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Medicinus : Jurnal Kedokteran

Medicinus : Jurnal Kedokteran
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Published by Universitas Pelita Harapan

ISSN : 19783094 EISSN : 26226995 DOI : -

Core Subject : Health,

Medicine & Pharmacology Public Health

Medicinus: Jurnal Kedokteran is an official journal of the Faculty of Medicine, Universitas Pelita Harapan launched in the year 2007. Medicinus is a peer-reviewed and open-access journal that covers basic, translational, or clinical aspects of health and medical science. Medicinus accepts original research articles, review articles, and also interesting case reports. Medicinus: Jurnal Kedokteran is published three times a year in February, June, and October.

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Articles 429 Documents

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The Therapeutic Potential of Neural Stem Cell in Ischemic Stroke: A Systematic Review Periyanto, Toni; Putri, Evira Agustina; Romano, Sultan Adhitya; Riantiarno, Chairizia; Kamal, M. Aulady Rifki; Aulia, Indri Noer; Sugianto, Michael Aquilar
Medicinus Vol. 14 No. 3 (2025): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v14i3.10165

Background: Ischemic stroke remains a leading cause of disability and mortality worldwide, with over 12 million new cases annually and limited treatment options confined to narrow therapeutic windows. Neural stem cells (NSCs) have emerged as a promising therapeutic avenue due to their ability to self-renew, differentiate into all neural lineages, and exert paracrine effects that modulate inflammation and promote neurogenesis. Preclinical studies have demonstrated functional improvements of up to 60% in animal stroke models, but a systematic evaluation of these findings is needed to inform future clinical applications. Methods: A systematic review was conducted following PRISMA 2020 guidelines. Databases searched included PubMed, EMBASE, and Scopus, covering literature up to May 8, 2025. Inclusion criteria comprised in vivo preclinical studies investigating NSC transplantation in animal models of ischemic stroke with at least one neurological, infarct, or histological outcome. Data extraction and risk of bias assessment (ROBINS-I) were independently performed by three reviewers. Due to study heterogeneity, a narrative synthesis was undertaken. Result: Eight studies met the inclusion criteria. NSC therapy improved neurological recovery in over 80% of cases, reduced infarct volume by up to 40%, and downregulated pro-inflammatory and apoptotic markers. Benefits were dose- and timing-dependent, with intracerebral and intravenous routes demonstrating variable efficacy. One study reported tumorigenicity, highlighting the need for safety profiling. Conclusions: Preclinical evidence supports the therapeutic potential of NSCs in ischemic stroke through neuroprotective and neurorestorative mechanisms. High-certainty findings justify continued investigation in clinical trials to refine dosing, delivery, and safety protocols.

Vaccine-Based Immunotherapy for Metastatic Colorectal Cancer: A Systematic Review Amelia, Sesa; Mathlubaa, Asya; Amly, Harzalina Zilfi; Jacobs, Christin Yosefin; Halim, Kurnia; Heriawan, Timotius Ivan; Guantoro, Vincent; Putri, Hesti Andika
Medicinus Vol. 14 No. 3 (2025): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v14i3.10166

Background: Metastatic colorectal cancer (mCRC) remains a therapeutic challenge, particularly in microsatellite stable (MSS) tumors, which are largely unresponsive to current immunotherapy approaches. Vaccine-based immunotherapy offers a strategy to elicit tumor-specific immune responses in these immunologically “cold” tumors. However, clinical results have been mixed, and the efficacy and safety of cancer vaccines in mCRC remain to be clarified. Methods: A systematic review and meta-analysis were conducted in accordance with PRISMA 2020 guidelines. Randomized controlled trials (RCTs) evaluating vaccine-based immunotherapy in mCRC were identified from PubMed, EMBASE, and Scopus as of May 2, 2025. Eligible studies included human subjects with mCRC receiving vaccine therapy with or without additional treatments, compared to standard or placebo regimens. The primary outcomes were overall survival (OS) and progression-free survival (PFS); safety was assessed by the incidence of grade ≥3 treatment-related adverse events. Result: Five RCTs comprising 804 patients met inclusion criteria. Pooled analysis showed a trend toward improved OS with vaccine-based immunotherapy (HR 0.81; 95% CI, 0.65–1.00; p = 0.05; I² = 0%), and a modest, non-significant improvement in PFS (HR 0.80; 95% CI, 0.62–1.05; p = 0.07; I² = 0%). The incidence of severe adverse events was lower with vaccine-based therapies (RR 0.31; 95% CI, 0.02–6.09; p = 0.23; I² = 90%). Conclusions: Vaccine-based immunotherapy in mCRC demonstrates potential clinical benefit, particularly in prolonging survival with a favorable safety profile. Further biomarker-driven studies are needed to optimize patient selection and therapeutic combinations.

