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Comparison of Endometriosis Characteristics in Adolescents and Women of Advanced Reproductive Age Paiki, Ottowgeissler Yabes Melaneson; Dewi, Marta Isyana; Harsono, Ali Budi
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 3 November 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i3.991

ABSTRACT Objective: To compare clinical and pathological characteristics of endometriosis between adolescents (10–19 years) and women of advanced reproductive age (35–45 years) to guide early diagnosis and tailored management. Methods: A retrospective, cross-sectional study of 68 patients (31 adolescents; 37 advanced-age women) with laparoscopically and histopathologically confirmed endometriosis at Dr. Margono Soekarjo Regional General Hospital between January 2022 and December 2024. Statistical analyses included independent t-tests, chi-square tests, and multivariate logistic regression. Results: Adolescents exhibited higher dysmenorrhea prevalence (80.6% vs. 43.2%; p=0.003), more early-stage disease (Stage I–II: 71% vs. 22%; p

Relationship between Antenatal Care in Severe Preeclampsia and Maternal and Neonatal Outcomes Iskandarsyah, Teuku Muhammad; Nurdiawan, Windi; Susiarno, Hadi
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 3 November 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i3.963

Objective: This study aims to evaluate the relationship between the frequency of antenatal care (ANC) visits and maternal and infant outcomes in cases of severe preeclampsia.Methods: The collected data were processed using computerized methods to convert them into analyzable information. Data analysis was conducted to describe the proportion of each variable descriptively. Furthermore, the results were elaborated through descriptive analysis and hypothesis testing.Result: Based on medical record data, 91.7% of patients had undergone antenatal care (ANC) visits; however, only about 80% received pre-eclampsia screening services according to the 10T standard.Conclusion: The study concluded that inadequate antenatal care (ANC) visits were significantly associated with an increased risk of eclampsia and acute renal failure. On the other hand, there was no statistically significant association between ANC compliance and the occurrence of complications such as placental abruption, HELLP syndrome, DIC, and maternal death.Hubungan Antenatal Care Pada Preeklampsia Berat terhadap Luaran Maternal dan NeonatalAbstrakTujuan: Penelitian ini bertujuan untuk mengevaluasi hubungan antara frekuensi kunjungan antenatal care (ANC) dan luaran maternal dan infant pada kasus preeklamsia berat.Metode: Data yang telah terkumpul diolah secara komputerisasi untuk mengubah data menjadi informasi. Analisis data dilakukan untuk melihat gambaran proporsi masing-masing variabel yang disajikan secara deskriptif. Selanjutnya, hasil analisis tersebut diuraikan ke dalam analisis deskriptif dan pengujian hipotesis.Hasil: Berdasarkan data rekam medis, ditemukan bahwa 91,7% pasien telah menjalani kunjungan antenatal care (ANC), namun hanya 80% yang mendapatkan pelayanan skrining preeklamsia sesuai standar 10T.Kesimpulan: Kesimpulan menunjukkan bahwa kunjungan Antenatal Care (ANC) yang tidak memadai memiliki hubungan yang signifikan dengan peningkatan risiko eklamsia dan gagal ginjal akut. Sementara di sisi lain, tidak terdapat hubungan yang signifikan secara statistik antara tingkat kepatuhan ANC dengan kejadian komplikasi seperti solusio plasenta, edema paru, Sindrom HELLP, DIC, dan kematian ibu.Kata kunci: Antenatal Care; Preeklamsia; Neonatal

Non-Severe Preeclampsia and Subclinical Inflammation: A Study of Cyclophilin A, NF-κB, PARP- 1, and Apoptosis in Human Placentas Resistantie, Novi; Wibowo, Noroyono; Prasmusinto, Damar; Jusman, Sri Widia Azraki; Yamin, Muhammad; Siregar, Nurjati Chairani; Prihartono, Joedo; Mose, Johannes Cornelius; Suhendro, Suhendro; Yunita, Ferdiana; Rosmanah, Lis; Margyaningsih, Nur Ita; Qotrunnada, Labibah; Roviqoh, Cindy Fawwaz; Rauf, Saidah
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 3 November 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i3.947

