cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
-
Editorial Address
-
Location
Kab. sleman,
Daerah istimewa yogyakarta
INDONESIA
Indonesian Journal of Chemistry
Published by Universitas Gadjah Mada
ISSN : 14119420     EISSN : 24601578     DOI : -
Core Subject : Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry
Indonesian Journal of Chemistry is an International, peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. The journal is accredited by The Ministry of Research, Technology and Higher Education (RISTEKDIKTI) No : 21/E/KPT/2018 (in First Rank) and indexed in Scopus since 2012. Since 2018 (Volume 18), Indonesian Journal of Chemistry publish four issues (numbers) annually (February, May, August and November).
Arjuna Subject : -
Articles 2,006 Documents
 197   198   199   200   201 
Nitration of Liquid Natural Rubber by Concentrated Nitric Acid in the Presence of Acetic Anhydride Doan, Khai Minh; Tran, Trung Bao; Nguyen, Tuan Duy; Ly, Vuong Quoc
Indonesian Journal of Chemistry Vol 26, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.108473

Abstract

Liquid natural rubber (LNR) is commonly used as a binder in energetic composites. One of the key areas of interest is the development of energetic polymers to enhance adhesion efficiency and energy. In this study, an energetic liquid polymer—nitrated liquid natural rubber (N-LNR)—was successfully synthesized via nitration of LNR using concentrated nitric acid (HNO3) in the presence of acetic anhydride (Ac2O) and dichloromethane as solvent. The effects of key parameters, including the HNO3/LNR ratio and reaction time, on the degree of nitration and reaction yield were systematically investigated. The degree of nitration was found to increase linearly with the HNO3/LNR ratio, ranging from 7.97% to 32.9%, with a maximum yield of 76.1%. The optimal reaction conditions were identified as an Ac2O/HNO3 molar ratio of 2:1, a reaction time of 1.75 h, and a temperature of 20 °C. Structural analyses by FTIR, 1H-NMR, and 13C-NMR confirmed the presence of cis-1,4-isoprene chains partially substituted with –NO2 and –ONO2 groups, verifying successful nitration at the C=C bonds. These results demonstrated a controllable and efficient method for preparing energetic LNR-based polymers with potential application as binders in propellants and plastic explosives.
Antihistamine Potential of Red Alga Acanthophora spicifera Through Combination In Vivo, In Vitro, and In Silico Study Wahyuni, Ilmi; Soekamto, Nunuk Hariani; Rasyid, Herlina; Annisa, Nurul; Adriana, Risda; Putri, Alifiah Alfaniah Alfattah; Basir, Djabal Nur; Ahmad, Ahyar; Fauziah, St.; Irfandi, Rizal
Indonesian Journal of Chemistry Vol 26, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.109199

Abstract

Red alga Acanthophora spicifera is a marine species with potential as a source of natural antihistamines. This study evaluated the bioactivity of its secondary metabolites through in vivo, in vitro, and in silico approaches. Extracts were obtained by successive maceration using n-hexane, ethyl acetate, and methanol. In vivo testing on BALB/c mice showed that extract administration did not cause significant weight loss. However, its effect on allergic symptoms was significant (p < 0.05), with the methanol extract identified as the most effective by the Mann–Whitney test. In vitro assays revealed a significant reduction in histamine levels (p < 0.05) during sensitization, treatment, and post-challenge phases, particularly in the methanol extract group. In silico docking demonstrated that two compounds from the methanol extract exhibited strong binding affinity to the H1 receptor (PDB ID: 3RZE), with binding energies of −6.27 and −5.06 kcal/mol. These findings suggest that A. spicifera, particularly its methanol extract, is a promising source of natural antihistamines with potential applications in the development of safer allergy treatments.
Preparation and Characterization of Cholesterol Esterase Inhibition Protein Hydrolysate from Whiteleg Shrimp (Litopenaeus vannamei) Head Vo, Bao Chi; Nguyen, Ha Thu; Vo, Linh Thi Truc; Cao, Khang Tran Gia; Vo, Tam Dinh Le
Indonesian Journal of Chemistry Vol 26, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.109424