Diagnosis and Surgical Management of Annular Pancreas in an 18-Day-Old Neonate: A Case Report Alim, Tasya Fabiola; Alim, Linawati; Alim, Kenny Dion
Medicinus Vol. 13 No. 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i2.10182

Background: This case report presents a rare and challenging condition—annular pancreas—in an 18-day-old neonate. Annular pancreas is a congenital anomaly where a ring of pancreatic tissue encircles the duodenum, leading to gastrointestinal obstruction. Early diagnosis and intervention are crucial for optimal patient outcomes. The rarity of this condition in neonates underscores its clinical significance. Case Description: The patient presented with a history of persistent vomiting since birth, which initially appeared green but later turned yellow. The infant had been fed various types of milk sequentially, with vomiting occurring after each feeding. Additionally, the infant developed jaundice a week prior to presentation, which was treated without improvement in symptoms. Diagnostic modalities included abdominal X-ray, ultrasound, and upper gastrointestinal contrast study, which collectively confirmed a partial obstruction at the gastroduodenal junction due to annular pancreas. The definitive treatment involved a laparotomy for exploratory surgery, followed by a duodenoduodenostomy using the Kimura technique to address the anatomical abnormality. Postoperative management included prophylactic antibiotics, anti-emetic therapy, acid suppression, and probiotics to support recovery. The outcome of the case was favorable, with successful resolution of the gastrointestinal obstruction following the surgical intervention. Conclusions: This case underscores the importance of early recognition, precise diagnosis, and multidisciplinary intervention in managing congenital anomalies like annular pancreas, ultimately leading to favorable outcomes and improved quality of life for neonatal patients..

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i2.10182

Efficacy and Safety of Stem Cell Therapy for Spinal Cord Injury in Adults: A Systematic Review and Meta-Analysis Rhadika, Anadya; Romano, Sultan Adhitya; Widyatmiko, Himawan; Tanuwijaya, Andrew Wilbert; Putra, Putu Surya Pradipta Hariantha; Amanah, Salma Rizqi; Elashry, Abdelrahman Ramadan; Javaid, Sarmad; Inggas, Made Agus Mahendra; Wijaya, Jeremiah Hilkiah
Medicinus Vol. 15 No. 1 (2025): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i1.10762

Background: Despite encouraging early results, clinical outcomes remain inconsistent across trials. This study aimed to systematically evaluate the efficacy and safety of stem cell therapy in adults with spinal cord injury (SCI). Methods: A systematic review and meta-analysis were conducted following PRISMA 2020 guidelines. PubMed, EMBASE, and Scopus were searched until 18 October 2025. Eligible studies included adult SCI patients receiving stem cell therapy with measurable neurological outcomes. Data synthesis was performed using Review Manager 5.4 under a random-effects model, reporting pooled risk ratios (RR) with 95% confidence intervals (CIs). Risk of bias was assessed using ROBINS-I, and evidence certainty was graded via GRADE. Result: Thirteen studies involving 470 participants (286 intervention, 184 control) were included. Stem cell therapy significantly improved neurological recovery compared with controls (RR = 2.64; 95% CI 1.70–4.10; p < 0.0001; I² = 0%). Subgroup analyses showed consistent benefits across baseline AIS classifications (RR = 2.61; 95% CI 1.71–3.98) and cell doses (RR = 2.75; 95% CI 1.63–4.64). No major safety signals were identified. GRADE assessment rated the certainty of efficacy evidence as moderate. Conclusions: Stem cell therapy yields significant neurological improvement in adult SCI with a favorable safety profile. The findings support its regenerative potential through neuroprotective and remyelinating mechanisms. However, larger randomized controlled trials are required to validate efficacy, optimize protocols, and assess long-term safety.