Objective: To compare the expression of CyP-A, NF-κB, PARP-1, and apoptotic index in Non-Severe Preeclampsia (NS-PE) and Normal Pregnancy (NP) and explore their roles in inflammation during preeclampsia.Methods: Conducted in Depok, Indonesia, the cross-sectional study involved 28 participants divided into NS-PE and NP groups based on ISSHP criteria. NP was defined as uncomplicated pregnancies at 38–40 weeks gestation. Placental weight was measured, and ELISA was used to assess biomolecule levels. Data were analyzed using T-tests or Mann-Whitney tests.Result: Maternal gestational age, body mass index, and leukocyte levels were significantly higher in NS-PE. The apoptotic index, measured by TUNEL assay, was also significantly elevated in NS-PE (41.56 ±24.87) compared to NP (23.96 ±18.79; p = 0.044). While CyP-A, PARP-1, and NF-κB levels were higher in NS-PE eventhough they were not statistically significant. Immunohistochemistry confirmed an overall increase in these molecules, supporting their clinical relevance.Conclusion: Despite the lack of statistical significance, increased inflammation and apoptosis in NS-PE may contribute to placental dysfunction and adverse pregnancy outcomes.Non-Severe Preeclampsia dan Inflamasi Subklinis: Studi CyP-A, NF-κB, PARP-1, dan Apoptosis pada Plasenta ManusiaAbstrak Tujuan: Penelitian ini bertujuan untuk mengetahui perbedaan ekspresi CyP-A, NF-κB, PARP-1, dan indeks apoptosis antara preeklamsia non-severe (NS-PE) dan kehamilan normal (NP), serta perannya dalam proses inflamasi pada preeklamsia.Metode: Metode penelitian yang digunakan dalam penelitian ini adalah cross-sectional. Penelitian ini dilakukan di Depok, Indonesia, dengan 28 partisipan yang dikelompokkan menjadi NS-PE dan NP berdasarkan kriteria ISSHP. Berat plasenta diukur dan kadar biomolekul dianalisis menggunakan ELISA. Uji T dan alternatif Mann-Whitney digunakan untuk analisis statistik.Hasil: Hasil penelitian menunjukkan bahwa usia kehamilan, indeks massa tubuh (IMT), dan kadar leukosit secara signifikan lebih tinggi pada NS-PE. Indeks apoptosis (TUNEL) juga lebih tinggi secara signifikan pada NS-PE (41,56 ±24,87) dibandingkan NP (23,96 ±18,79; p = 0,044). Kadar CyP-A, PARP-1, dan NF-κB lebih tinggi pada NS-PE meskipun tidak signifikan secara statistik, pemeriksaan IHK mengonfirmasi relevansi klinis peningkatan pada keseluruhan biomolekul tersebut. Kesimpulan: Meskipun signifikansi statistik rendah, peningkatan peradangan dan apoptosis pada NS-PE dapat menyebabkan disfungsi plasenta dan dampak buruk pada kehamilan.Kata kunci: Apoptosis; inflamasi; preeklamsia.

Analysis of Outpatient and Postpartum Family Planning Services in Makassar Teaching Hospitals for Two Years Madya, Fatmawati
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 3 November 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i3.983

