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INDONESIA
Indonesian Journal of Chemistry
ISSN : 14119420     EISSN : 24601578     DOI : -
Indonesian Journal of Chemistry is an International, peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. The journal is accredited by The Ministry of Research, Technology and Higher Education (RISTEKDIKTI) No : 21/E/KPT/2018 (in First Rank) and indexed in Scopus since 2012. Since 2018 (Volume 18), Indonesian Journal of Chemistry publish four issues (numbers) annually (February, May, August and November).
Arjuna Subject : -
Articles 1,981 Documents
THE EFFECT OF FORMALDEHYDE EXPOSURE AND YOGURT SUPPLEMENTATION ON PROFILE AND CHARACTER OF HEPAR TISSUE PROTEIN OF RATS (Rattus norvegicus) Chanif Mahdi; Aulaniam Aulaniam
Indonesian Journal of Chemistry Vol 10, No 1 (2010)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (630.444 KB) | DOI: 10.22146/ijc.21493

Abstract

Formaldehyde is a simplest organic compound of aldehyde or alkanal group. Formaldehyde is a toxic and carcinogenic substance. Formaldehyde contamination through food or feeding diet continuously is very dangerous for the body, especially for bodies organ for instances likes hepar and kidney. Because formaldehyde is sources of reactive oxygen species (ROS) and free radicals substances for the body. This purpose of the study is to know the effect of formaldehyde exposure and yogurt supplementation on profile and characters of rats (Rattus norvegicus) protein hepar tissues. The research methods is laboratory methods. The protein profiles determined by electrophoresis (SDS-PAGE) methods. The character of hepar protein tissue determined by ELISA, Dot Blot and Western Blot methods. The result showed that formaldehyde exposure through the feeding diet of rats affect on profile of hepar protein tissue, that characterized by appear of new band of specific protein with molecule weigh is 29.6 kDa (PSForm 29.6). Yogurt supplementation on rat that exposure by formaldehyde through the feeding diet of rat, that characterized by expressing of new band of specific protein with relative molecule weight 24.8 kDa (PSYogh 24.8 kDa), and followed by depressed or dispear of protein specific band of 29.6 kDa(PSForm 29.6 kDa). The result showed that isolated protein PSForm 29.6 kDa have a antigenecity character.
6,6’-DIMETHOXY-4,4’-DIHYDROXY-3’,2’-FURANO-ISOFLAVANE, A NEW COMPOUND FROM Melochia umbellata (Houtt.) Stapf var. Degrabrata K. (Paliasa) Erwin Erwin; Alfian Noor; Nunuk Hariani Soekamto; Tjodi Harlim
Indonesian Journal of Chemistry Vol 10, No 2 (2010)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (200.086 KB) | DOI: 10.22146/ijc.21463

Abstract

Using data from UV, IR, 1H-NMR, 13C-NMR, dan NMR-2D analysis, a compound of 6,6'-dimethoxy-4,4'-dihydroxy-3',2'-furano-isoflavane (1) was successfully isolated from chloroform fraction of heartwood in Melochia umbellata (Houtt.) Stapf var. Degrabarata K (Paliasa). Hitherto no report of such compound found in literature. The compound however has not shown a significant bioactivity according to either brine shrimp lethality test or evaluation of anti tumor activity against leukemia murine cell (P-388).
STRUCTURE AND THERMAL STABILITY OF THE BENZO-15-CROWN-5 WITH LANTHANUM (III) BROMIDE COMPLEX Muhammad Idiris Saleh; Eny Kusrini; Abdulssalam Salhin; Rohana Adnan; Ismail Ab. Rahman; Bahruddin Saad; Bohari M. Yamin
Indonesian Journal of Chemistry Vol 4, No 3 (2004)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (390.115 KB) | DOI: 10.22146/ijc.21843