Abstract

Protein hydrolysates with cholesterol esterase inhibition activity (CEIA) can reduce the de-esterification and absorption of dietary cholesterol, helping manage hypercholesterolemia. With a high protein content, whiteleg shrimp (Litopenaeus vannamei) heads (WLSH) are a promising source for producing such hydrolysates. Using a single-factor test by sequentially varying WLSH powder-to-water ratio (1:3–1:8 w/v), enzyme-to-substrate (E:S) ratio (10–50 U/g protein), and hydrolysis time (2–7 h), the best alcalase-catalyzed hydrolysis condition was determined as a 1:6 (w/v) WLSH powder-to-water ratio, a 30 U/g protein E:S ratio, and a 4-h hydrolysis time. The resulting hydrolysate displayed a CEIA of 58.00 ± 0.64% and retained over 70% of its activity after treatment with pH (1.0–6.0) or heat (100 °C for 2 h). Arg, the predominant amino acid in the hydrolysate, together with abundant hydrophobic amino acids, contributed to the hydrolysate’s activity. Furthermore, the notable foaming and emulsifying properties of the hydrolysate indicate its promise as a surface-active agent in food applications. Besides, the 1–3 kDa fraction from the hydrolysate exhibited the greatest CEIA, probably due to its easier access to the enzyme’s active site. With higher CEIA, compared to other hydrolysates, the WLSH hydrolysate and its 1–3 kDa fraction could serve as a new natural cholesterol-lowering agent.
Biofunctionalized Titanium Dioxide Nanoparticles with Bovine Serum Albumin for Targeted Cytotoxicity in MCF-7 Breast Cancer Cells Rahujo, Sanam; Talpur, Farah Naz; Laghari, Abdul Qadeer; Mert, Olcay; Afridi, Hassan Imran; Ali, Zafar; Razzaque, Noshad; Chandio, Imamdin; Zaman, Noor; Abro, Masroor
Indonesian Journal of Chemistry Vol 26, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.109676

Abstract

The titanium dioxide nanoparticles (TiO2NPs) were synthesized and functionalized with bovine serum albumin (BSA) to yield TiO2@BSA nanocomposites for targeted drug delivery. The chemotherapeutic drug vinorelbine (VRL), used for non-small cell lung and breast cancer, was loaded into the nanocomposites by a cost-efficient sol-gel method. The UV-vis spectrum exhibited an absorption peak at 361 nm, confirming the formation of TiO2 NPs. In the FTIR spectrum, the grafting of BSA was indicated by specific band shifts. XRD and FESEM revealed well-dispersed spherical particles with an average crystallite size of ⁓20 nm, and EDX confirmed elemental composition. The zeta potential of −29 mV indicated colloidal stability with a drug loading efficiency of 62%. In vitro release studies demonstrated pH-responsive behavior, with 98% cumulative release at an acidic pH (5.5) compared to 20% at physiological pH (7.4), indicating the suitability of this formulation for tumor-targeted delivery. Higuchi and Korsmeyer-Peppas models were used for the kinetics study, indicating that the mechanism was controlled by diffusion and swelling. Cytotoxicity evaluation via MTT assay showed enhanced uptake and anticancer activity of VRL-loaded TiO2@BSANPs against MCF-7 cells compared with free VRL. These results suggest TiO2@BSA nanocarriers as efficient, stable, and selective platforms for cancer therapy.
Natural Truffle Peels for Effective Removal of Rhodamine B Dye from Aqueous Solutions Alshaikh, Hind Abdullah; Saigl, Zainab Mohammad
Indonesian Journal of Chemistry Vol 26, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.110245