Objective: To evaluate the distribution and characteristics of the family planning (FP) service acceptors in the outpatient clinics and postpartum wards in the main teaching hospital and its affiliated hospitals in Makassar in a two-year period. Method: The retrospective descriptive study was conducted using FP service registers and patients’ medical records from January 2023 to January 2024. Data included sociodemographic characteristics (age, parity, education, occupation), type of procedure (postpartum vaginal delivery, caesarean section, curettage), and contraceptive method chosen (implant, intrauterine device [IUD], sterilization). All eligible acceptors during the study period were included. The Data were analyzed descriptively and presented as the frequencies and percentages. Result: The total of 5,684 FP acceptors is recorded. The most commonly used methods are IUD (2,882; 50.7%), implants (2,239; 39.4%), and sterilization (563; 9.9%). The majority of the acceptors are 20-35 years old (4,835; 85.1%) and have the parity two (1,978; 34.8%). The most contraceptive initiation occurs after the vaginal delivery (3,420; 60.2%). The high school graduates represent the largest education group (3,125; 54.9%), and housewives are the most frequent occupational group (3,974; 69.9%).Conclusion: The postpartum FP services remain the main entry point for the contraceptive use in the teaching and affiliated hospitals. The counseling strengthening, especially during the antenatal and postpartum care, may further improve the uptake of the appropriate contraception in line with the socio-demographic needs.Analisis Pelayanan Keluarga Berencana Rawat Jalan dan Pascasalin di Rumah Sakit Pendidikan di Makassar Selama Dua Tahun”Abstrak Tujuan: Penelitian ini bertujuan mengevaluasi distribusi dan karakteristik akseptor pelayanan keluarga berencana (KB) pada poliklinik rawat jalan dan ruang nifas di rumah sakit pendidikan utama dan rumah sakit jejaring di Makassar selama periode dua tahun.Metode: Metode yang digunakan dalam penelitian ini adalah deskriptif retrospektif dilakukan dengan menggunakan register pelayanan KB dan rekam medis pasien dari Januari 2023 hingga Januari 2024. Data yang dikaji meliputi karakteristik sosiodemografi (usia, paritas, pendidikan, pekerjaan), jenis tindakan (persalinan pervaginam pascapersalinan, seksio sesarea, kuretase), serta metode kontrasepsi yang dipilih (implan, alat kontrasepsi dalam rahim, sterilisasi). Semua akseptor yang memenuhi kriteria selama periode penelitian diikutsertakan. Data dianalisis secara deskriptif dan disajikan dalam bentuk frekuensi serta persentase.Hasil: Sebanyak 5.684 akseptor KB tercatat. Metode yang paling banyak digunakan adalah alat kontrasepsi dalam rahim (2.882; 50,7%), implan (2.239; 39,4%), dan sterilisasi (563; 9,9%). Mayoritas akseptor berusia 20-35 tahun (4.835; 85,1%) dan memiliki paritas dua (1.978; 34,8%). Sebagian besar inisiasi kontrasepsi dilakukan setelah persalinan pervaginam (3.420; 60,2%). Lulusan Sekolah Menengah Atas merupakan kelompok pendidikan terbesar (3.125; 54,9%), sedangkan ibu rumah tangga merupakan kelompok pekerjaan terbanyak (3.974; 69,9%).Kesimpulan: Pelayanan KB pascasalin tetap menjadi pintu masuk utama penggunaan kontrasepsi di rumah sakit pendidikan dan jejaring. Penguatan konseling, terutama pada masa antenatal dan pascasalin, dapat lebih meningkatkan pemilihan kontrasepsi yang tepat sesuai kebutuhan sosiodemografi.Kata kunci: Keluarga berencana, kontrasepsi pasca persalinan, Makassar, metode kontrasepsi, pelayanan rawat jalan

The Role of Neuron Growth Factor and Interleukin-10 in The Development of Pain in Adenomyosis: A Narrative Review Heriyanto, Agus; Tjahyadi, Dian; Rachmawati, Anita; Adlino, Luky
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 3 November 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i3.931

