenone with chloroacetyl chloride, and then reacted 1 with substituted benzaldehyde to obtain the corresponding derivatives as C17H13N2O4Cl 2, C18H16NO4Cl 3 and C19H18NO4Cl 4. The last step in this study was conducted to obtain the organic hydroselenoacetamide such as C10H11NO2Se 5, C17H14N2O4Se 6, C18H17NO4Se 7, and C19H19NO4Se 8 by reacting chloroaminochalcone and sodium hydrogen selenide. All compounds were characterized by Fourier Transform Infrared Spectroscopy (FTIR), proton nuclear magnetic resonance (1H-NMR), and elemental analysis (CHN). The corrosion inhibition activity of C17H14N2O4Se 6, C18H17NO4Se 7 and C19H18NO4Cl 4 for carbon steel in 1 M HCl solution was investigated by using weight loss methods and electrochemical study. The activation energy of the corrosion reaction was also calculated. The effect of different concentrations and temperatures on inhibition efficiency was investigated. The results showed that the corrosion rate decreased with the increase of the concentration of inhibitors, while the inhibition efficiency and covered area decreased with an increase in the temperature. Polarization studies demonstrated that the inhibitors were of mixed type. The purpose of this study was to prepare, characterize and evaluate the corrosion inhibition activity of hydroselenide compounds for carbon steel in 1 M HCl.
Total Synthesis of a Reversed-Bacicyclin Using a Combination of Solid- and Solution-Phase Methods Rani Maharani; Anastasya Firdausi; Tri Mayanti; Desi Harneti; Nurlelasari Nurlelasari; Safri Ishmayana; Kindi Farabi; Unang Supratman; Ace Tatang Hidayat
Indonesian Journal of Chemistry Vol 22, No 4 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.72956

Abstract

Bacicyclin is a cyclic hexapeptide with antibacterial activity against Enterococcus faecalis and Staphylococcus aureus with minimum inhibition concentration (MIC) values of 8 and 12 µM, respectively. Studies on a reversed sequence of bacicyclin were conducted to investigate how the reversed peptide sequence affects its biological properties. A reversed-bacicylin, cyclo-(Gly-Leu-Val-Ile-Ala-Phe), was successfully synthesized by constructing the linear precursor on 2-chlorotrityl chloride resin using a Fmoc-based strategy. The HATU/HOAt reagent was applied in all peptidic bond formations, and the desired linear hexapeptide (82% yield) was cleaved off the resin using a mixture of trifluoroacetic acid:dichloromethane (2:8). The linear peptide was cyclized using 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium-3-oxidehexa-fluorophosphate (HATU) as a coupling agent and diisopropylethylamine (DIPEA) as the base in a very dilute solution (0.001 M) in dichloromethane, then purified by octadecyl silica gel (ODS) column chromatography to obtain the reversed-bacicyclin (43.7% yield). The purity of the cyclic product was analyzed using analytical RP-HPLC (tR = 20.01 min), and characterized by HR-TOF-MS, 1H-NMR, and 13C-NMR. The biological activity of the reversed-bacicyclin is much lower compared to bacicyclin, indicating that the amino acid sequence of the cyclopeptide dictates the antibacterial activity. This finding gives additional information on the relationship between peptide sequence and biological properties.
Effect of Sensitive pH on Hydroxyapatite Properties Synthesized from Chicken Eggshell Ferli Septi Irwansyah; Azhari Yusuf; Diana Rakhmawaty Eddy; Risdiana Risdiana; Atiek Rostika Noviyanti
Indonesian Journal of Chemistry Vol 22, No 5 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.72959

Abstract

The hydrothermal method has effectively synthesized hydroxyapatite (HA). This study aimed to analyze the effect of pH on the properties (purity, crystallinity, and size) of HA crystals. HA synthesis of chicken eggshells was carried out using the hydrothermal method at temperatures of 230 °C with pH 9 and 9.34. The characteristics of HA are determined by XRF, XRD, FTIR, and TEM. The composition of the most significant compound obtained from the results of XRF analysis is CaO (97.5%). The XRD analysis showed that the purity of HA with pH 9.00 and 9.34 obtained was 97.8 and 96.6%, with the crystallinity of 56.46 and 56.96%. It was also obtained that the size of crystal HA was 21.8 and 15.7 nm for samples synthesized at pH 9.00 and 9.34. The results showed that the purity and size of HA were affected by differences in the pH synthesis and were relatively the same for its crystallinity which directly affects the value lattice parameter. The properties of HA produced by the hydrothermal method have met the criteria for biomedical applications.
Geochemistry and Potential Hydrocarbon Source Rocks of Rambatan Formation in Karangkobar Area, Central Java Praptisih Praptisih; Yoga Andriana Sendjaja; Vijaya Isnaniawardhani; Anggoro Tri Mursito; Purna Sulastya Putra; Septriono Hari Nugroho
Indonesian Journal of Chemistry Vol 22, No 6 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.73162