Abstract

This study evaluated truffle peel powder (TPs) as a sustainable biosorbent for removing Rhodamine B (RB) dye from aqueous solutions and real samples. TPs were characterized by FTIR, SEM, and EDX, revealing functional groups and porous surfaces favorable for adsorption. The adsorption process followed the Langmuir isotherm (R2 = 0.9969) with a maximum capacity of 0.0833 mg/g at 25 °C, confirming monolayer adsorption. Kinetics fit the pseudo-second-order model (R2 = 0.9981), indicating chemisorption. Thermodynamic analysis showed the removal process is spontaneous and exothermic (ΔH = −26.06 kJ/mol; ΔG = −4.00 kJ/mol; ΔS = −74.03 J/mol K), involving reduced randomness at the interface. The method achieved good recovery in various matrices, such as ice pop, seawater, bottled water, and tap water. Results demonstrate that truffle waste offers an effective, eco-friendly solution for dye-contaminated water, combining strong adsorption performance with environmental sustainability.
Physicochemical Properties, Heavy Metal Contamination, and Resource Recovery Potential of Petroleum Sludge in Indonesia Fadilah, Siska Nuri; Setiawan, Wahyu; Setiawan, Pratama; Putri, Aninda; Gulo, Fakhili
Indonesian Journal of Chemistry Vol 26, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.110376

Abstract

Petroleum sludge (PS) is a hazardous waste rich in hydrocarbons and heavy metals, posing significant risks to the environment. Although numerous studies have been conducted globally, a comprehensive characterization of PS originating from Indonesia remains scarce. This study aims to fill this gap by conducting a thorough physicochemical characterization, environmental pollution assessment, and sustainable utilization potential evaluation of PS. The results revealed that the sludge contains a high oil content (15.56%), an extremely high COD level, and is dominated by iron as a heavy metal (4,585.67 mg/L). The TCLP analysis showed that Pb exceeded the regulatory threshold, indicating a significant leaching potential and toxicity risk. BET analysis indicated a mesoporous structure with a specific surface area of 4.73 m2/g, suggesting its potential use as an adsorbent or catalyst support. The high elemental composition of carbon (25.05%), hydrogen (3.10%), and calorific value (3,418 kcal/kg) further highlights its potential for thermochemical conversions such as pyrolysis or gasification. These findings provide a scientific foundation for PS management in Indonesia and highlight its potential conversion into value-added resources, thereby supporting circular economy strategies and sustainable development goals.
Enhanced Organic Pollutant Adsorption Using Zeolite-Carbon Dots Composites Synthesized by the Impregnation Method Thanh, Ho Tan; Phuc, Nguyen Thien; Khoi, Dang Dinh; Long, Nguyen Quang
Indonesian Journal of Chemistry Vol 26, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.110466

Abstract

In this study, a novel zeolite–carbon dots (ZCD) composite was synthesized via impregnation to enhance the adsorption performance of zeolite. The attachment of carbon dots (CDs) onto the zeolite surface was confirmed by SEM/EDS, TEM, BET, and FT-IR analyses. These results showed that CDs were uniformly dispersed on the FAU-type zeolite, introduced additional –OH, –CHx, and –NH2 groups, and increased the BET surface area from 444.5 to 491.5 m2 g−1. The presence of functional groups on the surface of CDs enhanced the adsorption capacity of zeolite. Notably, ZCD exhibited a 45% higher adsorption capacity for methylene blue (MB) than pristine zeolite, with a maximum experimental uptake of 32.53 mg g−1. Adsorption isotherm and kinetic studies, best described by the Langmuir model (qm = 29.22 mg g−1, R2 = 0.9815) and the pseudo-second-order kinetic model (R2 = 0.9991), indicated that MB uptake on ZCD occurred through both physical and chemical interactions. These results suggest that the ZCD composite is a promising adsorbent for the removal of organic dyes in water treatment applications.
Adsorption of Methyl Violet 2B Dye by Silica from Glass Bottle Waste Ni’mah, Yatim Lailun; Faqih, Muhammad Zidan Chisa; Suprapto, Suprapto; Yuningsih, Nabila Eka; Jamari, Nor Laili-Azua
Indonesian Journal of Chemistry Vol 26, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.110644

