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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Kesehatan Reproduksi Majalah Obstetri dan Ginekologi Majalah Kesehatan FKUB Jurnal Kesehatan Reproduksi Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Journal of Community Empowerment for Health JHE (Journal of Health Education)
Anis Widyasari
Department Of Obstetric And Gynecology, Faculty Of Medicine, Public Health, And Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia
Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Incidence of Unintended Pregnancy after Laparoscopic Tubal Sterilization at Dr.Sardjito Hospital Widyasari, Anis; Wibowo, Prakoso Adhi; Rahman, M. Nurhadi; LUTFI, MUHAMMAD; Widad, SHOFWAL
JURNAL KESEHATAN REPRODUKSI Vol 4, No 2 (2017)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (179.045 KB) | DOI: 10.22146/jkr.35423

Abstract

Background:  Laparoscopic tubal ligation is one of the most commonly performed sterilization procedures and has many advantages such as high success rate and early return to normal activity. In Indonesia, the incidence of unintended pregancy in a study was 0,15 %. This rate is comparable with pregnancy rates for women using another contraceptive method.Objective: To assess the incidence of unintended pregnancy on women who underwent laparoscopic tubal sterilization at Dr. Sardjito Hospital.Method: A descriptive observational study with retrospective cross-sectional design was conducted. The data were acquired from medical record from January 2009 to April 2015. Reports of unintended pregnancy within two years after procedure were recorded.Result and Discussion: 55 women met the inclusion criterion and none were excluded. Method failures resulting on pregnancy occured in 3 cases (5.45 %), so the success rate of the procedure was 94.55 %. All of the reported pregnancies happened within two years after the procedures. There was no major complication occured in the procedure, but minor bleeding (<50 cc) did occur in some cases.Conclusion: The incidence of unintended pregnancy on women who underwent laparoscopic tubal sterilization at Dr. Sardjito Hospital was higher than the average incidence reported on another studies.Keyword: female sterilization, laparoscopic tubal sterilization, unintended pregnancy.
Efek biji mahkota dewa terhadap ekspresi Anis Widyasari; Yudanti Riastiti; Indwiani Astuti; Rina Susilowati; . Harijadi
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 38, No 01 (2006)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (332.738 KB)

Abstract

The effect of mahkota dewa seed (Phaleria macrocarpa (Schaff. Bowl.) on active caspase-3 expression in WiDr Ca colon cell line Background: Mahkota dewa (MD, Phaleria macrocarapa (Schaff) BoerII.) is widely used for cancer therapy, but its mechanism as anticancer has not been known yet. Recently, ethanol extract of MD seed has been shown to have cytotoxic effect on WiDr Ca colon cell line. Objective: The purpose of this study is to know active caspase-3 expression in WiDr Ca colon cell fine after MD treatment. Methods: WiDr Ca colon cell line was incubated with ethanol extract of MD seed in three concentrations for 48 hours. Active caspase-3 expression was shown using immunohistochemistry method. Results: In the cell line treated with ethanol extract of MD seed 11.35 uglml (1/2 IC50), 22.7 ug/mI (IC,) and 45.4 ug/ml (2x1050), immunopositive cells had been found to be 20.4%, 49% and 63%, respectively. The cell line treated with 5-Fluorouracil (5-FU) in IC50 dosage only had 27.4% imunopositive cell. ConclUsion: Ethanol extract of MD seed had cytotoxic effect on WiDr cell line through the increased active caspase 3 expression. The effect was greater than 5-FU. Key words: Mahkota Dewa, WiDr cell line, Caspase 3, apoptosis, 5 FU
Incidence of Unintended Pregnancy after Laparoscopic Tubal Sterilization at Dr.Sardjito Hospital Anis Widyasari; Prakoso Adhi Wibowo; M. Nurhadi Rahman; MUHAMMAD LUTFI; SHOFWAL Widad
JURNAL KESEHATAN REPRODUKSI Vol 4, No 2 (2017)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jkr.35423

