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INDONESIA
Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Published by Perkumpulan Obstetri dan Ginekologi Indonesia
ISSN : 23386401     EISSN : 23387335     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
The Indonesian Journal of Obstetrics and Gynecology is an official publication of the Indonesian Society of Obstetrics and Gynekology. INAJOG is published quarterly.
Arjuna Subject : -
Articles 1,778 Documents
 174   175   176   177   178 
Multidisciplinary Management of Breast Cancer in Pregnant Josef Maria Seno Adjie; Anna Sofyana; Yudianto Budi Saroyo; Jen Marisi Marbun; Intje Sheilla Dahlan
Indonesian Journal of Obstetrics and Gynecology Volume 14. No. 2 April 2026
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v14i2.2927

Abstract

Abstract Objective: The incidence of breast cancer in pregnant women is noted to be 1 in 3000 – 10000 women. This case report aims to examine the management of breast cancer in pregnant patients, taking into account holistic factors and the importance of teamwork among various professional disciplines. Methods: A Case Report Case Presentation : In this case report, a 37-year-old woman, G3P2, 23 weeks gestational ag with breast cancer during pregnancy. Biopsy results showed stage II invasive papillary carcinoma of the breast, which progressed to an advanced stage. The patient and her husband were convinced in a family meeting to continue the pregnancy with coordinated multidisciplinary team. After undergoing conservative management, a cesarean section was performed at 31 weeks of gestation . The patient gave birth to a baby boy weighing 1355 grams with an Apgar Score of 6/8. Currently, the patient is undergoing outpatient care in the hematology oncology department and the baby is undergoing outpatient care with the pediatrics department. Discussion:Clinical experience and patient values are essential considerations in making appropriate management decisions. The management dilemma in this case required a holistic approach, facilitated by a social obstetrics and gynecology consultant. Clinical assessment indicated that early termination of pregnancy would not necessarily improve maternal prognosis, supporting the decision to continue conservative management. The multidisciplinary team conducted counselling through family meetings, ensuring that both patient and family were actively involved in the decision-making process. Therefore, obstetricians and gynecologists, particularly those engaged in social obstetrics and gynecology, play a crucial role as facilitators to achieve mutual agreement that reflects the expectations of all parties. Conclusion: This case demonstrates the importance of understanding a holistic approach and multidisciplinary team collaboration in decision-making for patients with breast cancer during pregnancy. Keywords: Holistic, Breast Cancer, Pregnancy
Bilateral High-Grade Sertoli–Leydig Cell Tumors with Gallbladder Metastasis Presenting as Obstructive Jaundice Tejo Jayadi; Hanggoro Tri Rinonce; Lili Ananta Saputra; Theresia Hening Dwi Ambarwati; Merari Panti Astuti; Sutaryanu Sutaryanu
Indonesian Journal of Obstetrics and Gynecology Volume 14. No. 2 April 2026
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v14i2.2944