Abstract

In this study, silica gel was successfully synthesized using waste from chemical reagent glass bottles. The synthesized silica gel was then tested for its effectiveness in adsorbing methyl violet 2B dye. To optimize the adsorption process, Surface Response Methodology (RSM) was employed, utilizing the Box-Behnken design (BBD) for factor and input design. Characterization of the synthesized silica gel through XRD analysis revealed an amorphous structure and mesoporous pores, with a purity of 75.63%. The optimization process focused on four key factors: pH (3 to 9), initial concentration of methyl violet 2B (10 to 30 mg/L), adsorbent mass (30 to 100 mg), and contact time (15 to 60 min). The optimal conditions for adsorbing methyl violet 2B were determined to be a pH range of 7–9, an initial methyl violet 2B concentration of 27–30 mg/L, an adsorbent mass of 70–95 mg, and a contact time of 30–40 min. Under these optimized conditions, the methyl violet 2B removal efficiency of 98.69% was achieved. Further analysis indicated that the adsorption of methyl violet 2B onto the synthesized silica gel followed the Temkin isotherm and pseudo-second-order kinetics models.
Antioxidant and In Vitro Antidiabetic Properties of Lansium domesticum Leaves Extracted with Solvents of Varying Polarity Situmorang, Jiro Hasegawa; Yulyana, Ana; Astyka, Ririn; Syahputra, Hafid; Lubis, Muhammad Fauzan
Indonesian Journal of Chemistry Vol 26, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.110695

Abstract

Conventional therapies for diabetes mellitus, such as oral hypoglycemic agents, are often limited by side effects and incomplete glycemic control, highlighting the need for safer alternatives. Exploring natural remedies, such as Lansium domesticum, is compelling, as this plant has been traditionally used for diabetes therapy. This study aimed to investigate how solvent polarity and affinity influence phytochemical content, antioxidant activity, and enzyme inhibitory potential of L. domesticum leaf extracts. Extraction was conducted using methanol, ethanol, and acetone (50%, 75%, 100%), and distilled water. Total phenolic content (TPC) and total flavonoid content (TFC) were quantified, and antioxidant activities were assessed via total antioxidant activity (TAA), DPPH, and FRAP assays. Antidiabetic activity was evaluated in vitro through α-glucosidase and α-amylase inhibition assays. The results indicated that 100% ethanol extract exhibited the highest TPC and TFC, correlating strongly with superior antioxidant and enzyme inhibitory activities. The extract has also demonstrated the most potent inhibition of α-glucosidase and α-amylase, with IC50 values of 70.64 and 105.13 µg/mL, respectively. Pearson correlation analysis revealed strong negative correlations between phytochemical contents and IC50 values. Overall, ethanol proved to be the most effective solvent for extracting bioactive compounds from L. domesticum leaves, underscoring its potential as a natural antioxidant and antidiabetic agent.
Synthesis and Characterization of MnO2 Nanoparticle Composite and Palm Kernel Shell-Based Activated Carbon as Supercapacitor Electrode Candidates Arif, Ainun Rezkiva; Zakir, Muhammad; Ahmad, Ahyar; Raya, Indah; Taba, Paulina; Rasyid, Herlina
Indonesian Journal of Chemistry Vol 26, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.110797

Abstract

Palm kernel shells (PKS) are a biomass waste rich in carbon and low in ash content, making them suitable for conversion into supercapacitor electrode materials that support the principles of the blue economy and green technology. This study presents a novel synthesis approach for supercapacitor electrode materials by combining activated carbon derived from hydrothermally carbonized PKS biomass waste (AC-PKS) with MnO2 nanoparticles. Carbon activation in this study was carried out using chemical and physical activation approaches to produce a microporous structure with a high surface area. The AC-PKS/MnO2 composite was then synthesized through a redox reaction deposition using KMnO4 to create materials that exhibit potential properties between double-layer capacitance and pseudocapacitive behavior. Electrochemical testing with CV and GCD showed an increase in the specific capacitance of the AC-PKS/MnO2 composite of 67.85 and 46.91 F/g, respectively. These findings indicate the scientific contribution of combining biomass-derived activated carbon with metal oxides as a potential supercapacitor electrode. The implications of these results suggest that AC-PKS/MnO2 not only offers a sustainable material solution but also opens up opportunities for the development of high-capacity supercapacitor electrodes for future energy storage applications, particularly in renewable energy and environmentally friendly technologies.