Introduction: Adenomyosis, a benign uterine condition characterized by endometrial tissue within the myometrium, leads to uterine enlargement, infertility, dysmenorrhea, and heavy menstrual bleeding. While its precise etiology remains elusive, delayed pregnancy may contribute to its increasing incidence among infertile women. This condition, predominantly affecting parous women, is also associated with higher rates of early miscarriage. Although immune dysregulation in endometriosis is well-documented, comparable research in adenomyosis is limited.Objective: This review aims to explore the roles of Interleukin-10 (IL-10), an anti-inflammatory cytokine, and Neuronal Growth Factor (NGF), a neuroimmune factor, in adenomyosis.Discussion: Elevated IL-10 levels in ectopic endometrial tissue suggest a potential immunosuppressive mechanism that may exacerbate symptoms. NGF is also implicated in the pain and inflammation associated with adenomyosis. A deeper understanding of the interplay between IL-10 and NGF could offer critical insights into the inflammatory nature and pain mechanisms of this condition.Conclusion: This review proposes IL-10 as a potential inflammatory biomarker and NGF as a pain marker in adenomyosis, paving the way for future research into novel therapeutic targets. Elucidating these pathways could lead to treatments focused on mitigating inflammation and alleviating associated symptoms of adenomyosis.Keywords: adenomyosis; neuronal growth factor; interleukin-10; pelvic pain Peran Neuron Growth Factor (NGF) dan Interleukin-10 (IL-10) dalam pembentukan Nyeri pada Adenomyosis : Sebuah Review NaratifAbstrakPendahuluan: Adenomyosis, suatu kondisi rahim jinak yang ditandai dengan adanya jaringan endometrium di dalam miometrium, menyebabkan pembesaran rahim, infertilitas, dismenore, dan perdarahan menstruasi yang berat. Meskipun etiologi pastinya masih belum jelas, kehamilan yang tertunda kemungkinan berkontribusi pada peningkatan insidennya di kalangan wanita infertil. Kondisi ini, yang sebagian besar memengaruhi wanita multipara, juga dikaitkan dengan tingkat keguguran dini yang lebih tinggi. Meskipun disregulasi imun pada endometriosis telah didokumentasikan dengan baik, penelitian serupa pada adenomyosis masih terbatas.Tujuan: Tinjauan ini bertujuan untuk mengeksplorasi peran Interleukin-10 (IL-10), sitokin anti-inflamasi, Faktor Pertumbuhan Saraf (NGF) dan faktor neuroimun dalam adenomyosis.Diskusi: Peningkatan kadar IL-10 dalam jaringan endometrium ektopik menunjukkan mekanisme imunosupresif potensial yang dapat memperburuk gejala. NGF juga berperan dalam nyeri dan peradangan yang terkait dengan adenomyosis. Pemahaman yang lebih dalam tentang interaksi antara IL-10 dan NGF dapat memberikan wawasan penting mengenai sifat inflamasi dan mekanisme nyeri dari kondisi ini.Kesimpulan: Tinjauan ini mengusulkan IL-10 sebagai biomarker inflamasi potensial dan NGF sebagai penanda nyeri pada adenomyosis. Hal tersebut membuka jalan bagi penelitian lebih lanjut untuk target terapeutik baru. Menguraikan jalur-jalur ini dapat mengarah pada perawatan yang berfokus pada mitigasi peradangan dan mengurangi gejala adenomyosis.Kata kunci: adenomiosis; interleukin-10; neuronal growth factor; nyeri pelvis.

The Critical Role of CT Imaging in Detecting Acute Neurological Complications of Eclampsia: A Case Series Ronosulistyo, Ayu Angelina; Zulvayanti, Zulvayanti; Hidayat, Dini; Nurdiawan, Windi; Susiarno, Hadi; Pusianawati, Dini; Weningtyas, Vyanda Sri
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 3 November 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i3.924