Abstract

Introduction: Sertoli-Leydig cell tumor (SLCT) is a rare ovarian sex cord-stromal tumor.High-grade SLCT is more aggressive and potentially metastasizes, generally through expansion to the peritoneum or lymphovascular metastasis. Metastases to the walls of vesica fellea are very rare. Case description: A 52-year-old woman with heartburn for one week, accompanied by icteric eyes, nausea, vomiting, watery pale diarrhea for five days, and dark brown urine. Laboratory of all liver function were elevated, CEA slightly increased CEA, and CA-125 normal. Ultrasound and MSCT of the abdomen examination exhibited a solid mass of ovaries. MRCP showed multiple stones in the vesica fellea accompanied by cholangitis and obstructive jaundice. The clinical diagnosis was suspected of ovarian cancer with cholelithiasis and cholecystitis, complicated by jaundice is established. The patient underwent TAH-BSO surgery and cholecystectomy. The histopathological examination of the left and right ovaries revealed poorly differentiated, diffuse, and partially tubule-looking Sertoli-Leydig cells in hypercellular and hypocellular ovarian tumors. Polymorphic tumor cells, pleomorphic nuclei, partially with mucin-containing cytoplasm, form a signet ring. Immunohistochemicals of calretinin and inhibin were positively expressed, while EMA and CK were negatively expressed. High-grade SLCT was established as a definitive diagnosis. Histopathological examination of the vesica fellea showed a concluding secondary tumor from the ovary. Conclusion: SLCT incidence is <0.5% of ovarian tumors. Grade and histopathology type determine its nature. High-grade tumor prognosis is inferior serous carcinoma, signet-ring stromal tumor, and gastrointestinal adenocarcinoma metastases were the differential diagnoses because of histopathological morphology similarity. This may be the first case of bilateral high-grade SLCT with metastases to the vesica fellea causing obstructive jaundice.
Serum Zinc and Copper Levels and their Association with Mental Distress in Postmenopausal Women Irmiya Rachmiyani; Shofwal Widad; Agung Dewanto
Indonesian Journal of Obstetrics and Gynecology Volume 14. No. 2 April 2026
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v14i2.3085

Abstract

AbstractObjective: To investigate the relationship between serum zinc (Zn) and copper (Cu) levels and mental distress in postmenopausal women.Methods: This cross-sectional study included 87 postmenopausal women. Participants with a history of hysterectomy or estrogen therapy were excluded. Mental distress was assessed using the Self-Reporting Questionnaire-20 (SRQ-20). Serum Zn and Cu concentrations were measured using Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Data were analyzed using SPSS version 25, employing independent t-tests, Mann–Whitney tests, and Pearson correlation analysis.Results: The mean serum zinc levels in participants with and without mental distress were 67.93 ± 9.03 µg/dL and 71.07 ± 12.99 µg/dL, respectively (p = 0.390). The mean serum copper levels were 129.38 ± 12.31 µg/dL in participants with mental distress and 131.78 ± 18.22 µg/dL in those without (p = 0.638). No significant correlations were found between serum zinc or copper levels and mental distress (r = -0.03, p = 0.775; r = -0.002, p = 0.984, respectively). These findings suggest that zinc and copper may not serve as reliable biomarkers for screening mental distress in postmenopausal women.Conclusion: Serum zinc and copper levels were not significantly associated with mental distress in postmenopausal women.keywords: copper, mental distress, postmenopausal, zinc.
Oocyte Cryopreservation in Young Women with Low Ovarian Reserve Following Repeated Bilateral Ovarian Cystectomy Cepi Teguh Pramayadi; Rahmi Isman
Indonesian Journal of Obstetrics and Gynecology Volume 14. No. 2 April 2026
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v14i2.3109

Abstract

Abstract Background: Fertility preservation has become an important aspect for women at risk of diminished ovarian reserve, including patients with ovarian disease. Ovarian cystectomy is known to adversely affect ovarian reserve, particularly after repeated procedures. Oocyte cryopreservation has emerged as an established strategy for preserving fertility potential in such cases. Objective: We report a 23-year-old nulligravid, unmarried, and not sexually active patient with a history of repeated ovarian surgery for managing ovarian cysts. Ovarian reserve testing revealed a markedly reduced anti-Müllerian hormone (0.8 ng/mL), consistent with diminished ovarian reserve. The patient underwent oocyte cryopreservation initiated with controlled ovarian stimulation. Oocyte retrieval yielded three mature oocytes, which were successfully cryopreserved without complication. Consistent with our case, previous studies have shown a 30–50% decline in AMH after cystectomy, with more pronounced effects in bilateral disease or repeated surgery. Although the number of retrieved oocytes was limited, oocyte cryopreservation provided the patient with the possibility of future reproductive options. Conclusion: This case highlights that repeated ovarian surgery can significantly impair ovarian reserve, threatening the future reproductive potential of young women. Although the number of mature oocytes retrieved in patients with diminished ovarian reserve may be limited, oocyte cryopreservation remains an effective strategy to preserve fertility. Keywords: anti-Müllerian hormone, fertility preservation, oocyte cryopreservation, ovarian cystectomy, ovarian reserve, young women.
Effect of Kitolod (Hippobroma longiflora L.G. Don) Extract on Apoptosis through Bcl-2 and Caspase-3 Expression in Wistar Rats (Rattus norvegicus) Induced by Benzo[a]pyrene Ana Bina Sari; Eman Sutrisna; Daniel Joko Wahyono
Indonesian Journal of Obstetrics and Gynecology Volume 14. No. 2 April 2026
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v14i2.3131