Abstract

The reaction of benzo-15-crown-5 (C14H20O5) ligand with La(NO3)3.7H2O in the presence of HBr has resulted in the production of an exotic sandwich complex, [LaC28H36Br4O10][3Br]. The crystal system is triclinic with space group P1, a = 12.5834(14) Å, b = 13.5816(16) Å, c = 13.8403(16) Å, a = 70.751(2)°, b = 66.773(2)° and g = 67.631(2)°. The cation comprises of the lanthanum atom coordinated to two crowns via three oxygen atoms from each crown in a η3-sandwich fashion. The two phenyl groups of the crown are brominated. The La-OLigand bond lengths are between 2.857(7) and 2.949(7) Å. The trianion [3Br]3- is linear with Br-Br bond lengths of 2.518(2) and 2.560(2) Å respectively. The molecule is stabilized by intermolecular interactions of the type C-H...Br to form dimers and are arranged parallel to bc face.
ADSORPTION OF Pb(II), Cd(II), AND Cr(III) FROM AQUEOUS SOLUTION BY POLY-5-ALLYL-CALIX[4]ARENE TETRA CARBOXYLIC ACID Desi Suci Handayani; Jumina Jumina; Dwi Siswanta; Mustofa Mustofa; Keisuke Ohto; Hidetaka Kawakita
Indonesian Journal of Chemistry Vol 11, No 2 (2011)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (303.103 KB) | DOI: 10.22146/ijc.21409

Abstract

The aim research is application of poly-5-allyl-calix[4]arene tetra carboxylic acid as adsorbent of heavy metal cations. Adsorption was carried out towards Pb(II), Cd(II) and Cr(III) ions in batch system. Several variables including pH, contact time and initial concentration of metal ions were determined. The optimum adsorption conditions were achieved at pH 6.0 for Cd(II) and Cr(III), while at pH 5.5 for Pb(II) ions. In addition, the optimum contact time of Pb (II), Cd(II) and Cr(III) ion adsorption were 180 min. The adsorption kinetics of Pb(II), Cd(II) and Cr(III) ions using the calixarene polymer adsorbent followed a pseudo 2nd order kinetics model, with adsorption rate constants of 2x10-2; 5x10-3, and 3.1x10-2 g mole-1 min-1, respectively. Furthermore, the adsorption isotherm of Pb(II) and Cd(II) ions tends to follow the Freundlich isotherm, whereas the adsorption of Cr (III) tends to follow the Langmuir isotherm. The adsorption capacity of Pb(II), Cd(II) and Cr(III) metal ions were 104.04, 61.78 and 228.69 μmole/g, with adsorption energy of 24.87; 21.62 and 31.07 KJ/mole, respectively.
ACTIVITY OF PROPYL p-BENZOYLOXYBENZOATE AS A GLUTATHIONE S-TRANSFERASE(S) INHIBITOR: THE COMPARISON BETWEEN COMPUTATIONAL CHEMISTRY APPROACH AND EMPIRICAL OBSERVATION Enade Perdana Istyastono; Agnes Nora Iska Harnita; Sudibyo Martono
Indonesian Journal of Chemistry Vol 6, No 1 (2006)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (250.6 KB) | DOI: 10.22146/ijc.21781

Abstract

The activity of propyl p-benzoyloxybenzoate as a glutathione S-transferase(s) (GSTs) inhibitor has been examined through computational chemistry based theoretical approach and laboratory experiment. This research was related to the nature of GSTs as multifunctional enzymes, which play an important role in the detoxification of electrophilic compounds, the process of inflammation and the effectivities of anticancer compounds. Quantitative Structure-Activity Relationship (QSAR) study, which was established on curcumin and its derivatives using computational chemistry approach, was used to examine the theoretical activity of p-benzoyloxybenzoate as a GSTs inhibitor. Empirical observation on GSTs inhibition was examined using formation reaction model of GS-CNB conjugate through conjugation of 1-chloro-2,4-dinitrobenzene (CDNB) and glutathione (GSH) with GSTs (prepared from rat's liver) as catalysts. The result showed that the difference between the activities of propyl p-benzoyloxybenzoate as a GSTs inhibitor obtained from the computational chemistry approach and the empirical observation were not statistically significant at 95% level of confidence.
THEORETICAL STUDY OF THE [Fe(en)2(NCS)2] COMPLEX WITH REPARAMETERIZED DENSITY FUNCTIONALS Yusthinus T. Male; Djulia Onggo; Muhamad A. Martoprawiro; Ismunandar Ismunandar
Indonesian Journal of Chemistry Vol 9, No 3 (2009)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (475.336 KB) | DOI: 10.22146/ijc.21511