A Descriptive Study of Thesis Completion Challenges Among Medical Students Suryadinata, Neneng; Neolaka, Gladies Mercya; Siregar, Rohana Uly Pradita
Medicinus Vol. 15 No. 1 (2025): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i1.10763

Background: The Final Project (FP) is a mandatory course for medical education students, typically undertaken in the sixth semester. It is divided into two stages: Final Project 1 (FP1) and Final Project 2 (FP2). In FP1, students develop, document, and present a research proposal, while in FP2, they execute the planned research, analyze the results, and present their findings. A decline in FP2 completion rates was observed in 2024, raising concerns about factors affecting student performance. Methods: A descriptive analysis methods approach was used, combining quantitative surveys (n=91) and qualitative interviews. The survey, with 10 questions on a 4-point Likert scale, assessed factors affecting FP2 completion. Semi-structured interviews and written responses explored deeper insights, with thematic analysis identifying key barriers. Results: Survey results revealed moderate motivation (mean=2.77) and high procrastination (mean=3.01). Time management (mean=2.86) and personal issues (mean=2.35) were significant challenges. The main delays were lack of motivation (36.26%) and time management issues (27.47%). Themes from interviews included motivation, time management, supervisor support, data access, and mental health. Conclusions: Students face key challenges in completing the FP2 course, particularly low motivation, poor time management, and limited supervisor interaction. Addressing these issues through enhanced intrinsic motivation, effective feedback, and structured time management can foster more successful and high-effort student profiles.

Dietary Intake and Physical Activity of Medical School Students at Universitas Pelita Harapan, Indonesia Rivami, Dwi S.; Siregar, Rohana U.P.; Suryadinata, Neneng
Medicinus Vol. 15 No. 1 (2025): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i1.10764

Background: Medical students face high academic demands, which often lead to irregular eating patterns and a lack of physical activity, which can have a negative influence on their nutritional status and overall well-being. This study aimed to evaluate the dietary intake and physical activity levels among medical students at Universitas Pelita Harapan, Indonesia. Methods: A cross-sectional study was conducted on 70 undergraduate medical students. Demographic data and physical activity levels (assessed using the International Physical Activity Questionnaire, IPAQ) were collected. Dietary intake was evaluated using a semi-quantitative food frequency questionnaire (SQ-FFQ), and nutrient intakes were analyzed and compared with the Indonesian Recommended Dietary Allowances (RDA) for women aged 19–29 years. Data analysis included descriptive statistics for continuous and categorical variables. Results: There were 70 participants, with a mean age was 20.73 ± 0.81 years; the majority were female (n = 62). Physical activity levels were distributed as 35.7% low, 38.6% moderate, and 25.7% high. Mean daily energy intake (1677.58 kcal) was below the RDA, as were intakes of fat, carbohydrates, fiber, calcium, sodium, potassium, and vitamin A. Intakes of protein, phosphorus, iron, vitamin C, riboflavin, and niacin were above RDA recommendations. Conclusions: Medical students at Universitas Pelita Harapan were found to have suboptimal dietary intake, particularly with regard to energy, fiber, and several micronutrients, as well as varying levels of physical activity. These findings emphasize the need for targeted interventions to promote balanced nutrition and regular physical activity in this population.