Abstract

Background:  Laparoscopic tubal ligation is one of the most commonly performed sterilization procedures and has many advantages such as high success rate and early return to normal activity. In Indonesia, the incidence of unintended pregancy in a study was 0,15 %. This rate is comparable with pregnancy rates for women using another contraceptive method.Objective: To assess the incidence of unintended pregnancy on women who underwent laparoscopic tubal sterilization at Dr. Sardjito Hospital.Method: A descriptive observational study with retrospective cross-sectional design was conducted. The data were acquired from medical record from January 2009 to April 2015. Reports of unintended pregnancy within two years after procedure were recorded.Result and Discussion: 55 women met the inclusion criterion and none were excluded. Method failures resulting on pregnancy occured in 3 cases (5.45 %), so the success rate of the procedure was 94.55 %. All of the reported pregnancies happened within two years after the procedures. There was no major complication occured in the procedure, but minor bleeding (<50 cc) did occur in some cases.Conclusion: The incidence of unintended pregnancy on women who underwent laparoscopic tubal sterilization at Dr. Sardjito Hospital was higher than the average incidence reported on another studies.Keyword: female sterilization, laparoscopic tubal sterilization, unintended pregnancy.
Feasibility of HPV vaccination program implementation: A qualitative study Wiwin Lismidiati; Vivian Nanny Lia Dewi; Widyawati Widyawati; Wenny Artanty Nisman; Anis Widyasari; Ika Parmawati; Ova Emilia
Journal of Community Empowerment for Health Vol 5, No 1 (2022)
Publisher : Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jcoemph.69099

Abstract

The implementation of the Human Papillomavirus (HPV) vaccination program is still experiencing obstacles in several developing countries. This setback is related to the lack of knowledge and the high cost of the vaccine so that it affects people's behavior about the HPV vaccine. HPV vaccination in adolescents itself as primary prevention has not been widely conducted by adolescents in Indonesia. The results of previous studies showed that not many teenagers had vaccinated against HPV by using self-financing guarantees such as health savings. The obstacles faced in implementing HPV vaccination are that the vaccine is still expensive and there is lack of knowledge of parents and adolescents about the importance of HPV immunization. This formative research using qualitative methods was conducted to analyze the implementation plan of the HPV vaccination program. Data were collected through focus group discussions (FGD) and in-depth interviews. At the end of each FGD activity or interview, transcription and thematic analysis based on content were done. The FGD participants were ten teachers, while the in-depth interview participants were one school committee. This study found two main themes, namely the scheme of implementing the HPV vaccination program and obstacles to the implementation of HPV vaccination. Schools generally supported the program implementation. However, parents still question the importance of the HPV vaccination for their daughters and consider the vaccine costs expensive. Implementation of the HPV vaccination program must consider the existing program schemes in schools and possible obstacles. The results suggested that for the next HPV vaccination program, the facilitators should provide intense and relevant education to parents about the importance and side effects of HPV immunization, and are expected to build a willingness of parents to vaccinate their daughters and seek vaccination costs, one of which can be through a savings program.
Early detection and primary prevention system in COVID-19 transmission to staff and residents in the department of obstetrics and gynecology Muhammad Nurhadi Rahman; Detty Siti Nurdiati; Nuring Pangastuti; Anis Widyasari; Fauzan Achmad Maliki; Sarah Ayu Andari; Khairina Hashifah
Journal of Community Empowerment for Health Vol 4, No 1 (2021): Special Issue of COVID-19
Publisher : Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jcoemph.61165

Abstract

COVID-19 is currently a global pandemic because of its fast transmission in humans. The disease can be symptomatic or asymptomatic. Patients with the disease can transmit the infection to the medical team who are exposed without proper protection. Prevention of transmission is our main focus of attention as well as early recognition of exposed medical teams among obstetrics and gynecology residents and consultants in our hospital. This article aimed to describe the COVID-19 early detection and primary prevention system among staff and residents in the Obstetrics and Gynecology (OBSGYN) Department, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada and Dr. Sardjito General Hospital from April to June 2020. The data were acquired from the reports of the COVID-19 taskforce from the OBSGYN Department. In order to prevent the transmission of COVID-19 infection, actions taken by the OBSGYN Department are as follows: a) arrangement of staff and residents watch schedules, b) usage of PPE (Personal Protective Equipment) according to protocol, c) contact tracing, and d) early detection. Resident watch schedule arrangement is done by withdrawing residents from affiliated hospitals so that the division of daily duty schedules at Dr. Sardjito General Hospital is divided into 2 shifts of 12 hours each. The PPE usage policy is adjusted according to the risk of COVID-19 exposure in different environments and in accordance with established standards. A total of 65 out of 74 residents (88%) had been exposed to suspected COVID-19 cases, and among the exposed residents, 12 residents (18%) were self-isolated because of the occurrence of symptoms, exposure to patients with positive COVID-19 rapid antibody test, or exposure to patients with positive COVID-19 Polymerase Chain Reaction (PCR) test. The department also conducted early detection of COVID-19 infection among all staff members and residents. As many as 13 out of 27 staff (48%) underwent COVID-19 rapid antibody test with 100% negative results, 66 of the 74 residents (89%) also underwent COVID-19 rapid antibody test with 100% negative results. In conclusion, the OBSGYN Department has implemented several measures to prevent transmission of COVID-19 among its staff and residents with adequate satisfactory results.
Malformasi Genital Perempuan: Kasus di RSUP Dr. Sardjito Yogyakarta Tahun 2019 Anis Widyasari; Muhammad Nurhadi Rahman; Akbar Novan Dwi Saputra; Nuring Pangastuti
JURNAL KESEHATAN REPRODUKSI Vol 9, No 2 (2022)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jkr.75774