Abstract

Quantum chemical studies have been carried out on the Fe(en)2(NCS)2 (en = ethylenediamine) complex both in low and high spin states (S = 0 and S = 2) using hybrid exchange-correlation functional (B3LYP) and non-hybrid method (BLYP). Calculations were performed in vacuum and in methanol to study the effect of cis-trans geometry on the structure and energy difference between low-spin (LS) and high-spin (HS) states of iron (II) complexes. Full geometry optimizations of the complexes show that hybrid method consistently gives higher energy difference between LS and HS states than the nonhybrid methods. Calculations with reparameterized density functional theory that showed more reasonable electronic energy splittings in previous research was also carried out. In addition, the computational study of Fe(en)2(NCS)2 in vacuum and methanol with PCM method showed that the complexes tend to adopt cis geometry. This geometry showed much less charge transfer in the substitutions of NCS- ligands compare to trans geometry.
HOPEAPHENOL-O-GLYCOSIDE, A COMPOUND ISOLATED FROM STEM BARK Anisoptera marginata (Dipterocarpaceae) Sri Atun
Indonesian Journal of Chemistry Vol 9, No 1 (2009)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1990.33 KB) | DOI: 10.22146/ijc.21578

Abstract

Isolation and structure elucidation of some compounds from stem bark of Anisoptera marginata had been done. The isolation of those compounds was carried out by chromatographyc method and structure elucidation was performed by interpretation of spectroscopic data, including UV, IR,  1H and 13C NMR 1D and 2D, and FABMS. From acetone extract stem bark A. marginata we isolated five known compounds namely bergenin (1), (-)-ε-vinipherin (2), (-)-ampelopsin A (3), vaticanol B (4), (-)-hopeaphenol (5), and a glycoside compound namely hopeaphenol-O- glycoside (6).
STRUCTURE IDENTIFICATION OF A TRIMER STILBENOID COMPOUND FROM STEM BARK Hopea nigra (DIPTEROCARPACEAE) Sri Atun; Nurfina Aznama; Retno Arianingrum; Masatake Niwab
Indonesian Journal of Chemistry Vol 5, No 3 (2005)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (248.103 KB) | DOI: 10.22146/ijc.21791

Abstract

Bioactivity as antihephatotoxic directed fractionation of aceton extract from the stem bark of Hopea nigra (Dipterocarpaceae) afforded a stilbenoid trimer, namely vaticanol G (1). The structure of this compound were elucidated based on physical and spectroscopic data (UV, IR, MS, 1H and 13C NMR 1D and 2D).
ISOLATION OF ACTINOMYCIN D FROM MARINE DERIVED Streptomyces Abdullah Rasyid; Kyoko Adachi
Indonesian Journal of Chemistry Vol 7, No 3 (2007)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (249.493 KB) | DOI: 10.22146/ijc.21683

Abstract

The bioactive substance producing strain, a marine bacterium A5S-46 was found in the antibacterial screening. This strain was isolated from the artificial sponge set in the coastal seawater at Iriomote islands (Japan). The crude extract from culture broth of the strain A5S-46 was assayed to the antibacterial activity test against the seven kinds of bacterial test strains. The active substance accumulated in the both bacterial cells and culture supernatant. Based on the 1H NMR and the LC/PDA/MS data, the bioactive substance was identified to be actinomycin D.
Synthesis of Polyvinyl Pirrolidone (PVC) /Κ-Carrageenan Hydrogel Prepared by Gamma Radiation Processing As a Function of Dose and PVP Concentration Erizal Erizal; Tjahyono Tjahyono; Dian PP; Darmawan Darmawan
Indonesian Journal of Chemistry Vol 13, No 1 (2013)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1916.236 KB) | DOI: 10.22146/ijc.21324

Abstract

The aim of this research is to prepare a biomaterial to be used in health care. A series of hydrogels based on polyvinyl pyrrolidone (PVP)/κ-Carrageenan (KC) has been prepared by radiation technique. PVP (5-15%) were mixed with ΚC (2%) and irradiated by gamma rays at the doses from 25 kGy to 35 kGy (dose rate 7 kGy/h) at room temperature. The chemical change of hydrogels was characterized using Fourier Transform infra Red (FTIR). Gel fraction, water absorption and water evaporation were determined gravimetrically. Tensile strength and elongation at break was measured using Instron meter. It was found that with the increase irradiation dose and PVP concentration, the gel fraction and tensile strength of hydrogels increase. In contrast the elongation at break and water absorption of hydrogels decrease. The hydrogel of PVP/KC hydrogel produced by gamma radiation can be considered for wound dressings.

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