AbstractIntroduction: An intracranial hemorrhage (ICH) is a rare condition but potentially life-threatening event, especially in pregnancy, and could happen in patients with eclampsia. At Hasan Sadikin General Hospital (RSHS), several eclampsia cases are admitted annually, some with worsening neurological conditions. Neuroimaging using CT-Scan is indicated in patients with seizures, decreased consciousness, or visual disturbances to detect intracranial pathology. Case: We reported three cases of maternal eclampsia, two patients' chief complaint was seizures, but all of our patients were unconscious. All of our patients had a previous history of pre-eclampsia in the last pregnancy. All of our patients performed a CT scan performed in postpartum patients as a neurologic examination. All of our patients have worse outcomes. The Medical and Health Research Ethics Committee of the Faculty of Medicine, Padjajaran University with Ref no: DP.04.03/D/XIV.6.5/71/2025.Conclusion: Neuroimaging in patients with seizure-induced worsening of the condition has an important role in identifying other abnormalities, specifically intracranial hemorrhage. In this study, we conclude that patients with seizures in pregnancy should be screened with neuroimaging (computed tomography scan) to rule out central nervous system pathology, thereby improving the patient's condition and reducing maternal mortality.Keywords: CT scan, Convulsion, Eclampsia, Pregnancy Peran Kritis Pencitraan CT dalam Mendeteksi Komplikasi Neurologis Akut pada Eklampsia: Seri KasusAbstrakPendahuluan: Perdarahan intrakranial (PIK) merupakan kondisi langka namun berpotensi mengancam jiwa, terutama pada kehamilan, dan dapat terjadi pada pasien eklampsia. Neuroimaging menggunakan CT-Scan berperan dalam deteksi dini perburukan kondisi pasien dengan penurunan kesadaran.Kasus: Penelitian ini melaporkan tiga kasus eklampsia maternal, keluhan utama dua pasien adalah kejang, namun semua pasien pada penelitian ini tidak sadar. Semua pasien memiliki riwayat preeklampsia sebelumnya pada kehamilan terakhir. Semua pasien melakukan CT scan sebagai pemeriksaan neurologis. Semua pasien memiliki hasil yang lebih buruk. Komite Etik Penelitian Kedokteran dan Kesehatan Fakultas Kedokteran Universitas Padjadjaran dengan Ref no: DP.04.03/D/XIV.6.5/71/2025.Kesimpulan: Neuroimaging pada pasien dengan kondisi yang memburuk akibat kejang memiliki peran penting dalam mengidentifikasi kelainan lain, khususnya perdarahan intrakranial. Dalam penelitian ini, peneliti menyimpulkan bahwa pasien dengan kejang selama kehamilan harus diskrining dengan neuroimaging (pemindaian tomografi terkomputasi) untuk menyingkirkan patologi sistem saraf pusat sehingga memperbaiki kondisi pasien dan mengurangi angka kematian ibu.Kata kunci: CT scan, Eklampsia, Kehamilan, Kejang

Reframing Female Genital Cosmetic and Aesthetic Surgery: Ethics, Function, and Sexual Health Beyond Appearance Sukarsa, Mochamad Rizkar Arev
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 3 November 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i3.1033

In recent years, the convergence of aesthetic medicine and urogynecology has reshaped the dialogue on women’s health. Procedures once confined to reconstructive domains—repairing pelvic floor disorders, perineal trauma, or postpartum laxity—now coexist with aesthetic motivations emphasizing appearance and self-confidence. This editorial reflects on how female genital cosmetic surgery (FGCS) and female genital aesthetic surgery (FGAS) overlap yet differ ethically, functionally, and philosophically.Defining FGCS and FGASAccording to the American College of Obstetricians and Gynecologists (ACOG) and the Royal College of Obstetricians and Gynaecologists (RCOG), FGCS comprises elective surgical procedures that modify the appearance of genitalia without clear medical indication. These interventions originate in the cosmetic surgery paradigm, focusing on visual symmetry and patient satisfaction. In contrast, FGAS has evolved within gynecology and minimally invasive aesthetic medicine, aiming not only at external appearance but also at comfort, tissue quality, and functional harmony. The distinction matters: while FGCS is largely appearance-driven, FGAS aspires toward holistic well-being and sexual confidence. Recognizing these nuances helps physicians maintain ethical boundaries and ensure that patient motivation is grounded in informed understanding rather than social pressure.