Abstract

BackgroundReproductive tract malformations are rare in general population but are commonly encountered in women with infertility and recurrent pregnancy loss. Their true prevalence in the general population is not absolutely known mainly owing to methodological bias. Common uterine anomalies are important owing to their impact on fertility, and certain Mullerian malformations are particularly important because they cause serious clinical symptoms and affect woman’s quality of life. Identification of symptoms and timely diagnosis are an important key to the management of these defects. Although MRI being gold standard in delineating uterine anatomy, recent advances in imaging technology, specifically 3-dimensional ultrasound, achieve accurate diagnosis. Surgical management depend on the type of anomaly and its complexity and also involves multiple specialties; thus, patients should be referred to centres with experience in the treatment of complex genital malformationsObjectiveDetermined the description of cases of female genital malformation at Dr. Sardjito Hospital in 2019.MethodThis is descriptive study. The subject in this study were all new patient with female genital malformation at Obgyn Polyclinic Dr. Sardjito Hospital January-December 2019. Obtained  30 cases of female genital malformation.ResultThere is 30 cases of genital malformation in 2019. They were 4-44 years with mode at group 16-20 years. They consist of vaginal and cervicovaginal agenesis 14 cases, Mayer-Rokitansky-Küster-Hauser (MRKH) Syndrom 6 cases, hematometra of hemiuterine 4 cases, Herlyn-Werner-Wunderlich (HWW) syndrome 3 cases, imperforate hymen, didelphys uterus and genital ambiguous each 1 case. Five cases of cervicovaginal agenesis have been done sigmoid vaginoplasty, all of them have good sexual function after procedure. One case MRKH syndrome has been done sigmoid vaginoplasty with good sexual function after that. Two cases HWW syndrome have been surgical treatment that are vaginal septectomy and vaginal septectomy with laparascopic cystectomy.ConclusionThe correct knowledge of embryology of the genitourinary is essential for the understanding, study, diagnosis and management of genital malformations, especially complex ones and those that lead to reproductive problems. Surgical techniques for correcting genital malformations depend on the type of anomaly and complexity.
Diagnosis approach, treatment, evaluation and fertility preservation in patient with Herlyn-Werner-Wunderlich syndrome: a case report Indraswari, Lathifa Nadhya; Pangastuti, Nuring; Dwi Saputra, Akbar Novan; Widyasari, Anis
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 4 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005504202308

Abstract

Herlyn-Werner-Wunderlich (HWW) syndrome is a very rare female congenital anomaly of urogenital tract. The definite etiology of HWW syndrome is still unknown. It may be caused by the abnormal development of Mullerian and Wolffian ducts. The characteristic triad of this syndrome includes didelphys uterus, obstructed hemivagina, and ipsilateral renal agenesis, recently known as Obstructed Hemivagina and Ipsilateral Renal Anomaly (OHVIRA) syndrome.  A 17 y.o. presented with intermittent lower abdominal pain. Physical examination revealed in normal limit. From the ultrasonography examination, it was found uterus didelphys with left hemiuterus hematomethra, hematocolpos, with normal anatomy and function of the right kidney, but there was no left kidney. From pelvic magnetic resonance imaging (MRI) and laparoscopy showing a complete duplication of the uterus from the horn to the cervix with no connection between the two uterine cavities. Both ovaries were normal. The right fallopian tube was normal. The left tube was enlarged, attached to the uterus and the left ovary. No left kidney was found.  From the previous surgery, there was a misdiagnosed with brown cyst. Physical examination such as rectal toucher often missed, regardless it can be used to determine some differential diagnosis. MRI is most accurate for providing details regarding the altered anatomy and for identifying associated hematocolpos, hematosalping or hematometra for HWW syndrome cases. The laparoscopy guiding diagnostic and operative management of the vaginal septectomy procedure was performed. In conclusion,  misdiagnosis of HWW syndrome can be occurred on ultrasound examination. MRI is an examination that is considered appropriate to help confirm the diagnosis. Laparoscopy can be used with the aim of establishing a diagnosis or in surgical management, in this case, a septectomy is performed.
Collagen-1 and elastin expression in cervical tissue: A comparison across cervical elongation, pelvic organ prolapse, and combined conditions Widyasari, Anis; Hardianto, Gatut; Kusumastuti, Etty Hari; Kurniawati, Eighty Mardiyan
Majalah Obstetri & Ginekologi Vol. 32 No. 3 (2024): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V32I32024.189-195

