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Indonesian Journal of Chemistry

ijc
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Published by Universitas Gadjah Mada

ISSN : 14119420 EISSN : 24601578 DOI : -

Core Subject : Science, Engineering,

Chemical Engineering, Chemistry & Bioengineering Chemistry

Indonesian Journal of Chemistry is an International, peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. The journal is accredited by The Ministry of Research, Technology and Higher Education (RISTEKDIKTI) No : 21/E/KPT/2018 (in First Rank) and indexed in Scopus since 2012. Since 2018 (Volume 18), Indonesian Journal of Chemistry publish four issues (numbers) annually (February, May, August and November).

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Articles 1,981 Documents

67 68 69 70 71

Synthesis and In Vitro Evaluation of C-methylcalix[4]resorcinaryl octacinnamate and C-methylcalix[4]resorcinaryl octabenzoate as the Sunscreen Budiana I Gusti M. Ngurah; Jumina Jumina; Chairil Anwar; Sunardi Sunardi; Mustofa Mustofa
Indonesian Journal of Chemistry Vol 17, No 1 (2017)
Publisher : Universitas Gadjah Mada

The present study was aimed to synthesize and evaluate sunscreen activity of C-methylcalix[4]resorcinaryl octacinnamate and C-methylcalix[4]resorcinaryl octabenzoate. The target compounds were synthesized in 2 steps. They were a synthesis of C-methylcalix[4]-resorcinarene via acid catalyzed the condensation of resorcinol and acetaldehyde by using HCl catalyst, followed by esterification using cinnamoyl chloride and benzoyl chloride. The characterization of the target compounds was performed by IR, 1H-NMR, 13C-NMR, and LC-MS spectrometers. The sunscreen activity test was conducted by spectroscopic method and MTT-assay. Commercial sunscreen p-amino benzoic acid (PABA) was used as a comparator to the MTT assay. The sunscreen activity test used spectroscopic showed that C-methylcalix[4]resorcinaryl octacinnamate and C-methylcalix[4]resorcinaryl octabenzoate can absorb the ultraviolet radiation between 280 and 320 nm (UV-B) with the maximum absorption at 290 nm (ε = 31.535 M-1 cm-1) and 282 nm (ε = 42.217 M-1 cm-1), respectively. The results of MTT-assay indicated that the IC50 of C-methylcalix[4]resorcinaryl octacinnamate, C-methylcalix[4]resorcinaryl octabenzoate and PABA are 12.006, 20.568 and 12.564 ppm, respectively, it means that the order of sunscreen activity is C-methylcalix-[4]resorcinaryl octacinnamate, PABA and C-methylcalix[4]resorcinaryl octabenzoate.

Activated Carbon from Spent Brewery Barley Husks for Cadmium Ion Adsorption from Aqueous Solution Ilesanmi Osasona; Kayode Aiyedatiwa; Jonathan Johnson; Oluwabamise Lekan Faboya
Indonesian Journal of Chemistry Vol 18, No 1 (2018)
Publisher : Universitas Gadjah Mada

This study investigated the feasibility of using acid activated carbon prepared from brewery spent barley husks for the adsorption of cadmium from aqueous solution. The effects of operation parameters such as pH, contact time, adsorbent dosage, concentration and temperature were verified. The amount of cadmium adsorbed increased with increase in solution pH, initial solution concentration and with the amount of adsorbent dosed. A time of 5 minutes was required for attainment of equilibrium. The equilibrium data obtained were analysed using both Langmuir and Freundlich isotherm models and the data were better described by Langmuir model with correlation coefficient of 0.9183. The thermodynamic parameters revealed that the removal of cadmium by the activated carbon was exothermic and spontaneous. Thus, activated carbon obtained from brewery spent barley husk can be employed as an economically viable low-cost adsorbent for removing cadmium from aqueous solution.

New Prenylated Stilbenes and Antioxidant Activities of Cajanus cajan (L.) Millsp. (Pigeon pea) Taslim Ersam; Sri Fatmawati; Dini Nur Fauzia
Indonesian Journal of Chemistry Vol 16, No 2 (2016)
Publisher : Universitas Gadjah Mada

New Prenylated stilbene derivatives, 3-hydroxy-4-prenyl-5-methoxy-stilbene acid (1) and 5,4'-dihydroxy-3-methoxy-2-prenyl-stilbene (2) had been isolated from methanol extract of Cajanus cajan (L.) Millsp. (Pigeon pea), a member of family fabaceae. The aim of this present work was to evaluate its in vitro antioxidant activity using 2,2-diphenyl-1-picryhydrazyl (DPPH) radical-scavenging. Isolation of compounds was achieved by extraction (maceration) and chromatographic technique. The structures of the compounds were determined based on UV, IR, 1H-NMR and 13C-NMR spectra and also by comparing with the previously reported data. Antioxidant activities (IC50) of 1 and 2 were 413.68 μg/mL and 271.53 μg/mL, respectively.