Cadmium Exposure and Preeclampsia: A Systematic Review of Environmental Risk in Pregnancy Sanjaya, I Nyoman Hariyasa; Andonotopo, Wiku; Bachnas, Muhammad Adrianes; Dewantiningrum, Julian; Pramono, Mochammad Besari Adi; Mulyana, Ryan Saktika; Pangkahila, Evert Solomon; Akbar, Muhammad Ilham Aldika; Yeni, Cut Meurah; Aldiansyah, Dudy; Bernolian, Nuswil; Wiradnyana, Anak Agung Gede Putra; Pribadi, Adhi; Sulistyowati, Sri; Stanojevic, Milan; Kurjak, Asim
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 3 November 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i3.951

Objective: To systematically evaluate current scientific evidence on the association between cadmium (Cd) exposure and the risk of preeclampsia in pregnant women, and to explore underlying mechanisms and population-specific patterns.Methods: This systematic review was conducted according to PRISMA guidelines. Comprehensive literature searches were performed across PubMed, Scopus, Web of Science, ScienceDirect, and Google Scholar without time restriction, focusing on the past 15 years. Inclusion criteria encompassed original human studies measuring cadmium exposure—biological, dietary, or environmental—and reporting preeclampsia as an outcome. Risk of bias was assessed using the Newcastle-Ottawa Scale.Results: Twenty-five eligible studies were included, spanning case-control, cohort, and cross-sectional designs across diverse geographic regions. Most studies found a positive association between cadmium exposure and increased preeclampsia risk, though methodological heterogeneity exists. Proposed mechanisms include cadmium-induced oxidative stress, endothelial dysfunction, placental insufficiency, and hormonal dysregulation. Evidence also highlights differences in risk based on diet, region, and environmental regulation. However, inconsistencies in exposure metrics and population stratification remain.Conclusion: The cumulative evidence suggests cadmium is a plausible environmental risk factor for preeclampsia. Future research must standardize exposure assessments and address population-specific modifiers. This review provides critical groundwork for hypothesis-driven studies and policy frameworks addressing toxic metal exposure in maternal health.Paparan Kadmium dan Preeklampsia: Tinjauan Sistematis terhadap Risiko Lingkungan pada KehamilanAbstrakTujuan: Penelitian ini bertujuan untuk melakukan tinjauan sistematis terhadap bukti ilmiah terkini mengenai hubungan antara paparan kadmium (Cd) dan risiko preeklampsia pada ibu hamil, serta mengeksplorasi mekanisme biologis yang mendasari dan pola risiko spesifik populasi.Metode: Tinjauan sistematis ini disusun berdasarkan pedoman PRISMA. Pencarian literatur dilakukan secara menyeluruh melalui basis data PubMed, Scopus, Web of Science, ScienceDirect, dan Google Scholar tanpa batasan waktu, dengan fokus pada publikasi 15 tahun terakhir. Kriteria inklusi meliputi penelitian asli pada manusia yang mengukur paparan kadmium—baik secara biologis, dietetik, maupun lingkungan—dan melaporkan preeklampsia sebagai luaran. Risiko bias dinilai menggunakan Newcastle-Ottawa Scale.Hasil: Sebanyak 25 studi memenuhi kriteria dan dianalisis, mencakup desain studi kasus-kontrol, kohort, dan potong lintang dari berbagai wilayah geografis. Mayoritas studi menunjukkan adanya hubungan positif antara paparan kadmium dan peningkatan risiko preeklampsia, meskipun terdapat heterogenitas metodologis. Mekanisme yang diusulkan meliputi stres oksidatif akibat kadmium, disfungsi endotel, insufisiensi plasenta, dan disregulasi hormonal. Bukti juga menunjukkan perbedaan risiko berdasarkan pola diet, lokasi geografis, dan tingkat pengawasan lingkungan. Namun, masih terdapat ketidakkonsistenan dalam metrik paparan dan stratifikasi populasi.Kesimpulan: Bukti kumulatif mendukung bahwa kadmium merupakan faktor risiko lingkungan yang potensial terhadap preeklampsia. Penelitian selanjutnya perlu menstandarkan metode pengukuran paparan dan mempertimbangkan faktor-faktor spesifik populasi. Tinjauan ini memberikan landasan penting bagi studi berbasis hipotesis dan penyusunan kebijakan terkait paparan logam toksik dalam kesehatan maternal.Kata kunci: Komplikasi kehamilan; paparan kadmium; preeklampsia; stres oksidatif; toksikologi lingkungan