Exploring the Association Between HIV Knowledge and Prevention Attitudes Among Health Science Students Atmodjo, Wahyuni Lukita; Suryadinata, Neneng; Moningkey, Shirley; Siregar, Rohana Uly Pradita
Medicinus Vol. 15 No. 1 (2025): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i1.10765

ound: HIV continues to be a major public health concern worldwide, and comprehensive understanding has shown that HIV knowledge enhances effective prevention behaviors and helps prevent the transmission of the disease. Previous research conducted indicated that higher levels of knowledge were associated with more positive attitudes toward HIV prevention, specifically, 58.7% demonstrated good knowledge and 70.7% engaged in preventive actions. Health science students are a key group for HIV education, as they are future healthcare providers. However, limited research has been done among health science students. Methods: A cross-sectional study was conducted with 295 health science students consisting of 193 medical and 102 non-medical students. Participants completed two questionnaires, i.e., HIV knowledge with 24 true/false items and HIV prevention attitudes with 23 items on a Likert scale. Descriptive and inferential statistics, including chi-square tests and multivariate logistic regression, were used to analyze the data. Results: Of the respondents, 43.4% demonstrated good HIV knowledge, while 56.6% had poor knowledge. Regarding prevention attitudes, 59.7% exhibited favorable attitudes, while 40.3% had unfavorable attitudes. A significant positive association was found between HIV knowledge and prevention attitudes (p < 0.001, OR: 2.525, 95% CI: 1.546–4.123). Gender differences were noted, with females displaying more favorable attitudes (p < 0.001, OR: 2.551, 95% CI: 1.487–4.379). Medical students showed less favorable attitudes toward HIV prevention compared to non-medical students (p = 0.042, OR: 1.681, 95% CI: 1.017–2.778). Conclusions: This study highlights the influence of HIV knowledge, gender, and faculty on HIV prevention attitudes among health science students, with females and non-medical students showing more engagement in prevention efforts. These findings underscore the need for comprehensive HIV education in university curricula to enhance both knowledge and preventive behaviors.

Knowledge of coronary heart disease risk factors and associated dietary fat intake among medical students Zalukhu, Hansaro Andika; Nugroho, Haddiyya Wardhani; Pradhipta, Hanandhito Satya; Wijaya, Ratna Sari
Medicinus Vol. 15 No. 1 (2025): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i1.10766

Background: Coronary heart disease (CHD) prevalence has increased among young adults. The most common CHD risk factor among young adults was high daily fat intake. Knowledge regarding CHD risk factors was a crucial element in determining health behaviour, including healthy dietary patterns. However, the level of CHD knowledge and its association with dietary fat intake among medical students is still unclear. Methods: The study was performed among preclinical medical students at the Pelita Harapan University, Indonesia. The CHD risk factor knowledge was assessed using the validated Heart Disease Fact Questionnaire (HDFQ), comprising of 25 items. The dietary fat intake was evaluated using the validated Block Dietary Fat Screener (BDFS) questionnaire. Results: A total of 98 participants were included in this study. The median age of the participants was 19 years (IQR 18-20). Of the 98 participants, 71 (72%) participants had adequate knowledge of CHD risk factors. Older age, being female, and being in the third year of medical study were related to higher HDFQ scores. The daily fat intake was classified as high in 33 (34%) of participants and very high in 33 (34%) of participants. No significant difference in dietary fat intake level was observed between participants with and without adequate knowledge of CHD risk factors. Conclusion: This study reveals that most medical students had adequate knowledge of CHD risk factors. However, the knowledge factor did not lead to healthy dietary pattern adoption among medical students, suggesting that the implementation of an education and training program to motivate lifestyle modification was required.

⁠Dapsone Induced Methemoglobinemia in Pediatric Patient: A Case Report Addyanto, Brian; Lukman, Leni
Medicinus Vol. 15 No. 1 (2025): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i1.10767

Background: Acquired methemoglobinemia is significantly more common than the congenital form, though it remains a rare condition. Most cases arise from accidental chemical exposure or the use of topical and local anesthetics. Case Description: We present a case of 14-year-old male presented with complaints of dark grayish discoloration of the skin on the face and hands, persisting for the past two months prior to admission. He was later diagnosed with dapsone induced methemoglobinemia. Patient was then discharged with oral therapy consisting of agents with antioxidant properties and instructed to discontinue dapsone consumption. Conclusions: In pediatric patients undergoing dapsone therapy, the risk of dapsone induced methemoglobinemia should be carefully considered to ensure early identification and prompt management, thus minimizing the potential for severe complications.

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Julius July

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