Thermodynamic and Kinetic Study of Zinc bis-(Dipalmithyl Dithiophosphate) Activity as Anti-Corrosion Additive-Fatty Acid Based Through Potentiodynamic Polarization Technique Komar Sutriah; Zainal Alim Mas’ud; Mohammad Khotib; Denar Zuliandanu
Indonesian Journal of Chemistry Vol 16, No 2 (2016)
Publisher : Universitas Gadjah Mada

Zinc bis-(dipalmithyl dithiophosphate) (ZDTP16) is one product variant of zinc dialkyl dithiophosphate (ZDTP)-fatty acid based having function as corrosion inhibitor. By using 3% of effective dose for the application, its effectiveness of ZDTP16 corrosion inhibition will achieve 97% and it will be able to decrease Cu metal corrosion rate from 0.152 to 0.004 mm per year. Thermodynamic and kinetic parameter verification indicates the decreasing of spontaneity and corrosion rate by existence of ZDTP16 inhibitor. Gibbs free energy transition corrosion of Cu metal in electrolyte medium is measured in corrosion simulator increased from +85.22 to +91.77 kJ mol-1, while its activation energy increased from +16.66 to +33.68 kJ mol-1. Morphology observation of Cu metal substrate surface using SEM-EDX shows that the adsorption of ZDTP16 at substrate surface is able to protect surface from corrosion indicated by the existence of Zn, P, S, and C constituents representing composer atoms of ZDTP16, and the decreasing of Cl- corrosive constituent at substrate surface.

The Roles of Hydrazine and Ethylenediamine in Wet Synthesis of Cu Nanowire Harsojo Harsojo; Lutfi Ayu Puspita; Dedi Mardiansyah; Roto Roto; Kuwat Triyana
Indonesian Journal of Chemistry Vol 17, No 1 (2017)
Publisher : Universitas Gadjah Mada

A wet synthesis Cu nanowire using CuNO3 as a precursor and hydrazine as a reduction agent and ethylene diamine as a polymer capping agent in excessive sodium hydroxide solution 15 M NaOH has been done. The study was done by varying the volume of hydrazine 0.15, 0.25 and 0.75 mL and ethylenediamine (EDA) (0.5, 1.5 and 0.25 mL) in a total volume of 100 mL, to investigate the roles of these two agents in forming the nanowire and was done at 60 °C at 60 RPM stirring speed. The study revealed that the wet synthesis could be used to produce nanowires in the length of micrometers with a diameter of about hundred nanometers. The best CuNW was obtained at volume EDA 1.5 mL at hydrazine volume 0.15 mL with length to diameter ratio was 120 ± 30. The roles of both hydrazine and the EDA in the process of making nanowires and nanoparticles were also discussed.

Influence of Macrocyclic Ring Size on the Corrosion Inhibition Efficiency of Dibenzo Crown Ether: A Density Functional Study Saprizal Hadisaputra; Saprini Hamdiani; Muhammad Arsyik Kurniawan; Nuryono Nuryono
Indonesian Journal of Chemistry Vol 17, No 3 (2017)
Publisher : Universitas Gadjah Mada

The effect of macrocycle ring size on the corrosion inhibition efficiency of dibenzo-12-crown-4 (DB12C4), dibenzo-15-crown-5 (DB15C5), dibenzo-18-crown-6 (DB18C6), dibenzo-21-crown-7 (DB21C7) and dibenzo-24-crown-8 (DB24C8) have been elucidated by mean of density functional calculation at B3LYP/6-31G(d) level of theory in the gas and aqueous environment. The quantum chemical parameters including the frontier orbital energies (EHOMO, ELUMO), ionization potential (I), electron affinity (A), the absolute electronegativity (χ), hardness (η), softness (σ), and the fraction of electron transferred (ΔN) are positively correlated to the corrosion inhibition efficiency (IE%) of the studied crown ethers. The calculation results indicate that DB24C8 exhibits the highest corrosion inhibition efficiency, whereas DB12C4 exhibits the lowest corrosion inhibition efficiency. The results of this study will contribute to design crown ethers potential as corrosion inhibitors.

Synthesis of Chalcone Derivatives and Their in vitro Anticancer Test Against Breast (T47D) and Colon (WiDr) Cancer Cell Line Chairil Anwar; Yogo Dwi Prasetyo; Sabirin Matsjeh; Winarto Haryadi; Eti Nurwening Sholikhah; Nendrowati Nendrowati
Indonesian Journal of Chemistry Vol 18, No 1 (2018)
Publisher : Universitas Gadjah Mada