Page 200 of 201 | Total Record : 2006

 197   198   199   200   201 

Filter by Year

2001 2026


Reset
Filter By Issues
All Issue Vol 26, No 2 (2026) Vol 26, No 1 (2026) Vol 25, No 5 (2025) Vol 25, No 4 (2025) Vol 25, No 3 (2025) Vol 25, No 2 (2025) Vol 25, No 1 (2025) Vol 24, No 6 (2024) Vol 24, No 5 (2024) Vol 24, No 4 (2024) Vol 24, No 3 (2024) Vol 24, No 2 (2024) Vol 24, No 1 (2024) Vol 23, No 6 (2023) Vol 23, No 5 (2023) Vol 23, No 4 (2023) Vol 23, No 3 (2023) Vol 23, No 2 (2023) Vol 23, No 1 (2023) Vol 22, No 6 (2022) Vol 22, No 5 (2022) Vol 22, No 4 (2022) Vol 22, No 3 (2022) Vol 22, No 1 (2022) Vol 22, No 2 (2022) Vol 21, No 6 (2021) Vol 21, No 5 (2021) Vol 21, No 4 (2021) Vol 21, No 3 (2021) Vol 21, No 2 (2021) Vol 21, No 1 (2021) Vol 20, No 6 (2020) Vol 20, No 5 (2020) Vol 20, No 4 (2020) Vol 20, No 3 (2020) Vol 20, No 2 (2020) Vol 20, No 1 (2020) Vol 19, No 4 (2019) Vol 19, No 3 (2019) Vol 19, No 2 (2019) Vol 19, No 1 (2019) Vol 18, No 4 (2018) Vol 18, No 3 (2018) Vol 18, No 2 (2018) Vol 18, No 1 (2018) Vol 17, No 3 (2017) Vol 17, No 2 (2017) Vol 17, No 1 (2017) Vol 16, No 3 (2016) Vol 16, No 2 (2016) Vol 16, No 1 (2016) Vol 15, No 3 (2015) Vol 15, No 2 (2015) Vol 15, No 1 (2015) Vol 14, No 3 (2014) Vol 14, No 2 (2014) Vol 14, No 1 (2014) Vol 13, No 3 (2013) Vol 13, No 2 (2013) Vol 13, No 1 (2013) Vol 12, No 3 (2012) Vol 12, No 2 (2012) Vol 12, No 1 (2012) Vol 11, No 3 (2011) Vol 11, No 2 (2011) Vol 11, No 1 (2011) Vol 10, No 3 (2010) Vol 10, No 2 (2010) Vol 10, No 1 (2010) Vol 9, No 3 (2009) Vol 9, No 2 (2009) Vol 9, No 1 (2009) Vol 8, No 3 (2008) Vol 8, No 2 (2008) Vol 8, No 1 (2008) Vol 7, No 3 (2007) Vol 7, No 2 (2007) Vol 7, No 1 (2007) Vol 6, No 3 (2006) Vol 6, No 2 (2006) Vol 6, No 1 (2006) Vol 5, No 3 (2005) Vol 5, No 2 (2005) Vol 5, No 1 (2005) Vol 4, No 3 (2004) Vol 4, No 2 (2004) Vol 4, No 1 (2004) Vol 3, No 3 (2003) Vol 3, No 2 (2003) Vol 3, No 1 (2003) Vol 2, No 3 (2002) Vol 2, No 2 (2002) Vol 2, No 1 (2002) Vol 1, No 3 (2001) Vol 1, No 2 (2001) Vol 1, No 1 (2001) Article in press ARTICLE IN PRESS More Issue