Abstract

The purpose of the study in the Karangkobar area was to investigate the source rock potential of the fine-grained surface samples of clastic sediments. The use of surface samples for source rock potential study in Indonesia is still limited. We conducted geochemical laboratory analyses in this research, including Total Organic Carbon (TOC), Rock-Eval Pyrolysis (REP), and Gas chromatography–mass spectrometry (GCMS). Seventeen samples have been analyzed for their TOC content. The result shows that TOC values varied between 0.36–1.55%, indicating that the source rock potential level based on the surface samples is poor to fair organic richness. REP was conducted on 16 samples, and the results show that the hydrocarbon-generating characteristics (HI values) ranged from 15 to 163 mg HC/g TOC. The kerogens identified included type II and III kerogen, which indicated the oil and gas-generating potential. Pyrolysis temperature is at maximum (Tmax) in the 276–458 °C, indicating that the samples were thermally immature to mature. GCMS analysis of source rock indicated that the depositional environment of the organic material derived from an open marine and plankton environment. This study is essential to complete the understanding of the petroleum system in Central Java.
Strategies in Improving Sensitivity of Colorimetry Sensor Based on Silver Nanoparticles in Chemical and Biological Samples Hanim Istatik Badi'ah; Dinda Khoirul Ummah; Ni Nyoman Tri Puspaningsih; Ganden Supriyanto
Indonesian Journal of Chemistry Vol 22, No 6 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.73194

Abstract

Colorimetric sensors-based silver nanoparticles (AgNPs) are very interesting to be studied and developed because of the simplicity and ease in the principle of detection. It does not require sophisticated and affordable tools but still has high sensitivity. The coefficient extinction of AgNPs is relatively higher than AuNPs of the same size, making the sensitivity of AgNPs higher than AuNPs. The principle of detection is based on the aggregation of nanoparticles with analytes that causes shifting in Localized Surface Plasmon Resonance (LSPR) to a larger wavelength, commonly called a bathochromic shift or redshift. It is a favorite phenomenon because it is more easily observed with naked eyes. This sensor shows a good analytic performance with high sensitivity due to strong LSPR and good strategies that selectively bring interaction between analytes and AgNPs. AgNPs are characterized using UV-Visible (Ultra Violet-Visible), TEM (Transmission Electron Microscope), FTIR (Fourier Transform Infrared), and DLS (Dynamic Light Scattering), and many analytes have been detected with this sensor successfully. This article discusses several important parameters in increasing the sensitivity of AgNPs colorimetric sensors. Finally, it can be used as guidelines in the development of methods in the future.
Microwave-Assisted Chemical Co-reduction of Pd Nanoparticles Anchored on Reduced Graphene Oxide with Different Loading Amounts Dyah Ayu Fatmawati; Triyono Triyono; Wega Trisunaryanti; Uswatul Chasanah
Indonesian Journal of Chemistry Vol 22, No 5 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.73206

Abstract

Microwave-assisted Palladium/Reduced Graphene Oxide (Pd/RGO) synthesis was effectively carried out in this study, which looked at the effects of different Pd loading weights in Graphene Oxide (GO) on its physicochemical qualities. The Tour technique was used to make GO, with a KMnO4:graphite weight ratio of 3.5. Meanwhile, Pd/RGO was synthesized utilizing the in-situ reduction method of one-pot synthesis with ascorbic acid as the green reducing agent, yielding Pd-0.5/RGO, Pd-1.0/RGO, and Pd-2.0/RGO, respectively, with variations in Pd loading weight of 0.5, 1.0, and 2.0%. XRD, FTIR, SAA, SEM-EDX, and TEM were used to examine all material characterizations. As a result, Pd-1.0/RGO had the largest surface area of 65.168 m2/g among the Pd-based materials, with a pore volume of 0.111 cc/g, the pore diameter of 3.316 nm, Pd crystallite size of 28.29 nm, RGO nanostructure dimension of 3.37 × 28.53 nm, and reduction level (C/O) of 3.02. This material also contains specific functional groups, including O-H, C-H, CO2, C=C, C=O, and C-O, based on FTIR spectra. Therefore, optimal weight loading of metal on the surface of the supporting material will provide a large material surface area. Increasing the surface area of the material improves its performance as a catalyst.

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