Abstract

ABSTRACT Objective: This study aimed to evaluate the effect of ethanol extract of H. longiflora leaves on apoptosis regulation through Bcl-2 and Caspase-3 expression in BaP-induced Wistar rats (Rattus norvegicus). Methods: An experimental study with a post-test only control group design was conducted. Twenty-five female Wistar rats were randomly allocated into five groups: healthy control, negative control (BaP only), and three groups receiving kitolod extract at 100, 200, or 300 mg/kg BW. BaP administration was followed, one hour later, by co-treatment with the extract for 30 consecutive days. Cervical tissues were analyzed immunohistochemically for Bcl-2 and Caspase-3 expression. Results: Kitolod extract significantly reduced Bcl-2 expression compared with the negative control (p < 0.05) and increased Caspase-3 expression, with the strongest effect observed at 300 mg/kg BW. The healthy control group exhibited the lowest expression levels, while the negative control group showed the highest, demonstrating a consistent dose-response relationship. Conclusion: Ethanol extract of H. longiflora leaves suppressed Bcl-2 and enhanced Caspase-3 expression, thereby promoting activation of the intrinsic apoptotic pathway. Keywords: Hippobroma longiflora, benzo[a]pyrene, Bcl-2, Caspase-3, apoptosis, cervical cancer
Postpartum Hemorrhage and Preeclampsia in the Asia-Pacific Region: why are Mothers Still Dying? Deviana Soraya Riu
Indonesian Journal of Obstetrics and Gynecology Volume 14. No. 2 April 2026
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v14i2.3319

Abstract

N/A
Management of Postpartum Hemorrhage: A Comprehensive Review of Current Evidence and International Guideline Recommendations Eka Rusdianto Gunardi
Indonesian Journal of Obstetrics and Gynecology Volume 14. No. 2 April 2026
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v14i2.3325

Abstract

N/A
High-risk Human Papillomavirus Detection in Self-Sampling compared to Clinician Sampling: A Cross-Sectional Study Andrijono Andrijono; Junita Indarti; Gumilang Gumilang; Kristian Alda
Indonesian Journal of Obstetrics and Gynecology Volume 14. No. 2 April 2026
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v14i2.3376

Abstract

AbstractObjective: To evaluate the diagnostic accuracy of high-risk human papillomavirus (HPV) DNA detection using the Hybrid Capture II assay in self-collected samples compared with clinician-collected samples.Methods: This cross-sectional diagnostic accuracy study enrolled women with abnormal cervical cytology or positive visual inspection with acetic acid (VIA) results at Dr. Cipto Mangunkusumo General Hospital, Jakarta. Participants performed self sampling followed by clinician-collected sampling. High-risk HPV DNA was detected using the Hybrid Capture II assay. Clinician-collected samples served as the reference standard.Results: High-risk HPV prevalence was 44.9%. Self-sampling showed substantial agreement with clinician-collected sampling (κ = 0.76), with 88.41% accuracy, 80.65% sensitivity, 94.74% specificity, 92.59% PPV, and 85.71% NPV.Conclusion: Self-sampling demonstrated comparable diagnostic performance to clinician-collected sampling and may be a reliable alternative for improving cervical cancer screening coverage in Indonesia.Keywords: cervical cancer screening; clinician-collected sampling; high-risk human papillomavirus; Hybrid Capture II; selfsampling

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