Abstract

HIGHLIGHTS Pathogenesis of cervical elongation is still limited, including the histological and molecular differences between a cervical elongation and a normal cervix. The expression of collagen-1 level in the cervical elongation group was stronger compared to the cervical elongation with POP and control group.   ABSTRACT Objective: This study aimed to assess differences in the expression of collagen-1 and elastin in cervical tissues among patients with Cervical Elongation (CE), Pelvic Organ Prolapse (POP), a combination of CE with POP, and those without either condition. Materials and Methods: An analytical study with a cross-sectional design was conducted, using immunohistochemistry (IHC) to analyze cervical tissue samples preserved in paraffin blocks. Patient groups included those diagnosed with CE, POP, CE combined with POP, and a control group without CE or POP. All participants underwent surgery between January 2021 and April 2023. IHC was used to measure the expression levels of collagen-1 and elastin in each tissue sample. Observations were made under 400x magnification, focusing on five randomly selected visual-field areas in each sample to determine the area fraction. Two experienced pathologists conducted the analyses in a blinded manner to ensure objective evaluation. Results: Statistical analysis using the Kruskal-Wallis test revealed significant differences in the expression of collagen-1 across the four groups (CE, POP, CE with POP, and control). Patients with CE showed a higher expression of collagen-1 than those with CE and POP combined, as well as the control group. However, no significant differences in elastin expression were observed among the groups. Conclusion: Collagen-1 expression differs significantly across patients with CE, POP, and CE combined with POP, suggesting a distinct role in cervical tissue remodeling in these conditions. Conversely, elastin expression was consistent across all groups, indicating that it may not play a differentiating role in these pathologies. These findings highlight collagen-1’s potential involvement in the structural changes associated with CE and POP.
Laporan Kasus: PROSEDUR VAGINOPLASTI SIGMOID PADA DUA KASUS SINDROM MAYER-ROKITANSKY-KÜSTER-HAUSER (MRKH) Pangastuti, Nuring; Fitriani, Annisa; Setyawan, Nurcahya; Widyasari, Anis; Saputra, Akbar Novan Dwi
Majalah Kesehatan Vol. 12 No. 1 (2025): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/majalahkesehatan.2025.012.01.9

Abstract

Sindrom Mayer-Rokitansky-Kuster-Hauser (MRKH) atau Mullerian agenesis atau Mullerian aplasia adalah kelainan bawaan yang jarang terjadi pada saluran genetik seorang perempuan dengan agenesis parsial atau kompleks dari uterus, hipoplasia vagina, atau agenesis vagina, tetapi memiliki ovarium dan genitalia eksterna yang normal. Sindrom MRKH terbagi menjadi 3 jenis, dengan manifestasi masing-masing yang bisa berbeda meskipun tergolong jenis MRKH yang sama. Dilaporkan dua kasus sindrom MRKH tipe I dengan keluhan utama amenorea primer. Kasus pertama adalah perempuan berusia 27 tahun menjelang menikah, sedangkan kasus kedua adalah perempuan menikah berusia 26 tahun yang aktif secara seksual namun memiliki keluhan suami tidak bisa melakukan penetrasi pada aktivitas seksual. Kedua kasus dengan keluhan amenore primer. Hasil pemeriksaan fisik dan hormonal dalam batas normal, sedangkan pemeriksaan ultrasonografi transabdominal, Colon in Loop (CIL) dan Magnetic Resonance Imaging (MRI) mendukung diagnosis sindrom MRKH tipe I. Vaginoplasti sigmoid dilakukan untuk tujuan pembuatan neovagina untuk  aktivitas seksual, pada kasus pertama menggunakan teknik iso peristaltik dan pada kasus kedua teknik anti/kontra peristaltik. Pasca operasi, neovagina terbentuk dengan baik tanpa tanda-tanda infeksi pada kedua kasus, meski harus diberikan transfusi darah berupa 500 ml packed red cell serta dilakukan manajemen konservatif terhadap dehisensi luka operasi abdomen pada kasus kedua. Dijumpai stenosis ringan pada kedua kasus, yang dapat diatasi dengan prosedur dilatasi vagina menggunakan dilator Hegar mulai pada 3 pekan pasca operasi. Kesimpulannya, sindrom MRKH merupakan kasus yang jarang terjadi sehingga memerlukan penanganan yang cermat terkait prosedur pembentukan neovagina untuk tujuan penetrasi pada aktivitas seksual. Meskipun memerlukan keahlian khusus dan operasi dilakukan berkolaborasi dengan ahli bedah digestif, pada kedua kasus yang dilaporkan operasi berlangsung dengan baik, tidak terdapat komplikasi yang signifikan, serta menghasilkan kondisi pasca operasi yang memuaskan.
The Role of Probiotics in Urinary Tract Infections in Women: Peran Probiotik dalam Infeksi Saluran Kemih pada Perempuan Kurniawati, Eighty Mardiyan; Gatut Hardianto; Setyo Hadi, Tri Hastono; Paraton, Hari; Widyasari, Anis; Rahmawati, Nur Anisah
Indonesian Journal of Obstetrics and Gynecology Volume 11 No. 3 July 2023
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v11i3.1881