The synthesis of chalcone derivatives as target compounds and anticancer test against breast (T47D) and colon (WiDr) cell line had been performed. The synthesis was performed by Claisen-Schmidt condensation by using acetophenone and benzaldehyde derivatives. The anticancer activity test of chalcone derivatives was carried out by MTT assay against T47D and WiDr cell lines. The synthesis was started by reacting 4-hydroxyacetophenone and benzaldehyde derivatives such as p-anisaldehyde (chalcone A [(E)-4'-hydroxy-4-methoxychalcone]), veratraldehyde (chalcone B [(E)-4'-hydroxy-3,4-dimethoxychalcone]), 4-chlorobenzaldehyde (chalcone C [(E)-4'-hydroxy-4-chlorochalcone]) and 2,4-dihydroxyacetophenone with 4-chlorobenzaldehyde (chalcone D [(E)-2',4'-dihydroxy-4-chlorochalcone]) in methanol as solvent. The synthesis was carried out in alkaline condition (KOH) by stirring the mixture at room temperature for 48 h. The structures of products were identified by FTIR, GC-MS, 1H- and 13C-NMR spectrometers. The results showed that the chalcone derivatives (A-D) were yielded in 96; 97; 96; and 93%, respectively as yellow solid. The anticancer test indicated that the chalcone D was the most active towards T47D cell line with IC50 of 42.66 μg/mL and the chalcone C was the most active against WiDr cell line with IC50 of 20.42 μg/mL.

Cyclic Acetalization of Furfural on Porous Aluminosilicate Acid Catalysts Hartati Hartati; Didik Prasetyoko; Mardi Santoso
Indonesian Journal of Chemistry Vol 16, No 3 (2016)
Publisher : Universitas Gadjah Mada

Porous aluminosilicate materials included microporous and mesoporous ZSM-5, hierarchical aluminosilicates, and mesoporous aluminosilicate were tested for acetalization of furfural (furan-2-carbaldehyde) with propylene glycol. The existing synthesis methods for aluminosilicate and ZSM-5 were modified to produce aluminosilicate material with hierarchical porous structure. Catalytic activity in acetalization of furfural by propylene glycol were conducted by refluxed of the mixture of furfural, propylene glycol and catalyst, using toluene as solvent and nitrobenzene as internal standard, at 106 °C for 4 h. The result showed that a combination of two structure directing agents, tetrapropylammonium hydroxide (TPAOH) and cetyltrimethylammonium bromide (CTAB) and modification of catalytic crystallization produced an active aluminosilicate framework that provides a wide access for a bulky reactants and strong acid sites to catalyze the reaction. The pore structure and the strength of the Brønsted acid sites were crucial for the high conversion of furfural to produce a cyclic acetal.

A Rapid and Sensitive Diagnosis of Typhoid Fever Based On Nested PCR-Voltammetric DNA Biosensor Using Flagellin Gene Fragment Yeni Wahyuni Hartati; Santhy Wyantuti; M. Lutfi Firdaus; Nurul Auliany; Rini Surbakti; Shabarni Gaffar
Indonesian Journal of Chemistry Vol 16, No 1 (2016)
Publisher : Universitas Gadjah Mada

Typhoid fever caused by Salmonella typhi is an important issue for public health in the world. Laboratory methods for rapid and sensitive diagnosis are very important for disease management. The purpose of this study was to determine the performance of nested PCR–voltammetric DNA biosensor using flagellin gene (fla) of S. typhi as a marker. The differential pulse voltammetry using pencil graphite electrode was applied to measure the guanine oxidation signal of probes vs synthetic target stDNA and probes vs fla PCR product hybridizations. The probe DNA selectivity was examined by hybridized probes vs non-complementary sequence. The result showed that the first round nested PCR product can not be visualized by agarose electrophoresis, whereas using the voltammetric biosensor methods can be detected both for the first or second round nested PCR product. The average peak current of hybridized probe vs first and second round of PCR product was 2.32 and 1.47 μA respectively, at 0.9 V. Detection of the DNA sequences of the infectious diseases from PCR amplified real sample was also carried out using this voltammetric DNA biosensor methods.

Recovery of Fermented Spinach (Amaranthus sp.) Concentrate Through Ultrafiltration Membrane Process as Source of Folic Acid for Smart Food Formula Aspiyanto Aspiyanto; Agustine Susilowati; Puspa Dewi Lotulung; Hakiki Melanie; Yati Maryati
Indonesian Journal of Chemistry Vol 17, No 3 (2017)
Publisher : Universitas Gadjah Mada

Fermentation process on spinach (Amaranthus sp.) by Kombucha culture was done as an effort to recover naturally folic acid as bioactive components to increase smartness. The experimental activity was done by means of UF membrane (100,000 MWCO) fitted in Stirred Ultrafiltration Cell (SUFC) at stirrer rotation speed 200 and 400 rpm, room temperature, pressure 20 and 40 Psi for 30 min. Result of experimental activity showed that based on both selectivity and recovery of folic acid, process optimization of UF was reached at stirrer rotation speed 200 rpm and pressure 40 Psi. In the optimum condition, SUFC technique was able to recover folic acid in retentate 67.75% and in permeate 97.27% (63.19 µg/mL). Identification of monomer in permeate from the optimum process treatment was find out folic acid monomer with molecular weight (MW) 441.39 and relative intensity 93% at mass spectra T2.32 between m/z 257–304 and glutamic acids monomer with MW 148.57 and relative intensity 0.22% at mass spectra T2.82 between m/z 415–470. Other dominant monomer were folic acid fraction.

Page 69 of 199 | Total Record : 1981

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