A Comparative Analysis of Internal Radiation vs Box System in Treatment Efficacy and Patient Survival of Advanced Stage Cervical Cancer Marpaung, Mona Galatia; Iskandar, Teuku Mirza; Pramono, Noor; Suhartono, Suhartono
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 3 November 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i3.942

Objectives: To evaluate the comparative effectiveness of brachytherapy and the box system in therapeutic success and patient survival in cervical cancer, along with associated prognostic factors.Methods: This retrospective analytical study used medical records from the Obstetrics & Gynecology Oncology Clinic and Radiotherapy Unit at Dr. Kariadi General Hospital in Semarang. The study included cervical cancer patients with stage IIB-IIIB disease who were treated between January 2017 and December 2022. Data analysis involved both statistical methods and survival analysis using the Kaplan-Meier approach.Results: During the 2017-2022 study period, a total of 939 patients with stage IIB-IIIB cervical cancer who completed full radiation therapy were evaluated for their 2-year survival rate. The cohort included 89 patients in the box system group and 850 in the brachytherapy/internal radiation group. Complete response was achieved in 46.1% of box system patients compared to 75.5% in the brachytherapy group (p<0.0001); partial response rates were 53.9% and 24.5%, respectively. Kaplan-Meier analysis showed a 2-year survival rate (2 YSR) of 41.6% for the box system and 64.0% for brachytherapy. The mean survival time was 15.37 months for the box system and 19.09 months for brachytherapy.Conclusion: Internal radiation therapy (brachytherapy) showed significantly better clinical outcomes compared to the box system approach. It resulted in a longer mean survival time (19.09 vs 15.37 months; p<0.001) and higher 2-year survival rates (64.0% vs 41.6%; log-rank p<0.001).Keywords: Cervical cancer, box system, brachytherapy, therapy response, survivalPerbandingan antara Radiasi Interna vs Box System dalam KeberhasilanTerapi dan Kelangsungan Hidup Pasien Kanker Servik Stadium LanjutAbstrakTujuan: Penelitian ini bertujuan untuk mengetahui perbandingan radiasi interna dan box system dalam keberhasilan terapi dan kelangsungan hidup pasien kanker serviks serta faktor-faktor yang memengaruhi.Metode: Penelitian ini menggunakan metode analitik retrospektif dengan menggunakan rekam medis Poli Kandungan dan Onkologi dan Instalasi Radioterapi RSUP Dr. Kariadi Semarang. Subyek penelitian adalah pasien kanker servik stadium IIB-IIIB mulai periode januari 2017-Desember 2022. Analisis statistika menggunakan analisis analitik dan analisis survival menggunakan metode Kaplan Meier.Hasil: Hasil penelitian menunjukkan bahwa selama tahun 2017– 2022 didapatkan total 939 pasien dengan diagnosis kanker servik stadium IIB-IIIB yang menjalankan terapi radiasi lengkap dan dapat dilakukan evaluasi survival rate 2 tahun. Total subjek pada kelompok box system sebanyak 89, sedangkan kelompok brakiterapi/radiasi interna sebanyak 850 subjek. Respon terapi komplet sebesar 46,1% pada kelompok box system, dan 75,5% pada kelompok radiasi interna, respon terapi parsial 53,9% pada kelompok box system dan 24,5% pada kelompok radiasi interna, dengan nilai p <0.0001. Analisis survival dengan metode Kaplan -Meier didapatkan 2-YSR 41,6% pada kelompok Box system, sedangkan 64% pada kelompok radiasi interna sedangkan mean survival time pada kelompok box system 15,37 bulan dan kelompok radiasi interna 19,09 bulan dengan nilai p <0.001Kesimpulan: Pemberian radiasi interna memberikan keberhasilan terapi klinis yang lebih tinggi dengan nilai mean survival time lebih tinggi. Pemberian radiasi interna memberikan kelangsungan hidup 2 tahun sebanyak 64%, sedangkan box system sebanyak 41,6%Kata kunci: Kanker servik, box system, brakiterapi, respon terapi, survival