Abstract

Objective: To review the role of probiotics in urinary tractinfections in womenMethods: Systematic review was conducted by searchingfi ve databases with several keywords, namely “urinary tractinfection”, “cystitis”, “women” and “probiotics”. Articles thathave gone through peer review are included in the studyif they meet the inclusion and exclusion criteria. Reportingfollows the PRISMA rules.Results: The women included in this study varied from earlyadulthood to postmenopausal, most of whom were sexuallyactive, used birth control methods, and had recurrenturinary tract infections. The results showed that the use ofprobiotics in varied outcomes, either positive or not showedsignifi cant results. This is also due to the differences in theoutcomes studied and the additional materials used. Thisalso contributed to the emergence of adverse effects.Conclusion: The use of probiotics in the treatment ofcystitis and urinary tract infections has hope, although notall studies show signifi cant results. The side effects foundare still tolerable although they need to be considered.Keywords: cystitis, probiotic, urinary tract infection, women.AbstrakTujuan: Meninjau peran probiotik dalam infeksi salurankemih pada perempuan.Metode: Tinjauan sistematis dilakukan dengan mencari limadatabase dengan beberapa kata kunci, yaitu “infeksi salurankemih”, “sistitis”, “perempuan” dan “probiotik”. Artikel yangtelah melalui peer review diikutsertakan dalam penelitianjika memenuhi kriteria inklusi dan eksklusi. Pelaporanmengikuti aturan PRISMA.Hasil: Perempuan yang diikutsertakan dalam penelitian inibervariasi mulai dari dewasa awal hingga pascamenopause,sebagian besar aktif secara seksual, menggunakan metodekontrasepsi, dan mengalami infeksi saluran kemih berulang.Hasil penelitian menunjukkan bahwa penggunaan probiotikpada infeksi saluran kemih menunjukkan hasil yang positifmaupun tidak menunjukkan hasil yang signifi kan. Hal inijuga disebabkan perbedaan outcome dan bahan tambahanyang digunakan. Penggunaan bahan juga berkontribusipada munculnya efek samping.Kesimpulan: Penggunaan probiotik dalam pengobatansistitis dan infeksi saluran kemih memiliki harapan, walaupuntidak semua penelitian menunjukkan hasil yang signifi kan.Efek samping yang ditemukan masih dapat ditoleransimeskipun perlu diperhatikan.Kata kunci: infeksi saluran kemih, perempuan, probiotik,sistitis.
Co-Authors . Harijadi Akbar Novan Dwi Saputra Annisa Fitriani, Annisa Detty Siti Nurdiati Eighty Mardiyan K, Eighty Fauzan Achmad Maliki Gatut Hardianto, Gatut Hari Paraton Ika Parmawati Indraswari, Lathifa Nadhya Indwiani Astuti Jati, Puspa Silvia Khairina Hashifah Kusumastuti, Etty Hari Lia Dewi, Vivian Nanny M. Nurhadi Rahman MUHAMMAD LUTFI Muhammad Lutfi Muhammad Nurhadi Rahman Nurcahya Setyawan Nuring Pangastuti Nuring Pangastuti Nuring Pangastuti, Nuring Ova Emilia Parmawati, Ika Prakoso Adhi Wibowo Rahman, M. Nurhadi Rahmawati, Nur Anisah Rina Susilowati Sarah Ayu Andari Setyo Hadi, Tri Hastono Shofwal Widad Sri Mulyani Sri Warsini Sumekar, Lintang Ayu Suryani, Saltsa Rahmalia Wenny Artanty Nisman, Wenny Artanty Wibowo, Prakoso Adhi Widyawati Widyawati Wiwin Lismidiati Yudanti Riastiti Zulfa, Azizah Tiara