Characteristics of Patients with Diminished Ovarian Reserve Undergoing in Vitro Fertilization (IVF) at Hasan Sadikin Hospital from 2019-2023 Fitriyanto, Iqbal Anugrah; Rachmawati, Anita; Pramatirta, Akhmad Yogi
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 3 November 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i3.1004

Objective: This study aimed to describe the characteristics of patients with diminished ovarian reserve undergoing in vitro fertilization (IVF) to improve understanding of its implications for infertility.Methods: Cross-sectional descriptive study using medical records of patients who underwent IVF at Dr. Hasan Sadikin General Hospital (RSHS) from 2019 to 2023. Analyzed variables included age, education level, occupation, duration of marriage, body mass index, Anti-Müllerian hormone (AMH) level, and ovarian stimulation protocol.Results: A total of 57.14% of the 55 patients were aged 35 – 40 years, 87.5% nulliparous, and 55.36% had a body mass index greater than 24.9 kg/m2. The percentage that held a bachelor’s degree was 64.29%, and 55.36% had AMH levels below 1.1 ng/ml. A total of 78.57% received a short stimulation protocol, and 21.43% received a long stimulation protocol.Conclusion: Most patients with diminished ovarian reserve undergoing IVF at RSHS (2019 – 2023) were aged 35 – 40, nulliparous, obese class I–II, AMH value <1.1 ng/ml, and were subjected to a short IVF protocol.Karakteristik Pasien dengan Diminished Ovarian Reserve yang Melakukan In Vitro Fertilization (IVF) di Rumah Sakit Hasan Sadikin pada Tahun 2019 – 2023AbstrakTujuan: Penelitian ini bertujuan menggambarkan karakteristik pasien dengan cadangan ovarium menurun yang menjalani fertilisasi in vitro untuk meningkatkan pemahaman tentang implikasi cadangan ovarium menurun pada infertilitas.Metode: Metode yang digunakan dalam penelitian ini adalah deskriptif observasional potong lintang yang menggunakan data rekam medis pasien yang menjalani fertilisasi in vitro di Rumah Sakit Hasan Sadikin (RSHS) periode 2019 – 2023. Variabel yang dianalisis meliputi usia, tingkat pendidikan, pekerjaan, lama menikah, indeks massa tubuh, kadar hormon anti-Müllerian, dan protokol stimulasi ovarium.Hasil: Hasil penelitian menunjukkan bahwa dari 55 pasien, 57,14% berusia 35 – 40 tahun, 87,5% belum pernah melahirkan, 55,36% memiliki indeks massa tubuh lebih dari 24,9 kg/m2, 64,29% berpendidikan sarjana, dan 55,36% memiliki kadar hormon anti-Müllerian kurang dari 1,1 ng/ml. Sebanyak 78,57% menjalani protokol stimulasi pendek dan 21,43% menjalani protokol stimulasi panjang.Kesimpulan: Sebagian besar pasien dengan cadangan ovarium menurun yang menjalani fertilitasi in vitro di RS Dr. Hasan Sadikin (201 – 2023) berusia 35 – 40 tahun, nullipara, obesitas kelas I–II, nilai AMH <1.1 ng/ml dan menjalani protokol IVF pendek.Kata kunci: Anti-mullerian hormone; diminished ovarian reserve; FSH; infertilitas; in vitro fertilization (IVF), teknologi reproduksi berbantu

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Contact Name
Wiryawan Permadi

Contact Email
obgyniajurnal@gmail.com

Phone
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Journal Mail Official
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Location
Kota bandung,

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INDONESIA